Gene Symbol: pds5
Description: precocious dissociation of sisters 5
Alias: CG17509, Dmel\CG17509, PDS5, Pds5, anon-WO0118547.183, dPds5, l(2)k13312, precocious dissociation of sisters 5, CG17509-PA, CG17509-PB, cohiba, lethal (2) k13312, pds5-PA, pds5-PB
Species: fruit fly

Top Publications

  1. Gause M, Webber H, Misulovin Z, Haller G, Rollins R, Eissenberg J, et al. Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells. Chromosoma. 2008;117:51-66 pubmed
    ..These results support the idea that direct regulation of cohesin function underlies the diverse functions of Nipped-B and its orthologs...
  2. Dorsett D, Eissenberg J, Misulovin Z, Martens A, Redding B, McKim K. Effects of sister chromatid cohesion proteins on cut gene expression during wing development in Drosophila. Development. 2005;132:4743-53 pubmed
    ..We also find that cut expression is increased by a unique pds5 gene mutation that reduces the binding of cohesin to chromosomes...
  3. Barbosa V, Kimm N, Lehmann R. A maternal screen for genes regulating Drosophila oocyte polarity uncovers new steps in meiotic progression. Genetics. 2007;176:1967-77 pubmed
    ..complementation groups, including Kinesin heavy chain, the SR protein kinase cuaba, the cohesin-related gene dPds5/cohiba, and the Tudor-domain gene montecristo...
  4. Hallson G, Syrzycka M, Beck S, Kennison J, Dorsett D, Page S, et al. The Drosophila cohesin subunit Rad21 is a trithorax group (trxG) protein. Proc Natl Acad Sci U S A. 2008;105:12405-10 pubmed publisher
    ..Cohesin proteins SMC1, SMC3, Rad21, and stromalin (SA), along with associated proteins Nipped-B, Pds5, and EcoI, maintain sister chromatid cohesion before segregation to daughter cells during anaphase...
  5. Dorsett D, Kassis J. Checks and balances between cohesin and polycomb in gene silencing and transcription. Curr Biol. 2014;24:R535-9 pubmed publisher
  6. Krishnan B, Thomas S, Yan R, Yamada H, Zhulin I, McKee B. Sisters unbound is required for meiotic centromeric cohesion in Drosophila melanogaster. Genetics. 2014;198:947-65 pubmed publisher
    ..In conclusion, our data show that SUNN is an essential meiosis-specific Drosophila cohesion protein. ..
  7. Kusch T. Brca2-Pds5 complexes mobilize persistent meiotic recombination sites to the nuclear envelope. J Cell Sci. 2015;128:717-27 pubmed publisher
    ..and interaction studies reveal that the recombination mediator Brca2 associates with lamin and the cohesion factor Pds5 to secure persistent recombination sites at the nuclear envelope...
  8. Dorsett D. Cohesin, gene expression and development: lessons from Drosophila. Chromosome Res. 2009;17:185-200 pubmed publisher
  9. Gause M, Misulovin Z, Bilyeu A, Dorsett D. Dosage-sensitive regulation of cohesin chromosome binding and dynamics by Nipped-B, Pds5, and Wapl. Mol Cell Biol. 2010;30:4940-51 pubmed publisher
    ..Partial loss of the Nipped-B protein that loads cohesin onto chromosomes, or the Pds5 protein required for sister chromatid cohesion, alters gene expression and organism development, without affecting ..

More Information


  1. Brough R, Bajrami I, Vatcheva R, Natrajan R, Reis Filho J, Lord C, et al. APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer. EMBO J. 2012;31:1160-76 pubmed publisher
  2. Cunningham M, Gause M, Cheng Y, Noyes A, Dorsett D, Kennison J, et al. Wapl antagonizes cohesin binding and promotes Polycomb-group silencing in Drosophila. Development. 2012;139:4172-9 pubmed publisher
    ..Mutations in the cohesin-associated genes Nipped-B and pds5 suppress and enhance wapl(AG) phenotypes, respectively...