Genomes and Genes
Gene Symbol: PGRP-SC2
Alias: CG14745, CG14745 PGRP, Dmel\CG14745, PCRP-SC2, PGRP-SC, pgrp-sc2, PGRP-SC2, CG14745-PA, PGRP-SC2-PA, Peptidoglycan-recognition protein-SC2 precursor, peptidoglycan recognition protein SC2
Species: fruit fly
- Wagner C, Isermann K, Fehrenbach H, Roeder T. Molecular architecture of the fruit fly's airway epithelial immune system. BMC Genomics. 2008;9:446 pubmed publisher..This architecture will allow reacting if confronted with different bacterial or fungal elicitors by activation of a multitude of effectors. ..
- Horner M, Pardee K, Liu S, King Jones K, Lajoie G, Edwards A, et al. The Drosophila DHR96 nuclear receptor binds cholesterol and regulates cholesterol homeostasis. Genes Dev. 2009;23:2711-6 pubmed publisher..These studies define DHR96 as a central regulator of cholesterol homeostasis. ..
- Chen H, Zheng X, Zheng Y. Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia. Cell. 2014;159:829-43 pubmed publisher..paperflick: ..
- Fan X, Liang Q, Lian T, Wu Q, Gaur U, Li D, et al. Rapamycin preserves gut homeostasis during Drosophila aging. Oncotarget. 2015;6:35274-83 pubmed publisher..These results will further explain the mechanism of healthspan and lifespan extension by rapamycin in Drosophila. ..
- Hang S, Purdy A, Robins W, Wang Z, Mandal M, Chang S, et al. The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism. Cell Host Microbe. 2014;16:592-604 pubmed publisher..Thus, acetate consumption by V. cholerae alters host metabolism, and dietary acetate supplementation may ameliorate some sequelae of cholera. ..
- Jasper H. Exploring the physiology and pathology of aging in the intestine of Drosophila melanogaster. Invertebr Reprod Dev. 2015;59:51-58 pubmed..Here, I review recent studies exploring age-related changes in the fly intestine, and their insight into the regulation of health and lifespan of the animal. ..
- Ye Y, Chenoweth S, McGraw E. Effective but costly, evolved mechanisms of defense against a virulent opportunistic pathogen in Drosophila melanogaster. PLoS Pathog. 2009;5:e1000385 pubmed publisher..aeruginosa infection than previously reported. This work reveals novel pathways by which Drosophila can survive infection with a virulent pathogen that may be rare in wild populations, however, due to their cost. ..
- Jiggins F, Hurst G. The evolution of parasite recognition genes in the innate immune system: purifying selection on Drosophila melanogaster peptidoglycan recognition proteins. J Mol Evol. 2003;57:598-605 pubmed publisher..Therefore, interactions between these genes are unlikely to be the focus of host-parasite coevolution, at least in Drosophila. We also found evidence of gene conversion occurring between two genes, PGRP-SC1A and PGRP-SC1B...