Gene Symbol: pirk
Description: poor Imd response upon knock-in
Alias: BcDNA:SD16010, CG15678, Dmel\CG15678, PIMS, PIRK, Pims, Pirk, Rudra, pims, rudra, poor Imd response upon knock-in, CG15678-PA, CG15678-PB, PGRP-LC-interacting inhibitor of Imd signaling, pirk-PA, pirk-PB
Species: fruit fly

Top Publications

  1. Kleino A, Myllymäki H, Kallio J, Vanha aho L, Oksanen K, Ulvila J, et al. Pirk is a negative regulator of the Drosophila Imd pathway. J Immunol. 2008;180:5413-22 pubmed
    ..In this study we report that a previously uncharacterized gene, pirk, is highly induced upon Gram-negative bacterial infection in Drosophila in vitro and in vivo...
  2. Aggarwal K, Rus F, Vriesema Magnuson C, Erturk Hasdemir D, Paquette N, Silverman N. Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway. PLoS Pathog. 2008;4:e1000120 pubmed publisher
    ..Through two-hybrid screening with PGRP-LC, we identified Rudra, a new regulator of the IMD pathway, and demonstrate that it is a critical feedback inhibitor of peptidoglycan ..
  3. Lhocine N, Ribeiro P, Buchon N, Wepf A, Wilson R, Tenev T, et al. PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling. Cell Host Microbe. 2008;4:147-58 pubmed publisher
    ..a recently identified Drosophila immune regulator, which we call PGRP-LC-interacting inhibitor of Imd signaling (PIMS), is required to suppress the Imd innate immune signaling pathway in response to commensal bacteria...
  4. Paredes J, Welchman D, Poidevin M, Lemaitre B. Negative regulation by amidase PGRPs shapes the Drosophila antibacterial response and protects the fly from innocuous infection. Immunity. 2011;35:770-9 pubmed publisher
    ..Analysis of the immune phenotype of flies lacking all catalytic PGRPs and the Imd regulator Pirk reveals that the Imd-mediated immune response is highly constrained by the existence of multiple negative feedbacks. ..
  5. Doroszuk A, Jonker M, Pul N, Breit T, Zwaan B. Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension. BMC Genomics. 2012;13:167 pubmed publisher
    ..The results suggest that natural genetic variation for SR and lifespan can operate through similar transcriptional mechanisms as those of dietary restriction and life-extending mutations. ..
  6. Bosco Drayon V, Poidevin M, Boneca I, Narbonne Reveau K, Royet J, Charroux B. Peptidoglycan sensing by the receptor PGRP-LE in the Drosophila gut induces immune responses to infectious bacteria and tolerance to microbiota. Cell Host Microbe. 2012;12:153-65 pubmed publisher
    ..NF-?B-dependent responses to infectious bacteria but also immune tolerance to microbiota through upregulation of pirk and PGRP-LB, which negatively regulate IMD pathway activation...
  7. Orme M, Liccardi G, Moderau N, Feltham R, Wicky John S, Tenev T, et al. The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles. Nat Commun. 2016;7:10972 pubmed publisher
    ..Together, our results expose a conserved role for unconventional myosins in transducing caspase-dependent regulation of kinases, allowing them to take part in specific signalling events. ..
  8. Gendrin M, Welchman D, Poidevin M, Hervé M, Lemaitre B. Long-range activation of systemic immunity through peptidoglycan diffusion in Drosophila. PLoS Pathog. 2009;5:e1000694 pubmed publisher
    ..This immune response is downregulated by PGRP-LB and Pirk, known regulators of the Imd pathway, and can be suppressed by the overexpression of PGRP-LB in the haemolymph ..
  9. Fernando M, Kounatidis I, Ligoxygakis P. Loss of Trabid, a new negative regulator of the drosophila immune-deficiency pathway at the level of TAK1, reduces life span. PLoS Genet. 2014;10:e1004117 pubmed publisher
    ..These results indicate an elaborate and multi-tiered mechanism for regulating TAK1 activity and modulating its immune signal. ..

More Information


  1. El Chamy L, Matt N, Ntwasa M, Reichhart J. The multilayered innate immune defense of the gut. Biomed J. 2015;38:276-84 pubmed publisher
    ..Accordingly, the Drosophila gut innate immune response is tightly regulated to maintain the endogenous microbiota, while preventing infections by pathogenic microorganisms. ..
  2. Neyen C, Runchel C, Schüpfer F, Meier P, Lemaitre B. The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors. Nat Immunol. 2016;17:1150-8 pubmed publisher
    ..encodes an adaptor module that targets rPGRP-LC to membrane microdomains and interacts with the negative regulator Pirk and the ubiquitin ligase DIAP2...