Gene Symbol: Pp1-87B
Description: Protein phosphatase 1 at 87B
Alias: 87B, CG5650, DmPp1-87B, Dmel\CG5650, PP-1alpha, PP1, PP1 87B, PP1 beta87b, PP1-87B, PP187B, PP1A87B, PP1B, PP1alpha-87B, PP1alpha87B, PP1alpha[[2]], PP1c, PP1c 87B, PPI 87B, Pp-1alpha, Pp1, Pp1-87Bb, Pp1alpha-87B, Ppl-87B, Su(Var)3-6, Su(var)(3)6, Su(var)3-6, Su-var(3)6, Suvar(3)6, ck19, dPP1beta, l(3)87Bg, l(3)ck19, l(3)j6E7, pp1-87B, su-var(3)6, protein phosphatase 1 at 87B, CG5650-PA, Pp1-87B-PA, protein phosphatase 1, suppressor of variegation
Species: fruit fly

Top Publications

  1. Reuter G, Giarre M, Farah J, Gausz J, Spierer A, Spierer P. Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein. Nature. 1990;344:219-23 pubmed
    ..This novel arrangement of zinc-fingers could help in packaging the chromatin fibre into heterochromatin, and also reflect a novel method of controlling the expression from DNA domains. ..
  2. Helps N, Vergidou C, Gaskell T, Cohen P. Characterisation of a novel Drosophila melanogaster testis specific PP1 inhibitor related to mammalian inhibitor-2: identification of the site of interaction with PP1. FEBS Lett. 1998;438:131-6 pubmed
    ..bears 41% sequence similarity to human protein phosphatase inhibitor-2 has been identified using human protein phosphatase 1 (PP1) in the yeast two hybrid system...
  3. Kurenova E, Champion L, Biessmann H, Mason J. Directional gene silencing induced by a complex subtelomeric satellite from Drosophila. Chromosoma. 1998;107:311-20 pubmed
  4. Balasov M, Beliaeva E, Shestopal S, Makunin I, Zhimulev I. [Position effect variegation of the mosaic type, arising as a result of transposition AR4-24P[white, rosy] in the Drosophila melanogaster genome]. Genetika. 2000;36:782-91 pubmed
    ..The genomic fragments captured by the transposon may contain DNA sequences that autonomously induce mosaic PEV of the white gene. ..
  5. Kirchner J, Gross S, Bennett D, Alphey L. Essential, overlapping and redundant roles of the Drosophila protein phosphatase 1 alpha and 1 beta genes. Genetics. 2007;176:273-81 pubmed
    ..In Drosophila, four genes code for the catalytic subunit of PP1 (PP1c), three of which belong to the PP1 alpha subtype...
  6. Bennett D, Szoor B, Alphey L. The chaperone-like properties of mammalian inhibitor-2 are conserved in a Drosophila homologue. Biochemistry. 1999;38:16276-82 pubmed
    ..mammalian phosphoprotein that binds to the catalytic subunit of type 1 serine/threonine phosphoprotein phosphatase (PP1c) and inhibits its activity in vitro...
  7. Dombradi V, Axton J, Brewis N, da Cruz e Silva E, Alphey L, Cohen P. Drosophila contains three genes that encode distinct isoforms of protein phosphatase 1. Eur J Biochem. 1990;194:739-45 pubmed
    ..The sequence of Drosophila PP1 alpha 1 was deduced from a 2...
  8. Bennett D, Alphey L. PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster. Nat Genet. 2002;31:419-23 pubmed
    ..Sara) in a screen for proteins that bind the catalytic subunit of type 1 serine/threonine protein phosphatase (PP1c). We identified a PP1c-binding motif in Sara, disruption of which reduced the ability of Sara to bind PP1c...
  9. Dombradi V, Axton J, Glover D, Cohen P. Cloning and chromosomal localization of Drosophila cDNA encoding the catalytic subunit of protein phosphatase 1 alpha. High conservation between mammalian and insect sequences. Eur J Biochem. 1989;183:603-10 pubmed
    A 1.2-kb clone containing the full coding sequence of a protein phosphatase 1 catalytic subunit has been isolated from a Drosophila head cDNA library. It encodes a polypeptide of 302 amino acids with a molecular mass of 34.5 kDa...

More Information


  1. Dombradi V, Axton J, Barker H, Cohen P. Protein phosphatase 1 activity in Drosophila mutants with abnormalities in mitosis and chromosome condensation. FEBS Lett. 1990;275:39-43 pubmed
    A Drosophila gene encoding a protein phosphatase 1 (PP1) has been sequenced, and lethal mutations in this locus (87B) analysed...
  2. Dombradi V, Mann D, Saunders R, Cohen P. Cloning of the fourth functional gene for protein phosphatase 1 in Drosophila melanogaster from its chromosomal location. Eur J Biochem. 1993;212:177-83 pubmed
    Complementary DNA encoding a catalytic subunit of protein phosphatase 1, PP1 87B, hybridises at four positions (87B, 9C, 13C and 96A) to Drosophila melanogaster polytene chromosomes, three of which are known to be expressed [Dombrádi, V...
  3. Alphey L, Parker L, Hawcroft G, Guo Y, Kaiser K, Morgan G. KLP38B: a mitotic kinesin-related protein that binds PP1. J Cell Biol. 1997;138:395-409 pubmed
    ..its two-hybrid interaction with the catalytic subunit of type 1 serine/threonine phosphoprotein phosphatase (PP1). We demonstrate that recombinant KLP38B and PP1 associate in vitro...
  4. Vereshchagina N, Bennett D, Szoor B, Kirchner J, Gross S, Vissi E, et al. The essential role of PP1beta in Drosophila is to regulate nonmuscle myosin. Mol Biol Cell. 2004;15:4395-405 pubmed
    ..We show that Drosophila PP1beta, a specific isoform of serine/threonine protein phosphatase 1 (PP1), regulates nonmuscle myosin and that this is the essential role of PP1beta...
  5. Baksa K, Morawietz H, Dombradi V, Axton M, Taubert H, Szabo G, et al. Mutations in the protein phosphatase 1 gene at 87B can differentially affect suppression of position-effect variegation and mitosis in Drosophila melanogaster. Genetics. 1993;135:117-25 pubmed
    ..The locus is allelic to the ck19 complementation group previously shown to encode a type 1 serine-threonine protein phosphatase (PP1) catalytic ..
  6. Chen F, Archambault V, Kar A, Lio P, D Avino P, Sinka R, et al. Multiple protein phosphatases are required for mitosis in Drosophila. Curr Biol. 2007;17:293-303 pubmed
    ..Strong mitotic arrest and chromosome congression failure occurred after Pp1-87B downregulation...
  7. Raghavan S, Williams I, Aslam H, Thomas D, Szoor B, Morgan G, et al. Protein phosphatase 1beta is required for the maintenance of muscle attachments. Curr Biol. 2000;10:269-72 pubmed
    Type 1 serine/threonine protein phosphatases (PP1) are important regulators of many cellular and developmental processes, including glycogen metabolism, muscle contraction, and the cell cycle [1] [2] [3] [4] [5]...
  8. Helps N, Cohen P, Bahri S, Chia W, Babu K. Interaction with protein phosphatase 1 Is essential for bifocal function during the morphogenesis of the Drosophila compound eye. Mol Cell Biol. 2001;21:2154-64 pubmed
    ..morphogenesis in the Drosophila compound eye, encodes a protein that is shown to interact with protein phosphatase 1 (PP1) using the yeast two-hybrid system...
  9. Rudenko A, Bennett D, Alphey L. Trithorax interacts with type 1 serine/threonine protein phosphatase in Drosophila. EMBO Rep. 2003;4:59-63 pubmed
    The catalytic subunit of type 1 serine/threonine protein phosphatase (PP1c) was shown to bind trithorax (TRX) in the yeast two-hybrid system...
  10. Axton J, Dombradi V, Cohen P, Glover D. One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis. Cell. 1990;63:33-46 pubmed
    ..Germline transformation of mutant flies with the wild-type PP1 87B gene restores normal mitosis, viability, and fertility...
  11. Gatti M, Goldberg M. Mutations affecting cell division in Drosophila. Methods Cell Biol. 1991;35:543-86 pubmed
  12. Helps N, Cohen P. Drosophila melanogaster protein phosphatase inhibitor-2: identification of a site important for PP1 inhibition. FEBS Lett. 1999;463:72-6 pubmed
    ..The bacterially expressed protein was a specific inhibitor of protein phosphatase 1 with an IC(50) of <1 nM, confirming that it is the Drosophila homologue of mammalian inhibitor-2...
  13. Fang Y, Sathyanarayanan S, Sehgal A. Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1). Genes Dev. 2007;21:1506-18 pubmed
    ..Here we demonstrate a role for protein phosphatase 1 (PP1) in the regulation of the major timekeeping molecules in the Drosophila clock, TIMELESS (TIM) and ..
  14. Davis R. Mushroom bodies and Drosophila learning. Neuron. 1993;11:1-14 pubmed
  15. Orr Weaver T. Developmental modification of the Drosophila cell cycle. Trends Genet. 1994;10:321-7 pubmed
    ..The field is now poised for the identification of the intervening steps between the developmental signals and their ultimate effects on known cell cycle regulators. ..
  16. Pile L, Schlag E, Wassarman D. The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels. Mol Cell Biol. 2002;22:4965-76 pubmed
    ..Loss of SIN3 does not affect global acetylation of histones H3 and H4, suggesting that the G(2) phase delay is due not to global changes in genome integrity but rather to derepression of SIN3 target genes. ..
  17. Ciurciu A, Duncalf L, Jonchère V, Lansdale N, Vasieva O, Glenday P, et al. PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth. PLoS Genet. 2013;9:e1003885 pubmed publisher
    ..b>Protein phosphatase 1 (PP1) is one of several enzymes that has been reported to dephosphorylate the RNAPII CTD...
  18. Bai Y, Casola C, BETRAN E. Quality of regulatory elements in Drosophila retrogenes. Genomics. 2009;93:83-9 pubmed publisher
    ..Future experiments are needed to determine the function and role of the new elements presented here. ..
  19. Mann D, Dombradi V, Cohen P. Drosophila protein phosphatase V functionally complements a SIT4 mutant in Saccharomyces cerevisiae and its amino-terminal region can confer this complementation to a heterologous phosphatase catalytic domain. EMBO J. 1993;12:4833-42 pubmed
    ..PPV is 40-41% identical to Drosophila PP1, 53% identical to Drosophila PP2A and 63% identical to Saccharomyces cerevisiae SIT4...
  20. Cohen P, Philp A, Vázquez Martin C. Protein phosphatase 4--from obscurity to vital functions. FEBS Lett. 2005;579:3278-86 pubmed
    ..Antitumour agents, cantharidin and fostriecin, potently inhibit the activity of Ppp4. Orthologues of mammalian Ppp4 subunits in Saccharomyces cerevisiae confer resistance to the anticancer, DNA-binding drugs, cisplatin and oxaliplatin. ..
  21. Helps N, Brewis N, Lineruth K, Davis T, Kaiser K, Cohen P. Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos. J Cell Sci. 1998;111 ( Pt 10):1331-40 pubmed
    ..These findings indicate that PP4 is required for nucleation, growth and/or stabilisation of microtubules at centrosomes/spindle pole bodies. ..
  22. Karpen G. Position-effect variegation and the new biology of heterochromatin. Curr Opin Genet Dev. 1994;4:281-91 pubmed
    ..Investigations published within the past few years demonstrate that position-effect variegation is caused by multiple mechanisms, and that direct tests of hypotheses are possible with numerous model systems. ..
  23. Chen M, Chen Y, Cohen P. Polymerase chain reactions using Saccharomyces, Drosophila and human DNA predict a large family of protein serine/threonine phosphatases. FEBS Lett. 1992;306:54-8 pubmed
    ..the polymerase chain reaction (PCR) to examine the protein serine/threonine phosphatase (PP) family which includes PP1, PP2A and PP2B, we have identified two, seven, and four novel protein phosphatase genes in Saccharomyces cerevisiae,..
  24. Afonso O, Matos I, Pereira A, Aguiar P, Lampson M, Maiato H. Feedback control of chromosome separation by a midzone Aurora B gradient. Science. 2014;345:332-336 pubmed publisher
    ..b>PP1/PP2A phosphatases counteracted this gradient and promoted chromosome decondensation and NER...
  25. Henikoff S. Dosage-dependent modification of position-effect variegation in Drosophila. Bioessays. 1996;18:401-9 pubmed
  26. Rodrigues N, Lekomtsev S, Jananji S, Kriston Vizi J, Hickson G, Baum B. Kinetochore-localized PP1-Sds22 couples chromosome segregation to polar relaxation. Nature. 2015;524:489-92 pubmed publisher
    ..This is independent of furrow formation, centrosomes and microtubules and, instead, depends on PP1 phosphatase and its regulatory subunit Sds22 (refs 2, 3)...
  27. Yang Y, Ballinger D. Mutations in calphotin, the gene encoding a Drosophila photoreceptor cell-specific calcium-binding protein, reveal roles in cellular morphogenesis and survival. Genetics. 1994;138:413-21 pubmed
    ..Analysis of these mutations suggest that Calphotin plays important roles in both rhabdomere development and in photoreceptor cell survival. ..
  28. Su Y, Ospina J, Zhang J, Michelson A, Schoen A, Zhu A. Sequential phosphorylation of smoothened transduces graded hedgehog signaling. Sci Signal. 2011;4:ra43 pubmed publisher
    ..We found that protein phosphatase 1 (PP1) directly dephosphorylated PKA-phosphorylated Smo to reduce signaling mediated by intermediate ..
  29. Mlodzik M, Hiromi Y, Weber U, Goodman C, Rubin G. The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates. Cell. 1990;60:211-24 pubmed
    ..Molecular analysis of svp reveals that it is a member of the steroid receptor gene superfamily and is likely to be a Drosophila homolog of the human transcription factor COUP. ..
  30. Takahashi A, Tsaur S, Coyne J, Wu C. The nucleotide changes governing cuticular hydrocarbon variation and their evolution in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2001;98:3920-5 pubmed
    ..Whether this CH variation could be a component of the sexual isolation between Zimbabwe and other cosmopolitan populations remains an interesting and unresolved question. ..
  31. Morley K, Montgomery G. The genetics of cognitive processes: candidate genes in humans and animals. Behav Genet. 2001;31:511-31 pubmed
    ..This survey confirms that many genes are associated with cognitive variation and highlights the potential importance of animal models in the study of human cognition. ..
  32. Luo W, Peterson A, Garcia B, Coombs G, Kofahl B, Heinrich R, et al. Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J. 2007;26:1511-21 pubmed
    ..Using a directed RNAi screen we find that protein phosphatase 1 (PP1), a ubiquitous serine/threonine phosphatase, is a novel potent positive physiologic regulator of the ..
  33. Tiebe M, Lutz M, De La Garza A, Buechling T, Boutros M, Teleman A. REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1. Dev Cell. 2015;33:272-84 pubmed publisher
    ..In vivo functional analysis using knockout flies reveals that REPTOR and REPTOR-BP play critical roles in maintaining energy homeostasis and promoting animal survival upon nutrient restriction. ..
  34. Asztalos Z, von Wegerer J, Wustmann G, Dombradi V, Gausz J, Spatz H, et al. Protein phosphatase 1-deficient mutant Drosophila is affected in habituation and associative learning. J Neurosci. 1993;13:924-30 pubmed
    ..strains carrying the Su-var(3)6(01) mutation, which is known to affect the structural gene of a protein phosphatase 1 isoenzyme, PP1(87B), were studied in various behavioral paradigms...
  35. Sass G, Henikoff S. Comparative analysis of position-effect variegation mutations in Drosophila melanogaster delineates the targets of modifiers. Genetics. 1998;148:733-41 pubmed
    ..In addition, our observations support a model in which there are different constraints on the process of heterochromatin-induced silencing in classical vs. nonclassical PEV mutations. ..
  36. Weiler K, Wakimoto B. Heterochromatin and gene expression in Drosophila. Annu Rev Genet. 1995;29:577-605 pubmed
  37. Díaz Castillo C, Golic K. Evolution of gene sequence in response to chromosomal location. Genetics. 2007;177:359-74 pubmed
    ..We also observe a similar trend in the transition from telomeric heterochromatin to euchromatin. We propose that the methylation of DNA is one of the forces driving this sequence evolution. ..
  38. Erhardt S, Lyko F, Ainscough J, Surani M, Paro R. Polycomb-group proteins are involved in silencing processes caused by a transgenic element from the murine imprinted H19/Igf2 region in Drosophila. Dev Genes Evol. 2003;213:336-44 pubmed
    ..Polycomb group proteins are essential for gene silencing during development. Our results indicate that Polycomb group proteins may also be involved in the regulation of mammalian imprinted genes. ..
  39. Cohen P. Important roles for novel protein phosphatases dephosphorylating serine and threonine residues. Biochem Soc Trans. 1993;21:884-8 pubmed
  40. Abramov Y, Shatskikh A, Maksimenko O, Bonaccorsi S, Gvozdev V, Lavrov S. The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in Drosophila. Genetics. 2016;202:93-106 pubmed publisher
    ..We demonstrate that trans-inactivation is followed by de novo HP1a accumulation in the affected transgene; trans-inactivation is specifically favored by the chromatin remodeler SAYP and prevented by Argonaute AGO2. ..
  41. Lu C, Hodge J, Mehren J, Sun X, Griffith L. Regulation of the Ca2+/CaM-responsive pool of CaMKII by scaffold-dependent autophosphorylation. Neuron. 2003;40:1185-97 pubmed
    ..This interaction provides a mechanism by which the active postsynaptic pool of CaMKII can be controlled locally to differentiate active and inactive synapses. ..
  42. Reuter G, Gausz J, Gyurkovics H, Friede B, Bang R, Spierer A, et al. Modifiers of position-effect variegation in the region from 86C to 88B of the Drosophila melanogaster third chromosome. Mol Gen Genet. 1987;210:429-36 pubmed
    ..The positions of deficiency breakpoints delimiting the suppressor locus indicate that all the necessary sequences for its function are located within 10 kb of cloned DNA. ..
  43. Swanhart L, Sanders A, Duronio R. Normal regulation of Rbf1/E2f1 target genes in Drosophila type 1 protein phosphatase mutants. Dev Dyn. 2007;236:2567-77 pubmed
    ..Current molecular and biochemical evidence suggests that type 1 protein phosphatases (PP1) dephosphorylate and thereby activate pRb, but the functional significance of this has not been addressed in the ..
  44. Bennett D, Szoor B, Gross S, Vereshchagina N, Alphey L. Ectopic expression of inhibitors of protein phosphatase type 1 (PP1) can be used to analyze roles of PP1 in Drosophila development. Genetics. 2003;164:235-45 pubmed
    ..Reactivation of I-2Dm:PP1c complexes suggests that inhibition of PP1 activity in vivo does not result in a compensating increase in synthesis ..
  45. Strübbe G, Popp C, Schmidt A, Pauli A, Ringrose L, Beisel C, et al. Polycomb purification by in vivo biotinylation tagging reveals cohesin and Trithorax group proteins as interaction partners. Proc Natl Acad Sci U S A. 2011;108:5572-7 pubmed publisher
    ..Furthermore, our analysis revealed an association of PcG protein complexes with the cohesin complex and showed that Polycomb-dependent silencing of a transgenic reporter depends on cohesin function. ..
  46. Armstrong C, Dombradi V, Mann D, Cohen P. Cloning of a novel testis specific protein serine/threonine phosphatase, PPN 58A, from Drosophila melanogaster. Biochim Biophys Acta. 1998;1399:234-8 pubmed
    ..The deduced amino acid sequence of PPN 58A exhibits 59-62% identity to D. melanogaster PP1 isoforms, 51% identity to D. melanogaster PPY 55A and < or = 40% identity to other members of the PPP family...
  47. Davis R. Physiology and biochemistry of Drosophila learning mutants. Physiol Rev. 1996;76:299-317 pubmed
    ..An appendix describing the currently used paradigms to test Drosophila behavior is included...
  48. Lu B, Eissenberg J. Time out: developmental regulation of heterochromatic silencing in Drosophila. Cell Mol Life Sci. 1998;54:50-9 pubmed
  49. Roubinet C, Decelle B, Chicanne G, Dorn J, Payrastre B, Payre F, et al. Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis. J Cell Biol. 2011;195:99-112 pubmed publisher
    ..We find that the Pp1-87B phosphatase restricts high Moesin activity to early mitosis and down-regulates Moesin at the polar cortex, ..
  50. Jiang Y, Scott K, Kwak S, Chen R, Mardon G. Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling. Oncogene. 2011;30:3248-60 pubmed publisher
    ..Sds22, a regulatory subunit of protein phosphatase 1 (PP1), has recently been linked to regulation of epithelial polarity in Drosophila...
  51. Kunda P, Rodrigues N, Moeendarbary E, Liu T, Ivetic A, Charras G, et al. PP1-mediated moesin dephosphorylation couples polar relaxation to mitotic exit. Curr Biol. 2012;22:231-6 pubmed publisher
    ..interference (RNAi) screen for phosphatases involved in the temporal and spatial control of moesin, we identify PP1-87B RNAi as having elevated p-moesin levels and reduced cortical compliance...
  52. Hwang K, Eissenberg J, Worman H. Transcriptional repression of euchromatic genes by Drosophila heterochromatin protein 1 and histone modifiers. Proc Natl Acad Sci U S A. 2001;98:11423-7 pubmed
    ..These data provide genetic evidence that an HP1-family protein represses the expression of euchromatic genes in a metazoan, and that histone modifiers cooperate with HP1 in euchromatic gene repression. ..
  53. Sreesankar E, Bharathi V, Mishra R, Mishra K. Drosophila Rif1 is an essential gene and controls late developmental events by direct interaction with PP1-87B. Sci Rep. 2015;5:10679 pubmed publisher
    ..causes enlarged larval imaginal discs and early pupal lethality which is completely reversed by co-expression of PP1 87B, the major protein phosphatase in Drosophila, indicating genetic and functional interaction...
  54. Sehgal A. Ac-ing the clock. Neuron. 2008;57:8-10 pubmed publisher
    ..Degradation of these proteins usually involves ubiquitylation or sumoylation, and some of the relevant E3 ligases are known. In addition, Hirayama et al. recently identified acetylation as a clock regulatory mechanism. ..
  55. Parkes T, Hilliker A, Phillips J. Genetic and biochemical analysis of glutathione-S-transferase in the oxygen defense system of Drosophila melanogaster. Genome. 1993;36:1007-14 pubmed
    ..By measuring GST specific activity in flies carrying deficiencies for the 87B region, we confirm an earlier report that this region contains active GST-encoding genes...
  56. Dombradi V, Cohen P. Protein phosphorylation is involved in the regulation of chromatin condensation during interphase. FEBS Lett. 1992;312:21-6 pubmed
    ..in the heterozygous state, have point mutations (Gly220-->Ser and Gly220-->Asp, respectively) in a protein phosphatase 1 catalytic subunit located at 87B (PP1 87B)...
  57. Wustmann G, Szidonya J, Taubert H, Reuter G. The genetics of position-effect variegation modifying loci in Drosophila melanogaster. Mol Gen Genet. 1989;217:520-7 pubmed
    ..Most of these loci proved not to display significant triplo-effects (35). The group of haplo-abnormal loci with a triplo-effect may represent genes which play an important role in heterochromatin packaging. ..
  58. Kerekes E, Kókai E, Páldy F, Dombradi V. Functional analysis of the glycogen binding subunit CG9238/Gbs-70E of protein phosphatase 1 in Drosophila melanogaster. Insect Biochem Mol Biol. 2014;49:70-9 pubmed publisher
    ..The interaction between Gbs-70E and all catalytic subunits of protein phosphatase 1 (Pp1-87B, Pp1-9C, Pp1-96A and Pp1-13C) of Drosophila melanogaster was confirmed by pairwise yeast two-..
  59. Grusche F, Hidalgo C, Fletcher G, Sung H, Sahai E, Thompson B. Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology]. BMC Dev Biol. 2009;9:14 pubmed publisher
    ..In yeast, sds22 encodes a PP1 phosphatase regulatory subunit...
  60. Moura M, Osswald M, Leça N, Barbosa J, Pereira A, Maiato H, et al. Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing. elife. 2017;6: pubmed publisher
    ..Here we show in vitro and in Drosophila that Protein Phosphatase 1 (PP1) inactivates Mps1 by dephosphorylating its T-loop...
  61. Tan S, Lyulcheva E, Dean J, Bennett D. Mars promotes dTACC dephosphorylation on mitotic spindles to ensure spindle stability. J Cell Biol. 2008;182:27-33 pubmed publisher
    ..As well as associating with spindle MTs in vivo, Mars binds directly to protein phosphatase 1 (PP1) and coimmunoprecipitates from embryo extracts with minispindles and Drosophila transforming acidic ..
  62. Babu K, Bahri S, Alphey L, Chia W. Bifocal and PP1 interaction regulates targeting of the R-cell growth cone in Drosophila. Dev Biol. 2005;288:372-86 pubmed
    ..We show here that Bif and PP1-87B as well as their ability to interact with each other are required for photoreceptor growth cone targeting in the ..
  63. Dubnau J, Tully T. Gene discovery in Drosophila: new insights for learning and memory. Annu Rev Neurosci. 1998;21:407-44 pubmed
    ..Second, because core cellular mechanisms of simple forms of learning are evolutionarily conserved, biological pathways discovered in invertebrates are likely to be conserved in vertebrate systems as well. ..
  64. Reuter G, Spierer P. Position effect variegation and chromatin proteins. Bioessays. 1992;14:605-12 pubmed