Pc

Summary

Gene Symbol: Pc
Description: Polycomb
Alias: CG32443, CG7618, DmPc, Dmel\CG32443, Pc-G, PcG, dPC, polycomb, CG32443-PA, Pc-PA
Species: fruit fly
Products:     Pc

Top Publications

  1. Garaulet D, Foronda D, Calleja M, Sánchez Herrero E. Polycomb-dependent Ultrabithorax Hox gene silencing induced by high Ultrabithorax levels in Drosophila. Development. 2008;135:3219-28 pubmed publisher
    ..The mechanism of permanent repression depends on Polycomb-group genes...
  2. Tolhuis B, Blom M, Kerkhoven R, Pagie L, Teunissen H, Nieuwland M, et al. Interactions among Polycomb domains are guided by chromosome architecture. PLoS Genet. 2011;7:e1001343 pubmed publisher
    b>Polycomb group (PcG) proteins bind and regulate hundreds of genes. Previous evidence has suggested that long-range chromatin interactions may contribute to the regulation of PcG target genes...
  3. Kodjabachian L, Delaage M, Maurel C, Miassod R, Jacq B, Rosset R. Mutations in ccf, a novel Drosophila gene encoding a chromosomal factor, affect progression through mitosis and interact with Pc-G mutations. EMBO J. 1998;17:1063-75 pubmed
    ..We also find that mutations in the Pc-G genes Polycomb, polyhomeotic and Enhancer of zeste are enhanced by ccf mutations...
  4. Chang Y, Peng Y, Pan I, Sun D, King B, Huang D. Essential role of Drosophila Hdac1 in homeotic gene silencing. Proc Natl Acad Sci U S A. 2001;98:9730-5 pubmed
    ..We show that Drosophila Hdac1, an Rpd3-type gene, interacts cooperatively with Polycomb group repressors in silencing the homeotic genes that are essential for axial patterning of body segments...
  5. Gutierrez L, Zurita M, Kennison J, Vázquez M. The Drosophila trithorax group gene tonalli (tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein. Development. 2003;130:343-54 pubmed
    ..We identified the tonalli (tna) gene in Drosophila by genetic interactions with brahma. tna mutations suppress Polycomb phenotypes and tna is required for the proper expressions of the Antennapedia, Ultrabithorax and Sex combs ..
  6. Bantignies F, Grimaud C, Lavrov S, Gabut M, Cavalli G. Inheritance of Polycomb-dependent chromosomal interactions in Drosophila. Genes Dev. 2003;17:2406-20 pubmed
    ..b>Polycomb-group (PcG) and trithorax-group (trxG) proteins maintain memory of chromatin states through binding at cis-..
  7. Breiling A, O Neill L, D Eliseo D, Turner B, Orlando V. Epigenome changes in active and inactive polycomb-group-controlled regions. EMBO Rep. 2004;5:976-82 pubmed
    The Polycomb group (PcG) of proteins conveys epigenetic inheritance of repressed transcriptional states...
  8. Classen A, Bunker B, Harvey K, Vaccari T, Bilder D. A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling. Nat Genet. 2009;41:1150-5 pubmed publisher
    A prevailing paradigm posits that Polycomb Group (PcG) proteins maintain stem cell identity by repressing differentiation genes, and abundant evidence points to an oncogenic role for PcG proteins in human cancer...
  9. Langlais K, Brown J, Kassis J. Polycomb group proteins bind an engrailed PRE in both the "ON" and "OFF" transcriptional states of engrailed. PLoS ONE. 2012;7:e48765 pubmed publisher
    b>Polycomb group (PcG) and trithorax Group (trxG) proteins maintain the "OFF" and "ON" transcriptional states of HOX genes and other targets by modulation of chromatin structure...
  10. Mohd Sarip A, van der Knaap J, Wyman C, Kanaar R, Schedl P, Verrijzer C. Architecture of a polycomb nucleoprotein complex. Mol Cell. 2006;24:91-100 pubmed
    b>Polycomb group (PcG) epigenetic silencing proteins act through cis-acting DNA sequences, named Polycomb response elements (PREs)...

Detail Information

Publications103 found, 100 shown here

  1. Garaulet D, Foronda D, Calleja M, Sánchez Herrero E. Polycomb-dependent Ultrabithorax Hox gene silencing induced by high Ultrabithorax levels in Drosophila. Development. 2008;135:3219-28 pubmed publisher
    ..The mechanism of permanent repression depends on Polycomb-group genes...
  2. Tolhuis B, Blom M, Kerkhoven R, Pagie L, Teunissen H, Nieuwland M, et al. Interactions among Polycomb domains are guided by chromosome architecture. PLoS Genet. 2011;7:e1001343 pubmed publisher
    b>Polycomb group (PcG) proteins bind and regulate hundreds of genes. Previous evidence has suggested that long-range chromatin interactions may contribute to the regulation of PcG target genes...
  3. Kodjabachian L, Delaage M, Maurel C, Miassod R, Jacq B, Rosset R. Mutations in ccf, a novel Drosophila gene encoding a chromosomal factor, affect progression through mitosis and interact with Pc-G mutations. EMBO J. 1998;17:1063-75 pubmed
    ..We also find that mutations in the Pc-G genes Polycomb, polyhomeotic and Enhancer of zeste are enhanced by ccf mutations...
  4. Chang Y, Peng Y, Pan I, Sun D, King B, Huang D. Essential role of Drosophila Hdac1 in homeotic gene silencing. Proc Natl Acad Sci U S A. 2001;98:9730-5 pubmed
    ..We show that Drosophila Hdac1, an Rpd3-type gene, interacts cooperatively with Polycomb group repressors in silencing the homeotic genes that are essential for axial patterning of body segments...
  5. Gutierrez L, Zurita M, Kennison J, Vázquez M. The Drosophila trithorax group gene tonalli (tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein. Development. 2003;130:343-54 pubmed
    ..We identified the tonalli (tna) gene in Drosophila by genetic interactions with brahma. tna mutations suppress Polycomb phenotypes and tna is required for the proper expressions of the Antennapedia, Ultrabithorax and Sex combs ..
  6. Bantignies F, Grimaud C, Lavrov S, Gabut M, Cavalli G. Inheritance of Polycomb-dependent chromosomal interactions in Drosophila. Genes Dev. 2003;17:2406-20 pubmed
    ..b>Polycomb-group (PcG) and trithorax-group (trxG) proteins maintain memory of chromatin states through binding at cis-..
  7. Breiling A, O Neill L, D Eliseo D, Turner B, Orlando V. Epigenome changes in active and inactive polycomb-group-controlled regions. EMBO Rep. 2004;5:976-82 pubmed
    The Polycomb group (PcG) of proteins conveys epigenetic inheritance of repressed transcriptional states...
  8. Classen A, Bunker B, Harvey K, Vaccari T, Bilder D. A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling. Nat Genet. 2009;41:1150-5 pubmed publisher
    A prevailing paradigm posits that Polycomb Group (PcG) proteins maintain stem cell identity by repressing differentiation genes, and abundant evidence points to an oncogenic role for PcG proteins in human cancer...
  9. Langlais K, Brown J, Kassis J. Polycomb group proteins bind an engrailed PRE in both the "ON" and "OFF" transcriptional states of engrailed. PLoS ONE. 2012;7:e48765 pubmed publisher
    b>Polycomb group (PcG) and trithorax Group (trxG) proteins maintain the "OFF" and "ON" transcriptional states of HOX genes and other targets by modulation of chromatin structure...
  10. Mohd Sarip A, van der Knaap J, Wyman C, Kanaar R, Schedl P, Verrijzer C. Architecture of a polycomb nucleoprotein complex. Mol Cell. 2006;24:91-100 pubmed
    b>Polycomb group (PcG) epigenetic silencing proteins act through cis-acting DNA sequences, named Polycomb response elements (PREs)...
  11. Bienz M, Muller J. Transcriptional silencing of homeotic genes in Drosophila. Bioessays. 1995;17:775-84 pubmed
    ..We propose that this complex consists of specific non-histone proteins, the so-called Polycomb group proteins, and that it is anchored at SIL-M elements and at the promoter.
  12. Wang L, Brown J, Cao R, Zhang Y, Kassis J, Jones R. Hierarchical recruitment of polycomb group silencing complexes. Mol Cell. 2004;14:637-46 pubmed
    b>Polycomb group (PcG) proteins maintain the transcriptional silence of target genes through many cycles of cell division...
  13. Casares F, Bender W, Merriam J, Sánchez Herrero E. Interactions of Drosophila Ultrabithorax regulatory regions with native and foreign promoters. Genetics. 1997;145:123-37 pubmed
    ..The deletion derivatives also stimulate transvection, a pairing-dependent interaction with the Ubx promoter on the homologous chromosome. ..
  14. Martinez A, Colomb S, Déjardin J, Bantignies F, Cavalli G. Polycomb group-dependent Cyclin A repression in Drosophila. Genes Dev. 2006;20:501-13 pubmed
    b>Polycomb group (PcG) and trithorax group (trxG) proteins are well known for their role in the maintenance of silent and active expression states of homeotic genes...
  15. Min J, Zhang Y, Xu R. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev. 2003;17:1823-8 pubmed
    The chromodomain of Drosophila Polycomb protein is essential for maintaining the silencing state of homeotic genes during development...
  16. Bloyer S, Cavalli G, Brock H, Dura J. Identification and characterization of polyhomeotic PREs and TREs. Dev Biol. 2003;261:426-42 pubmed
    The polyhomeotic (ph) gene is a member of the Polycomb group of genes (Pc-G), which are required for the maintenance of the spatial expression pattern of homeotic genes...
  17. Perrini B, Piacentini L, Fanti L, Altieri F, Chichiarelli S, Berloco M, et al. HP1 controls telomere capping, telomere elongation, and telomere silencing by two different mechanisms in Drosophila. Mol Cell. 2004;15:467-76 pubmed
    ..Here, we tested this model, and we found that the capping function of HP1 is due to its direct binding to telomeric DNA, while the silencing of telomeric sequences and telomere elongation is due to its interaction with H3-MeK9. ..
  18. Rastelli L, Chan C, Pirrotta V. Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function. EMBO J. 1993;12:1513-22 pubmed
    b>Polycomb group genes are necessary for maintaining homeotic genes repressed in appropriate parts of the body plan. Some of these genes, e.g. Psc, Su(z)2 and E(z), are also modifiers of the zeste-white interaction...
  19. Bantignies F, Goodman R, Smolik S. Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers. Mol Cell Biol. 2000;20:9317-30 pubmed
    ..Our results thus implicate a second class of chromatin-associated proteins in mediating dCBP function and imply that dCBP might be involved in the regulation of higher-order chromatin structure. ..
  20. Zhimulev I, Belyaeva E, Makunin I, Pirrotta V, Volkova E, Alekseyenko A, et al. Influence of the SuUR gene on intercalary heterochromatin in Drosophila melanogaster polytene chromosomes. Chromosoma. 2003;111:377-98 pubmed
    ..In the 4xSuUR(+) strain, 60% of the weak points coincide with the localization of Polycomb group (PcG) proteins...
  21. Chen X, Hiller M, Sancak Y, Fuller M. Tissue-specific TAFs counteract Polycomb to turn on terminal differentiation. Science. 2005;310:869-72 pubmed
    b>Polycomb transcriptional silencing machinery is implicated in the maintenance of precursor fates, but how this repression is reversed to allow cell differentiation is unknown...
  22. Muller J, Gaunt S, Lawrence P. Function of the Polycomb protein is conserved in mice and flies. Development. 1995;121:2847-52 pubmed
    ..In Drosophila, in those groups of cells where particular selector genes must remain inactive, it is the Polycomb-Group of genes that keep them silenced...
  23. Lonie A, D ANDREA R, Paro R, Saint R. Molecular characterisation of the Polycomblike gene of Drosophila melanogaster, a trans-acting negative regulator of homeotic gene expression. Development. 1994;120:2629-36 pubmed
    The Polycomblike gene of Drosophila melanogaster, a member of the Polycomb Group of genes, is required for the correct spatial expression of the homeotic genes of the Antennapaedia and Bithorax Complexes...
  24. Maeda R, Karch F. The ABC of the BX-C: the bithorax complex explained. Development. 2006;133:1413-22 pubmed
    ..This primer attempts to distill and explain our current knowledge about this classic, complex locus. ..
  25. Yamamoto Y, Girard F, Bello B, Affolter M, Gehring W. The cramped gene of Drosophila is a member of the Polycomb-group, and interacts with mus209, the gene encoding Proliferating Cell Nuclear Antigen. Development. 1997;124:3385-94 pubmed
    ..characterized the cramped (crm) gene of Drosophila melanogaster, and show that it can be classified as a Polycomb-group (Pc-G) gene...
  26. Srinivasan S, Dorighi K, Tamkun J. Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase II. PLoS Genet. 2008;4:e1000217 pubmed publisher
    b>Polycomb and trithorax group proteins regulate cellular pluripotency and differentiation by maintaining hereditable states of transcription...
  27. Strübbe G, Popp C, Schmidt A, Pauli A, Ringrose L, Beisel C, et al. Polycomb purification by in vivo biotinylation tagging reveals cohesin and Trithorax group proteins as interaction partners. Proc Natl Acad Sci U S A. 2011;108:5572-7 pubmed publisher
    ..Such a cellular memory function is conveyed by the complex interplay of the Polycomb and Trithorax groups of proteins (PcG/TrxG)...
  28. Hannah Alava A. Developmental Genetics of the Posterior Legs in Drosophila Melanogaster. Genetics. 1958;43:878-905 pubmed
  29. Hauenschild A, Ringrose L, Altmutter C, Paro R, Rehmsmeier M. Evolutionary plasticity of polycomb/trithorax response elements in Drosophila species. PLoS Biol. 2008;6:e261 pubmed publisher
    ..Among these elements are enhancers, which establish gene expression states, and Polycomb/Trithorax response elements (PREs), which take over from enhancers and maintain transcription states of several ..
  30. Lo S, Ahuja N, Francis N. Polycomb group protein Suppressor 2 of zeste is a functional homolog of Posterior Sex Combs. Mol Cell Biol. 2009;29:515-25 pubmed publisher
    The Drosophila melanogaster Polycomb group protein Posterior Sex Combs is a component of Polycomb repressive complex 1 and is central to Polycomb group-mediated silencing...
  31. Duncan I. Polycomblike: a gene that appears to be required for the normal expression of the bithorax and antennapedia gene complexes of Drosophila melanogaster. Genetics. 1982;102:49-70 pubmed
    ..Since the wild-type allele of another gene, called Polycomb (Pc), has previously been shown to have many of the same properties as Pcl+, it appears that the BX-C and perhaps ..
  32. Gellon G, McGinnis W. Shaping animal body plans in development and evolution by modulation of Hox expression patterns. Bioessays. 1998;20:116-25 pubmed
    ..for maintenance of Hox expression pattern seem more conserved among different phyla, and rely on the action of Pc and trx group genes as well as auto- and cross-regulation among Hox genes...
  33. Fanti L, Perrini B, Piacentini L, Berloco M, Marchetti E, Palumbo G, et al. The trithorax group and Pc group proteins are differentially involved in heterochromatin formation in Drosophila. Chromosoma. 2008;117:25-39 pubmed
    In Drosophila, the Polycomb group and trithorax group proteins play a critical role in controlling the expression states of homeotic gene complexes during development...
  34. Franke A, Messmer S, Paro R. Mapping functional domains of the polycomb protein of Drosophila melanogaster. Chromosome Res. 1995;3:351-60 pubmed
    In Drosophila the Polycomb group (Pc-G) proteins are responsible for the stable and heritable silencing of genes...
  35. Poux S, Kostic C, Pirrotta V. Hunchback-independent silencing of late Ubx enhancers by a Polycomb Group Response Element. EMBO J. 1996;15:4713-22 pubmed
    ..are kept silent outside of their appropriate expression domains by a repressive chromatin complex formed by the Polycomb Group proteins...
  36. Shao Z, Raible F, Mollaaghababa R, Guyon J, Wu C, Bender W, et al. Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell. 1999;98:37-46 pubmed
    The Polycomb group (PcG) genes are required for maintenance of homeotic gene repression during development. Mutations in these genes can be suppressed by mutations in genes of the SWI/SNF family...
  37. Swaminathan J, Baxter E, Corces V. The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin. Genes Dev. 2005;19:65-76 pubmed
    ..His2Av behaves genetically as a PcG gene and mutations in His2Av suppress position effect variegation (PEV), suggesting that this histone variant is ..
  38. Klymenko T, Papp B, Fischle W, Kocher T, Schelder M, Fritsch C, et al. A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities. Genes Dev. 2006;20:1110-22 pubmed
    b>Polycomb response elements (PREs) are specific cis-regulatory sequences needed for transcriptional repression of HOX and other target genes by Polycomb group (PcG) proteins...
  39. Petruk S, Smith S, Sedkov Y, Mazo A. Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity. Development. 2008;135:2383-90 pubmed publisher
    b>Polycomb group (PcG) and trithorax group (trxG) proteins act in an epigenetic fashion to maintain active and repressive states of expression of the Hox and other target genes by altering their chromatin structure...
  40. Li H, Muller M, Bahechar I, Kyrchanova O, Ohno K, Georgiev P, et al. Insulators, not Polycomb response elements, are required for long-range interactions between Polycomb targets in Drosophila melanogaster. Mol Cell Biol. 2011;31:616-25 pubmed publisher
    The genomic binding sites of Polycomb group (PcG) complexes have been found to cluster, forming Polycomb "bodies" or foci in mammalian or fly nuclei...
  41. Schaaf C, Misulovin Z, Gause M, Koenig A, Gohara D, Watson A, et al. Cohesin and polycomb proteins functionally interact to control transcription at silenced and active genes. PLoS Genet. 2013;9:e1003560 pubmed publisher
    ..assays in Drosophila developing wings and cultured cells, we find that cohesin functionally interacts with Polycomb group (PcG) silencing proteins at both silenced and active genes...
  42. Schuettengruber B, Cavalli G. Polycomb domain formation depends on short and long distance regulatory cues. PLoS ONE. 2013;8:e56531 pubmed publisher
    b>Polycomb group (PcG) proteins dynamically define cellular identities through the epigenetic repression of key developmental genes...
  43. Busturia A, Morata G. Ectopic expression of homeotic genes caused by the elimination of the Polycomb gene in Drosophila imaginal epidermis. Development. 1988;104:713-20 pubmed
    ..We find that many of these genes become indiscriminately active in the adult epidermis when the Pc gene is eliminated...
  44. Cao R, Wang L, Wang H, Xia L, Erdjument Bromage H, Tempst P, et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science. 2002;298:1039-43 pubmed
    b>Polycomb group (PcG) proteins play important roles in maintaining the silent state of HOX genes. Recent studies have implicated histone methylation in long-term gene silencing...
  45. Ficz G, Heintzmann R, Arndt Jovin D. Polycomb group protein complexes exchange rapidly in living Drosophila. Development. 2005;132:3963-76 pubmed
    Fluorescence recovery after photobleaching (FRAP) microscopy was used to determine the kinetic properties of Polycomb group (PcG) proteins in whole living Drosophila organisms (embryos) and tissues (wing imaginal discs and salivary glands)..
  46. Bejarano F, González I, Vidal M, Busturia A. The Drosophila RYBP gene functions as a Polycomb-dependent transcriptional repressor. Mech Dev. 2005;122:1118-29 pubmed
    The Polycomb and trithorax groups of genes control the maintenance of homeotic gene expression in a variety of organisms. A putative participant in the regulation of this process is the murine RYBP (Ring and YY1 Binding Protein) gene...
  47. Schwartz Y, Kahn T, Nix D, Li X, Bourgon R, Biggin M, et al. Genome-wide analysis of Polycomb targets in Drosophila melanogaster. Nat Genet. 2006;38:700-5 pubmed
    b>Polycomb group (PcG) complexes are multiprotein assemblages that bind to chromatin and establish chromatin states leading to epigenetic silencing...
  48. Gambetta M, Oktaba K, Muller J. Essential role of the glycosyltransferase sxc/Ogt in polycomb repression. Science. 2009;325:93-6 pubmed publisher
    b>Polycomb group proteins are conserved transcriptional repressors that control animal and plant development...
  49. Herz H, Madden L, Chen Z, Bolduc C, Buff E, Gupta R, et al. The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila. Mol Cell Biol. 2010;30:2485-97 pubmed publisher
    ..In summary, these data suggest that dUTX is a suppressor of Notch- and Rbf-dependent tumors in Drosophila melanogaster and may provide a model for UTX-dependent tumorigenesis in humans. ..
  50. Paro R, Hogness D. The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila. Proc Natl Acad Sci U S A. 1991;88:263-7 pubmed
    The Polycomb (Pc) gene of Drosophila melanogaster is a member of a large class of genes (Pc group) required for the segment-specific repression of homeotic selector genes...
  51. Gerasimova T, Corces V. Chromatin insulators and boundaries: effects on transcription and nuclear organization. Annu Rev Genet. 2001;35:193-208 pubmed
    ..Insulators might modulate transcription by organizing the chromatin fiber within the nucleus through the establishment of higher-order domains of chromatin structure. ..
  52. Blastyak A, Mishra R, Karch F, Gyurkovics H. Efficient and specific targeting of Polycomb group proteins requires cooperative interaction between Grainyhead and Pleiohomeotic. Mol Cell Biol. 2006;26:1434-44 pubmed
    Specific targeting of the protein complexes formed by the Polycomb group of proteins is critically required to maintain the inactive state of a group of developmentally regulated genes...
  53. Sing A, Pannell D, Karaiskakis A, Sturgeon K, Djabali M, Ellis J, et al. A vertebrate Polycomb response element governs segmentation of the posterior hindbrain. Cell. 2009;138:885-97 pubmed publisher
    Chromatin remodeling by Polycomb group (PcG) and trithorax group (trxG) proteins regulates gene expression in all metazoans...
  54. Tamkun J. The role of brahma and related proteins in transcription and development. Curr Opin Genet Dev. 1995;5:473-7 pubmed
    The differential transcription of Drosophila homeotic genes is maintained by the Polycomb and trithorax groups of regulatory proteins, many of which are thought to modulate chromatin structure...
  55. Park S, Schwartz Y, Kahn T, Asker D, Pirrotta V. Regulation of Polycomb group genes Psc and Su(z)2 in Drosophila melanogaster. Mech Dev. 2012;128:536-47 pubmed publisher
    Certain Polycomb group (PcG) genes are themselves targets of PcG complexes...
  56. Schlossherr J, Eggert H, Paro R, Cremer S, Jack R. Gene inactivation in Drosophila mediated by the Polycomb gene product or by position-effect variegation does not involve major changes in the accessibility of the chromatin fibre. Mol Gen Genet. 1994;243:453-62 pubmed
    In Drosophila position effect variegation and Polycomb-dependent regulation of homeotic gene expression are phenomena in which genes are inactivated in a clonally inherited manner...
  57. Mishra R, Mihaly J, Barges S, Spierer A, Karch F, Hagstrom K, et al. The iab-7 polycomb response element maps to a nucleosome-free region of chromatin and requires both GAGA and pleiohomeotic for silencing activity. Mol Cell Biol. 2001;21:1311-8 pubmed
    In the work reported here we have undertaken a functional dissection of a Polycomb response element (PRE) from the iab-7 cis-regulatory domain of the Drosophila melanogaster bithorax complex (BX-C)...
  58. González I, Busturia A. High levels of dRYBP induce apoptosis in Drosophila imaginal cells through the activation of reaper and the requirement of trithorax, dredd and dFADD. Cell Res. 2009;19:747-57 pubmed publisher
    Drosophila RYBP (dRYBP; Ring1 and YY1 Binding Protein) is a Polycomb and trithorax interacting protein, whose homologous RYBP/DEDAF mammalian counterparts exhibit tumor cell-specific killing activity...
  59. Shearn A. The ash-1, ash-2 and trithorax genes of Drosophila melanogaster are functionally related. Genetics. 1989;121:517-25 pubmed
    ..The third test was to examine the interaction with a mutation of the Polycomb gene...
  60. Martin E, Adler P. The Polycomb group gene Posterior Sex Combs encodes a chromosomal protein. Development. 1993;117:641-55 pubmed
    The Posterior Sex Combs (Psc) gene of Drosophila has been studied at the molecular level both because it is a Polycomb group (Pc-G) gene and hence required for the maintenance of segmental determination, and because it is the Drosophila ..
  61. Papp B, Muller J. Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins. Genes Dev. 2006;20:2041-54 pubmed
    b>Polycomb group (PcG) and trithorax group (trxG) proteins act as antagonistic regulators to maintain transcriptional OFF and ON states of HOX and other target genes...
  62. Mulholland N, King I, Kingston R. Regulation of Polycomb group complexes by the sequence-specific DNA binding proteins Zeste and GAGA. Genes Dev. 2003;17:2741-6 pubmed
    Repression and activation of the expression of homeotic genes are maintained by proteins encoded by the Polycomb group (PcG) and trithorax group (trxG) genes...
  63. Furuyama T, Banerjee R, Breen T, Harte P. SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex. Curr Biol. 2004;14:1812-21 pubmed
    ..Evidence is presented that Drosophila SIR2 is also involved in epigenetic silencing by the Polycomb group proteins...
  64. Di Croce L, Helin K. Transcriptional regulation by Polycomb group proteins. Nat Struct Mol Biol. 2013;20:1147-55 pubmed publisher
    b>Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles in stem-cell identity, differentiation and disease...
  65. Pirrotta V, Rastelli L. White gene expression, repressive chromatin domains and homeotic gene regulation in Drosophila. Bioessays. 1994;16:549-56 pubmed
    ..Another type of repressive domain is established, beginning at specific sequences, by complexes of Polycomb Group proteins...
  66. Orlando V, Jane E, Chinwalla V, Harte P, Paro R. Binding of trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis. EMBO J. 1998;17:5141-50 pubmed
    ..The Polycomb group (PcG) and trithorax group (trxG) genes encode proteins involved in chromatin remodelling...
  67. Lagarou A, Mohd Sarip A, Moshkin Y, Chalkley G, Bezstarosti K, Demmers J, et al. dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing. Genes Dev. 2008;22:2799-810 pubmed publisher
    ..This pathway was uncovered through the identification of dRING-associated factors (dRAF), a novel Polycomb group (PcG) silencing complex harboring the histone H2A ubiquitin ligase dRING, PSC and the F-box protein, and ..
  68. Riddle N, Minoda A, Kharchenko P, Alekseyenko A, Schwartz Y, Tolstorukov M, et al. Plasticity in patterns of histone modifications and chromosomal proteins in Drosophila heterochromatin. Genome Res. 2011;21:147-63 pubmed publisher
    ..This comprehensive analysis provides a foundation for future studies of gene activity and chromosomal functions that are influenced by or dependent upon heterochromatin...
  69. Touma J, Weckerle F, Cleary M. Drosophila Polycomb complexes restrict neuroblast competence to generate motoneurons. Development. 2012;139:657-66 pubmed publisher
    ..We have found that Polycomb repressor complexes (PRCs) are necessary and sufficient to restrict competence in NB7-1...
  70. Pirrotta V. Chromatin complexes regulating gene expression in Drosophila. Curr Opin Genet Dev. 1995;5:466-72 pubmed
    b>Polycomb-group proteins form chromatin complexes at target genes such as Ubx, providing a cellular memory of gene activity in early development and determining the later activity of the gene...
  71. Dietzel S, Niemann H, Bruckner B, Maurange C, Paro R. The nuclear distribution of Polycomb during Drosophila melanogaster development shown with a GFP fusion protein. Chromosoma. 1999;108:83-94 pubmed
    The chromatin protein Polycomb (PC) is necessary for keeping homeotic genes repressed in a permanent and heritable manner...
  72. Salvaing J, Lopez A, Boivin A, Deutsch J, Peronnet F. The Drosophila Corto protein interacts with Polycomb-group proteins and the GAGA factor. Nucleic Acids Res. 2003;31:2873-82 pubmed
    In Drosophila, PcG complexes provide heritable transcriptional silencing of target genes...
  73. Tariq M, Nussbaumer U, Chen Y, Beisel C, Paro R. Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression. Proc Natl Acad Sci U S A. 2009;106:1157-62 pubmed publisher
    ..Trx is a member of the TrxG chromatin proteins controlling, together with the members of the Polycomb group, the developmental fate of cells by modulating epigenetic signals...
  74. Huen D, Russell S. On the use of resampling tests for evaluating statistical significance of binding-site co-occurrence. BMC Bioinformatics. 2010;11:359 pubmed publisher
    ..have developed a new, pragmatically-devised hybrid approach that, when applied to the experimental results of an Polycomb/Trithorax study, yielded p-values consistent with the findings of that study...
  75. Follmer N, Wani A, Francis N. A polycomb group protein is retained at specific sites on chromatin in mitosis. PLoS Genet. 2012;8:e1003135 pubmed publisher
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