Gene Symbol: PPP1R15
Description: Protein phosphatase 1 regulatory subunit 15
Alias: CG3825, Dm-GADD34, Dmel\CG3825, GADD34, Gadd34, dGADD34, dPPP1R15, gadd34, protein phosphatase 1 regulatory subunit 15, CG3825-PA, PPP1R15-PA, growth arrest and DNA-damage-inducible 34
Species: fruit fly
Malzer E, Szajewska Skuta M, Dalton L, Thomas S, Hu N, Skaer H, et al
. Coordinate regulation of eIF2Î± phosphorylation by PPP1R15 and GCN2 is required during Drosophila development. J Cell Sci. 2013;126:1406-15 pubmed publisher
..Moreover, we show that its expression is necessary for embryonic and larval development and that this is to oppose the inhibitory effects of GCN2 on anabolic growth. ..
Kashevsky H, Wallace J, Reed B, Lai C, Hayashi Hagihara A, Orr Weaver T. The anaphase promoting complex/cyclosome is required during development for modified cell cycles. Proc Natl Acad Sci U S A. 2002;99:11217-22 pubmed
..The mr mutants further indicate that transient mitotic functions in endo cycles change chromosome morphology from polytene to polyploid. ..
Garrey J, Lee Y, Au H, Bushell M, Jan E. Host and viral translational mechanisms during cricket paralysis virus infection. J Virol. 2010;84:1124-38 pubmed publisher
..Forced dephosphorylation of deIF2alpha by overexpression of dGADD34, which activates protein phosphatase I, did not prevent translational shutoff nor alter virus production, ..
Kim H, Raphael A, LADOW E, McGurk L, Weber R, Trojanowski J, et al
. Therapeutic modulation of eIF2? phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models. Nat Genet. 2014;46:152-60 pubmed publisher
..These findings indicate that the dysfunction induced by prolonged stress granule formation might contribute directly to ALS and that compounds that mitigate this process may represent a novel therapeutic approach. ..
Demay Y, Perochon J, Szuplewski S, Mignotte B, Gaumer S. The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model. Cell Death Dis. 2014;5:e1452 pubmed publisher
..Thanks to a novel chronic ER stress model, these results establish a new pathway that both participates in tissue homeostasis and triggers apoptosis through an original regulation. ..
Carra S, Boncoraglio A, Kanon B, Brunsting J, Minoia M, Rana A, et al
. Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases. J Biol Chem. 2010;285:37811-22 pubmed publisher
..Our current data further support the link between the HSPB8-BAG3 complex, autophagy, and folding diseases and demonstrate that impairment or loss of function of HSPB8 might accelerate the progression and/or severity of folding diseases. ..
Chambers J, Dalton L, Clarke H, Malzer E, Dominicus C, Patel V, et al
. Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2Î± dephosphorylation. elife. 2015;4: pubmed publisher
..by selective eIF2Î± phosphatases comprising a catalytic protein phosphatase 1 (PP1) subunit in complex with a PPP1R15-type regulatory subunit...
Ryoo H. Drosophila as a model for unfolded protein response research. BMB Rep. 2015;48:445-53 pubmed
..The fact that the basic UPR pathways are conserved, together with the availability of many human disease models in this organism, makes Drosophila a powerful tool for studying human disease mechanisms. ..