Gene Symbol: poe
Description: purity of essence
Alias: 3420, CG14472, Calo, Dmel\CG14472, POE, POE_DROME, Poe, calo, ms(2)01659, ms(2)27C, ms(2)3420, ms(2)5970, push, purity of essence, CG14472-PA, CG14472-PB, calossin, male sterile(2)27C, male sterile(2)3420, poe-PA, poe-PB, pushover
Species: fruit fly

Top Publications

  1. Thomson T, Liu N, Arkov A, Lehmann R, Lasko P. Isolation of new polar granule components in Drosophila reveals P body and ER associated proteins. Mech Dev. 2008;125:865-73 pubmed publisher
    ..Our recovery of ER associated proteins TER94 and ME31B confirms that polar granules are closely linked to the translational machinery and to mRNP assembly. ..
  2. Richards S, Hillman T, Stern M. Mutations in the Drosophila pushover gene confer increased neuronal excitability and spontaneous synaptic vesicle fusion. Genetics. 1996;142:1215-23 pubmed
    We describe the identification of a gene called pushover (push), which affects both behavior and synaptic transmission at the neuromuscular junction...
  3. Xu X, Wes P, Chen H, Li H, Yu M, Morgan S, et al. Retinal targets for calmodulin include proteins implicated in synaptic transmission. J Biol Chem. 1998;273:31297-307 pubmed
    ..proteins included Pollux, a protein with similarity to a portion of a yeast Rab GTPase activating protein, and Calossin, an enormous protein of unknown function conserved throughout animal phylogeny...
  4. Yager J, Richards S, Hekmat Scafe D, Hurd D, Sundaresan V, Caprette D, et al. Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways. Proc Natl Acad Sci U S A. 2001;98:10445-50 pubmed
    ..five genes: ine, which encodes a putative neurotransmitter transporter; eag, which encodes a potassium channel; push, which encodes a large, Zn(2+)-finger-containing protein; amn, which encodes a putative neuropeptide related to the ..
  5. Ditzel M, Broemer M, Tenev T, Bolduc C, Lee T, Rigbolt K, et al. Inactivation of effector caspases through nondegradative polyubiquitylation. Mol Cell. 2008;32:540-53 pubmed publisher
    ..Taken together, our findings demonstrate that effector caspases regulate their own inhibition through a negative feedback mechanism involving DIAP1 "activation" and nondegradative polyubiquitylation. ..
  6. Hashimoto H, Shintani N, Baba A. Higher brain functions of PACAP and a homologous Drosophila memory gene amnesiac: insights from knockouts and mutants. Biochem Biophys Res Commun. 2002;297:427-31 pubmed
    ..A functional comparison between PACAP and amnesiac underlines phylogenetically conserved functions across phyla and may provide insights into the possible mechanisms of action and evolution of this neuropeptidergic system. ..
  7. Arama E, Agapite J, Steller H. Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila. Dev Cell. 2003;4:687-97 pubmed
    ..These observations suggest that an apoptosis-like mechanism is required for spermatid differentiation in Drosophila. ..
  8. Riesgo Escovar J, Woodard C, Gaines P, Carlson J. Development and organization of the Drosophila olfactory system: an analysis using enhancer traps. J Neurobiol. 1992;23:947-64 pubmed
  9. Sekelsky J, McKim K, Messina L, French R, Hurley W, Arbel T, et al. Identification of novel Drosophila meiotic genes recovered in a P-element screen. Genetics. 1999;152:529-42 pubmed
    ..Although most of these are alleles of previously undescribed genes, five were in the known genes alphaTubulin67C, CycE, push, and Trl. The five mutations in known genes produce novel phenotypes for those genes.

More Information


  1. Fabrizio J, Hime G, Lemmon S, Bazinet C. Genetic dissection of sperm individualization in Drosophila melanogaster. Development. 1998;125:1833-43 pubmed
    ..but result in a breakdown in the complex after it begins to translocate down the cyst, and (4) mutations (purity of essence class) that allow the assembly of a motile but morphologically altered or reduced individualization complex...
  2. Ashton Beaucage D, Lemieux C, Udell C, Sahmi M, Rochette S, Therrien M. The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila. PLoS Biol. 2016;14:e1002539 pubmed publisher
    ..Using an RNAi-based genetic interaction screening strategy, we identified UBC6, POE/UBR4, and UFD4, respectively, as E2 and E3 enzymes that oppose USP47 activity...