Gene Symbol: Pp4-19C
Description: Protein phosphatase 19C
Alias: CG1459, CG1596, CG18339, CG32505, DmPpp4-19C, Dmel\CG32505, PP1, PP4, PP4 19C, PP4-19C, PP4-19c, PP4C, PP4c, PPP4c, PPX, PpX, Ppp4c, dPP4, pp4, protein phosphatase 19C, CG32505-PA, CG32505-PE, CG32505-PG, CG32505-PH, CG32505-PI, Pp4-19C-PA, Pp4-19C-PE, Pp4-19C-PG, Pp4-19C-PH, Pp4-19C-PI, phosphoprotein phosphatase 4, protein phosphatase 1, protein phosphatase 4, protein phosphatase X
Species: fruit fly

Top Publications

  1. Sousa Nunes R, Chia W, Somers W. Protein phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions. Genes Dev. 2009;23:359-72 pubmed publisher
    ..In a clonal screen of larval neuroblasts we identified the evolutionarily conserved Protein Phosphatase 4 (PP4) regulatory subunit PP4R3/Falafel (Flfl) as a key mediator specific for the localization of Miranda (..
  2. Jia H, Liu Y, Yan W, Jia J. PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development. 2009;136:307-16 pubmed publisher
    ..Using an in vivo RNAi screen, we identified PP4 and PP2A as phosphatases that influence Hh signaling by regulating Smo and Ci, respectively...
  3. Chen F, Archambault V, Kar A, Lio P, D Avino P, Sinka R, et al. Multiple protein phosphatases are required for mitosis in Drosophila. Curr Biol. 2007;17:293-303 pubmed
    ..Strong mitotic arrest and chromosome congression failure occurred after Pp1-87B downregulation...
  4. Cohen P, Philp A, Vázquez Martin C. Protein phosphatase 4--from obscurity to vital functions. FEBS Lett. 2005;579:3278-86 pubmed
    b>Protein phosphatase 4 (Ppp4) is a ubiquitous serine/threonine phosphatase in the PPP family that is now recognised to regulate a variety of cellular functions independently of protein phosphatase 2A (PP2A)...
  5. Su Y, Ospina J, Zhang J, Michelson A, Schoen A, Zhu A. Sequential phosphorylation of smoothened transduces graded hedgehog signaling. Sci Signal. 2011;4:ra43 pubmed publisher
    ..We found that protein phosphatase 1 (PP1) directly dephosphorylated PKA-phosphorylated Smo to reduce signaling mediated by intermediate ..
  6. Bielinski V, Mumby M. Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase. Exp Cell Res. 2007;313:3117-26 pubmed
    ..Knockdown of PP4 caused a 20% decrease in dS6K phosphorylation and knockdown of PP6 had no effect...
  7. Cohen P. Important roles for novel protein phosphatases dephosphorylating serine and threonine residues. Biochem Soc Trans. 1993;21:884-8 pubmed
  8. Chen M, Chen Y, Cohen P. Polymerase chain reactions using Saccharomyces, Drosophila and human DNA predict a large family of protein serine/threonine phosphatases. FEBS Lett. 1992;306:54-8 pubmed
    ..the polymerase chain reaction (PCR) to examine the protein serine/threonine phosphatase (PP) family which includes PP1, PP2A and PP2B, we have identified two, seven, and four novel protein phosphatase genes in Saccharomyces cerevisiae,..
  9. Brookfield J. Population genetics: the signature of selection. Curr Biol. 2001;11:R388-90 pubmed
    ..New work on Drosophila genes that seem to have been subject to adaptive changes illustrates the difficulties in calculating the statistical significance of data trends that seem to show this. ..

More Information


  1. Nurminsky D, Aguiar D, Bustamante C, Hartl D. Chromosomal effects of rapid gene evolution in Drosophila melanogaster. Science. 2001;291:128-30 pubmed publisher
    ..These findings imply that the pattern of genetic variation along a chromosome may be useful for inferring its evolutionary history and for revealing regions in which recent adaptive fixations have taken place...
  2. Martin Granados C, Philp A, Oxenham S, Prescott A, Cohen P. Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases. Int J Biochem Cell Biol. 2008;40:2315-32 pubmed publisher
    The mechanisms that co-ordinate centrosome maturation and the migration of human cells remain elusive. Protein phosphatase 4 (Ppp4) is a ubiquitous protein serine/threonine phosphatase in eukaryotes that is enriched at centrosomes...
  3. Wang N, Leung H, Mazalouskas M, Watkins G, Gomez R, Wadzinski B. Essential roles of the Tap42-regulated protein phosphatase 2A (PP2A) family in wing imaginal disc development of Drosophila melanogaster. PLoS ONE. 2012;7:e38569 pubmed publisher
    Protein ser/thr phosphatase 2A family members (PP2A, PP4, and PP6) are implicated in the control of numerous biological processes, but our understanding of the in vivo function and regulation of these enzymes is limited...
  4. Silverstein A, Barrow C, Davis A, Mumby M. Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits. Proc Natl Acad Sci U S A. 2002;99:4221-6 pubmed
    Individual subunits of protein phosphatase 2A (PP2A), protein phosphatase 4, and protein phosphatase 5 were knocked out in Drosophila Schneider 2 cells by using RNA interference...
  5. Helps N, Brewis N, Lineruth K, Davis T, Kaiser K, Cohen P. Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos. J Cell Sci. 1998;111 ( Pt 10):1331-40 pubmed
    The protein serine/threonine phosphatase 4 (PP4), which localises to centrosomes/spindle pole bodies in human cells, is shown to exhibit a similar localisation in Drosophila cells and embryos and possess a highly conserved (91% identical)..
  6. Sousa Nunes R, Somers W. Phosphorylation and dephosphorylation events allow for rapid segregation of fate determinants during Drosophila neuroblast asymmetric divisions. Commun Integr Biol. 2010;3:46-9 pubmed
    ..We then discuss models previously proposed, as well as a new model, for apical-to-basal transition of the Mira complex in light of our new results. ..
  7. Zhang F, Huang Z, Bao H, Cong F, Wang H, Chai P, et al. Phosphotyrosyl phosphatase activator facilitates localization of Miranda through dephosphorylation in dividing neuroblasts. Development. 2016;143:35-44 pubmed publisher
    ..Furthermore, PTPA associates with the Protein phosphatase 4 complex to mediate localization of Mira...
  8. de Carcer G, do Carmo Avides M, Lallena M, Glover D, Gonzalez C. Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability. EMBO J. 2001;20:2878-84 pubmed
  9. Gonzalez C, Tavosanis G, Mollinari C. Centrosomes and microtubule organisation during Drosophila development. J Cell Sci. 1998;111 ( Pt 18):2697-706 pubmed
    ..In this review we present some of the many examples which illustrate how centrosomes and microtubule organisation changes through development in Drosophila and discuss some of its implications. ..
  10. Bulat V, Rast M, Pielage J. Presynaptic CK2 promotes synapse organization and stability by targeting Ankyrin2. J Cell Biol. 2014;204:77-94 pubmed publisher
    ..Our study identifies phosphorylation of structural synaptic components as a compelling mechanism to actively control the development and longevity of synaptic connections. ..
  11. Lipinszki Z, Lefevre S, Savoian M, Singleton M, Glover D, Przewloka M. Centromeric binding and activity of Protein Phosphatase 4. Nat Commun. 2015;6:5894 pubmed publisher
    ..b>Phosphoprotein phosphatase 4 (PP4) has been recently shown to participate in the regulation of cell cycle progression...