Gene Symbol: png
Description: pan gu
Alias: CG11420, Dmel\CG11420, EG:8D8.5, PNG, Png, fs(1)M2, pan-gnu, pan gu, CG11420-PA, png-PA
Species: fruit fly

Top Publications

  1. Grossniklaus U, Bellen H, Wilson C, Gehring W. P-element-mediated enhancer detection applied to the study of oogenesis in Drosophila. Development. 1989;107:189-200 pubmed
    ..On the basis of our results, we suggest new strategies, which are not primarily based on the generation of mutants, to screen for and isolated female sterile genes. ..
  2. Loppin B, Dubruille R, Horard B. The intimate genetics of Drosophila fertilization. Open Biol. 2015;5: pubmed publisher
  3. Elfring L, Axton J, Fenger D, Page A, Carminati J, Orr Weaver T. Drosophila PLUTONIUM protein is a specialized cell cycle regulator required at the onset of embryogenesis. Mol Biol Cell. 1997;8:583-93 pubmed
    ..The pan gu (png) and giant nuclei (gnu) genes also affect the S-phase in the unfertilized egg and early embryo...
  4. Kronja I, Yuan B, Eichhorn S, Dzeyk K, Krijgsveld J, Bartel D, et al. Widespread changes in the posttranscriptional landscape at the Drosophila oocyte-to-embryo transition. Cell Rep. 2014;7:1495-1508 pubmed publisher
    ..Our results show that PNG kinase is a critical regulator of the extensive changes in the translatome, acting uniquely at this developmental ..
  5. Lerit D, Gavis E. Transport of germ plasm on astral microtubules directs germ cell development in Drosophila. Curr Biol. 2011;21:439-48 pubmed publisher
    ..Transport on astral microtubules may provide a general mechanism for the segregation of cell fate determinants. ..
  6. Thomsen S, Anders S, Janga S, Huber W, Alonso C. Genome-wide analysis of mRNA decay patterns during early Drosophila development. Genome Biol. 2010;11:R93 pubmed publisher
    ..Our data also provide a valuable resource for further experimental and computational studies investigating the process of mRNA decay. ..
  7. Lee L, Lee E, Anderson M, Vardy L, Tahinci E, Ali S, et al. Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. Dev Cell. 2005;8:435-42 pubmed
    ..Gene Collection were used in a Drosophila in vitro expression cloning ("DIVEC") screen for substrates of PAN GU kinase, which is crucial for S-M embryonic cell cycles...
  8. Vardy L, Orr Weaver T. The Drosophila PNG kinase complex regulates the translation of cyclin B. Dev Cell. 2007;12:157-66 pubmed
    The Drosophila PAN GU (PNG) kinase complex regulates the developmental translation of cyclin B. cyclin B mRNA becomes unmasked during oogenesis independent of PNG activity, but PNG is required for translation from egg activation...
  9. Hara M, Petrova B, Orr Weaver T. Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation. elife. 2017;6: pubmed publisher
    The oocyte-to-embryo transition involves extensive changes in mRNA translation, regulated in Drosophila by the PNG kinase complex whose activity we show here to be under precise developmental control...

More Information


  1. Shamanski F, Orr Weaver T. The Drosophila plutonium and pan gu genes regulate entry into S phase at fertilization. Cell. 1991;66:1289-300 pubmed
    Mutations in the Drosophila maternal genes plutonium (plu) and pan gu (png) have the striking phenotype that DNA replication initiates in unfertilized eggs...
  2. Onischenko E, Gubanova N, Kiseleva E, Hallberg E. Cdk1 and okadaic acid-sensitive phosphatases control assembly of nuclear pore complexes in Drosophila embryos. Mol Biol Cell. 2005;16:5152-62 pubmed
  3. Vardy L, Pesin J, Orr Weaver T. Regulation of Cyclin A protein in meiosis and early embryogenesis. Proc Natl Acad Sci U S A. 2009;106:1838-43 pubmed publisher
    ..The PAN GU (PNG) kinase positively promotes translation of Cyclin A, beginning in oogenesis, an earlier onset than previously ..
  4. Lee L, Van Hoewyk D, Orr Weaver T. The Drosophila cell cycle kinase PAN GU forms an active complex with PLUTONIUM and GNU to regulate embryonic divisions. Genes Dev. 2003;17:2979-91 pubmed
    Early embryonic cell cycles in Drosophila consist of rapidly alternating S and M phases. Three genes, pan gu (png), plutonium (plu), and giant nuclei (gnu) coordinate these early S-M cycles by ensuring adequate Cyclin B protein levels...
  5. Fenger D, Carminati J, Burney Sigman D, Kashevsky H, Dines J, Elfring L, et al. PAN GU: a protein kinase that inhibits S phase and promotes mitosis in early Drosophila development. Development. 2000;127:4763-74 pubmed
    ..In Drosophila, this replication block requires the products of the pan gu (png), plutonium (plu) and giant nuclei (gnu) genes...
  6. Sitaram P, Merkle J, Lee E, Lee L. asunder is required for dynein localization and dorsal fate determination during Drosophila oogenesis. Dev Biol. 2014;386:42-52 pubmed publisher
    ..Taken together, our data indicate that asun is a critical regulator of dynein localization and dynein-mediated processes during Drosophila oogenesis. ..
  7. Liu J, Lin H, Lopez J, Wolfner M. Formation of the male pronuclear lamina in Drosophila melanogaster. Dev Biol. 1997;184:187-96 pubmed
    ..mutant embryos defective for the function of either the male pronucleus (mh, K81, and pal or both pronuclei (gnu, png, and plu)...
  8. Pellicena Palle A, Stitzinger S, Salz H. The function of the Drosophila thioredoxin homologue encoded by the deadhead gene is redox-dependent and blocks the initiation of development but not DNA synthesis. Mech Dev. 1997;62:61-5 pubmed
    ..The observed epistatic relationship between these mutations clearly indicates that deadhead is not essential for DNA metabolism. The possibility of a regulatory role in controlling the initiation of S-phase is discussed. ..
  9. Renault A, Zhang X, Alphey L, Frenz L, Glover D, Saunders R, et al. giant nuclei is essential in the cell cycle transition from meiosis to mitosis. Development. 2003;130:2997-3005 pubmed
    ..Drosophila requires the cell cycle regulators encoded by the genes, giant nuclei (gnu), plutonium (plu) and pan gu (png)...