Gene Symbol: Pi4KIIalpha
Alias: CG2929, Dmel\CG2929, PI4KII, PI4KIIalpha, PI4KIIbeta, Pi4KIIa, Pi4KIIalpha, CG2929-PA, CG2929-PB, CG2929-PC, Pi4KIIalpha-PA, Pi4KIIalpha-PB, Pi4KIIalpha-PC
Species: fruit fly
Burgess J, Del Bel L, Ma C, Barylko B, Polevoy G, Rollins J, et al
. Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila. Development. 2012;139:3040-50 pubmed publisher
Type II phosphatidylinositol 4-kinase (PI4KII) produces the lipid phosphatidylinositol 4-phosphate (PI4P), a key regulator of membrane trafficking. Here, we generated genetic models of the sole Drosophila melanogaster PI4KII gene...
Barylko B, Wlodarski P, Binns D, Gerber S, Earnest S, Sudhof T, et al
. Analysis of the catalytic domain of phosphatidylinositol 4-kinase type II. J Biol Chem. 2002;277:44366-75 pubmed
..Here we define the minimal catalytic domain of a rat PI4KII isoform, PI4KIIalpha, and identify conserved amino acid residues required for catalysis...
Raghu P, Coessens E, Manifava M, Georgiev P, Pettitt T, Wood E, et al
. Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels. J Cell Biol. 2009;185:129-45 pubmed publisher
..We propose that PA levels are critical for apical membrane transport events required for rhabdomere biogenesis. ..
Tan J, Oh K, Burgess J, Hipfner D, Brill J. PI4KIII? is required for cortical integrity and cell polarity during Drosophila oogenesis. J Cell Sci. 2014;127:954-66 pubmed publisher
..requirement for PI4KIII?, as egg chambers from flies mutant for either of the other Drosophila PI4Ks, fwd or PI4KII, show Golgi but not plasma membrane phenotypes...
Corrigan L, Redhai S, Leiblich A, Fan S, Perera S, Patel R, et al
. BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior. J Cell Biol. 2014;206:671-88 pubmed publisher
..These results demonstrate a new function for the MVB-exosome pathway in the reproductive tract that appears to be conserved across evolution. ..