Gene Symbol: Pkc98E
Description: Protein C kinase 98E
Alias: 98F, CG1954, Dmel\CG1954, Dpkc3, Nc98F, PK-C, PKC, PKC 98F, PKC d98F, PKC-98F, PKC98C, PKC98E, Pkc3, dPKC98F, nPKC, protein C kinase 98E, CG1954-PA, CG1954-PB, CG1954-PC, CG1954-PD, Neural-conserved-at-98F, PKC-brain, Pkc98E-PA, Pkc98E-PB, Pkc98E-PC, Pkc98E-PD, protein kinase C, protein kinase-c3
Species: fruit fly

Top Publications

  1. Schaeffer E, Smith D, Mardon G, Quinn W, Zuker C. Isolation and characterization of two new drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells. Cell. 1989;57:403-12 pubmed
    We have isolated and characterized two new protein kinase C (PKC) genes from D. melanogaster...
  2. Shieh B, Parker L, Popescu D. Protein kinase C (PKC) isoforms in Drosophila. J Biochem. 2002;132:523-7 pubmed
    Six protein kinase C (PKC) genes are present in Drosophila, comprising two classical PKCs (PKC53E and eye-PKC), two novel PKCs (PKC98E and PKCdelta), an atypical PKC (DaPKC), and a PKC-related kinase...
  3. Andjelkovic M, Jones P, Grossniklaus U, Cron P, Schier A, Dick M, et al. Developmental regulation of expression and activity of multiple forms of the Drosophila RAC protein kinase. J Biol Chem. 1995;270:4066-75 pubmed
    ..DRAC-PK possesses an intrinsic kinase activity that is approximately 8-fold higher in adult flies than in 0-3-h embryos undergoing rapid mitotic cycles. ..
  4. Brubaker Purkey B, Woodruff R. Vitellogenesis in the fruit fly, Drosophila melanogaster: antagonists demonstrate that the PLC, IP3/DAG, PK-C pathway is triggered by calmodulin. J Insect Sci. 2013;13:68 pubmed publisher
  5. Wang S, Wang J, Sun Y, Song Q, Li S. PKC-mediated USP phosphorylation at Ser35 modulates 20-hydroxyecdysone signaling in Drosophila. J Proteome Res. 2012;11:6187-96 pubmed publisher
    ..Our previous studies in Drosophila suggest that PKC modulates 20E signaling by phosphorylating EcR-USP...
  6. Sun Y, An S, Henrich V, Sun X, Song Q. Proteomic identification of PKC-mediated expression of 20E-induced protein in Drosophila melanogaster. J Proteome Res. 2007;6:4478-88 pubmed publisher
    ..Using a proteomic approach, we have shown that protein kinase C (PKC) activity is necessary for mediating 20E-induced expression of 14 specific proteins, including three ..
  7. Kokoza V, Baricheva E, Katokhin A. [Cloning and cytogenetic localization of evolutionarily conserved genomic sequences which are expressed in the head of the Drosophila melanogaster imago]. Genetika. 1991;27:51-60 pubmed
    ..The possibility of further analysis of some clones to study developmental and functional processes in neural system of Drosophila is discussed. ..
  8. Wodarz A, Ramrath A, Grimm A, Knust E. Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J Cell Biol. 2000;150:1361-74 pubmed
    ..Here we show that Baz directly binds to the Drosophila atypical isoform of protein kinase C and that both proteins are mutually dependent on each other for correct apical localization...
  9. Pandur P, Maurus D, Kuhl M. Increasingly complex: new players enter the Wnt signaling network. Bioessays. 2002;24:881-4 pubmed

More Information


  1. Robinson L, Marchant J. Calcium influx: beyond 'current' biology. Curr Biol. 2006;16:R548-50 pubmed
    ..This huge advance will enable molecular dissection of the CRAC channel complex, moving the field beyond Icrac signature to structure. ..
  2. Zacharogianni M, Kondylis V, Tang Y, Farhan H, Xanthakis D, Fuchs F, et al. ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association. EMBO J. 2011;30:3684-700 pubmed publisher
    ..These results reveal the existence of new signalling circuits participating in the complex regulation of cell growth. ..
  3. Tremmel D, Resad S, Little C, Wesley C. Notch and PKC are involved in formation of the lateral region of the dorso-ventral axis in Drosophila embryos. PLoS ONE. 2013;8:e67789 pubmed publisher
    ..They show that Notch activities are inextricably linked to that of Pkc98E, the homolog of mammalian PKC?...
  4. Chen J, Zhang Y, Shen P. Protein kinase C deficiency-induced alcohol insensitivity and underlying cellular targets in Drosophila. Neuroscience. 2010;166:34-9 pubmed publisher
    Multiple subtypes of protein kinase C (PKC) isozymes are implicated in various neurological disorders including alcohol insensitivity, a trait strongly associated with alcoholism in humans, but molecular and cellular mechanisms underlying ..
  5. Zhang J, Yin J, Wesley C. From Drosophila development to adult: clues to Notch function in long-term memory. Front Cell Neurosci. 2013;7:222 pubmed publisher
    ..Our studies in the model organism Drosophila reveal that a non-canonical Notch-protein kinase C activity that plays critical roles in embryonic development also regulates cyclic-AMP response element ..
  6. Zhang J, Little C, Tremmel D, Yin J, Wesley C. Notch-inducible hyperphosphorylated CREB and its ultradian oscillation in long-term memory formation. J Neurosci. 2013;33:12825-34 pubmed publisher
    ..Notch in conjunction with PKC activity upregulates the level of a hyperphosphorylated form of CREB (hyper-PO4 CREB) and triggers its ultradian ..
  7. Chen J, Zhang Y, Shen P. A protein kinase C activity localized to neuropeptide Y-like neurons mediates ethanol intoxication in Drosophila melanogaster. Neuroscience. 2008;156:42-7 pubmed publisher
    ..Here we report a critical role of the conserved protein kinase C (PKC) pathway in mediating the intoxicating effect of ethanol...
  8. Hardie R, Raghu P. Visual transduction in Drosophila. Nature. 2001;413:186-93 pubmed
    ..Analysis in Drosophila has revealed many of the underlying molecular strategies, leading to the discovery and characterization of signalling molecules of widespread importance. ..
  9. Sossin W, Schwartz J. Ca(2+)-independent protein kinase Cs contain an amino-terminal domain similar to the C2 consensus sequence. Trends Biochem Sci. 1993;18:207-8 pubmed
  10. Franke T, Tartof K, Tsichlis P. The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1. Oncogene. 1994;9:141-8 pubmed
    ..carboxyterminal catalytic domain is closely related to the catalytic domains of all the known members of the protein kinase C (PKC) family...
  11. Voets T, Nilius B. TRPs make sense. J Membr Biol. 2003;192:1-8 pubmed
    ..In this review we discuss recent evidence that implicates members of the TRP superfamily in sensory signal transduction. ..
  12. Getahun M, Olsson S, Lavista Llanos S, Hansson B, Wicher D. Insect odorant response sensitivity is tuned by metabotropically autoregulated olfactory receptors. PLoS ONE. 2013;8:e58889 pubmed publisher
    ..Our results indicate that Orco-mediated regulation of OR sensitivity provides tunable ionotropic receptors capable of detecting odors over a wider range of concentrations, providing broadened sensitivity over IRs themselves. ..
  13. Siegfried E, Ambrosio L, Perrimon N. Serine/threonine protein kinases in Drosophila. Trends Genet. 1990;6:357-62 pubmed
    ..This review discusses these recent findings and describes the potential for genetic analyses of kinase activity and signal transduction. ..