Gene Symbol: Pcf11
Description: Protein 1 of cleavage and polyadenylation factor 1
Alias: CG10228, Dmel\CG10228, Inr-a, anon-WO0118547.146, dPcf11, l(2)k08015, pcf11, protein 1 of cleavage and polyadenylation factor 1, CG10228-PB, CG10228-PC, CG10228-PD, CG10228-PE, CG10228-PF, CG10228-PG, CG10228-PH, Pcf11-PB, Pcf11-PC, Pcf11-PD, Pcf11-PE, Pcf11-PF, Pcf11-PG, Pcf11-PH, inverse regulator a, lethal (2) k08015
Species: fruit fly

Top Publications

  1. Sekelsky J, Hollis K, Eimerl A, Burtis K, Hawley R. Nucleotide excision repair endonuclease genes in Drosophila melanogaster. Mutat Res. 2000;459:219-28 pubmed
    ..The Drosophila Ercc1 gene maps to polytene region 51D1-2. The nucleotide excision repair gene mus210 maps nearby (51E-F) but is distinct from Ercc1. ..
  2. Rabinow L, Nguyen Huynh A, Birchler J. A trans-acting regulatory gene that inversely affects the expression of the white, brown and scarlet loci in Drosophila. Genetics. 1991;129:463-80 pubmed
    ..These experiments demonstrate that a single regulatory gene can exert an inverse effect on a target structural locus, a situation postulated from segmental aneuploid studies of gene expression and dosage compensation. ..
  3. Zhang Z, Gilmour D. Pcf11 is a termination factor in Drosophila that dismantles the elongation complex by bridging the CTD of RNA polymerase II to the nascent transcript. Mol Cell. 2006;21:65-74 pubmed
    ..We show that Pcf11 is directly involved in termination in Drosophila. dPcf11 is concentrated at the 3' end of the hsp70 gene in cells, and depletion of dPcf11 with RNAi causes Pol II to ..
  4. Pal Bhadra M, Bhadra U, Birchler J. Role of multiple trans-acting regulators in modifying the effect of the retrotransposon copia on host gene expression in Drosophila. Mol Gen Genet. 1998;259:198-206 pubmed
    ..In general, double combinations do not elevate the level of copia transcripts more than twofold. The role of suppressor mutations in modifying the effect of transposable elements on host gene expression is discussed. ..
  5. Xie W, Birchler J. Identification of Inverse Regulator-a (Inr-a) as Synonymous with Pre-mRNA Cleavage Complex II Protein (Pcf11) in Drosophila. G3 (Bethesda). 2012;2:701-6 pubmed publisher
    ..of the location of this gene on the second chromosome led to a candidate pre-mRNA cleavege complex II protein (Pcf11) as the only gene in the remaining region whose mutations exhibit recessive lethality as do alleles of Inr-a...
  6. Bhadra U, Bhadra M, Birchler J. Interactions among dosage-dependent trans-acting modifiers of gene expression and position-effect variegation in Drosophila. Genetics. 1998;150:251-63 pubmed
    ..The highly multigenic nature of dosage-sensitive modulation of both gene expression and PEV suggests that dosage effects can be progressively transduced through a series of steps in a hierarchical manner...
  7. Dworak H, Charles M, Pellerano L, Sink H. Characterization of Drosophila hibris, a gene related to human nephrin. Development. 2001;128:4265-76 pubmed
    ..We propose that Hibris is an extracellular partner for Dumbfounded and potentially mediates the response of myoblasts to this attractant. ..
  8. Yao J, Ardehali M, Fecko C, Webb W, Lis J. Intranuclear distribution and local dynamics of RNA polymerase II during transcription activation. Mol Cell. 2007;28:978-90 pubmed
    ..Pol II at highly transcribed developmental loci exhibits dynamics resembling combinations of these Hsp70 transcription modes. ..