Gene Symbol: porin
Description: porin
Alias: CG6647, DVDAC, DmPorin1, DmVDAC, Dmel\CG6647, POR-1, PORIN, Porin, VDAC, VDAC1, Vdac, anon-WO02059370.56, cg6647, l(2)k05123, porin, CG6647-PA, CG6647-PB, CG6647-PC, CG6647-PD, CG6647-PE, VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL, mitochondrial porin, porin 1, porin-PA, porin-PB, porin-PC, porin-PD, porin-PE, voltage-dependent anion channel
Species: fruit fly

Top Publications

  1. Lee S, Leung H, Kim E, Jang J, Lee E, Baek K, et al. Effects of a mutation in the Drosophila porin gene encoding mitochondrial voltage-dependent anion channel protein on phototransduction. Dev Neurobiol. 2007;67:1533-45 pubmed
    ..So far three distinct isoforms of VDAC (VDAC1-3) have been reported in vertebrates, but their functions remain unknown...
  2. Graham B, Craigen W. Mitochondrial voltage-dependent anion channel gene family in Drosophila melanogaster: complex patterns of evolution, genomic organization, and developmental expression. Mol Genet Metab. 2005;85:308-17 pubmed
    ..sequence of Drosophila melanogaster revealed three genes (CG17137, CG31722-A, and CG31722-B) with homology to porin, the previously described Drosophila VDAC...
  3. Graham B, Li Z, Alesii E, Versteken P, Lee C, Wang J, et al. Neurologic dysfunction and male infertility in Drosophila porin mutants: a new model for mitochondrial dysfunction and disease. J Biol Chem. 2010;285:11143-53 pubmed publisher
    ..In Drosophila melanogaster, porin is the ubiquitously expressed VDAC isoform...
  4. Oliva M, Messina A, Ragone G, Caggese C, De Pinto V. Sequence and expression pattern of the Drosophila melanogaster mitochondrial porin gene: evidence of a conserved protein domain between fly and mouse. FEBS Lett. 1998;430:327-32 pubmed
    We have recently cloned a cDNA encoding mitochondrial porin in Drosophila melanogaster and shown its chromosomal localization (Messina et al., FEBS Lett. (1996) 384, 9-13). Such cDNA was used as a probe for screening a genomic library...
  5. Guarino F, Specchia V, Zapparoli G, Messina A, Aiello R, Bozzetti M, et al. Expression and localization in spermatozoa of the mitochondrial porin isoform 2 in Drosophila melanogaster. Biochem Biophys Res Commun. 2006;346:665-70 pubmed
    ..A lethal mutant of D. melanogaster carrying a P-element in the first intron of the porin (Porin 1) gene hinders the expression of both Porin 1 and 2...
  6. Komarov A, Graham B, Craigen W, Colombini M. The physiological properties of a novel family of VDAC-like proteins from Drosophila melanogaster. Biophys J. 2004;86:152-62 pubmed
    ..Although multiple isoforms of VDAC have been found in different organisms, only one isoform (porin/DVDAC) has been previously reported for Drosophila melanogaster...
  7. Park J, Kim Y, Choi S, Koh H, Lee S, Kim J, et al. Drosophila Porin/VDAC affects mitochondrial morphology. PLoS ONE. 2010;5:e13151 pubmed publisher
    ..To confirm this hypothesis in vivo, we generated and characterized Drosophila VDAC (porin) mutants and found that Porin is not required for mitochondrial apoptosis, which is consistent with the previous ..
  8. Lee S, Lee K, Huh S, Liu S, Lee D, Hong S, et al. Polo Kinase Phosphorylates Miro to Control ER-Mitochondria Contact Sites and Mitochondrial Ca(2+) Homeostasis in Neural Stem Cell Development. Dev Cell. 2016;37:174-189 pubmed publisher
    ..Our results elucidate a regulatory mechanism underlying Ca²? mito homeostasis and how its dysregulation may affect NSC metabolism/development and contribute to disease. ..
  9. Specchia V, Guarino F, Messina A, Bozzetti M, De Pinto V. Porin isoform 2 has a different localization in Drosophila melanogaster ovaries than porin 1. J Bioenerg Biomembr. 2008;40:219-26 pubmed publisher
    ..In previous work we reported about the transcriptional and translational analysis of porin 1 and porin 2, and we proposed the specific presence of the latter in spermatozoa of the fly...

More Information


  1. Terhzaz S, Southall T, Lilley K, Kean L, Allan A, Davies S, et al. Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. J Biol Chem. 2006;281:18849-58 pubmed
    ..The results highlight the dynamic nature and both spatial and temporal heterogeneity of calcium signaling possible in differentiated, organotypic cells and provide a new model for neuroendocrine control of V-ATPase. ..
  2. Aiello R, Messina A, Schiffler B, Benz R, Tasco G, Casadio R, et al. Functional characterization of a second porin isoform in Drosophila melanogaster. DmPorin2 forms voltage-independent cation-selective pores. J Biol Chem. 2004;279:25364-73 pubmed
    ..The recombinant DmPorin2 protein is able to form channels similar to those formed by DmPorin1 reconstituted in artificial membranes...
  3. Cho J, Park J, Chung C, Shim H, Jeon K, Yu S, et al. Parkin-mediated responses against infection and wound involve TSPO-VDAC complex in Drosophila. Biochem Biophys Res Commun. 2015;463:1-6 pubmed publisher
    ..Here, we identified mitochondrial TSPO-VDAC complex to genetically interact with parkin in mediating responses against infection and wound in Drosophila...
  4. Sieber M, Thomsen M, Spradling A. Electron Transport Chain Remodeling by GSK3 during Oogenesis Connects Nutrient State to Reproduction. Cell. 2016;164:420-32 pubmed publisher
    ..Our studies reveal an important link between metabolism and oocyte maturation. ..
  5. Blachly Dyson E, Song J, Wolfgang W, Colombini M, Forte M. Multicopy suppressors of phenotypes resulting from the absence of yeast VDAC encode a VDAC-like protein. Mol Cell Biol. 1997;17:5727-38 pubmed
    ..membrane to most metabolites is believed to be based in an outer membrane, channel-forming protein known as VDAC (voltage-dependent anion channel)...
  6. Sen A, Kalvakuri S, Bodmer R, Cox R. Clueless, a protein required for mitochondrial function, interacts with the PINK1-Parkin complex in Drosophila. Dis Model Mech. 2015;8:577-89 pubmed publisher
    ..protein required for normal mitochondrial function, can associate with Translocase of the outer membrane (TOM) 20, Porin and PINK1, and is thus located at the mitochondrial outer membrane...
  7. Regulski M, Stasiv Y, Tully T, Enikolopov G. Essential function of nitric oxide synthase in Drosophila. Curr Biol. 2004;14:R881-2 pubmed
  8. Schwarze S, Weindruch R, Aiken J. Decreased mitochondrial RNA levels without accumulation of mitochondrial DNA deletions in aging Drosophila melanogaster. Mutat Res. 1998;382:99-107 pubmed
    ..No difference, however, was apparent in the nuclear-encoded beta-ATPase RNA level, suggesting only mitochondrial RNA (mtRNA) declines are associated with life expectancy. ..
  9. Craigen W, Graham B. Genetic strategies for dissecting mammalian and Drosophila voltage-dependent anion channel functions. J Bioenerg Biomembr. 2008;40:207-12 pubmed publisher
    ..Drosophila melanogaster has recently revealed three additional genes (CG17137, CG17139, CG17140) with homology to porin, the previously described gene that encodes the VDAC of D. melanogaster...
  10. Huang Y, Xie J, Wang T. A Fluorescence-Based Genetic Screen to Study Retinal Degeneration in Drosophila. PLoS ONE. 2015;10:e0144925 pubmed publisher
    ..Our findings demonstrate that this "Rh1::GFP ey-flp/hid" method enables high-throughput F1 genetic screens to rapidly and precisely identify mutations of retinal degeneration. ..
  11. Caggese C, Ragone G, Perrini B, Moschetti R, De Pinto V, Caizzi R, et al. Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database. Mol Gen Genet. 1999;261:64-70 pubmed
    ..Our experimental strategy represents an efficient approach to the identification and interspecies comparison of genes encoding products targeted to the mitochondrion. ..
  12. Ryerse J, Blachly Dyson E, Forte M, Nagel B. Cloning and molecular characterization of a voltage-dependent anion-selective channel (VDAC) from Drosophila melanogaster. Biochim Biophys Acta. 1997;1327:204-12 pubmed
    ..The cDNA clone (denoted DmVDAC) is 1082 base pairs (bp) in length and contains an open reading frame (bp 62-907) encoding a 282 amino acid ..
  13. Peralta S, Clemente P, Sanchez Martinez A, Calleja M, Hernández Sierra R, Matsushima Y, et al. Coiled coil domain-containing protein 56 (CCDC56) is a novel mitochondrial protein essential for cytochrome c oxidase function. J Biol Chem. 2012;287:24174-85 pubmed publisher
    ..melanogaster. We propose CCDC56 as a candidate factor required for COX biogenesis/assembly. ..
  14. Devorkin L, Go N, Hou Y, Moradian A, Morin G, Gorski S. The Drosophila effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB. J Cell Biol. 2014;205:477-92 pubmed publisher
    ..These data reveal a new mitochondrial-associated molecular link between nonapoptotic caspase function and autophagy regulation in vivo. ..
  15. Messina A, Neri M, Perosa F, Caggese C, Marino M, Caizzi R, et al. Cloning and chromosomal localization of a cDNA encoding a mitochondrial porin from Drosophila melanogaster. FEBS Lett. 1996;384:9-13 pubmed
    We have raised polyclonal antibodies against purified the Drosphila melanogaster mitochondrial porin. They showed high titre and specificity and were thus used as a tool for screening an expression library...
  16. Sardiello M, Tripoli G, Oliva M, Santolamazza F, Moschetti R, Barsanti P, et al. A comparative study of the porin genes encoding VDAC, a voltage-dependent anion channel protein, in Anopheles gambiae and Drosophila melanogaster. Gene. 2003;317:111-5 pubmed
    The protein called voltage-dependent anion-selective channel (VDAC), or mitochondrial porin, forms channels that provide the major pathway for small metabolites across the mitochondrial outer membrane...
  17. Burden D, Osheroff N. In vitro evolution of preferred topoisomerase II DNA cleavage sites. J Biol Chem. 1999;274:5227-35 pubmed
    ..melanogaster, implying that it may be a site for the physiological action of this enzyme. ..
  18. De Pinto V, Benz R, Caggese C, Palmieri F. Characterization of the mitochondrial porin from Drosophila melanogaster. Biochim Biophys Acta. 1989;987:1-7 pubmed
    b>Mitochondrial porin was isolated from the fruit fly Drosophila melanogaster at different developmental stages, starting from whole mitochondria. The porin from adults' mitochondria was fully characterized...
  19. Rival T, Macchi M, Arnauné Pelloquin L, Poidevin M, Maillet F, Richard F, et al. Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways. EMBO Rep. 2011;12:223-30 pubmed publisher
    ..This shows that mitochondrial networks can be shaped in higher eukaryotes by at least two separate pathways: one PMI-dependent and one DRP1/MFN-dependent. ..
  20. DUBOFF B, Götz J, Feany M. Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron. 2012;75:618-32 pubmed publisher
    ..Our results thus identify actin-mediated disruption of mitochondrial dynamics as a direct mechanism of tau toxicity in neurons in vivo...
  21. Zhang K, Li Z, Jaiswal M, Bayat V, Xiong B, Sandoval H, et al. The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit. J Cell Biol. 2013;200:807-20 pubmed publisher
    ..Our data indicate that cytosolic chaperones are required for the subcellular transport of ND42. ..
  22. Groebe K, Klemm Manns M, Schwall G, Hübenthal H, Unterluggauer H, Jansen Durr P, et al. Age-dependent posttranslational modifications of voltage-dependent anion channel 1. Exp Gerontol. 2010;45:632-7 pubmed publisher
    ..mitochondrial Hsp22 and controls, we found age-related redundant isoforms of voltage-dependent anion channel 1 (VDAC-1)...
  23. Banerjee S, Chinthapalli B. A proteomic screen with Drosophila Opa1-like identifies Hsc70-5/Mortalin as a regulator of mitochondrial morphology and cellular homeostasis. Int J Biochem Cell Biol. 2014;54:36-48 pubmed publisher
    ..Taken together, we have identified a novel interaction between Hsc70-5/Mortalin and Opa1-like that influences cellular homeostasis through mitochondrial fusion. ..
  24. Khalil B, El Fissi N, Aouane A, Cabirol Pol M, Rival T, Liévens J. PINK1-induced mitophagy promotes neuroprotection in Huntington's disease. Cell Death Dis. 2015;6:e1617 pubmed publisher
    ..Altogether, our findings suggest that mitophagy is altered in the presence of mHtt and that increasing PINK1/Parkin mitochondrial quality control pathway may improve mitochondrial integrity and neuroprotection in HD. ..
  25. Oliva M, De Pinto V, Barsanti P, Caggese C. A genetic analysis of the porin gene encoding a voltage-dependent anion channel protein in Drosophila melanogaster. Mol Genet Genomics. 2002;267:746-56 pubmed
    The voltage-dependent anion channel (VDAC, also known as porin) is an abundant protein in the outer mitochondrial membrane that forms transmembrane channels permeable to solutes...
  26. Mesilaty Gross S, Reich A, Motro B, Wides R. The Drosophila STAM gene homolog is in a tight gene cluster, and its expression correlates to that of the adjacent gene ial. Gene. 1999;231:173-86 pubmed
    ..By comparison to cDNAs isolated and characterized, this region contains four tightly clustered genes: ial, mitochondrial porin, and the two newly discovered genes, STAM and DNZ1...
  27. M Angale P, Staveley B. Loss of porin function in dopaminergic neurons of Drosophila is suppressed by Buffy. J Biomed Sci. 2016;23:84 pubmed
    b>Mitochondrial porin, also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions...