Gene Symbol: Pp1-Y2
Description: Protein phosphatase 1, Y-linked 2
Alias: CG40448, DmPp1-Y2, Dmel\CG40448, Pp1Y2, protein phosphatase 1, Y-linked 2, CG40448-PC, Pp1-Y2-PC
Species: fruit fly

Top Publications

  1. Koerich L, Wang X, Clark A, Carvalho A. Low conservation of gene content in the Drosophila Y chromosome. Nature. 2008;456:949-51 pubmed publisher
    ..3-52.5), indicating a clear tendency of the Y chromosomes to increase in gene content. In contrast with the mammalian Y chromosome, gene gains have a prominent role in the evolution of the Drosophila Y chromosome...
  2. Adám C, Henn L, Miskei M, Erdelyi M, Friedrich P, Dombradi V. Conservation of male-specific expression of novel phosphoprotein phosphatases in Drosophila. Dev Genes Evol. 2010;220:123-8 pubmed publisher
    ..Interestingly, the PpD6 gene was found to be Y-linked only in Drosophila ananassae. ..
  3. Carvalho A, Dobo B, Vibranovski M, Clark A. Identification of five new genes on the Y chromosome of Drosophila melanogaster. Proc Natl Acad Sci U S A. 2001;98:13225-30 pubmed
    ..There remains a strong functional coherence to male function among the genes on the Drosophila Y chromosome. ..
  4. Carvalho A, Clark A. Y chromosome of D. pseudoobscura is not homologous to the ancestral Drosophila Y. Science. 2005;307:108-10 pubmed publisher
    ..pseudoobscura, and none are shared with the D. melanogaster Y. Hence, the Y chromosome in the D. pseudoobscura lineage appears to have arisen de novo and is not homologous to the D. melanogaster Y...
  5. Díaz Castillo C, Golic K. Evolution of gene sequence in response to chromosomal location. Genetics. 2007;177:359-74 pubmed
    ..We also observe a similar trend in the transition from telomeric heterochromatin to euchromatin. We propose that the methylation of DNA is one of the forces driving this sequence evolution. ..
  6. Abad J, de Pablos B, Agudo M, Molina I, Giovinazzo G, Martin Gallardo A, et al. Genomic and cytological analysis of the Y chromosome of Drosophila melanogaster: telomere-derived sequences at internal regions. Chromosoma. 2004;113:295-304 pubmed
    ..Collectively, our data provide further evidence for the hypothesis that the Drosophila Y chromosomes might have evolved from supernumerary chromosomes. ..
  7. Cohen P, Philp A, Vázquez Martin C. Protein phosphatase 4--from obscurity to vital functions. FEBS Lett. 2005;579:3278-86 pubmed
    ..Antitumour agents, cantharidin and fostriecin, potently inhibit the activity of Ppp4. Orthologues of mammalian Ppp4 subunits in Saccharomyces cerevisiae confer resistance to the anticancer, DNA-binding drugs, cisplatin and oxaliplatin. ..
  8. Miskei M, Adám C, Kovacs L, Karanyi Z, Dombradi V. Molecular evolution of phosphoprotein phosphatases in Drosophila. PLoS ONE. 2011;6:e22218 pubmed publisher
    ..Thus the PPP enzymes exemplify the various types of dynamic rearrangements that accompany the molecular evolution of a gene family in Drosophilidae. ..
  9. Singh N, Koerich L, Carvalho A, Clark A. Positive and purifying selection on the Drosophila Y chromosome. Mol Biol Evol. 2014;31:2612-23 pubmed publisher
    ..Finally, we find evidence of recurrent positive selection for 4 of the 11 genes studied here. Our results thus highlight the variable nature of the mode and impact of natural selection on the Drosophila Y chromosome...

More Information


  1. Francisco F, Lemos B. How do y-chromosomes modulate genome-wide epigenetic States: genome folding, chromatin sinks, and gene expression. J Genomics. 2014;2:94-103 pubmed publisher
    ..We also discuss how the discovery of this new function impacts the current knowledge about Y chromosome origin, its current dynamics, and future fate. ..
  2. Hoskins R, Carlson J, Wan K, Park S, Mendez I, Galle S, et al. The Release 6 reference sequence of the Drosophila melanogaster genome. Genome Res. 2015;25:445-58 pubmed publisher
    ..Further significant improvements will require sequencing technologies that do not depend on molecular cloning and that produce very long reads. ..