Gene Symbol: Pkd2
Description: Polycystic kidney disease 2
Alias: AMO, Amo, CG6504, Dmel\CG6504, Dmpkd2, PKD2, TRPP, TRPP2, amo, pkd2, polycystic kidney disease 2, CG6504-PA, Pkd2-PA, almost there, polycystic kidney disease 2 ortholog, polycystic kidney disease gene-2, polycystin-2
Species: fruit fly

Top Publications

  1. Kwon Y, Kim S, Ronderos D, Lee Y, Akitake B, Woodward O, et al. Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Curr Biol. 2010;20:1672-8 pubmed publisher
  2. Gao Z, Joseph E, Ruden D, Lu X. Drosophila Pkd2 is haploid-insufficient for mediating optimal smooth muscle contractility. J Biol Chem. 2004;279:14225-31 pubmed
    Humans heterozygous for PKD1 or PKD2 develop autosomal dominant polycystic kidney disease, a common genetic disorder characterized by renal cyst formation and extrarenal complications such as hypertension and vascular aneurysms...
  3. Kwon Y, Shim H, Wang X, Montell C. Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade. Nat Neurosci. 2008;11:871-3 pubmed publisher
    ..We propose that activation of TRPA1 through a signaling cascade promotes amplification of small differences in temperature and facilitates adaptation to temperatures within the comfortable range. ..
  4. Watnick T, Jin Y, Matunis E, Kernan M, Montell C. A flagellar polycystin-2 homolog required for male fertility in Drosophila. Curr Biol. 2003;13:2179-84 pubmed
    ..A targeted mutation in this gene, almost there (amo), caused nearly complete male sterility...
  5. Venglarik C, Gao Z, Lu X. Evolutionary conservation of Drosophila polycystin-2 as a calcium-activated cation channel. J Am Soc Nephrol. 2004;15:1168-77 pubmed
    ..It is here shown that expression of DmPKD2 in Drosophila S2 cells produced a novel channel...
  6. Gao Z, Ruden D, Lu X. PKD2 cation channel is required for directional sperm movement and male fertility. Curr Biol. 2003;13:2175-8 pubmed
    ..Here, we report genetic analysis of Drosophila Pkd2 at 33E3 (Pkd2, CG6504), which encodes a Ca(2+)-activated, nonselective cation channel homologous to the human Pkd2 autosomal dominant ..
  7. Zhang Y, Raghuwanshi R, Shen W, Montell C. Food experience-induced taste desensitization modulated by the Drosophila TRPL channel. Nat Neurosci. 2013;16:1468-76 pubmed publisher
    ..We propose that dynamic regulation of taste receptors by ubiquitin-mediated protein degradation comprises an important molecular mechanism that allows an animal to alter its taste behavior in response to a changing food environment. ..
  8. Yang Y, Lu X. Drosophila sperm motility in the reproductive tract. Biol Reprod. 2011;84:1005-15 pubmed publisher
    ..studies have shown that sperm motility is regulated by intraflagellar calcium concentrations; in particular, the Pkd2 calcium channel has been shown to affect sperm storage...
  9. Hofherr A, Wagner C, Watnick T, Köttgen M. Targeted rescue of a polycystic kidney disease mutation by lysosomal inhibition. Kidney Int. 2016;89:949-55 pubmed publisher
    ..Here we show that the ADPKD missense variant TRPP2(D511V) greatly reduces TRPP2 protein stability, and that TRPP2(D511V) function can be rescued in vivo by small ..

More Information


  1. Roos J, DiGregorio P, Yeromin A, Ohlsen K, Lioudyno M, Zhang S, et al. STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol. 2005;169:435-45 pubmed
    ..We propose that STIM1, a ubiquitously expressed protein that is conserved from Drosophila to mammalian cells, plays an essential role in SOC influx and may be a common component of SOC and CRAC channels. ..
  2. Yang Y, Cochran D, Gargano M, King I, Samhat N, Burger B, et al. Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50. Mol Biol Cell. 2011;22:976-87 pubmed publisher
    Eukaryotic cilia and flagella are vital sensory and motile organelles. The calcium channel PKD2 mediates sensory perception on cilia and flagella, and defects in this can contribute to ciliopathic diseases...
  3. Begun D, Holloway A, Stevens K, Hillier L, Poh Y, Hahn M, et al. Population genomics: whole-genome analysis of polymorphism and divergence in Drosophila simulans. PLoS Biol. 2007;5:e310 pubmed
    ..simulans. ..
  4. Venkatachalam K, Hofmann T, Montell C. Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1. J Biol Chem. 2006;281:17517-27 pubmed
    ..These data demonstrate that there is a hierarchy controlling the subcellular distributions of the TRPMLs such that TRPML1 and TRPML2 dictate the localization of TRPML3 and not vice versa. ..
  5. Kwon Y, Shen W, Shim H, Montell C. Fine thermotactic discrimination between the optimal and slightly cooler temperatures via a TRPV channel in chordotonal neurons. J Neurosci. 2010;30:10465-71 pubmed publisher
    ..We conclude that the decision to select the preferred over slightly cooler temperatures requires iav and is achieved by activating chordotonal neurons, which in turn induces repulsive behaviors, due to an increase in high angle turns. ..
  6. Schnakenberg S, Siegal M, Bloch Qazi M. Oh, the places they'll go: Female sperm storage and sperm precedence in Drosophila melanogaster. Spermatogenesis. 2012;2:224-235 pubmed
    ..In this review, we describe male and female factors, as well as their interactions, involved in female sperm storage and differential male fertilization success. ..
  7. Venkatachalam K, Luo J, Montell C. Evolutionarily conserved, multitasking TRP channels: lessons from worms and flies. Handb Exp Pharmacol. 2014;223:937-62 pubmed publisher
    ..Thus, worms and flies offer the potential to decipher roles for mammalian TRPs, which would otherwise not be suspected. ..
  8. Chen Z, Wang Q, Wang Z. The amiloride-sensitive epithelial Na+ channel PPK28 is essential for drosophila gustatory water reception. J Neurosci. 2010;30:6247-52 pubmed publisher
    ..Thus, the amiloride-sensitive PPK28 channel may serve as the osmolarity sensor for gustatory water reception in the fruit fly. ..
  9. Sun J, Spradling A. NR5A nuclear receptor Hr39 controls three-cell secretory unit formation in Drosophila female reproductive glands. Curr Biol. 2012;22:862-71 pubmed publisher
    ..Hr39 functions as a master regulator of a program that may have been conserved throughout animal evolution for the production of female reproductive glands and other secretory tissues. ..
  10. Montell C. Drosophila TRP channels. Pflugers Arch. 2005;451:19-28 pubmed
    ..As a result, the repertoire of biological roles attributed to Drosophila TRPs has increased considerably and is likely to lead to many additional surprises over the next few years. ..
  11. Köttgen M, Hofherr A, Li W, Chu K, Cook S, Montell C, et al. Drosophila sperm swim backwards in the female reproductive tract and are activated via TRPP2 ion channels. PLoS ONE. 2011;6:e20031 pubmed publisher
    ..Amo is a homolog of the human transient receptor potential channel TRPP2 (also known as PKD2), which is mutated in autosomal dominant polycystic kidney disease...
  12. Van Goethem E, Silva E, Xiao H, Franc N. The Drosophila TRPP cation channel, PKD2 and Dmel/Ced-12 act in genetically distinct pathways during apoptotic cell clearance. PLoS ONE. 2012;7:e31488 pubmed publisher
    ..Using a nearby genetically interacting deficiency, we have found that the polycystic kidney disease 2 gene, pkd2, which encodes a member of the TRPP channel family, is also required for phagocytosis of ..
  13. Fowler M, Montell C. Drosophila TRP channels and animal behavior. Life Sci. 2013;92:394-403 pubmed publisher
    ..quot; Drosophila TRPs also function in the sensation of botanically derived insect repellents, and related TRPs in insect pests are potential targets for the development of improved repellents to combat insect-borne diseases. ..
  14. Charlu S, Wisotsky Z, Medina A, Dahanukar A. Acid sensing by sweet and bitter taste neurons in Drosophila melanogaster. Nat Commun. 2013;4:2042 pubmed publisher
    ..The two mechanisms may allow the fly to better evaluate the risk of ingesting acidic foods and modulate its feeding decisions accordingly. ..