Pig1

Summary

Gene Symbol: Pig1
Description: Pre-intermoult gene 1
Alias: CG10790, Dmel\CG10790, EG:96G10.1, Pig-1, gsg, pig1, CG10790-PB, Pig1-PB, Pre-intermolt gene 1, gland specific gene
Species: fruit fly

Top Publications

  1. pmc A transcriptional switch between the Pig-1 and Sgs-4 genes of Drosophila melanogaster
    E Mougneau
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Mol Cell Biol 13:184-95. 1993
  2. ncbi Effect of ecd1 mutation on the expression of genes mapped at the Drosophila melanogaster 3C11-12 intermoult puff
    M Furia
    Dipartimento di Genetica, Biologia Generale e Molecolare, Universita di Napoli, Italia
    Genet Res 59:19-26. 1992
  3. pmc The Broad-Complex directly controls a tissue-specific response to the steroid hormone ecdysone at the onset of Drosophila metamorphosis
    L von Kalm
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    EMBO J 13:3505-16. 1994
  4. ncbi Progress in understanding the Drosophila dnc locus
    A Nighorn
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Comp Biochem Physiol Biochem Mol Biol 108:1-9. 1994
  5. ncbi Dense cluster of genes is located at the ecdysone-regulated 3C puff of Drosophila melanogaster
    M Furia
    Dipartimento di Genetica, Biologia Generale e Molecolare, Universita di Napoli, Italy
    J Mol Biol 231:531-8. 1993
  6. ncbi Drosophila Sgs genes: stage and tissue specificity of hormone responsiveness
    M Lehmann
    Institut für Genetik Freie Universität Berlin, Germany
    Bioessays 18:47-54. 1996
  7. ncbi The transcriptional switch between the Drosophila genes Pig-1 and Sgs-4 depends on a SEBP1 binding site within a shared enhancer region
    A Hofmann
    Institut für Genetik der Freien Universität Berlin, Germany
    Mol Gen Genet 259:656-63. 1998
  8. pmc Spt5 and spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogaster
    C D Kaplan
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 14:2623-34. 2000
  9. pmc The Drosophila dosage compensation complex binds to polytene chromosomes independently of developmental changes in transcription
    I V Kotlikova
    Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia
    Genetics 172:963-74. 2006
  10. ncbi The role of the BR-C locus on the expression of genes located at the ecdysone-regulated 3C puff of Drosophila melanogaster
    P P D'Avino
    Dipartimento di Genetica, Biologia Generale e Molecolare, Universita di Napoli, Italy
    Mech Dev 49:161-71. 1995

Scientific Experts

  • Jeffrey D Jensen
  • I V Kotlikova
  • M Lehmann
  • C D Kaplan
  • M Furia
  • A Hofmann
  • P P D'Avino
  • M I Kuroda
  • I F Zhimulev
  • V V Shloma
  • O V Demakova
  • L V Boldyreva
  • V F Semeshin
  • L C Polito
  • S K Beckendorf
  • C Wu
  • J R Morris
  • S Crispi
  • F Winston
  • R L Davis
  • A Nighorn
  • L von Kalm
  • D Von Seggern
  • E Mougneau
  • D Artiaco
  • T Fowler
  • Y Qiu
  • F A Digilio
  • G M Guild
  • K Crossgrove
  • J Rosenblatt
  • T Jongens
  • C N Chen
  • D Gietzen
  • B Rogers
  • E Giordano
  • G Korge
  • H Saumweber
  • T A Jongens
  • Y H Qiu
  • T Malone
  • S W Barnett
  • M K Webster
  • A W Shermoen
  • L Richter
  • M Frasch
  • B Dauwalder
  • D Cavaliere
  • K Flynn

Detail Information

Publications20

  1. pmc A transcriptional switch between the Pig-1 and Sgs-4 genes of Drosophila melanogaster
    E Mougneau
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Mol Cell Biol 13:184-95. 1993
    ..We present evidence suggesting that the changing interactions between these regulatory elements and the Sgs-4 and Pig-1 promoters lead to the correct pattern of expression of the two genes...
  2. ncbi Effect of ecd1 mutation on the expression of genes mapped at the Drosophila melanogaster 3C11-12 intermoult puff
    M Furia
    Dipartimento di Genetica, Biologia Generale e Molecolare, Universita di Napoli, Italia
    Genet Res 59:19-26. 1992
    ....
  3. pmc The Broad-Complex directly controls a tissue-specific response to the steroid hormone ecdysone at the onset of Drosophila metamorphosis
    L von Kalm
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    EMBO J 13:3505-16. 1994
    ..Thus, the Broad-Complex directly mediates a temporal and tissue-specific response to ecdysone as larvae become committed to metamorphosis...
  4. ncbi Progress in understanding the Drosophila dnc locus
    A Nighorn
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Comp Biochem Physiol Biochem Mol Biol 108:1-9. 1994
    ..This paper reviews the recent developments in the understanding of the structure and function of the gene identified by the first and best-characterized of these mutants, the Drosophila dunce mutant...
  5. ncbi Dense cluster of genes is located at the ecdysone-regulated 3C puff of Drosophila melanogaster
    M Furia
    Dipartimento di Genetica, Biologia Generale e Molecolare, Universita di Napoli, Italy
    J Mol Biol 231:531-8. 1993
    ..Interestingly to note, the entire cluster shows a peculiar genomic location, extending across two introns of the memory gene dunce, a large gene of Drosophila whose organization has proved to be remarkably complex...
  6. ncbi Drosophila Sgs genes: stage and tissue specificity of hormone responsiveness
    M Lehmann
    Institut für Genetik Freie Universität Berlin, Germany
    Bioessays 18:47-54. 1996
    ..g. secretion enhancer binding proteins, which act together in a synergistic manner with the 20E receptor and early gene products to establish a stage- and tissue-specific expression pattern...
  7. ncbi The transcriptional switch between the Drosophila genes Pig-1 and Sgs-4 depends on a SEBP1 binding site within a shared enhancer region
    A Hofmann
    Institut für Genetik der Freien Universität Berlin, Germany
    Mol Gen Genet 259:656-63. 1998
    ....
  8. pmc Spt5 and spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogaster
    C D Kaplan
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 14:2623-34. 2000
    ..Furthermore, Spt5 and Spt6 do not colocalize widely with the unphosphorylated, nonelongating form of Pol II. These results strongly suggest that Spt5 and Spt6 play closely related roles associated with active transcription in vivo...
  9. pmc The Drosophila dosage compensation complex binds to polytene chromosomes independently of developmental changes in transcription
    I V Kotlikova
    Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia
    Genetics 172:963-74. 2006
    ..These data imply that, independently of other MSL proteins, the RNA-helicase MLE might participate in general transcriptional regulation or RNA processing...
  10. ncbi The role of the BR-C locus on the expression of genes located at the ecdysone-regulated 3C puff of Drosophila melanogaster
    P P D'Avino
    Dipartimento di Genetica, Biologia Generale e Molecolare, Universita di Napoli, Italy
    Mech Dev 49:161-71. 1995
    ....
  11. pmc Functional redundancy in the tissue-specific enhancer of the Drosophila Sgs-4 gene
    T A Jongens
    Department of Molecular Biology, University of California, Berkeley 94720
    EMBO J 7:2559-67. 1988
    ..For at least this regulatory activity the enhancer is internally redundant. Any pairwise combination of the three elements is sufficient to direct salivary gland expression, although none of the three can act alone...
  12. ncbi The Drosophila dunce locus: learning and memory genes in the fly
    R L Davis
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Trends Genet 7:224-9. 1991
    ..In addition, the recent cloning and characterization of dunce counterparts from mammals has revealed that these too may participate in animal behavior and, in particular, in the regulation of mood...
  13. ncbi Characterization of the memory gene dunce of Drosophila melanogaster
    Y H Qiu
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    J Mol Biol 222:553-65. 1991
    ..The results suggest that the remarkable structural complexity of dnc may reflect an intricate control of the spatial and/or temporal expression of various isoforms of cAMP PDEase...
  14. ncbi Noncoordinate expression of Drosophila glue genes: Sgs-4 is expressed at many stages and in two different tissues
    S W Barnett
    Department of Molecular Biology, University of California, Berkeley 94720
    Dev Biol 140:362-73. 1990
    ..Appearance of the glue gene RNAs in mid third instar salivary glands is noncoordinate, even for the chromosomally clustered genes Sgs-3, Sgs-7, and Sgs-8...
  15. ncbi Molecular organization of the Drosophila melanogaster Pig-1 gene
    M Furia
    Dipartimento di Genetica, Universita di Napoli, Italy
    Chromosoma 101:49-54. 1991
    ..We also report that the level of Pig-1 transcript is nearly fourfold reduced in a variant strain carrying a deletion within the Pig-1 upstream sequence, thus identifying a regulatory element required for high level gene expression...
  16. pmc A new gene nested within the dunce genetic unit of Drosophila melanogaster
    M Furia
    Dipartimento di Genetica, Biologia Generale e Molecolare, Universita di Napoli, Italy
    Nucleic Acids Res 18:5837-41. 1990
    ..The gene is developmentally regulated and transcribed with the same polarity of dunce; several lines of evidence indicate that it might encode for a salivary gland secreted (Sgs) protein...
  17. ncbi Two puff-specific proteins bind within the 2.5 kb upstream region of the Drosophila melanogaster Sgs-4 gene
    H Saumweber
    Institut für Entwicklungsphysiologie Universität zu Köln, Federal Republic of Germany
    Chromosoma 99:52-60. 1990
    ..A strain containing a 52 bp deletion within this region fails to bind Bx42 protein suggesting that the missing DNA, which overlaps a hypersensitive region, may be required for the binding of the Bx42 protein...
  18. ncbi At least two genes reside within a large intron of the dunce gene of Drosophila
    C N Chen
    Department of Biochemistry, Michigan State University, East Lansing 48824
    Nature 329:721-4. 1987
    ..The location of dunce exons relative to the molecular breakpoints of chromosomal aberrations with defined cytological positions indicates that the dunce gene extends over more than five polytene chromosome bands...
  19. ncbi Upstream sequences of dosage-compensated and non-compensated alleles of the larval secretion protein gene Sgs-4 in Drosophila
    A Hofmann
    Institut fur Genetik, Freie Universitat Berlin
    Chromosoma 96:1-7. 1987
    ..A polyadenylated 0.5 kb RNA was found to be transcribed from the GTT-rich region of the strand opposite to that of Sgs-4. The corresponding gene is active only in larval salivary glands and, therefore, is named gland specific gene, gsg.
  20. pmc Patterns of sequence variability and divergence at the diminutive gene region of Drosophila melanogaster: complex patterns suggest an ancestral selective sweep
    Jeffrey D Jensen
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genetics 177:1071-85. 2007
    ....