Gene Symbol: PI4KIIIalpha
Description: Phosphatidylinositol 4-kinase III alpha
Alias: CG10260, Dmel\CG10260, EG:BACR7C10.2, PI4K, PI4KIII[[alpha]], PI4KinaseIIIalpha, Pi4KIIIalpha, Stt4, ZW-2, l(1)17-59, l(1)3Ah, l(1)VA722, l(1)zw2, stt4, zw-2, zw2, phosphatidylinositol 4-kinase III alpha, CG10260-PC, CG10260-PD, PI4KIIIalpha-PC, PI4KIIIalpha-PD, lethal (1) 3Ah, phosphatidylinositol 4-kinase IIIalpha, zeste-white 2
Species: fruit fly

Top Publications

  1. Yavari A, Nagaraj R, Owusu Ansah E, Folick A, Ngo K, Hillman T, et al. Role of lipid metabolism in smoothened derepression in hedgehog signaling. Dev Cell. 2010;19:54-65 pubmed publisher
    ..Loss of STT4 kinase, which is required for the generation of PI4P, exhibits hh loss-of-function phenotypes, whereas loss of Sac1 ..
  2. Yan Y, Denef N, Tang C, Schupbach T. Drosophila PI4KIIIalpha is required in follicle cells for oocyte polarization and Hippo signaling. Development. 2011;138:1697-703 pubmed publisher
    In a genetic screen we isolated mutations in CG10260, which encodes a phosphatidylinositol 4-kinase (PI4KIIIalpha), and found that PI4KIIIalpha is required for Hippo signaling in Drosophila ovarian follicle cells...
  3. Khuong T, Habets R, Slabbaert J, Verstreken P. WASP is activated by phosphatidylinositol-4,5-bisphosphate to restrict synapse growth in a pathway parallel to bone morphogenetic protein signaling. Proc Natl Acad Sci U S A. 2010;107:17379-84 pubmed publisher
    ..We propose a model in which PI(4,5)P(2)- and WSP-mediated signaling at presynaptic termini controls actin-dependent synapse growth in a pathway at least in part in parallel to synaptic BMP signaling. ..
  4. Akimana C, Al Khodor S, Abu Kwaik Y. Host factors required for modulation of phagosome biogenesis and proliferation of Francisella tularensis within the cytosol. PLoS ONE. 2010;5:e11025 pubmed publisher
    ..tularensis. Our data will facilitate deciphering molecular ecology, patho-adaptation of F. tularensis to the arthropod vector and its role in bacterial ecology and patho-evolution to infect mammals. ..
  5. Jiang K, Liu Y, Fan J, Zhang J, Li X, Evers B, et al. PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail. PLoS Biol. 2016;14:e1002375 pubmed publisher
  6. Devergne O, Tsung K, Barcelo G, Schupbach T. Polarized deposition of basement membrane proteins depends on Phosphatidylinositol synthase and the levels of Phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A. 2014;111:7689-94 pubmed publisher
    ..We propose that PIP2, through the control of Crag's subcellular localization, restricts the secretion of BM proteins to the basal side. ..
  7. Tan J, Oh K, Burgess J, Hipfner D, Brill J. PI4KIII? is required for cortical integrity and cell polarity during Drosophila oogenesis. J Cell Sci. 2014;127:954-66 pubmed publisher
    ..Thus, PI4KIII? is a vital regulator of a functionally distinct pool of PtdIns4P that is essential for PtdIns(4,5)P2-dependent processes in Drosophila development...
  8. Lin H, Wolfner M. Cloning and analysis of fs(1) Ya, a maternal effect gene required for the initiation of Drosophila embryogenesis. Mol Gen Genet. 1989;215:257-65 pubmed
    ..The transcript is not detected in later stages of embryonic development. This expression pattern correlates closely with the genetic and developmental characteristics expected of the fs(1) Ya gene product. ..
  9. Raghu P, Coessens E, Manifava M, Georgiev P, Pettitt T, Wood E, et al. Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels. J Cell Biol. 2009;185:129-45 pubmed publisher
    ..We propose that PA levels are critical for apical membrane transport events required for rhabdomere biogenesis. ..

More Information


  1. Judd B, Shen M, Kaufman T. The anatomy and function of a segment of the X chromosome of Drosophila melanogaster. Genetics. 1972;71:139-56 pubmed
    ..The data clearly show one functional group per chromomere. It is postulated that a chromomere is one cistron within which much of the DNA is regulatory in function. ..
  2. Paradi E, Vogel E, Szilagyi E. Effect of storage and dose on MMS-induced deletions. Complementation analysis of X-chromosomal recessive lethals in the zeste-white and maroon-like regions of Drosophila melanogaster. Mutat Res. 1983;111:145-59 pubmed
    ..An interesting aspect for further analysis is the apparent infrequency in the zeste-white region of alkylation-induced chromosomal breakage, as observed by various investigators for MMS, EMS and MNNG. ..
  3. Liu C, Lim J. Complementation analysis of methyl methane-sulfonate-induced recessive lethal mutations in the zeste-white region of the X chromosome of Drosophila melanogaster. Genetics. 1975;79:601-11 pubmed
  4. Perrimon N, Engstrom L, Mahowald A. The effects of zygotic lethal mutations on female germ-line functions in Drosophila. Dev Biol. 1984;105:404-14 pubmed
    ..Three loci were found which, in germ-line clones, produced embryonic phenotypes that resemble maternal effect mutations. The implications of this study for the genetic analysis of early development are discussed. ..
  5. Robbins L. Maternal-Zygotic Lethal Interactions in DROSOPHILA MELANOGASTER : Zeste-White Region Single-Cistron Mutations. Genetics. 1983;103:633-48 pubmed
    ..Lethal interactions were found for one or more alleles at 10 of the 13 loci. The implications of these observations with respect to gene regulation and developmental sequence are considered. ..
  6. Roubinet C, Decelle B, Chicanne G, Dorn J, Payrastre B, Payre F, et al. Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis. J Cell Biol. 2011;195:99-112 pubmed publisher
    ..These complementary pathways provide a spatiotemporal framework to explain how the cell cortex is remodeled throughout cell division. ..
  7. Thierry Mieg D. Paralog, a control mutant in Drosophila melanogaster. Genetics. 1982;100:209-37 pubmed
    ..We interpret the data by postulating that the expression of sets of dispersed genes might be controlled by the local topology of the chromosome, itself constrained by pairing of dispersed repeated elements. We call the mutation paralog. ..
  8. Nomura T, Kurokawa N. Comparative study on germ cell mutation induced by urethane (ethyl carbamate) gas and X-rays in Drosophila melanogaster. Jpn J Cancer Res. 1997;88:461-7 pubmed
    ..Urethane-induced mutations were strikingly non-random with two hot spots at zw-1 and zw-2, whereas the distribution of X-ray-induced mutations was more nearly random. ..
  9. Garcia Bellido A, Robbins L. Viability of Female Germ-Line Cells Homozygous for Zygotic Lethals in DROSOPHILA MELANOGASTER. Genetics. 1983;103:235-47 pubmed
    ..The abundance of genes whose products are required for oogenesis, whose products are required in the oocyte, and whose activity is required during zygotic development is discussed. ..
  10. Lim J, Snyder L. Cytogenetic and complementation analyses of recessive lethal mutations induced in the X chromosome of Drosophila by three alkylating agents. Genet Res. 1974;24:1-10 pubmed
  11. Forrest S, Chai A, Sanhueza M, Marescotti M, Parry K, Georgiev A, et al. Increased levels of phosphoinositides cause neurodegeneration in a Drosophila model of amyotrophic lateral sclerosis. Hum Mol Genet. 2013;22:2689-704 pubmed publisher
    ..These data underscore the importance of DVAP-Sac1 interaction in controlling phosphoinositide metabolism and provide mechanistic evidence for a crucial role of phosphoinositide levels in VAP-induced ALS. ..
  12. Williams B, Karr T, Montgomery J, Goldberg M. The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation, is redistributed at anaphase onset. J Cell Biol. 1992;118:759-73 pubmed
    ..Upon anaphase onset, there is an extremely rapid redistribution of the zw10 protein to a location at or near the kinetochores of the separating chromosomes. ..
  13. Page S, Hawley R. The Drosophila meiotic mutant mei-352 is an allele of klp3A and reveals a role for a kinesin-like protein in crossover distribution. Genetics. 2005;170:1797-807 pubmed
  14. Kemppainen E, Fernández Ayala D, Galbraith L, O Dell K, Jacobs H. Phenotypic suppression of the Drosophila mitochondrial disease-like mutant tko(25t) by duplication of the mutant gene in its natural chromosomal context. Mitochondrion. 2009;9:353-63 pubmed publisher
    ..Increased mutant gene dosage can thus compensate the mutant phenotype, but only when located in its normal chromosomal context. ..
  15. Shannon M, Kaufman T, Shen M, Judd B. Lethality patterns and morphology of selected lethal and semi-lethal mutations in the zeste-white region of Drosophila melanogaster. Genetics. 1972;72:615-38 pubmed
    ..These results provide additional evidence that only one function is associated with each chromomere.-The results of the lethality pattern analysis are also compared with previous studies of lethal mutants of Drosophila. ..
  16. Perrimon N, Smouse D. Multiple functions of a Drosophila homeotic gene, zeste-white 3, during segmentation and neurogenesis. Dev Biol. 1989;135:287-305 pubmed
    ..The multiple roles of zw3 during development and its possible interactions with the zygotic gene nkd are discussed. ..
  17. Goldberg M, Colvin R, Mellin A. The Drosophila zeste locus is nonessential. Genetics. 1989;123:145-55 pubmed
    ..This suggests that the zeste protein normally is either a very weak transcription factor, or that its function can be substituted by that of other regulatory proteins. ..
  18. Montgomery E, Huang S, Langley C, Judd B. Chromosome rearrangement by ectopic recombination in Drosophila melanogaster: genome structure and evolution. Genetics. 1991;129:1085-98 pubmed
  19. Bulat V, Rast M, Pielage J. Presynaptic CK2 promotes synapse organization and stability by targeting Ankyrin2. J Cell Biol. 2014;204:77-94 pubmed publisher
    ..Our study identifies phosphorylation of structural synaptic components as a compelling mechanism to actively control the development and longevity of synaptic connections. ..
  20. Pastink A, Vreeken C, Vogel E, Eeken J. Mutations induced at the white and vermilion loci in Drosophila melanogaster. Mutat Res. 1990;231:63-71 pubmed
    ..This was confirmed by sequence analysis of 25 ENU-induced vermilion mutants. In all mutants the alterations are due to base-pair changes, the majority being GC to AT transitions (61%). ..
  21. Zhang X, Wang W, Jiang L, Liu H, Zhang B, Lim N, et al. Downregulation of RBO-PI4KIIIα Facilitates Aβ42 Secretion and Ameliorates Neural Deficits in Aβ42-Expressing Drosophila. J Neurosci. 2017;37:4928-4941 pubmed publisher
    ..This study suggests the RBO-PI4KIIIα complex as a novel therapeutic target, and PI4KIIIα inhibitors as new drug candidates. ..
  22. Bourouis M, Moore P, Ruel L, Grau Y, Heitzler P, Simpson P. An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily. EMBO J. 1990;9:2877-84 pubmed
    ..Ubiquitous expression of sgg transcripts was found during embryonic stages. A possible role of the sgg protein in a signal transduction pathway necessary for intercellular communication at different stages of development is discussed. ..