Pink1

Summary

Gene Symbol: Pink1
Description: PTEN-induced putative kinase 1
Alias: :Pink1, BEST:GH23468, CG4523, Dmel\CG4523, PINK, PINK1, Pink, dPINK1, dPINk1, dPink1, pink1, PTEN-induced putative kinase 1, CG4523-PA, CG4523-PB, CG4523-PC, CG4523-PD, CG4523-PE, CG4523-PF, CG4523-PG, CG4523-PH, CG4523-PI, PINK1, PTEN induced putative kinase 1, PTEN-induced kinase 1, Pink1-PA, Pink1-PB, Pink1-PC, Pink1-PD, Pink1-PE, Pink1-PF, Pink1-PG, Pink1-PH, Pink1-PI, phosphatase and tensin homolog-induced putative kinase 1
Species: fruit fly

Top Publications

  1. Venderova K, Kabbach G, Abdel Messih E, Zhang Y, Parks R, Imai Y, et al. Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Hum Mol Genet. 2009;18:4390-404 pubmed publisher
    ..transgenic flies, various indices of the eye and dopaminergic survival were modified in a complex fashion by a concomitant expression of PINK1, DJ-1 or Parkin. This evidence suggests a genetic interaction between these PD-relevant genes.
  2. Hao L, Giasson B, Bonini N. DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function. Proc Natl Acad Sci U S A. 2010;107:9747-52 pubmed publisher
    ..In Drosophila, deletions in parkin and pink1 result in swollen and dysfunctional mitochondria in energy-demanding tissues...
  3. Wang D, Qian L, Xiong H, Liu J, Neckameyer W, Oldham S, et al. Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila. Proc Natl Acad Sci U S A. 2006;103:13520-5 pubmed
    ..We here show that inactivation of Drosophila PINK1 (dPINK1) using RNAi results in progressive loss of dopaminergic neurons and in ommatidial degeneration of the compound eye,..
  4. Todd A, Staveley B. Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease. Genome. 2008;51:1040-6 pubmed publisher
    ..It has been suggested that parkin and Pink1 function in the same pathway in Drosophila, with Pink1 acting upstream of parkin...
  5. Park J, Lee G, Chung J. The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process. Biochem Biophys Res Commun. 2009;378:518-23 pubmed publisher
    ..Therefore, we investigated its physiological function in Drosophila. Because Drosophila PINK1 and parkin mutants show changes in mitochondrial morphology in both indirect flight muscles and dopaminergic ..
  6. Shiba Fukushima K, Inoshita T, Hattori N, Imai Y. PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila. PLoS Genet. 2014;10:e1004391 pubmed publisher
    ..We have reported that Parkin is phosphorylated at Ser65 within the ubiquitin-like domain by PINK1 in mammalian cultured cells...
  7. Ziviani E, Tao R, Whitworth A. Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc Natl Acad Sci U S A. 2010;107:5018-23 pubmed publisher
    ..Here we show in Drosophila cells that PINK1 is required to recruit Parkin to dysfunctional mitochondria and promote their degradation...
  8. Tain L, Mortiboys H, Tao R, Ziviani E, Bandmann O, Whitworth A. Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nat Neurosci. 2009;12:1129-35 pubmed publisher
    Mutations in PINK1 and PARK2 cause autosomal recessive parkinsonism, a neurodegenerative disorder that is characterized by the loss of dopaminergic neurons...
  9. Pimenta de Castro I, Costa A, Lam D, Tufi R, Fedele V, Moisoi N, et al. Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster. Cell Death Differ. 2012;19:1308-16 pubmed publisher
    ..Here we show that mutations in both human and fly PINK1 result in higher levels of misfolded components of respiratory complexes and increase in markers of the ..

More Information

Publications74

  1. Koh H, Chung J. PINK1 as a molecular checkpoint in the maintenance of mitochondrial function and integrity. Mol Cells. 2012;34:7-13 pubmed publisher
    ..Genetic studies using Drosophila models demonstrate that PINK1, a mitochondrial kinase encoded by a PD-linked gene PINK1, is critical for maintaining mitochondrial function and ..
  2. Song S, Jang S, Park J, Bang S, Choi S, Kwon K, et al. Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila. J Biol Chem. 2013;288:5660-72 pubmed publisher
    Mutations in PINK1 (PTEN-induced putative kinase 1) are tightly linked to autosomal recessive Parkinson disease (PD)...
  3. Wu Z, Sawada T, Shiba K, Liu S, Kanao T, Takahashi R, et al. Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance. Genes Dev. 2013;27:157-62 pubmed publisher
    ..Parkinson's disease-associated PINK1 and Parkin actively participate in MQC. However, the signaling events involved are largely unknown...
  4. Yang Y, Ouyang Y, Yang L, Beal M, McQuibban A, Vogel H, et al. Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A. 2008;105:7070-5 pubmed publisher
    ..Here, we show that Pink1, a mitochondria-targeted Ser/Thr kinase linked to familial PD, genetically interacts with the mitochondrial ..
  5. Poole A, Thomas R, Andrews L, McBride H, Whitworth A, Pallanck L. The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A. 2008;105:1638-43 pubmed publisher
    ..Genetic studies in Drosophila indicate that PINK1 acts upstream of Parkin in a common pathway that influences mitochondrial integrity in a subset of tissues, ..
  6. Tufi R, Gandhi S, de Castro I, Lehmann S, Angelova P, Dinsdale D, et al. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Nat Cell Biol. 2014;16:157-66 pubmed publisher
    Mutations in PINK1 cause early-onset Parkinson's disease (PD). Studies in Drosophila melanogaster have highlighted mitochondrial dysfunction on loss of Pink1 as a central mechanism of PD pathogenesis...
  7. Koh H, Kim H, Kim M, Park J, Lee H, Chung J. Silent information regulator 2 (Sir2) and Forkhead box O (FOXO) complement mitochondrial dysfunction and dopaminergic neuron loss in Drosophila PTEN-induced kinase 1 (PINK1) null mutant. J Biol Chem. 2012;287:12750-8 pubmed publisher
    ..Moreover, another Parkinson disease-linked gene, parkin, functions downstream of PINK1 in protecting mitochondria and dopaminergic (DA) neuron...
  8. Kim N, Tresse E, Kolaitis R, Molliex A, Thomas R, Alami N, et al. VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron. 2013;78:65-80 pubmed publisher
    ..We developed a Drosophila model of VCP mutation-dependent degeneration. The phenotype is reminiscent of PINK1 and parkin mutants, including a pronounced mitochondrial defect...
  9. Burchell V, Nelson D, Sanchez Martinez A, Delgado Camprubi M, Ivatt R, Pogson J, et al. The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Nat Neurosci. 2013;16:1257-65 pubmed publisher
    ..Here we show that Fbxo7 participates in mitochondrial maintenance through direct interaction with PINK1 and Parkin and acts in Parkin-mediated mitophagy...
  10. Clark I, Dodson M, Jiang C, Cao J, Huh J, Seol J, et al. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature. 2006;441:1162-6 pubmed
    ..Here we show that removal of Drosophila PINK1 homologue (CG4523; hereafter called pink1) function results in male sterility, apoptotic muscle degeneration, defects in ..
  11. Poole A, Thomas R, Yu S, Vincow E, Pallanck L. The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway. PLoS ONE. 2010;5:e10054 pubmed publisher
    Loss-of-function mutations in the PINK1 or parkin genes result in recessive heritable forms of parkinsonism...
  12. Lutz A, Exner N, Fett M, Schlehe J, Kloos K, Lämmermann K, et al. Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem. 2009;284:22938-51 pubmed publisher
    Loss-of-function mutations in the parkin gene (PARK2) and PINK1 gene (PARK6) are associated with autosomal recessive parkinsonism...
  13. Yun J, Cao J, Dodson M, Clark I, Kapahi P, Chowdhury R, et al. Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo. J Neurosci. 2008;28:14500-10 pubmed publisher
    ..In vitro studies have suggested that Omi/HtrA2 acts downstream of PINK1, mutations in which mediate recessive forms of PD...
  14. Vos M, Esposito G, Edirisinghe J, Vilain S, Haddad D, Slabbaert J, et al. Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. Science. 2012;336:1306-10 pubmed publisher
    ..We identified Drosophila UBIAD1/Heix as a modifier of pink1, a gene mutated in Parkinson's disease that affects mitochondrial function...
  15. Tain L, Chowdhury R, Tao R, Plun Favreau H, Moisoi N, Martins L, et al. Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin. Cell Death Differ. 2009;16:1118-25 pubmed publisher
    ..studies in Drosophila have provided valuable insight into the function of other PD-linked genes, in particular PINK1 and parkin, and their role in maintaining mitochondrial integrity...
  16. Yang Y, Gehrke S, Imai Y, Huang Z, Ouyang Y, Wang J, et al. Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A. 2006;103:10793-8 pubmed
    Mutations in Pink1, a gene encoding a Ser/Thr kinase with a mitochondrial-targeting signal, are associated with Parkinson's disease (PD), the most common movement disorder characterized by selective loss of dopaminergic neurons...
  17. Klein P, Müller Rischart A, Motori E, Schönbauer C, Schnorrer F, Winklhofer K, et al. Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. EMBO J. 2014;33:341-55 pubmed publisher
    Parkinson's disease (PD)-associated Pink1 and Parkin proteins are believed to function in a common pathway controlling mitochondrial clearance and trafficking...
  18. Park J, Lee S, Lee S, Kim Y, Song S, Kim S, et al. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature. 2006;441:1157-61 pubmed
    ..Here, we show that PINK1 mutants exhibit indirect flight muscle and dopaminergic neuronal degeneration accompanied by locomotive defects...
  19. Wang X, Winter D, Ashrafi G, Schlehe J, Wong Y, Selkoe D, et al. PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell. 2011;147:893-906 pubmed publisher
    ..We report here that two Parkinson's disease proteins, the Ser/Thr kinase PINK1 and ubiquitin ligase Parkin, participate in this regulation by arresting mitochondrial movement...
  20. Woodroof H, Pogson J, Begley M, Cantley L, Deak M, Campbell D, et al. Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations. Open Biol. 2011;1:110012 pubmed publisher
    ..To date, little is known about the intrinsic catalytic properties of PINK1 since the human enzyme displays such low kinase activity in vitro...
  21. Kim Y, Park J, Kim S, Song S, Kwon S, Lee S, et al. PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem Biophys Res Commun. 2008;377:975-80 pubmed publisher
    ..Using both mammalian and Drosophila systems, we here demonstrate that the PINK1 kinase activity is required for its function in mitochondria...
  22. Costa A, Loh S, Martins L. Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease. Cell Death Dis. 2013;4:e467 pubmed publisher
    ..chaperone TNF receptor-associated protein 1 (TRAP1) was recently reported to be a cellular substrate for the PINK1 kinase...
  23. Deng H, Dodson M, Huang H, Guo M. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A. 2008;105:14503-8 pubmed publisher
    ..Here, we explore interactions between pink1/parkin and the mitochondrial fusion/fission machinery...
  24. Whitworth A, Lee J, Ho V, Flick R, Chowdhury R, McQuibban G. Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin. Dis Model Mech. 2008;1:168-74; discussion 173 pubmed publisher
    ..Studies in Drosophila melanogaster have shown that pink1 and parkin act in a common genetic pathway that maintains mitochondrial integrity, but other upstream or ..
  25. Liu S, Sawada T, Lee S, Yu W, Silverio G, Alapatt P, et al. Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria. PLoS Genet. 2012;8:e1002537 pubmed publisher
    ..In Drosophila, downregulation of dMiro or other components of the mitochondrial transport machinery rescued dPINK1 mutant phenotypes in the muscle and dopaminergic (DA) neurons, whereas dMiro overexpression alone caused DA neuron ..
  26. Zhang L, Karsten P, Hamm S, Pogson J, Müller Rischart A, Exner N, et al. TRAP1 rescues PINK1 loss-of-function phenotypes. Hum Mol Genet. 2013;22:2829-41 pubmed publisher
    ..Mutations in Pink1 cause early-onset Parkinson's disease (PD)...
  27. Fernandes C, Rao Y. Genome-wide screen for modifiers of Parkinson's disease genes in Drosophila. Mol Brain. 2011;4:17 pubmed publisher
    ..parkin and Pink1 encode a ubiquitin-protein ligase and a mitochondrially localized serine/threonine kinase, respectively...
  28. Liu S, Lu B. Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster. PLoS Genet. 2010;6:e1001237 pubmed publisher
    Mutations in PINK1 and Parkin cause familial, early onset Parkinson's disease...
  29. Morais V, Verstreken P, Roethig A, Smet J, Snellinx A, Vanbrabant M, et al. Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med. 2009;1:99-111 pubmed publisher
    ..Studies on loss of function and overexpression implicate PINK1 in apoptosis, abnormal mitochondrial morphology, impaired dopamine release and motor deficits...
  30. Vincow E, Merrihew G, Thomas R, Shulman N, Beyer R, MacCoss M, et al. The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo. Proc Natl Acad Sci U S A. 2013;110:6400-5 pubmed publisher
    ..Recently, in vitro studies of the PD-related proteins Parkin and PINK1 have found that these factors act in a common pathway to promote the selective autophagic degradation of damaged ..
  31. Esposito G, Vos M, Vilain S, Swerts J, De Sousa Valadas J, Van Meensel S, et al. Aconitase causes iron toxicity in Drosophila pink1 mutants. PLoS Genet. 2013;9:e1003478 pubmed publisher
    The PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase, and pink1 mutations cause early onset Parkinson's disease (PD) in humans...
  32. Burman J, Yu S, Poole A, Decal R, Pallanck L. Analysis of neural subtypes reveals selective mitochondrial dysfunction in dopaminergic neurons from parkin mutants. Proc Natl Acad Sci U S A. 2012;109:10438-43 pubmed publisher
    Studies of the familial Parkinson disease-related proteins PINK1 and Parkin have demonstrated that these factors promote the fragmentation and turnover of mitochondria following treatment of cultured cells with mitochondrial depolarizing ..
  33. Morais V, Haddad D, Craessaerts K, De Bock P, Swerts J, Vilain S, et al. PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science. 2014;344:203-7 pubmed publisher
    Under resting conditions, Pink1 knockout cells and cells derived from patients with PINK1 mutations display a loss of mitochondrial complex I reductive activity, causing a decrease in the mitochondrial membrane potential...
  34. Vilain S, Esposito G, Haddad D, Schaap O, Dobreva M, Vos M, et al. The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants. PLoS Genet. 2012;8:e1002456 pubmed publisher
    Pink1 is a mitochondrial kinase involved in Parkinson's disease, and loss of Pink1 function affects mitochondrial morphology via a pathway involving Parkin and components of the mitochondrial remodeling machinery...
  35. Liu W, Acin Perez R, Geghman K, Manfredi G, Lu B, Li C. Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission. Proc Natl Acad Sci U S A. 2011;108:12920-4 pubmed publisher
    ..Taken together, these results suggest a unique pathogenic mechanism of PINK1 PD: The loss of PINK1 impairs mitochondrial fission, which causes defective assembly of the ETC complexes, leading ..
  36. Imai Y, Kanao T, Sawada T, Kobayashi Y, Moriwaki Y, Ishida Y, et al. The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. PLoS Genet. 2010;6:e1001229 pubmed publisher
    ..Another early onset PD gene product, Parkin, has been suggested to function downstream of the PINK1 signalling pathway based on genetic studies in Drosophila...
  37. Navarro J, Heßner S, Yenisetti S, Bayersdorfer F, Zhang L, Voigt A, et al. Analysis of dopaminergic neuronal dysfunction in genetic and toxin-induced models of Parkinson's disease in Drosophila. J Neurochem. 2014;131:369-82 pubmed publisher
    ..In an attempt to re-evaluate and clarify this issue, we have examined three different genetic (?-synuclein, Pink1, parkin) and two toxin-based (rotenone and paraquat) models of the disease for neuronal cell loss...
  38. Khalil B, El Fissi N, Aouane A, Cabirol Pol M, Rival T, Liévens J. PINK1-induced mitophagy promotes neuroprotection in Huntington's disease. Cell Death Dis. 2015;6:e1617 pubmed publisher
    ..Consistently, we found that PINK1 overexpression alleviated mitochondrial spheroid formation in HD flies...
  39. Koehler C, Perkins G, Ellisman M, Jones D. Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging. J Cell Biol. 2017;216:2315-2327 pubmed publisher
    ..ISC/EB-specific knockdown of the mitophagy-related genes Pink1 or Parkin suppresses the age-related loss of tissue homeostasis, despite dramatic changes in mitochondrial ..
  40. Chen J, Xue J, Ruan J, Zhao J, Tang B, Duan R. Drosophila CHIP protects against mitochondrial dysfunction by acting downstream of Pink1 in parallel with Parkin. FASEB J. 2017;31:5234-5245 pubmed publisher
    ..These results indicate that CHIP is involved in mitochondrial integrity and may act downstream of Pink1 in parallel with Parkin.-Chen, J., Xue, J., Ruan, J., Zhao, J., Tang, B., Duan, R...
  41. Pallanck L, Greenamyre J. Neurodegenerative disease: pink, parkin and the brain. Nature. 2006;441:1058 pubmed
  42. Todd A, Staveley B. Expression of Pink1 with ?-synuclein in the dopaminergic neurons of Drosophila leads to increases in both lifespan and healthspan. Genet Mol Res. 2012;11:1497-502 pubmed publisher
    ..Our laboratory has previously co-expressed the parkin and Pink1 genes to rescue ?-synuclein-induced phenotypes within a Drosophila model...
  43. Schmidt I, Thomas S, Kain P, Risse B, Naffin E, Kl mbt C. Kinesin heavy chain function in Drosophila glial cells controls neuronal activity. J Neurosci. 2012;32:7466-76 pubmed publisher
    ..Our work shows that the role of Khc for neuronal excitability must be considered in the light of its necessity for directed transport in glia...
  44. Bhandari P, Song M, Chen Y, Burelle Y, Dorn G. Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin. Circ Res. 2014;114:257-65 pubmed publisher
    ..Limiting mitochondrial contagion by inhibiting organelle fusion shows promise for minimizing organ dysfunction produced by defective mitophagic signaling...
  45. Malik B, Godena V, Whitworth A. VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin. Hum Mol Genet. 2015;24:6106-17 pubmed publisher
    ..This process is also promoted by two other PD-lined genes parkin (PARK2) and PINK1 (PARK6). We demonstrate here that vps35 genetically interacts with parkin but interestingly not with pink1...
  46. Jansen R, Brogan B, Whitworth A, Okello E. Effects of five Ayurvedic herbs on locomotor behaviour in a Drosophila melanogaster Parkinson's disease model. Phytother Res. 2014;28:1789-95 pubmed publisher
    ..Tests were performed in both PINK1 mutant flies and healthy wild-type (WT) flies...
  47. Choo Y, Vogler G, Wang D, Kalvakuri S, Iliuk A, Tao W, et al. Regulation of parkin and PINK1 by neddylation. Hum Mol Genet. 2012;21:2514-23 pubmed publisher
    ..Here, we report that Parkinson's disease (PD)-related parkin and PINK1 are NEDD8 conjugated...
  48. Bingol B, Tea J, Phu L, Reichelt M, Bakalarski C, Song Q, et al. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Nature. 2014;510:370-5 pubmed publisher
    ..mitochondria, antagonizes mitophagy driven by the ubiquitin ligase parkin (also known as PARK2) and protein kinase PINK1, which are encoded by two genes associated with Parkinson's disease...
  49. Thomas R, Andrews L, Burman J, Lin W, Pallanck L. PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix. PLoS Genet. 2014;10:e1004279 pubmed publisher
    Loss-of-function mutations in PINK1, which encodes a mitochondrially targeted serine/threonine kinase, result in an early-onset heritable form of Parkinson's disease...
  50. Liu Y, Lin J, Zhang M, Chen K, Yang S, Wang Q, et al. PINK1 is required for timely cell-type specific mitochondrial clearance during Drosophila midgut metamorphosis. Dev Biol. 2016;419:357-372 pubmed publisher
    ..Although PINK1/PARKIN represent the canonical pathway for the elimination of impaired mitochondria in varied pathological ..
  51. Senyilmaz D, Virtue S, Xu X, Tan C, Griffin J, Miller A, et al. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015;525:124-8 pubmed publisher
    ..counteract the mitochondrial dysfunction caused by genetic defects such as loss of the Parkinson's disease genes Pink or Parkin in Drosophila...
  52. Sen A, Kalvakuri S, Bodmer R, Cox R. Clueless, a protein required for mitochondrial function, interacts with the PINK1-Parkin complex in Drosophila. Dis Model Mech. 2015;8:577-89 pubmed publisher
    ..for normal mitochondrial function, can associate with Translocase of the outer membrane (TOM) 20, Porin and PINK1, and is thus located at the mitochondrial outer membrane...
  53. Truscott M, Islam A, Lopez Bigas N, Frolov M. mir-11 limits the proapoptotic function of its host gene, dE2f1. Genes Dev. 2011;25:1820-34 pubmed publisher
    ..Thus, our data support a model in which the coexpression of miR-11 limits the proapoptotic function of its host gene, dE2f1, upon DNA damage by directly modulating a dE2F1-dependent apoptotic transcriptional program. ..
  54. Tsai P, Course M, Lovas J, Hsieh C, Babic M, Zinsmaier K, et al. PINK1-mediated phosphorylation of Miro inhibits synaptic growth and protects dopaminergic neurons in Drosophila. Sci Rep. 2014;4:6962 pubmed publisher
    Mutations in the mitochondrial Ser/Thr kinase PINK1 cause Parkinson's disease. One of the substrates of PINK1 is the outer mitochondrial membrane protein Miro, which regulates mitochondrial transport...
  55. de Castro I, Costa A, Celardo I, Tufi R, Dinsdale D, Loh S, et al. Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants. Cell Death Dis. 2013;4:e873 pubmed publisher
    ..Furthermore, we show that expression of Ref(2)P is able to ameliorate the defects caused by loss of Pink1 and that this depends on the presence of functional Parkin...
  56. Wang Z, Clark C, Geisbrecht E. Drosophila clueless is involved in Parkin-dependent mitophagy by promoting VCP-mediated Marf degradation. Hum Mol Genet. 2016;25:1946-1964 pubmed
    ..Drosophila clueless (clu) was found to interact genetically with PINK1 and parkin to regulate mitochondrial clustering in germ cells...
  57. Wu K, Liu J, Zhuang N, Wang T. UCP4A protects against mitochondrial dysfunction and degeneration in pink1/parkin models of Parkinson's disease. FASEB J. 2014;28:5111-21 pubmed publisher
    Genetic mutations in parkin or pink1 are the most common causes of familial Parkinson's disease. PINK1 and Parkin are components of a mitochondrial quality control pathway that degrades dysfunctional mitochondria via autophagy...
  58. Chen Y, Deng J, Wang P, Yang M, Chen X, Zhu L, et al. PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration. Hum Mol Genet. 2016;25:5059-5068 pubmed publisher
    ..Down-regulating expression of either Pink1 or Parkin genes ameliorated FUS-induced neurodegeneration phenotypes...
  59. Vos M, Lovisa B, Geens A, Morais V, Wagnieres G, van den Bergh H, et al. Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model. PLoS ONE. 2013;8:e78562 pubmed publisher
    ..We tested the hypothesis that 808 nm infrared light that effectively penetrates tissues rescues pink1 mutants...
  60. van der Merwe C, Jalali Sefid Dashti Z, Christoffels A, Loos B, Bardien S. Evidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1. Eur J Neurosci. 2015;41:1113-25 pubmed publisher
    ..Animal and cellular models have verified a direct link between parkin and PINK1, whereby PINK1 phosphorylates and activates parkin at the outer mitochondrial membrane, resulting in removal of ..
  61. Lesnik C, Golani Armon A, Arava Y. Localized translation near the mitochondrial outer membrane: An update. RNA Biol. 2015;12:801-9 pubmed publisher
    ..Finally we discuss future challenges in characterizing the mechanisms for localized translation and its physiological significance. ..
  62. Shiba Fukushima K, Inoshita T, Hattori N, Imai Y. Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy. J Biol Chem. 2014;289:33131-6 pubmed publisher
    ..suppression of Lys-63-linked polyubiquitination through the removal of Ubc13 activity essentially affects neither PINK1 activation nor the degradation of depolarized mitochondria...
  63. Mensah L, Davison C, Fan S, Morris J, Goberdhan D, Wilson C. Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster. PLoS ONE. 2015;10:e0143818 pubmed publisher
  64. Huang Z, Ren S, Jiang Y, Wang T. PINK1 and Parkin cooperatively protect neurons against constitutively active TRP channel-induced retinal degeneration in Drosophila. Cell Death Dis. 2016;7:e2179 pubmed publisher
    ..Further, increasing autophagy flux prevented cell death in Trp(P365) mutant flies, and this depended on the PINK1/Parkin pathway...
  65. Amo T, Sato S, Saiki S, Wolf A, Toyomizu M, Gautier C, et al. Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects. Neurobiol Dis. 2011;41:111-8 pubmed publisher
    ..decreased membrane potential and increased vulnerability against mitochondrial toxins, but the exact function of PINK1 in mitochondria has not been investigated using cells with null expression of PINK1...