Gene Symbol: Pka-R1
Description: Protein kinase, cAMP-dependent, regulatory subunit type 1
Alias: 18304, CG12452, CG18677, CG3263, CG42341, CdkR, DRI, Dmel\CG42341, Dmel_CG12452, Dmel_CG3263, PKA, PKA-R1, PKA-RI, PKAR, PKAi, PKAr, PKa-R1, Pka-RI, PkaR, dPKA-RI, dr[[1]], pKA, pkA, pka-R1, protein kinase, cAMP-dependent, regulatory subunit type 1, CG42341-PAA, CG42341-PAB, CG42341-PAC, CG42341-PK, CG42341-PL, CG42341-PM, CG42341-PN, CG42341-PO, CG42341-PP, CG42341-PQ, CG42341-PR, CG42341-PS, CG42341-PT, CG42341-PU, CG42341-PV, CG42341-PW, CG42341-PX, CG42341-PZ, Pka-R1-PAA, Pka-R1-PAB, Pka-R1-PAC, Pka-R1-PK, Pka-R1-PL, Pka-R1-PM, Pka-R1-PN, Pka-R1-PO, Pka-R1-PP, Pka-R1-PQ, Pka-R1-PR, Pka-R1-PS, Pka-R1-PT, Pka-R1-PU, Pka-R1-PV, Pka-R1-PW, Pka-R1-PX, Pka-R1-PZ, cAMP-dependent protein kinase, cAMP-dependent protein kinase R1, protein kinase A, regulatory subunit of PKA, regulatory subunit of protein kinase A, type I regulatory subunit of cAMP-dependent protein kinase
Species: fruit fly

Top Publications

  1. Rodan A, Kiger J, Heberlein U. Functional dissection of neuroanatomical loci regulating ethanol sensitivity in Drosophila. J Neurosci. 2002;22:9490-501 pubmed
    ..ethanol sensitivity in Drosophila by targeting the expression of an inhibitor of cAMP-dependent protein kinase (PKA) to specific regions in the fly's brain...
  2. Ohlmeyer J, Kalderon D. Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos. Genes Dev. 1997;11:2250-8 pubmed
    ..b>Protein kinase A (PKA) has been implicated in the mechanism of Hh signal transduction because it acts to repress Hh target ..
  3. Davis G, DiAntonio A, Petersen S, Goodman C. Postsynaptic PKA controls quantal size and reveals a retrograde signal that regulates presynaptic transmitter release in Drosophila. Neuron. 1998;20:305-15 pubmed
    Two distinct mechanisms regulate synaptic efficacy at the Drosophila neuromuscular junction (NMJ): a PKA-dependent modulation of quantal size and a retrograde regulation of presynaptic release...
  4. Baines R. Postsynaptic protein kinase A reduces neuronal excitability in response to increased synaptic excitation in the Drosophila CNS. J Neurosci. 2003;23:8664-72 pubmed
    ..Genetic or pharmacological manipulations that either elevate cAMP or increase protein kinase A (PKA) activity in wild-type aCC/RP2 mimic both the reductions in membrane excitability and INa...
  5. Kiger J, Eklund J, Younger S, O Kane C. Transgenic inhibitors identify two roles for protein kinase A in Drosophila development. Genetics. 1999;152:281-90 pubmed
    We have initiated an analysis of protein kinase A (PKA) in Drosophila using transgenic techniques to modulate PKA activity in specific tissues during development...
  6. Corl A, Rodan A, Heberlein U. Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster. Nat Neurosci. 2005;8:18-9 pubmed
    ..These findings suggest a previously unknown role for this highly conserved pathway in regulating the behavioral responses to an addictive drug. ..
  7. Hong S, Bang S, Hyun S, Kang J, Jeong K, Paik D, et al. cAMP signalling in mushroom bodies modulates temperature preference behaviour in Drosophila. Nature. 2008;454:771-5 pubmed publisher
    ..Here we show that mushroom bodies (MBs) and the cyclic AMP-cAMP-dependent protein kinase A (cAMP-PKA) pathway are essential for controlling TPB...
  8. Luan H, Lemon W, Peabody N, Pohl J, Zelensky P, Wang D, et al. Functional dissection of a neuronal network required for cuticle tanning and wing expansion in Drosophila. J Neurosci. 2006;26:573-84 pubmed
    ..Because suppression of synaptic transmission and protein kinase A (PKA) activity throughout NCCAP, but not in NCCAP-c929, also blocks tanning and wing expansion, we conclude ..
  9. Park S, Sedore S, Cronmiller C, Hirsh J. Type II cAMP-dependent protein kinase-deficient Drosophila are viable but show developmental, circadian, and drug response phenotypes. J Biol Chem. 2000;275:20588-96 pubmed
    We identified a unique type II cAMP-dependent protein kinase regulatory subunit (PKA-RII) gene in Drosophila melanogaster and a severely hypomorphic if not null mutation, pka-RII(EP(2)2162)...

More Information


  1. Kula Eversole E, Nagoshi E, Shang Y, Rodriguez J, Allada R, Rosbash M. Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila. Proc Natl Acad Sci U S A. 2010;107:13497-502 pubmed publisher
    ..The results suggest that RNA cycling is much more prominent in circadian neurons than elsewhere in heads and may be particularly important for the functioning of these neurons. ..
  2. Li W, Ohlmeyer J, Lane M, Kalderon D. Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Cell. 1995;80:553-62 pubmed
    Reduced protein kinase A (PKA) activity in anterior imaginal disc cells leads to cell-autonomous induction of decapentaplegic (dpp), wingless (wg), and patched (ptc) transcription that is independent of hedgehog (hh) gene activity...
  3. Mehren J, Ejima A, Griffith L. Unconventional sex: fresh approaches to courtship learning. Curr Opin Neurobiol. 2004;14:745-50 pubmed
    ..Advances in transgenic tools and developments in behavioral assays have increased the power of studying courtship learning in the fruit fly. ..
  4. Davis R. Mushroom bodies, Ca(2+) oscillations, and the memory gene amnesiac. Neuron. 2001;30:653-6 pubmed
    ..Slow and spontaneous oscillations of calcium levels are elevated in the mushroom body neurons of amnesiac mutants and may contribute to memory consolidation. ..
  5. Xu J, Li M, Shen P. A G-protein-coupled neuropeptide Y-like receptor suppresses behavioral and sensory response to multiple stressful stimuli in Drosophila. J Neurosci. 2010;30:2504-12 pubmed publisher
    ..Our findings suggest that suppression of TRP channel-mediated neural excitation by the conserved NPF/NPFR1 system may be a major mechanism for attaining its broad anti-stress function. ..
  6. Tao Y, Chen S, Hartl D, Laurie C. Genetic dissection of hybrid incompatibilities between Drosophila simulans and D. mauritiana. I. Differential accumulation of hybrid male sterility effects on the X and autosomes. Genetics. 2003;164:1383-97 pubmed
    ..Possible mechanisms of a "large X" effect include selective fixation of new mutations that are recessive or partially recessive and the evolution of sex-ratio distortion systems...
  7. Chen Y, Cardinaux J, Goodman R, Smolik S. Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling. Development. 1999;126:3607-16 pubmed
    ..The ratio of these forms, which is regulated positively by hh signaling and negatively by PKA activity, determines the on/off status of hh target gene expression...
  8. Kimura K, Kodama A, Hayasaka Y, Ohta T. Activation of the cAMP/PKA signaling pathway is required for post-ecdysial cell death in wing epidermal cells of Drosophila melanogaster. Development. 2004;131:1597-606 pubmed
    ..such as a membrane permeant analog of cAMP, or ectopic expression of constitutively active forms of G proteins or PKA, induced precocious death. Conversely, cell death was inhibited in wing clones lacking G protein or PKA function...
  9. Guichard A, Park J, Cruz Moreno B, Karin M, Bier E. Anthrax lethal factor and edema factor act on conserved targets in Drosophila. Proc Natl Acad Sci U S A. 2006;103:3244-9 pubmed
    ..cyclase, inhibits the hh pathway during wing development, consistent with the known role of cAMP-dependent PKA in suppressing the Hedgehog response...
  10. Copf T. Developmental shaping of dendritic arbors in Drosophila relies on tightly regulated intra-neuronal activity of protein kinase A (PKA). Dev Biol. 2014;393:282-297 pubmed publisher vivo the effects of cell-autonomous dose-dependent changes in the activity levels of the cAMP-dependent Protein Kinase A (PKA) on the formation of complex dendritic arbors...
  11. Baines R. Synaptic strengthening mediated by bone morphogenetic protein-dependent retrograde signaling in the Drosophila CNS. J Neurosci. 2004;24:6904-11 pubmed
  12. Ou C, Lin Y, Chen Y, Chien C. Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Genes Dev. 2002;16:2403-14 pubmed
    ..In cells anterior to the MF, Ci proteolytic processing promoted by PKA requires the activity of the Nedd8-modified Cul1-based SCF(Slimb) complex...
  13. Venkatesh K, Siddhartha G, Joshi R, Patel S, Hasan G. Interactions between the inositol 1,4,5-trisphosphate and cyclic AMP signaling pathways regulate larval molting in Drosophila. Genetics. 2001;158:309-18 pubmed judged by phenotypes obtained through expression of dominant negative and dominant active forms of protein kinase A (PKA) in tissues that normally express the InsP(3) receptor...
  14. Baum B, Li W, Perrimon N. A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast. Curr Biol. 2000;10:964-73 pubmed
    ..As CAP controls the spatial distribution of actin filaments and mRNA determinants in both yeast and Drosophila, we conclude that CAP has an evolutionarily conserved function in the genesis of eukaryotic cell polarity. ..
  15. Dubnau J, Tully T. Gene discovery in Drosophila: new insights for learning and memory. Annu Rev Neurosci. 1998;21:407-44 pubmed
    ..Second, because core cellular mechanisms of simple forms of learning are evolutionarily conserved, biological pathways discovered in invertebrates are likely to be conserved in vertebrate systems as well. ..
  16. Zhou Q, Apionishev S, Kalderon D. The contributions of protein kinase A and smoothened phosphorylation to hedgehog signal transduction in Drosophila melanogaster. Genetics. 2006;173:2049-62 pubmed
    b>Protein kinase A (PKA) silences the Hedgehog (Hh) pathway in Drosophila in the absence of ligand by phosphorylating the pathway's transcriptional effector, Cubitus interruptus (Ci)...
  17. Mee C, Pym E, Moffat K, Baines R. Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene. J Neurosci. 2004;24:8695-703 pubmed
    ..We show, through use of anemone toxin (ATX II), that alteration in persistent I(Na) is sufficient to regulate membrane excitability in these two motoneurons. ..
  18. Morley K, Montgomery G. The genetics of cognitive processes: candidate genes in humans and animals. Behav Genet. 2001;31:511-31 pubmed
    ..This survey confirms that many genes are associated with cognitive variation and highlights the potential importance of animal models in the study of human cognition. ..
  19. Wang G, Wang B, Jiang J. Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes Dev. 1999;13:2828-37 pubmed
    ..The proteolytic processing of Ci is promoted by the activities of protein kinase A (PKA) and Slimb, whereas it is inhibited by Hh...
  20. Roman G, Davis R. Molecular biology and anatomy of Drosophila olfactory associative learning. Bioessays. 2001;23:571-81 pubmed
    ..In this review, we discuss the nature of the behavioral tasks, the molecules, and the neuronal circuits involved in olfactory learning in Drosophila. ..
  21. Sulkowski M, Kim Y, Serpe M. Postsynaptic glutamate receptors regulate local BMP signaling at the Drosophila neuromuscular junction. Development. 2014;141:436-47 pubmed publisher
    ..Altering type-A receptor activities via protein kinase A (PKA) revealed that synaptic pMad depends on the activity and not the net levels of postsynaptic type-A ..
  22. Apionishev S, Katanayeva N, Marks S, Kalderon D, Tomlinson A. Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nat Cell Biol. 2005;7:86-92 pubmed
    ..Together, Protein Kinase A, Casein Kinase 1 and Glycogen Synthase Kinase 3 silence the pathway in the absence of ligand by ..
  23. Dubnau J, Chiang A, Tully T. Neural substrates of memory: from synapse to system. J Neurobiol. 2003;54:238-53 pubmed
    ..Our objective here is to offer a conceptually unifying perspective and to discuss this perspective in relation to an experiment analysis of memory in Drosophila. ..
  24. Ohlmeyer J, Kalderon D. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature. 1998;396:749-53 pubmed
  25. Yang C, Rumpf S, Xiang Y, Gordon M, Song W, Jan L, et al. Control of the postmating behavioral switch in Drosophila females by internal sensory neurons. Neuron. 2009;61:519-26 pubmed publisher
    ..sensory neurons, sex peptide appears to act through Pertussis toxin-sensitive G proteins and suppression of protein kinase A activity to reduce synaptic output...
  26. Jia J, Tong C, Wang B, Luo L, Jiang J. Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature. 2004;432:1045-50 pubmed
    ..Here we show that protein kinase A (PKA) and casein kinase I (CKI) regulate Smo cell-surface accumulation and activity in response to Hh...
  27. Lee H, Rohila S, Han K. The octopamine receptor OAMB mediates ovulation via Ca2+/calmodulin-dependent protein kinase II in the Drosophila oviduct epithelium. PLoS ONE. 2009;4:e4716 pubmed publisher
    ..Conditional inhibition of Ca2+/Calmodulin-dependent protein kinase II (CaMKII), but not protein kinase A or C, in the oviduct epithelium inhibited ovulation...
  28. Russell S, Kaiser K. Drosophila melanogaster male germ line-specific transcripts with autosomal and Y-linked genes. Genetics. 1993;134:293-308 pubmed
    ..This protein may be a distant relative of the histone H1 family perhaps involved in sperm chromatin condensation. ..
  29. Cheng S, Maier D, Hipfner D. Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling. Development. 2012;139:85-94 pubmed publisher
    ..of target genes was restored in gprk2 mutants by stimulating cAMP production or activating the cAMP-dependent Protein kinase A (Pka)...
  30. Pavot P, Carbognin E, Martin J. PKA and cAMP/CNG Channels Independently Regulate the Cholinergic Ca(2+)-Response of Drosophila Mushroom Body Neurons(1,2,3). Eneuro. 2015;2: pubmed publisher
    ..Third, genetic manipulation of protein kinase A (PKA), a direct effector of cAMP, suggests that cAMP also has PKA-independent effects through the cyclic ..
  31. Vervoort M, Crozatier M, Valle D, Vincent A. The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing. Curr Biol. 1999;9:632-9 pubmed
  32. Shi Q, Li S, Li S, Jiang A, Chen Y, Jiang J. Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator. Proc Natl Acad Sci U S A. 2014;111:E5651-60 pubmed publisher
  33. Bantignies F, Goodman R, Smolik S. Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers. Mol Cell Biol. 2000;20:9317-30 pubmed
    ..Two genes with mutant versions that act as dominant suppressors of the wing phenotype were identified: the PKA-C1/DCO gene, encoding the catalytic subunit of cyclic AMP protein kinase, and ash1, a member of the trithorax group ..
  34. Zhang W, Zhao Y, Tong C, Wang G, Wang B, Jia J, et al. Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev Cell. 2005;8:267-78 pubmed
    ..In Drosophila, Hh counteracts phosphorylation by PKA, GSK3, and CKI to prevent Cubitus interruptus (Ci) processing through unknown mechanisms...
  35. Lissandron V, Rossetto M, Erbguth K, Fiala A, Daga A, Zaccolo M. Transgenic fruit-flies expressing a FRET-based sensor for in vivo imaging of cAMP dynamics. Cell Signal. 2007;19:2296-303 pubmed
    ..Here we report the generation of transgenic fruit-flies expressing a FRET-based, GFP-PKA sensor and their use in real-time optical recordings of cAMP signalling both ex vivo and in vivo in adult and ..
  36. Kang J, Kim J, Choi K. Novel cytochrome P450, cyp6a17, is required for temperature preference behavior in Drosophila. PLoS ONE. 2011;6:e29800 pubmed publisher
    ..TPB) in Drosophila melanogaster, one of poikilothermal animals, is regulated by cAMP-dependent protein kinase (PKA) signaling in mushroom bodies of the brain...
  37. Alcedo J, Zou Y, Noll M. Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system. Mol Cell. 2000;6:457-65 pubmed
  38. Seluzicki A, Flourakis M, Kula Eversole E, Zhang L, Kilman V, Allada R. Dual PDF signaling pathways reset clocks via TIMELESS and acutely excite target neurons to control circadian behavior. PLoS Biol. 2014;12:e1001810 pubmed publisher
    ..Yet the mechanisms by which PDF functions are not clear. We demonstrate that genetic inhibition of protein kinase A (PKA) in PDF(-) clock neurons can phenocopy PDF mutants while activated PKA can partially rescue PDF receptor ..
  39. Ogden S, Ascano M, Stegman M, Robbins D. Regulation of Hedgehog signaling: a complex story. Biochem Pharmacol. 2004;67:805-14 pubmed
    ..Here, we review what is known about regulation of individual Hh signaling components, concentrating on the mechanisms by which the Hh signal is propagated through Smo to the HSC. ..
  40. Gonzales E, Tanenhaus A, Zhang J, Chaffee R, Yin J. Early-onset sleep defects in Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling. Hum Mol Genet. 2016;25:837-52 pubmed publisher
    ..Elevated PKA/CREB activity in healthy flies produces patterns of sleep and activity similar to those in our HD models...
  41. Aszodi A, Muller U, Friedrich P, Spatz H. Signal convergence on protein kinase A as a molecular correlate of learning. Proc Natl Acad Sci U S A. 1991;88:5832-6 pubmed
    The response of a reaction network composed of protein kinase A, calpain, and protein phosphatase to transient cAMP and Ca2+ signals was studied...
  42. Yao W, Rusch J, Poo M, Wu C. Spontaneous acetylcholine secretion from developing growth cones of Drosophila central neurons in culture: effects of cAMP-pathway mutations. J Neurosci. 2000;20:2626-37 pubmed
    ..and PKA-RI, which disrupt a cAMP-specific phosphodiesterase and the regulatory subunit of cAMP-dependent protein kinase A, respectively...
  43. Tully T, Bolwig G, Christensen J, Connolly J, Delvecchio M, DeZazzo J, et al. A return to genetic dissection of memory in Drosophila. Cold Spring Harb Symp Quant Biol. 1996;61:207-18 pubmed
  44. Chen J, Zhang Y, Shen P. A protein kinase C activity localized to neuropeptide Y-like neurons mediates ethanol intoxication in Drosophila melanogaster. Neuroscience. 2008;156:42-7 pubmed publisher
    ..These findings reveal an uncharacterized role of PKC in NPY/NPF-mediated acute ethanol sensitivity in flies and possibly mammals. ..
  45. Tripodi M, Evers J, Mauss A, Bate M, Landgraf M. Structural homeostasis: compensatory adjustments of dendritic arbor geometry in response to variations of synaptic input. PLoS Biol. 2008;6:e260 pubmed publisher
    ..We provide evidence that suggest a role for the postsynaptic activity state of protein kinase A in mediating this structural adjustment, which modifies dendritic growth in response to synaptic activity...
  46. Zhou Q, Kalderon D. Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses. Dev Cell. 2011;20:802-14 pubmed publisher
    ..In this model, Smo acts like many transmembrane receptors associated with cytoplasmic kinases, such that pathway activation is mediated by kinase oligomerization and trans-phosphorylation. ..
  47. Melendez A, Li W, Kalderon D. Activity, expression and function of a second Drosophila protein kinase A catalytic subunit gene. Genetics. 1995;141:1507-20 pubmed
    The DC2 gene was isolated previously on the basis of sequence similarity to DC0, the major Drosophila protein kinase A (PKA) catalytic subunit gene...
  48. Lim C, Lee J, Choi C, Kim J, Doh E, Choe J. Functional role of CREB-binding protein in the circadian clock system of Drosophila melanogaster. Mol Cell Biol. 2007;27:4876-90 pubmed
    ..Our data suggest that the Drosophila circadian clock system has evolved a distinct mechanism to tightly regulate the robust transcriptional potency of the dCLK/CYC heterodimer. ..
  49. Ingham P. Transducing Hedgehog: the story so far. EMBO J. 1998;17:3505-11 pubmed
    ..Elucidating the mechanisms by which Hedgehog signals are transduced will thus have widespread implications for our understanding of both normal development and disease. ..
  50. Van Buskirk C, Schupbach T. Versatility in signalling: multiple responses to EGF receptor activation during Drosophila oogenesis. Trends Cell Biol. 1999;9:1-4 pubmed
    ..In posterior follicle cells, EGFR activity is translated into an on-off response, whereas, in dorsal follicle cells, patterning mechanisms are initiated and refined by feedback that modulates receptor activity over time. ..
  51. Aravamudan B, Broadie K. Synaptic Drosophila UNC-13 is regulated by antagonistic G-protein pathways via a proteasome-dependent degradation mechanism. J Neurobiol. 2003;54:417-38 pubmed
    ..Both cAMP modulation and PKA function are required for DUNC-13 synaptic up-regulation, suggesting that the cAMP pathway enhances synaptic ..
  52. Kiger J, O SHEA C. Genetic evidence for a protein kinase A/cubitus interruptus complex that facilitates processing of cubitus interruptus in Drosophila. Genetics. 2001;158:1157-66 pubmed
    ..Ci-155 is phosphorylated by protein kinase A (PKA), inducing proteolysis to Ci-75, a transcriptional repressor...
  53. Lasko P. Cell-cell signalling, microtubule organization and RNA localization: is PKA a link?. Bioessays. 1995;17:105-7 pubmed
    ..A recent paper reports that protein kinase A (PKA) activity is essential for many of these RNA localizations and for the correct polarization of the ..
  54. Crocker A, Sehgal A. Octopamine regulates sleep in drosophila through protein kinase A-dependent mechanisms. J Neurosci. 2008;28:9377-85 pubmed publisher
    ..Because protein kinase A (PKA) is a putative target of octopamine signaling and is also implicated in Drosophila sleep, we ..
  55. Tao Y, Zeng Z, Li J, Hartl D, Laurie C. Genetic dissection of hybrid incompatibilities between Drosophila simulans and D. mauritiana. II. Mapping hybrid male sterility loci on the third chromosome. Genetics. 2003;164:1399-418 pubmed
    ..These results are consistent with the gradual evolution of hybrid incompatibilities as a by-product of genetic divergence in allopatric populations...
  56. Steinert J, Kuromi H, Hellwig A, Knirr M, Wyatt A, Kidokoro Y, et al. Experience-dependent formation and recruitment of large vesicles from reserve pool. Neuron. 2006;50:723-33 pubmed
    ..during a period of enhanced replenishment of the reserve pool of vesicles, from which they are recruited via a PKA- and actin-dependent mechanism...
  57. Cho K, Lee J, Kim S, Kim D, Koh H, Lee J, et al. Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway. Proc Natl Acad Sci U S A. 2001;98:6144-9 pubmed
  58. Yamazaki D, Horiuchi J, Miyashita T, Saitoe M. Acute inhibition of PKA activity at old ages ameliorates age-related memory impairment in Drosophila. J Neurosci. 2010;30:15573-7 pubmed publisher
    ..In Drosophila, AMI is highly correlated with PKA activity in the mushroom bodies, neural centers essential for forming associative olfactory memories...
  59. Johnson R, Scott M. New players and puzzles in the Hedgehog signaling pathway. Curr Opin Genet Dev. 1998;8:450-6 pubmed
    ..The role of Hh in carcinogenesis is underscored by the identification of mutations in several pathway components in skin and brain tumors. ..
  60. Sha K, Choi S, Im J, Lee G, Loeffler F, Park J. Regulation of ethanol-related behavior and ethanol metabolism by the Corazonin neurons and Corazonin receptor in Drosophila melanogaster. PLoS ONE. 2014;9:e87062 pubmed publisher
    ..Transgenic inhibition of cyclic AMP-dependent protein kinase (PKA) also results in significantly increased ADH activity and Adh mRNA levels, indicating PKA-dependent transcriptional ..
  61. Scopelliti A, Cordero J, Diao F, Strathdee K, White B, Sansom O, et al. Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut. Curr Biol. 2014;24:1199-211 pubmed publisher
    ..We therefore identify a novel paradigm in the regulation of ISC quiescence involving the conserved ligand/receptor Bursicon/DLGR2 and a previously unrecognized tissue-intrinsic role of enteroendocrine cells. ..
  62. Yoshida S, Müller H, Wodarz A, Ephrussi A. PKA-R1 spatially restricts Oskar expression for Drosophila embryonic patterning. Development. 2004;131:1401-10 pubmed
    ..Here we report that the type 1 regulatory subunit of cAMP-dependent protein kinase (Pka-R1) is crucial for the restriction of Oskar protein to the oocyte posterior...
  63. Jia J, Zhang L, Zhang Q, Tong C, Wang B, Hou F, et al. Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell. 2005;9:819-30 pubmed
    ..Ci processing requires sequential phosphorylation by PKA, GSK3, and a casein kinase I (CKI) family member(s)...
  64. Crocker A, Shahidullah M, Levitan I, Sehgal A. Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior. Neuron. 2010;65:670-81 pubmed publisher
    ..These studies define the cellular and molecular basis of octopamine action and suggest that the PI is a sleep:wake-regulating neuroendocrine structure like the mammalian hypothalamus. ..
  65. Shakiryanova D, Zettel G, Gu T, Hewes R, Levitan E. Synaptic neuropeptide release induced by octopamine without Ca2+ entry into the nerve terminal. Proc Natl Acad Sci U S A. 2011;108:4477-81 pubmed publisher
  66. Wu M, Ho K, Crocker A, Yue Z, Koh K, Sehgal A. The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor. J Neurosci. 2009;29:11029-37 pubmed publisher
    ..Finally, the effects of caffeine on sleep are blocked in flies that have reduced neuronal PKA activity...
  67. Goodrich L, Scott M. Hedgehog and patched in neural development and disease. Neuron. 1998;21:1243-57 pubmed
  68. Hong S, Lee K, Kwak S, Kim A, Bai H, Jung M, et al. Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals. PLoS Genet. 2012;8:e1002857 pubmed publisher
    ..neuronal cells and mouse hypothalamic cells, sNPF and NPY modulated the mnb and Dyrk1a expression through the PKA-CREB pathway...
  69. Goodwin S, del Vecchio M, Velinzon K, Hogel C, Russell S, Tully T, et al. Defective learning in mutants of the Drosophila gene for a regulatory subunit of cAMP-dependent protein kinase. J Neurosci. 1997;17:8817-27 pubmed
    ..These results establish a role for an RI regulatory subunit of PKA in Pavlovian olfactory conditioning.