Proc

Summary

Gene Symbol: Proc
Description: Proctolin
Alias: CG7105, Dmel\CG7105, PROC, PROCT, Prct, Proct, proct, proctolin, CG7105-PA, CG7105-PB, Proc-PA, Proc-PB
Species: fruit fly

Top Publications

  1. Iversen A, Cazzamali G, Williamson M, Hauser F, Grimmelikhuijzen C. Molecular cloning and functional expression of a Drosophila receptor for the neuropeptides capa-1 and -2. Biochem Biophys Res Commun. 2002;299:628-33 pubmed
    ..Because capa-1 and -2 and related insect neuropeptides stimulate fluid secretion in insect Malpighian (renal) tubules, the identification of this first insect capa receptor will advance our knowledge on insect renal function. ..
  2. Iversen A, Cazzamali G, Williamson M, Hauser F, Grimmelikhuijzen C. Molecular identification of the first insect ecdysis triggering hormone receptors. Biochem Biophys Res Commun. 2002;299:924-31 pubmed
    ..Ecdysis (cuticle shedding) is an important behaviour, allowing growth and metamorphosis in insects and other arthropods. Our paper is the first report on the molecular identification of ecdysis triggering hormone receptors from insects. ..
  3. Rosenkilde C, Cazzamali G, Williamson M, Hauser F, Søndergaard L, DeLotto R, et al. Molecular cloning, functional expression, and gene silencing of two Drosophila receptors for the Drosophila neuropeptide pyrokinin-2. Biochem Biophys Res Commun. 2003;309:485-94 pubmed
    ..The two Drosophila pyrokinin receptors are, to our knowledge, the first invertebrate pyrokinin receptors to be identified. ..
  4. J rgensen L, Hauser F, Cazzamali G, Williamson M, Grimmelikhuijzen C. Molecular identification of the first SIFamide receptor. Biochem Biophys Res Commun. 2006;340:696-701 pubmed publisher
    ..This paper is the first report on the identification of a SIFamide receptor...
  5. Birse R, Johnson E, Taghert P, Nassel D. Widely distributed Drosophila G-protein-coupled receptor (CG7887) is activated by endogenous tachykinin-related peptides. J Neurobiol. 2006;66:33-46 pubmed
    ..Our findings suggest that DTKR is a DTK receptor in Drosophila and that this ligand-receptor system plays multiple functional roles. ..
  6. Egerod K, Reynisson E, Hauser F, Cazzamali G, Williamson M, Grimmelikhuijzen C. Molecular cloning and functional expression of the first two specific insect myosuppressin receptors. Proc Natl Acad Sci U S A. 2003;100:9808-13 pubmed
    ..To our knowledge, this paper is the first report on the molecular identification of specific insect myosuppressin receptors. ..
  7. Johnson E, Tift F, McCauley A, Liu L, Roman G. Functional characterization of kurtz, a Drosophila non-visual arrestin, reveals conservation of GPCR desensitization mechanisms. Insect Biochem Mol Biol. 2008;38:1016-22 pubmed publisher
    ..Furthermore, we report that kurtz mutants exhibit hypersensitivity to osmotic stress, implicating GPCR desensitization as an important feature of the endocrine events that shape this stress response. ..
  8. Han M, Park D, Vanderzalm P, Mains R, Eipper B, Taghert P. Drosophila uses two distinct neuropeptide amidating enzymes, dPAL1 and dPAL2. J Neurochem. 2004;90:129-41 pubmed
    ..dPAL1 expression is highly correlated with the non-amidated peptide proctolin. Tissue immunostaining demonstrates that dPAL1 is largely localized to the cell soma, whereas dPAL2 is ..
  9. Anderson M, Halpern M, Keshishian H. Identification of the neuropeptide transmitter proctolin in Drosophila larvae: characterization of muscle fiber-specific neuromuscular endings. J Neurosci. 1988;8:242-55 pubmed
    The cellular localization of the peptide neurotransmitter proctolin was determined for larvae of the fruitfly Drosophila melanogaster...

More Information

Publications22

  1. Salmand P, Iché Torres M, Perrin L. Tissue-specific cell sorting from Drosophila embryos: application to gene expression analysis. Fly (Austin). 2011;5:261-5 pubmed
    ..5 to 1% of total cells within the whole embryo. Based on widely available fluorescent reporter transgenes, this method should be applicable to a number of tissues and organs. ..
  2. Hector C, Bretz C, Zhao Y, Johnson E. Functional differences between two CRF-related diuretic hormone receptors in Drosophila. J Exp Biol. 2009;212:3142-7 pubmed publisher
    ..The functional characterization of this diuretic hormone receptor in Drosophila demonstrates a high degree of conservation of CRF-like signaling. ..
  3. Johnson E, Shafer O, Trigg J, Park J, Schooley D, Dow J, et al. A novel diuretic hormone receptor in Drosophila: evidence for conservation of CGRP signaling. J Exp Biol. 2005;208:1239-46 pubmed
    ..Therefore, it appears that both the molecular details as well as the functional organization of CGRP signaling have been conserved. ..
  4. Min S, Chae H, Jang Y, Choi S, Lee S, Jeong Y, et al. Identification of a Peptidergic Pathway Critical to Satiety Responses in Drosophila. Curr Biol. 2016;26:814-20 pubmed publisher
    ..Together, our results reveal a novel anorexigenic pathway that controls satiety in Drosophila and provide a new avenue to study how the brain actively maintains a constant BW. ..
  5. Kahsai L, Winther A. Chemical neuroanatomy of the Drosophila central complex: distribution of multiple neuropeptides in relation to neurotransmitters. J Comp Neurol. 2011;519:290-315 pubmed publisher
    ..different neuropeptides; Drosophila tachykinin, short neuropeptide F, myoinhibitory peptide, allatostatin A, proctolin, SIFamide, neuropeptide F, and FMRFamide...
  6. Taylor C, Winther A, Siviter R, Shirras A, Isaac R, Nassel D. Identification of a proctolin preprohormone gene (Proct) of Drosophila melanogaster: expression and predicted prohormone processing. J Neurobiol. 2004;58:379-91 pubmed
    b>Proctolin was the first insect neuropeptide to be sequenced and has been the subject of many physiological and pharmacological studies in insects and crustaceans...
  7. Ui Tei K, Sakuma M, Watanabe Y, Miyake T, Miyata Y. Chemical analysis of neurotransmitter candidates in clonal cell lines from Drosophila central nervous system, II: Neuropeptides and amino acids. Neurosci Lett. 1995;195:187-90 pubmed
    ..Substance P and proctolin were found in seven and eight out of ten clones, respectively...
  8. Miguel Aliaga I, Thor S. Segment-specific prevention of pioneer neuron apoptosis by cell-autonomous, postmitotic Hox gene activity. Development. 2004;131:6093-105 pubmed
    ..In addition, they provide a novel mechanism linking Hox positional information to differences in neuronal architecture along the anteroposterior axis by the selective elimination of mature neurons. ..
  9. Mazzocco C, Fukasawa K, Auguste P, Puiroux J. Characterization of a functionally expressed dipeptidyl aminopeptidase III from Drosophila melanogaster. Eur J Biochem. 2003;270:3074-82 pubmed
    ..The partially purified enzyme hydrolysed the insect myotropic neuropeptide proctolin (Arg-Tyr-Leu-Pro-Thr) at the Tyr-Leu bond (Km approximately 4 micro m)...
  10. Egerod K, Reynisson E, Hauser F, Williamson M, Cazzamali G, Grimmelikhuijzen C. Molecular identification of the first insect proctolin receptor. Biochem Biophys Res Commun. 2003;306:437-42 pubmed
    ..Screening of a neuropeptide library revealed that the expressed receptor was specific for the neuropeptide proctolin (EC(50), 6x10(-10)M)...
  11. Cazzamali G, Saxild N, Grimmelikhuijzen C. Molecular cloning and functional expression of a Drosophila corazonin receptor. Biochem Biophys Res Commun. 2002;298:31-6 pubmed
    ..Furthermore, a receptor that is structurally very similar to the Drosophila corazonin receptor can be found in the genomic database from the malaria mosquito Anopheles gambiae. ..
  12. Wegener C, Gorbashov A. Molecular evolution of neuropeptides in the genus Drosophila. Genome Biol. 2008;9:R131 pubmed publisher
    ..The last common ancestor of Drosophila obviously had a set of neuropeptides and peptide hormones identical to that of modern fruit flies. This is remarkable, since drosophilid flies have adapted to very different environments. ..
  13. Johnson E, Bohn L, Taghert P. Drosophila CG8422 encodes a functional diuretic hormone receptor. J Exp Biol. 2004;207:743-8 pubmed
    ..The identification of a Drosophila receptor for the DH neuropeptide provides a basis for genetic analysis of this critical factor's roles in maintaining physiological homeostasis. ..