pck

Summary

Gene Symbol: pck
Description: pickel
Alias: CG14779, Dmel\CG14779, EG:80H7.2, Mega, PCK, Pck, l(1)G0044, mega, pickel, CG14779-PA, CG14779-PC, CG14779-PD, megatrachea, pck-PA, pck-PC, pck-PD
Species: fruit fly

Top Publications

  1. Paul S, Ternet M, Salvaterra P, Beitel G. The Na+/K+ ATPase is required for septate junction function and epithelial tube-size control in the Drosophila tracheal system. Development. 2003;130:4963-74 pubmed
  2. Behr M, Riedel D, Schuh R. The claudin-like megatrachea is essential in septate junctions for the epithelial barrier function in Drosophila. Dev Cell. 2003;5:611-20 pubmed
    ..We identified Megatrachea (Mega), a Drosophila transmembrane protein homologous to claudins, and show that it acts in septate junctions, ..
  3. Kertesz M, Iovino N, Unnerstall U, Gaul U, Segal E. The role of site accessibility in microRNA target recognition. Nat Genet. 2007;39:1278-84 pubmed
    ..Our study thus demonstrates that target accessibility is a critical factor in microRNA function. ..
  4. Hong X, Hammell M, Ambros V, Cohen S. Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets. Proc Natl Acad Sci U S A. 2009;106:15085-90 pubmed publisher
    ..This study reveals a complex relationship among different features in miRNA-target recognition and poses a new challenge for computational prediction. ..
  5. Degelmann A. Genetic analysis of the X-chromosomal region 1E-2A of Drosophila melanogaster. Mol Gen Genet. 1993;239:257-68 pubmed
    ..These analyses provide an overall genetic map of the interval 1E-2A. In addition, the smaller deletions were physically mapped within cloned genomic DNA of the 2A region. ..
  6. Tonning A, Hemphälä J, Tång E, Nannmark U, Samakovlis C, Uv A. A transient luminal chitinous matrix is required to model epithelial tube diameter in the Drosophila trachea. Dev Cell. 2005;9:423-30 pubmed
    ..We propose that the transient luminal protein/polysaccharide matrix is sensed by the epithelial cells and coordinates cytoskeletal organization to ensure uniform lumen diameter. ..
  7. Moussian B, Tång E, Tonning A, Helms S, Schwarz H, NUSSLEIN VOLHARD C, et al. Drosophila Knickkopf and Retroactive are needed for epithelial tube growth and cuticle differentiation through their specific requirement for chitin filament organization. Development. 2006;133:163-71 pubmed
    ..We propose a model in which Knk and the predicted chitin-binding protein Rtv form membrane complexes essential for epithelial tubulogenesis and cuticle formation through their specific role in directing chitin filament assembly...
  8. Jaspers M, Nolde K, Behr M, Joo S, Plessmann U, Nikolov M, et al. The claudin Megatrachea protein complex. J Biol Chem. 2012;287:36756-65 pubmed publisher
    ..Using specific antibodies against the claudin Megatrachea for immunoprecipitation and mass spectrometry, we identified 142 proteins associated with Megatrachea in ..
  9. Nelson K, Furuse M, Beitel G. The Drosophila Claudin Kune-kune is required for septate junction organization and tracheal tube size control. Genetics. 2010;185:831-9 pubmed publisher
    ..being ultrastructurally distinct from the vertebrate tight junction, also contains the claudin-family proteins Megatrachea and Sinuous...

More Information

Publications25

  1. Harder B, Schomburg A, Pflanz R, Küstner K, Gerlach N, Schuh R. TEV protease-mediated cleavage in Drosophila as a tool to analyze protein functions in living organisms. Biotechniques. 2008;44:765-72 pubmed publisher
    ..Thereby, this technique is a powerful tool that allows the in vivo manipulation of selected proteins in a time- and tissue-specific manner. ..
  2. Bassett A, Azzam G, Wheatley L, Tibbit C, Rajakumar T, McGowan S, et al. Understanding functional miRNA-target interactions in vivo by site-specific genome engineering. Nat Commun. 2014;5:4640 pubmed publisher
    ..These methods facilitate analysis of the direct phenotypic consequences resulting from blocking specific miRNA-MRE interactions at any point during development. ..
  3. Hall S, Bone C, Oshima K, Zhang L, McGraw M, Lucas B, et al. Macroglobulin complement-related encodes a protein required for septate junction organization and paracellular barrier function in Drosophila. Development. 2014;141:889-98 pubmed publisher
    ..Together, these studies demonstrate that Mcr is a core component of epithelial SJs and also highlight an interesting relationship between innate immunity and epithelial barrier functions. ..
  4. Jaspers M, Pflanz R, Riedel D, Kawelke S, Feussner I, Schuh R. The fatty acyl-CoA reductase Waterproof mediates airway clearance in Drosophila. Dev Biol. 2014;385:23-31 pubmed publisher
    ..Considering its conservation throughout evolution, Waterproof orthologues may play a similar role in the vertebrate lung. ..
  5. Wu V, Beitel G. A junctional problem of apical proportions: epithelial tube-size control by septate junctions in the Drosophila tracheal system. Curr Opin Cell Biol. 2004;16:493-9 pubmed
    ..Possible tube-size functions of septate junctions include patterning of the apical extracellular matrix and regulation of conserved cell polarity genes such as Scribble and Discs Large. ..
  6. Oshima K, Fehon R. Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs large. J Cell Sci. 2011;124:2861-71 pubmed publisher
    ..These results indicate that formation of a stable SJ core complex is separable from its proper subcellular localization, and provide new insights into the complex processes that regulate epithelial polarity and assembly of the SJ. ..
  7. Caussinus E, Kanca O, Affolter M. Fluorescent fusion protein knockout mediated by anti-GFP nanobody. Nat Struct Mol Biol. 2011;19:117-21 pubmed publisher
    ..It is traceable, because the GFP tag can be used to monitor the protein knockout. In many cases, it is a ready-to-use solution, as GFP protein-trap stock collections are being generated in Drosophila melanogaster and in Danio rerio. ..
  8. Bätz T, Förster D, Luschnig S. The transmembrane protein Macroglobulin complement-related is essential for septate junction formation and epithelial barrier function in Drosophila. Development. 2014;141:899-908 pubmed publisher
    ..Thus, Mcr represents a novel paradigm for investigating functional links between occluding junction formation and pathogen defense mechanisms. ..
  9. Wu V, Schulte J, Hirschi A, Tepass U, Beitel G. Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control. J Cell Biol. 2004;164:313-23 pubmed
  10. Melnick M, Noll E, Perrimon N. The Drosophila stubarista phenotype is associated with a dosage effect of the putative ribosome-associated protein D-p40 on spineless. Genetics. 1993;135:553-64 pubmed
    ..This phenomenon is reminiscent of the enhancing effect observed with Minute mutations, one of which, rp49, has previously been shown to encode a ribosomal protein. ..
  11. Laprise P, Paul S, Boulanger J, Robbins R, Beitel G, Tepass U. Epithelial polarity proteins regulate Drosophila tracheal tube size in parallel to the luminal matrix pathway. Curr Biol. 2010;20:55-61 pubmed publisher
    ..Together, these data indicate that Yrt, Cora, Crb, and Scrib operate independently of the Verm pathway. Our data support a model in which Cora and Yrt act through Crb to regulate epithelial tube size. ..
  12. Stork T, Engelen D, Krudewig A, Silies M, Bainton R, Klämbt C. Organization and function of the blood-brain barrier in Drosophila. J Neurosci. 2008;28:587-97 pubmed publisher
  13. Metta M, Schlotterer C. Non-random genomic integration - an intrinsic property of retrogenes in Drosophila?. BMC Evol Biol. 2010;10:114 pubmed publisher
    ..Rather, we propose that the movement away from the X-chromosome represents a general property of retroposition in Drosophila. ..
  14. Furuse M, Tsukita S. Claudins in occluding junctions of humans and flies. Trends Cell Biol. 2006;16:181-8 pubmed
    ..Interestingly, claudin-like molecules have recently been identified in septate junctions of Drosophila. Here, we present an overview of recent progress in claudin studies conducted in mammals and flies. ..
  15. Hildebrandt A, Pflanz R, Behr M, Tarp T, Riedel D, Schuh R. Bark beetle controls epithelial morphogenesis by septate junction maturation in Drosophila. Dev Biol. 2015;400:237-47 pubmed publisher
    ..We propose a model in which Bark acts as a scaffold protein that mediates cell adhesion and mounting of SJ core complexes during cell rearrangement in tissue morphogenesis. ..
  16. Luschnig S, Bätz T, Armbruster K, Krasnow M. serpentine and vermiform encode matrix proteins with chitin binding and deacetylation domains that limit tracheal tube length in Drosophila. Curr Biol. 2006;16:186-94 pubmed