Gene Symbol: pnr
Description: pannier
Alias: CG3978, CG3978-PA, Dmel\CG3978, GATA, GATA4, GATAa, GATAa/Pannier, PNR, Pnr, dGATAa, dGATAa/pannier, l(3)89B3, prn, pannier, CG3978-PA, CG3978-PB, CG3978-PC, CG3978-PD, pnr-PA, pnr-PB, pnr-PC, pnr-PD
Species: fruit fly

Top Publications

  1. Vervoort M, Dambly Chaudiere C, Ghysen A. Cell fate determination in Drosophila. Curr Opin Neurobiol. 1997;7:21-8 pubmed
    ..Recent results illuminate, for several of these steps, the nature of the local heterogeneities and the mechanism used to interpret them in terms of cell fate decisions. ..
  2. Reim I, Frasch M. The Dorsocross T-box genes are key components of the regulatory network controlling early cardiogenesis in Drosophila. Development. 2005;132:4911-25 pubmed
    ..In an early step, the Dorsocross genes act in parallel with tinman to activate the expression of pannier, a cardiogenic gene encoding a Gata factor...
  3. Southon A, Farlow A, Norgate M, Burke R, Camakaris J. Malvolio is a copper transporter in Drosophila melanogaster. J Exp Biol. 2008;211:709-16 pubmed publisher
    ..These results demonstrate Mvl is a functional Cu transporter and that despite partial functional redundancy with the Ctr1 proteins, Cu uptake through this pathway is necessary for optimal viability at the cellular and organismal levels. ..
  4. Lin W, Huang L, Yeh J, Hoheisel J, Lehrach H, Sun Y, et al. Expression of a Drosophila GATA transcription factor in multiple tissues in the developing embryos. Identification of homozygous lethal mutants with P-element insertion at the promoter region. J Biol Chem. 1995;270:25150-8 pubmed
    b>GATA transcription factors are DNA-binding proteins that recognize the core consensus sequence, WGATAR. Previous studies indicated that GATA factors play ann important role in the development of tissue-specific functions in vertebrates...
  5. Reim I, Mohler J, Frasch M. Tbx20-related genes, mid and H15, are required for tinman expression, proper patterning, and normal differentiation of cardioblasts in Drosophila. Mech Dev. 2005;122:1056-69 pubmed
    ..Through this activity, mid and H15 are required for the normal functional diversification of cardioblasts and the expression of tin-dependent terminal differentiation genes within the dorsal vessel. ..
  6. Affolter M, Marty T, Vigano M, Jazwinska A. Nuclear interpretation of Dpp signaling in Drosophila. EMBO J. 2001;20:3298-305 pubmed
    ..It remains to be seen whether similar molecular mechanisms operate in the nucleus in vertebrate systems. ..
  7. Gajewski K, Zhang Q, Choi C, Fossett N, Dang A, Kim Y, et al. Pannier is a transcriptional target and partner of Tinman during Drosophila cardiogenesis. Dev Biol. 2001;233:425-36 pubmed
    ..The GATA factor gene pannier is similarly expressed in the dorsal-most part of the mesoderm where it is required for the formation of the ..
  8. Fromental Ramain C, Vanolst L, Delaporte C, Ramain P. pannier encodes two structurally related isoforms that are differentially expressed during Drosophila development and display distinct functions during thorax patterning. Mech Dev. 2008;125:43-57 pubmed
    Previous studies have shown that the pannier (pnr) gene of Drosophila encodes a GATA transcription factor which is involved in various biological processes, including heart development, dorsal closure during embryogenesis as well as ..
  9. Marty T, Muller B, Basler K, Affolter M. Schnurri mediates Dpp-dependent repression of brinker transcription. Nat Cell Biol. 2000;2:745-9 pubmed
    ..The existence of several Shn-like proteins in vertebrates and the observation that Brk functions in BMP signalling in Xenopus indicates that a similar regulatory cascade may be conserved in higher organisms. ..

More Information


  1. Letizia A, Barrio R, Campuzano S. Antagonistic and cooperative actions of the EGFR and Dpp pathways on the iroquois genes regulate Drosophila mesothorax specification and patterning. Development. 2007;134:1337-46 pubmed
    ..of the EGFR and Dpp pathways, mediated by the transcription factors Pointed (downstream of EGFR pathway) and Pannier/U-shaped and Mothers against Dpp (Mad), in the case of Dpp...
  2. Cubadda Y, Heitzler P, Ray R, Bourouis M, Ramain P, Gelbart W, et al. u-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila. Genes Dev. 1997;11:3083-95 pubmed
    ..The effects of u-shaped mutants are similar to those of a class of dominant alleles of the gene pannier with which they display allele-specific interactions, suggesting that the products of both genes cooperate in the ..
  3. Miskolczi McCallum C, Scavetta R, Svendsen P, Soanes K, Brook W. The Drosophila melanogaster T-box genes midline and H15 are conserved regulators of heart development. Dev Biol. 2005;278:459-72 pubmed
    ..midline and H15 in the dorsal vessel is dependent on Wingless signaling and the transcription factors tinman and pannier. We find that the selection of two midline-expressing cells from a pool of competent progenitors is dependent on ..
  4. Mann T, Bodmer R, Pandur P. The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis. Development. 2009;136:317-26 pubmed publisher
    ..Indeed, tup mutants are characterized by a reduction of the essential early cardiac transcription factors Tin, Pnr and Dorsocross1-3 (Doc)...
  5. W lbeck C, Simpson P. Expression of achaete-scute homologues in discrete proneural clusters on the developing notum of the medfly Ceratitis capitata, suggests a common origin for the stereotyped bristle patterns of higher Diptera. Development. 2000;127:1411-20 pubmed
    ..that relies on an array of cis-regulatory elements and spatially restricted transcriptional activators such as Pannier. Other species of derived schizophoran Diptera have equally stereotyped, but different, bristle patterns...
  6. Klinedinst S, Bodmer R. Gata factor Pannier is required to establish competence for heart progenitor formation. Development. 2003;130:3027-38 pubmed
    ..We present evidence that the Gata transcription factor, Pannier, and its binding partner U-shaped, also a zinc-finger protein, cooperate in the process of heart development...
  7. Skaer N, Simpson P. Genetic analysis of bristle loss in hybrids between Drosophila melanogaster and D. simulans provides evidence for divergence of cis-regulatory sequences in the achaete-scute gene complex. Dev Biol. 2000;221:148-67 pubmed
  8. Winick J, Abel T, Leonard M, Michelson A, Chardon Loriaux I, Holmgren R, et al. A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster. Development. 1993;119:1055-65 pubmed
    ..that GATA proteins may also be involved in Drosophila development, we have isolated and characterized a gene (dGATAa) encoding a factor that is quite similar to mammalian GATA factors...
  9. Cavodeassi F, Modolell J, Gomez Skarmeta J. The Iroquois family of genes: from body building to neural patterning. Development. 2001;128:2847-55 pubmed
    ..Later in development in both Drosophila and vertebrates, the Iro genes function again to subdivide those territories into smaller domains...
  10. Simpson P, Woehl R, Usui K. The development and evolution of bristle patterns in Diptera. Development. 1999;126:1349-64 pubmed
  11. Boettiger A, Levine M. Synchronous and stochastic patterns of gene activation in the Drosophila embryo. Science. 2009;325:471-3 pubmed publisher
    ..Transcriptional synchrony might ensure the orderly deployment of the complex gene regulatory networks that control embryogenesis. ..
  12. Senger K, Harris K, Levine M. GATA factors participate in tissue-specific immune responses in Drosophila larvae. Proc Natl Acad Sci U S A. 2006;103:15957-62 pubmed
    ..The regulation of antimicrobial genes in larval fat depends on linked Rel/NF-kappaB and GATA binding sites. Serpent functions as the major GATA transcription factor in the larval fat body...
  13. Qian L, Liu J, Bodmer R. Neuromancer Tbx20-related genes (H15/midline) promote cell fate specification and morphogenesis of the Drosophila heart. Dev Biol. 2005;279:509-24 pubmed
    ..In exploring the regulation of nmr, we find that the GATA factor Pannier is essential for cardiac expression, and acts synergistically with Tinman in promoting nmr expression...
  14. Sellin J, Albrecht S, Kölsch V, Paululat A. Dynamics of heart differentiation, visualized utilizing heart enhancer elements of the Drosophila melanogaster bHLH transcription factor Hand. Gene Expr Patterns. 2006;6:360-75 pubmed
  15. Calleja M, Renaud O, Usui K, Pistillo D, Morata G, Simpson P. How to pattern an epithelium: lessons from achaete-scute regulation on the notum of Drosophila. Gene. 2002;292:1-12 pubmed
    ..It is suggested that in the medial notum, the selector-like gene pannier regulates the entire pattern, and is the only factor to directly activate AS-C genes...
  16. de Navascués J, Modolell J. tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specification. Development. 2007;134:1779-88 pubmed
    ..Our data support a model in which the EGFR and Dpp signalling pathways, with their respective downstream Iro-C and tup genes, converge and cooperate to commit cells to the notum developmental fate. ..
  17. Gibert J, Marcellini S, David J, Schlotterer C, Simpson P. A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription factor poils-au-dos, a repressor of achaete-scute. Dev Biol. 2005;288:194-205 pubmed
    ..In addition, we show that pad interacts synergistically with the repressor hairy and with Dpp signaling in posterior and anterior regions of the notum, respectively. ..
  18. Ashe H, Mannervik M, Levine M. Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryo. Development. 2000;127:3305-12 pubmed
    ..Brk was found to repress two target genes, tailup and pannier, that exhibit different limits of expression within the dorsal ectoderm...
  19. Gajewski K, Fossett N, Molkentin J, Schulz R. The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila. Development. 1999;126:5679-88 pubmed
    ..We show that the GATA gene pannier is expressed in the dorsal mesoderm and required for cardial cell formation while repressing a pericardial cell ..
  20. Calleja M, Herranz H, Estella C, Casal J, Lawrence P, Simpson P, et al. Generation of medial and lateral dorsal body domains by the pannier gene of Drosophila. Development. 2000;127:3971-80 pubmed
    The pannier (pnr) gene encodes a GATA transcription factor and acts in several developmental processes in Drosophila, including embryonic dorsal closure, specification of cardiac cells and bristle determination...
  21. Ryu J, Najand N, Brook W. Tinman is a direct activator of midline in the Drosophila dorsal vessel. Dev Dyn. 2011;240:86-95 pubmed publisher
    Heart development requires a conserved core of transcription factors comprised of Nkx2.5, GATA and T-box family transcription factors. In Drosophila melanogaster, the Nkx2...
  22. Heitzler P, Haenlin M, Ramain P, Calleja M, Simpson P. A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in Drosophila. Genetics. 1996;143:1271-86 pubmed
    A genetic and phenotypic analysis of the gene pannier is described. Animals mutant for strong alleles die as embryos in which the cells of the amnioserosa are prematurely lost. This leads to a dorsal cuticular hole...
  23. Davidson E, Erwin D. Gene regulatory networks and the evolution of animal body plans. Science. 2006;311:796-800 pubmed
    ..Conservation of phyletic body plans may have been due to the retention since pre-Cambrian time of GRN kernels, which underlie development of major body parts. ..
  24. Singh A, Choi K. Initial state of the Drosophila eye before dorsoventral specification is equivalent to ventral. Development. 2003;130:6351-60 pubmed
    ..In Drosophila eye disc, a dorsal-specific GATA family transcription factor pannier (pnr) controls Iroquois-Complex (Iro-C) genes to establish the dorsal eye fate whereas Lobe (L), which is ..
  25. Herranz H, Morata G. The functions of pannier during Drosophila embryogenesis. Development. 2001;128:4837-46 pubmed
    The pannier (pnr) gene of Drosophila encodes a zinc-finger transcription factor of the GATA family and is involved in several developmental processes during embryonic and imaginal development...
  26. Ramain P, Heitzler P, Haenlin M, Simpson P. pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1. Development. 1993;119:1277-91 pubmed
    The gene pannier acts as a repressor of achaete and scute, two transcription factors expressed in discrete subsets of cells at the sites where neural precursors develop...
  27. Biryukova I, Heitzler P. The Drosophila LIM-homeo domain protein Islet antagonizes pro-neural cell specification in the peripheral nervous system. Dev Biol. 2005;288:559-70 pubmed
    ..In the mesothorax, the GATA1 transcription factor Pannier (Pnr), together with its cofactor Chip, activates ac/sc genes directly through binding to the dorso-central ..
  28. Ghazi A, Paul L, Vijayraghavan K. Prepattern genes and signaling molecules regulate stripe expression to specify Drosophila flight muscle attachment sites. Mech Dev. 2003;120:519-28 pubmed
    ..activities of the wingless (wg), decapentaplegic (dpp) and Notch (N) signaling pathways, and the prepattern genes pannier (pnr) and u-shaped (ush) establish domains of sr expression. N is required for initiation of sr expression...
  29. Haenlin M, Cubadda Y, Blondeau F, Heitzler P, Lutz Y, Simpson P, et al. Transcriptional activity of pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila. Genes Dev. 1997;11:3096-108 pubmed
    The genes pannier (pnr) and u-shaped (ush) are required for the regulation of achaete-scute during establishment of the bristle pattern in Drosophila...
  30. Alvarez A, Shi W, Wilson B, Skeath J. pannier and pointedP2 act sequentially to regulate Drosophila heart development. Development. 2003;130:3015-26 pubmed
    ..We go on to show that the GATA transcription factor pannier acts early in dorsal mesoderm development to promote the development of the cardiac mesoderm and thus all heart ..
  31. García García M, Ramain P, Simpson P, Modolell J. Different contributions of pannier and wingless to the patterning of the dorsal mesothorax of Drosophila. Development. 1999;126:3523-32 pubmed
    In Drosophila, the GATA family transcription factor Pannier and the Wnt secreted protein Wingless are known to be important for the patterning of the notum, a part of the dorsal mesothorax of the fly...
  32. Wülbeck C, Simpson P. The expression of pannier and achaete-scute homologues in a mosquito suggests an ancient role of pannier as a selector gene in the regulation of the dorsal body pattern. Development. 2002;129:3861-71 pubmed
    The Drosophila gene pannier (pnr) has recently been assigned to a new class of selector genes (Calleja, M., Herranz, H., Estella, C., Casal, J., Lawrence, P., Simpson, P. and Morata, G. (2000). Development 127, 3971-3980; (Mann, R. S...
  33. Oktaba K, Gutierrez L, Gagneur J, Girardot C, Sengupta A, Furlong E, et al. Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila. Dev Cell. 2008;15:877-89 pubmed publisher
    ..Analysis of cell cycle regulators indicates that the PcG system also dynamically modulates the expression levels of certain genes, providing a possible explanation for the tumor phenotype of PcG mutants. ..
  34. Zecchini V, Brennan K, Martinez Arias A. An activity of Notch regulates JNK signalling and affects dorsal closure in Drosophila. Curr Biol. 1999;9:460-9 pubmed
    ..In the Drosophila embryo, this activity plays an important role in the morphogenetic movements that drive dorsal closure. ..
  35. Modolell J, Campuzano S. The achaete-scute complex as an integrating device. Int J Dev Biol. 1998;42:275-82 pubmed
    ..Thus, the AS-C integrates the positional information embodied in the relatively broad distributions of prepattern factors and creates a sharper and topographically more precise pattern. ..
  36. Campos Ortega J. Cellular interactions in the developing nervous system of Drosophila. Cell. 1994;77:969-75 pubmed
  37. Raftery L, Sutherland D. Gradients and thresholds: BMP response gradients unveiled in Drosophila embryos. Trends Genet. 2003;19:701-8 pubmed
    ..The transition between two gradients of different shape yields new insights into the progression of Drosophila dorsal-ventral patterning and raises new issues about the mechanisms of gradient formation. ..
  38. Down T, Bergman C, Su J, Hubbard T. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS Comput Biol. 2007;3:e7 pubmed
    ..We suggest that further improvements in computational motif discovery should narrow the gap between the set of known motifs and the total number of transcription factors in metazoan genomes. ..
  39. Zitserman D, Gupta S, Kruger W, Karbowniczek M, Roegiers F. The TSC1/2 complex controls Drosophila pigmentation through TORC1-dependent regulation of catecholamine biosynthesis. PLoS ONE. 2012;7:e48720 pubmed publisher
  40. Amodio V, Tevy M, Traina C, Ghosh T, Capovilla M. Transactivation in Drosophila of human enhancers by human transcription factors involved in congenital heart diseases. Dev Dyn. 2012;241:190-9 pubmed publisher
    The human transcription factors (TFs) GATA4, NKX2.5 and TBX5 form part of the core network necessary to build a human heart and are involved in Congenital Heart Diseases (CHDs)...
  41. Grimm C, Matos R, Ly Hartig N, Steuerwald U, Lindner D, Rybin V, et al. Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt. EMBO J. 2009;28:1965-77 pubmed publisher
  42. Erceg J, Saunders T, Girardot C, Devos D, Hufnagel L, Furlong E. Subtle changes in motif positioning cause tissue-specific effects on robustness of an enhancer's activity. PLoS Genet. 2014;10:e1004060 pubmed publisher
    ..This result has important implications for human eQTL studies in which many associated mutations are found in cis-regulatory regions, though the mechanism for how they affect tissue-specific gene expression is often not understood. ..
  43. Staehling Hampton K, Laughon A, Hoffmann F. A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling. Development. 1995;121:3393-403 pubmed
    ..We conclude that shn function is critical for cells to respond properly to dpp and propose that shn protein is the first identified downstream component of the signal transduction pathway used by dpp and its receptors. ..
  44. Akasaka T, Klinedinst S, Ocorr K, Bustamante E, Kim S, Bodmer R. The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman. Proc Natl Acad Sci U S A. 2006;103:11999-2004 pubmed
    ..are critical to dSUR expression, and further genetic manipulations suggest that the GATA transcription factor Pannier is synergistically involved in cardiac-restricted dSUR expression in vivo...
  45. Zhang H, Levine M, Ashe H. Brinker is a sequence-specific transcriptional repressor in the Drosophila embryo. Genes Dev. 2001;15:261-6 pubmed
    ..We discuss other examples of transcriptional repressors constraining the activities of signaling pathways. ..
  46. Okumura T, Matsumoto A, Tanimura T, Murakami R. An endoderm-specific GATA factor gene, dGATAe, is required for the terminal differentiation of the Drosophila endoderm. Dev Biol. 2005;278:576-86 pubmed
    b>GATA factors play an essential role in endodermal specification in both protostomes and deuterostomes. In Drosophila, the GATA factor gene serpent (srp) is critical for differentiation of the endoderm...
  47. Lossky M, Wensink P. Regulation of Drosophila yolk protein genes by an ovary-specific GATA factor. Mol Cell Biol. 1995;15:6943-52 pubmed
    ..The sequence of the element consists of two recognition sites for the GATA family of transcription factors...
  48. Lu Y, Wu L, Anderson K. The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase. Genes Dev. 2001;15:104-10 pubmed
    ..The ird5 gene encodes a Drosophila homolog of mammalian IkappaB kinases (IKKs). The ird5 phenotype and sequence suggest that the gene is specifically required for the activation of Relish, a Drosophila NF-kappaB family member. ..
  49. Fuda N, Buckley M, Wei W, Core L, Waters C, Reinberg D, et al. Fcp1 dephosphorylation of the RNA polymerase II C-terminal domain is required for efficient transcription of heat shock genes. Mol Cell Biol. 2012;32:3428-37 pubmed publisher
    ..Our results indicate that Fcp1 is required to maintain the pool of initiation-competent unphosphorylated Pol II, and this function is particularly important for the highly transcribed heat shock genes. ..
  50. Xu R, Deng K, Zhu Y, Wu Y, Ren J, Wan M, et al. A large-scale functional approach to uncover human genes and pathways in Drosophila. Cell Res. 2008;18:1114-27 pubmed publisher
    ..In summary, the functions of many human genes appear to be highly conserved, and the ability to identify them in Drosophila represents a powerful genetic tool for large-scale analysis of human transcripts in vivo. ..
  51. Calleja M, Moreno E, Pelaz S, Morata G. Visualization of gene expression in living adult Drosophila. Science. 1996;274:252-5 pubmed
    ..The boundary between two of these domains coincides with localized expression of the signaling molecule wingless. ..
  52. Chen J, Fishman M. Genetics of heart development. Trends Genet. 2000;16:383-8 pubmed
    ..Mutational analysis in mice and, as particular focus of this review, in zebrafish, reveals the additional genes brought into play to fashion these evolutionarily 'new' organotypic components. ..
  53. Ricos M, Harden N, Sem K, Lim L, Chia W. Dcdc42 acts in TGF-beta signaling during Drosophila morphogenesis: distinct roles for the Drac1/JNK and Dcdc42/TGF-beta cascades in cytoskeletal regulation. J Cell Sci. 1999;112 ( Pt 8):1225-35 pubmed
    ..Signaling in the transforming-growth-factor-beta-like pathway is mediated by Dcdc42, and acts during the closure process to control the mechanics of the migration process, most likely via its putative effector kinase DPAK. ..
  54. Künnapuu J, Tauscher P, Tiusanen N, Nguyen M, Löytynoja A, Arora K, et al. Cleavage of the Drosophila screw prodomain is critical for a dynamic BMP morphogen gradient in embryogenesis. Dev Biol. 2014;389:149-59 pubmed publisher
    ..These data reveal novel mechanisms by which post-translational regulation of Scw can modulate Dpp signaling activity. ..
  55. Alfieri C, Gambetta M, Matos R, Glatt S, Sehr P, Fraterman S, et al. Structural basis for targeting the chromatin repressor Sfmbt to Polycomb response elements. Genes Dev. 2013;27:2367-79 pubmed publisher
    ..Our results support a model where DNA tethering of Sfmbt by Pho and multivalent interactions of Sfmbt with histone modifications and other PcG proteins create a hub for PcG protein complex assembly at PREs. ..
  56. Robinson R. Small change: study of enhancer supports evolution model. PLoS Biol. 2006;4:e419 pubmed publisher
  57. Whittle J. How is developmental stability sustained in the face of genetic variation?. Int J Dev Biol. 1998;42:495-9 pubmed
    ..This phenomenon is examined and possible mechanisms contributing to stability of this developmental event are discussed, but the notion that the character is canalized is found not to be heuristic. ..
  58. Asmar J, Biryukova I, Heitzler P. Drosophila dLMO-PA isoform acts as an early activator of achaete/scute proneural expression. Dev Biol. 2008;316:487-97 pubmed publisher
    ..Mediodorsal proneural patterning is mediated through the GATA transcription factor Pannier (Pnr) that activates ac/sc directly through binding to the dorsocentral (DC) enhancer of ac/sc...
  59. Ramain P, Khechumian R, Khechumian K, Arbogast N, Ackermann C, Heitzler P. Interactions between chip and the achaete/scute-daughterless heterodimers are required for pannier-driven proneural patterning. Mol Cell. 2000;6:781-90 pubmed
    The GATA factor Pannier activates the achaete-scute (ASC) proneural complex through enhancer binding and provides positional information for sensory bristle patterning in Drosophila...
  60. Tokusumi T, Russell M, Gajewski K, Fossett N, Schulz R. U-shaped protein domains required for repression of cardiac gene expression in Drosophila. Differentiation. 2007;75:166-74 pubmed
    ..acts to control cardioblast specification, working as a negative attenuator of the cardiogenic GATA factor Pannier. Pannier and the homeodomain protein Tinman normally work together to specify heart cells and activate ..
  61. de Navascués J, Modolell J. The pronotum LIM-HD gene tailup is both a positive and a negative regulator of the proneural genes achaete and scute of Drosophila. Mech Dev. 2010;127:393-406 pubmed publisher
    ..We conclude that tailup acts on bristle development by several, even antagonistic, mechanisms. ..
  62. Xu P, Johnson T, Stoller Conrad J, Schulz R. Spire, an actin nucleation factor, regulates cell division during Drosophila heart development. PLoS ONE. 2012;7:e30565 pubmed publisher
    ..In addition, genetic interaction analysis shows that spir functionally interacts with Dorsocross, tin, and pannier to properly specify the cardiac fate...
  63. Holmqvist P, Boija A, Philip P, Crona F, Stenberg P, Mannervik M. Preferential genome targeting of the CBP co-activator by Rel and Smad proteins in early Drosophila melanogaster embryos. PLoS Genet. 2012;8:e1002769 pubmed publisher
    ..We conclude that CBP occupancy in Drosophila embryos preferentially overlaps factors controlling dorso-ventral patterning and that CBP binds silent genes without causing histone hyperacetylation. ..
  64. Gurdon J, Bourillot P. Morphogen gradient interpretation. Nature. 2001;413:797-803 pubmed
  65. Furlong E. Integrating transcriptional and signalling networks during muscle development. Curr Opin Genet Dev. 2004;14:343-50 pubmed
    ..The integration of additional signalling inputs with localised repression within these competence domains results in diverse transcriptional responses within neighbouring cells, which in turn generates muscle diversity. ..
  66. Tuxworth R, Vivancos V, O Hare M, Tear G. Interactions between the juvenile Batten disease gene, CLN3, and the Notch and JNK signalling pathways. Hum Mol Genet. 2009;18:667-78 pubmed publisher
    ..We have identified previously unknown interactions between CLN3 and the Notch and Jun N-terminal kinase signalling pathways and have uncovered a potential role for the RNA splicing and localization machinery in regulating CLN3 function. ..
  67. Biryukova I, Heitzler P. Drosophila C-terminal binding protein, dCtBP is required for sensory organ prepattern and sharpens proneural transcriptional activity of the GATA factor Pnr. Dev Biol. 2008;323:64-75 pubmed publisher
    ..Moreover, we found that dCtBP mediates multivalent interaction with the GATA transcriptional activator Pannier and acts as a direct co-repressor of the Pannier-mediated activation of proneural genes...
  68. Norgate M, Southon A, Greenough M, Cater M, Farlow A, Batterham P, et al. Syntaxin 5 is required for copper homeostasis in Drosophila and mammals. PLoS ONE. 2010;5:e14303 pubmed publisher
    ..Thus Syx5 plays an essential role in copper homeostasis and is a candidate gene for copper-related disease in humans. ..
  69. Ghysen A, Dambly Chaudiere C. A genetic programme for neuronal connectivity. Trends Genet. 2000;16:221-6 pubmed
    ..The ongoing analysis of pathfinding mutants suggests plausible mechanisms for the translation of neuronal identity into axonal behaviour. ..
  70. Zenvirt S, Nevo Caspi Y, Rencus Lazar S, Segal D. Drosophila LIM-only is a positive regulator of transcription during thoracic bristle development. Genetics. 2008;179:1989-99 pubmed publisher
    ..This phenotype is typical of malfunction of a thoracic multiprotein transcription complex, composed of CHIP, PANNIER (PNR), ACHAETE (AC), and DAUGHTERLESS (DA)...
  71. Huang F. Syntagms in development and evolution. Int J Dev Biol. 1998;42:487-94 pubmed
    ..In this review, we will describe a series of developmental syntagms, and explore the consequences of this discontinuous organization of the developmental program on evolution. ..
  72. Gillis W, BOWERMAN B, Schneider S. The evolution of protostome GATA factors: molecular phylogenetics, synteny, and intron/exon structure reveal orthologous relationships. BMC Evol Biol. 2008;8:112 pubmed publisher
    Invertebrate and vertebrate GATA transcription factors play important roles in ectoderm and mesendoderm development, as well as in cardiovascular and blood cell fate specification...