Prestin

Summary

Gene Symbol: Prestin
Description: prestin
Alias: CG5485, CG5845, Dmel\CG5485, Slc26a5, dPrestin, dpres, prestin, CG5485-PA, Prestin-PA
Species: fruit fly

Top Publications

  1. Hirata T, Czapar A, Brin L, Haritonova A, Bondeson D, LINSER P, et al. Ion and solute transport by Prestin in Drosophila and Anopheles. J Insect Physiol. 2012;58:563-9 pubmed publisher
    ..and two Ag homologues of mammalian Slc26a5 (Prestin) and Slc26a6 (aka, PAT1, CFEX) were identified and designated dPrestin, AgPrestinA and AgPrestinB...
  2. Weber T, Gopfert M, Winter H, Zimmermann U, Kohler H, Meier A, et al. Expression of prestin-homologous solute carrier (SLC26) in auditory organs of nonmammalian vertebrates and insects. Proc Natl Acad Sci U S A. 2003;100:7690-5 pubmed
    b>Prestin, the fifth member of the anion transporter family SLC26, is the outer hair cell molecular motor thought to be responsible for active mechanical amplification in the mammalian cochlea...
  3. Hirata T, Cabrero P, Berkholz D, Bondeson D, Ritman E, Thompson J, et al. In vivo Drosophilia genetic model for calcium oxalate nephrolithiasis. Am J Physiol Renal Physiol. 2012;303:F1555-62 pubmed publisher
    ..The Slc26 anion transporter dPrestin (Slc26a5/6) is strongly expressed in Drosophilia kidney, and biophysical analysis shows that it is a potent ..
  4. Kavlie R, Fritz J, Nies F, Göpfert M, Oliver D, Albert J, et al. Prestin is an anion transporter dispensable for mechanical feedback amplification in Drosophila hearing. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2015;201:51-60 pubmed publisher
    In mammals, the membrane-based protein Prestin confers unique electromotile properties to cochlear outer hair cells, which contribute to the cochlear amplifier...
  5. Landry G, Hirata T, Anderson J, Cabrero P, Gallo C, Dow J, et al. Sulfate and thiosulfate inhibit oxalate transport via a dPrestin (Slc26a6)-dependent mechanism in an insect model of calcium oxalate nephrolithiasis. Am J Physiol Renal Physiol. 2016;310:F152-9 pubmed publisher
    ..investigated using the Drosophila model, as well as electrophysiological effects on both Drosophila (Slc26a5/6; dPrestin) and mouse (mSlc26a6) oxalate transporters utilizing the Xenopus laevis oocyte heterologous expression system...