Gene Symbol: peng
Alias: CG1685, Dmel\CG1685, pen, penguin, CG1685-PA, peng-PA
Species: fruit fly
Campbell H, Schimansky T, Claudianos C, Ozsarac N, Kasprzak A, Cotsell J, et al
. The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans. Proc Natl Acad Sci U S A. 1993;90:11386-90 pubmed
..The presence of a highly conserved homologue in nematodes, flies, and humans is indicative of a fundamental role for this protein in many metazoans. ..
Prout M, Damania Z, Soong J, Fristrom D, Fristrom J. Autosomal mutations affecting adhesion between wing surfaces in Drosophila melanogaster. Genetics. 1997;146:275-85 pubmed
..Mutations in three other genes (kakapo, kiwi and moa) may also affect cell adhesion or muscle function at hatching. These new mutants provide valuable material for the study of integrin-dependent cell-to-cell adhesion. ..
Maleszka R, Hanes S, Hackett R, de Couet H, Miklos G. The Drosophila melanogaster dodo (dod) gene, conserved in humans, is functionally interchangeable with the ESS1 cell division gene of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1996;93:447-51 pubmed
..four transcription units within it, which we have named tweety (twe), flightless (fli), dodo (dod), and penguin (pen)...
Maleszka R, de Couet H, Miklos G. Data transferability from model organisms to human beings: insights from the functional genomics of the flightless region of Drosophila. Proc Natl Acad Sci U S A. 1998;95:3731-6 pubmed
Meiklejohn C, Landeen E, Cook J, Kingan S, Presgraves D. Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation. PLoS Biol. 2011;9:e1001126 pubmed publisher
..These findings help to resolve several previously conflicting reports and have implications for patterns of genome evolution and speciation in Drosophila...
Hsu T, McRackan D, Vincent T, Gert de Couet H. Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis. Nat Cell Biol. 2001;3:538-43 pubmed
..Its function is to facilitate the degradation of transcription factor CF2, which requires, a priori, activated epidermal growth factor receptor-MAPK signalling. ..
Hoskins R, Landolin J, Brown J, Sandler J, Takahashi H, Lassmann T, et al
. Genome-wide analysis of promoter architecture in Drosophila melanogaster. Genome Res. 2011;21:182-92 pubmed publisher
..Our results contribute to the emerging view that core promoters are functionally diverse and control patterning of gene expression in Drosophila and mammals. ..