Gene Symbol: plx
Description: pollux
Alias: CG1093, CG14674, CG34122, CG42612, Dmel\CG42612, Dmel_CG1093, Dmel_CG14674, Dmel_CG34122, Plx, pollux, CG42612-PA, CG42612-PC, CG42612-PD, CG42612-PE, CG42612-PF, plx-PA, plx-PC, plx-PD, plx-PE, plx-PF
Species: fruit fly

Top Publications

  1. Neuwald A. A shared domain between a spindle assembly checkpoint protein and Ypt/Rab-specific GTPase-activators. Trends Biochem Sci. 1997;22:243-4 pubmed
  2. Zhang S, Kassis J, Olde B, Mellerick D, Odenwald W. Pollux, a novel Drosophila adhesion molecule, belongs to a family of proteins expressed in plants, yeast, nematodes, and man. Genes Dev. 1996;10:1108-19 pubmed
    ..Here we describe a new member of the adhesive repertoire encoded by the Drosophila pollux (plx) gene...
  3. Tatomer D, Rizzardi L, Curry K, Witkowski A, Marzluff W, Duronio R. Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions. Nucleus. 2014;5:613-25 pubmed publisher
    ..This localization depends on the RNA binding protein ypsilon schachtel. CPSF-73 and a number of mRNAs are localized at this same site, suggesting that Symplekin participates in cytoplasmic polyadenylation at tricellular junctions. ..
  4. Xu X, Wes P, Chen H, Li H, Yu M, Morgan S, et al. Retinal targets for calmodulin include proteins implicated in synaptic transmission. J Biol Chem. 1998;273:31297-307 pubmed
    ..Two other calmodulin-binding proteins included Pollux, a protein with similarity to a portion of a yeast Rab GTPase activating protein, and Calossin, an enormous ..
  5. Gabernet Castello C, O Reilly A, Dacks J, Field M. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Mol Biol Cell. 2013;24:1574-83 pubmed publisher
    ..The reconstruction also shows conservation of ancestral TBC subfamilies, continuing evolution of new TBCs, and frequent secondary losses. These patterns give additional insights into the sculpting of the endomembrane system. ..
  6. Jha A, Zhou D, Brown C, Kreitman M, Haddad G, White K. Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Mol Biol Evol. 2016;33:501-17 pubmed publisher
    ..Thus, our results indicate that selection for hypoxia tolerance can act on standing genetic variation in similar genes and pathways present in organisms diverged by hundreds of millions of years. ..
  7. Hitier R, Chaminade M, Preat T. The Drosophila castor gene is involved in postembryonic brain development. Mech Dev. 2001;103:3-11 pubmed
    ..We show that cas interacts genetically with lio and nob. These interactions do not involve direct transcription regulation but probably cellular communication processes. ..
  8. Zhang S, Odenwald W. Misexpression of the white (w) gene triggers male-male courtship in Drosophila. Proc Natl Acad Sci U S A. 1995;92:5525-9 pubmed
    ..These findings demonstrate that, in Drosophila, both genetic and environmental factors play a role in male sexual behavior...
  9. Speicher S, Garcia Alonso L, Carmena A, Martin Bermudo M, De La Escalera S, Jimenez F. Neurotactin functions in concert with other identified CAMs in growth cone guidance in Drosophila. Neuron. 1998;20:221-33 pubmed
    ..This result provides evidence for functional cooperativity in vivo between the adhesion and signaling pathways controlled by neurotactin and the other three genes. ..

More Information


  1. Yedvobnick B, Smoller D. Sequence and expression analysis of a Drosophila gene product related to the tre oncogene. Biochim Biophys Acta. 1998;1395:275-80 pubmed
    ..The deduced encoded protein, DRN-TRE, contains residues that are highly conserved across a wide phylogenetic spectrum. The temporal and spatial transcription pattern of DRN-TRE suggest that it functions in a broad range of tissues. ..
  2. Chen Z, Sturgill D, Qu J, Jiang H, Park S, Boley N, et al. Comparative validation of the D. melanogaster modENCODE transcriptome annotation. Genome Res. 2014;24:1209-23 pubmed publisher
    ..We report that the vast majority of elements in the annotation are evolutionarily conserved, indicating that the annotation will be an important springboard for functional genetic testing by the Drosophila community. ..
  3. Mellerick D, Kassis J, Zhang S, Odenwald W. castor encodes a novel zinc finger protein required for the development of a subset of CNS neurons in Drosophila. Neuron. 1992;9:789-803 pubmed