Gene Symbol: pita
Description: pita
Alias: CG3941, Dmel\CG3941, PITA, Pita, spdk, pita, CG3941-PA, CG3941-PB, pita-PA, pita-PB, spotted dick
Species: fruit fly
Products:     pita

Top Publications

  1. Laundrie B, Peterson J, Baum J, Chang J, Fileppo D, Thompson S, et al. Germline cell death is inhibited by P-element insertions disrupting the dcp-1/pita nested gene pair in Drosophila. Genetics. 2003;165:1881-8 pubmed
    ..P-element insertions in the caspase gene dcp-1 disrupt both dcp-1 and the outlying gene, pita, leading to lethality and defective nurse cell death in late oogenesis...
  2. Peterson J, Bass B, Jue D, Rodriguez A, Abrams J, McCall K. Noncanonical cell death pathways act during Drosophila oogenesis. Genesis. 2007;45:396-404 pubmed
    ..These results indicate that novel pathways must control PCD in the ovary. ..
  3. Cuartero S, Fresán U, Reina O, Planet E, Espinàs M. Ibf1 and Ibf2 are novel CP190-interacting proteins required for insulator function. EMBO J. 2014;33:637-47 pubmed publisher
    ..Taken together our data reveal a novel pathway of CP190 recruitment to chromatin that is required for insulator activity. ..
  4. Nezis I, Stravopodis D, Papassideri I, Stergiopoulos C, Margaritis L. Morphological irregularities and features of resistance to apoptosis in the dcp-1/pita double mutated egg chambers during Drosophila oogenesis. Cell Motil Cytoskeleton. 2005;60:14-23 pubmed
    ..demonstrate the most novel characteristic morphological features of Drosophila egg chambers lacking both dcp-1 and pita functions in the germline cells...
  5. Minakhina S, Steward R. Melanotic mutants in Drosophila: pathways and phenotypes. Genetics. 2006;174:253-63 pubmed
    ..Our results show that the phenotype of each mutant not only reflects its connection to a particular genetic pathway but also points to the tissue-specific role of the individual gene. ..
  6. Liu W, Gnanasambandam R, Benjamin J, Kaur G, Getman P, Siegel A, et al. Mutations in cytochrome c oxidase subunit VIa cause neurodegeneration and motor dysfunction in Drosophila. Genetics. 2007;176:937-46 pubmed
    ..The levy mutants provide a genetic model to understand the mechanisms underlying COX-mediated mitochondrial encephalomyopathies and to explore possible therapeutic interventions. ..
  7. Chung H, Löhr U, Jackle H. Lineage-specific expansion of the zinc finger associated domain ZAD. Mol Biol Evol. 2007;24:1934-43 pubmed
  8. Zolotarev N, Fedotova A, Kyrchanova O, Bonchuk A, Penin A, Lando A, et al. Architectural proteins Pita, Zw5,and ZIPIC contain homodimerization domain and support specific long-range interactions in Drosophila. Nucleic Acids Res. 2016;44:7228-41 pubmed publisher
    ..Transcription factors ZIPIC, Pita and Zw5 belong to the class of chromatin insulator proteins and preferentially bind to promoters near the TSS and ..
  9. Kyrchanova O, Zolotarev N, Mogila V, Maksimenko O, Schedl P, Georgiev P. Architectural protein Pita cooperates with dCTCF in organization of functional boundaries in Bithorax complex. Development. 2017;144:2663-2672 pubmed publisher
    ..The C2H2 zinc-finger protein Pita binds to several BX-C boundaries, including Fab-7 and Mcp To study Pita functions, we have used a ..

More Information


  1. Maksimenko O, Bartkuhn M, Stakhov V, Herold M, Zolotarev N, Jox T, et al. Two new insulator proteins, Pita and ZIPIC, target CP190 to chromatin. Genome Res. 2015;25:89-99 pubmed publisher
    ..We have identified two DNA-binding zinc-finger proteins, Pita, and a new factor named ZIPIC, that interact with CP190 in vivo and in vitro at specific interaction domains...