Gene Symbol: p120ctn
Description: Adherens junction protein p120
Alias: CG17484, Dmel\CG17484, Dp120[ctn], Dp120ctn, P120, P120-catenin, P120ctn, dP120ctn, dp120ctn, p120, p120[ctn], adherens junction protein p120, Adherens-junction-protein-p120, CG17484-PA, P120-Catenin, p120 catenin, p120catenin, p120ctn-PA
Species: fruit fly
Products:     p120ctn

Top Publications

  1. Magie C, Pinto Santini D, Parkhurst S. Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila. Development. 2002;129:3771-82 pubmed
    ..Here we show interactions between Drosophila Rho1 and the adherens junction components alpha-catenin and p120(ctn)...
  2. Myster S, Cavallo R, Anderson C, Fox D, Peifer M. Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. J Cell Biol. 2003;160:433-49 pubmed
    ..This region is the binding site for p120, leading to the hypothesis that p120 is a key regulator of cell adhesion...
  3. Pacquelet A, Lin L, Rorth P. Binding site for p120/delta-catenin is not required for Drosophila E-cadherin function in vivo. J Cell Biol. 2003;160:313-9 pubmed
    ..in vivo, using mutant variants of Drosophila epithelial cadherin (DE-cadherin) that are selectively defective in p120ctn (DE-cadherin-AAA) or beta-catenin-armadillo (DE-cadherin-Delta beta) interactions...
  4. Tepass U. Genetic analysis of cadherin function in animal morphogenesis. Curr Opin Cell Biol. 1999;11:540-8 pubmed
    ..Fat-like cadherins are required for epithelial morphogenesis, proliferation control, and epithelial planar polarization. ..
  5. Kowalczyk A, Moses K. Photoreceptor cells in flies and mammals: Crumby homology?. Dev Cell. 2002;2:253-4 pubmed
    ..This supports the previous observation that disruption of CRB1 function can cause retinal degeneration in humans. ..
  6. Martin P, Wood W. Epithelial fusions in the embryo. Curr Opin Cell Biol. 2002;14:569-74 pubmed
    ..It is now clear that there are intriguing parallels with more complex morphogenetic tissue movements in vertebrates. ..
  7. Lee M, Lee S, Zadeh A, Kolodziej P. Distinct sites in E-cadherin regulate different steps in Drosophila tracheal tube fusion. Development. 2003;130:5989-99 pubmed
  8. Pacquelet A, Rørth P. Regulatory mechanisms required for DE-cadherin function in cell migration and other types of adhesion. J Cell Biol. 2005;170:803-12 pubmed
    ..The nature of this additional function is discussed. ..
  9. Hunter M, Lee D, Harris T, Fernandez Gonzalez R. Polarized E-cadherin endocytosis directs actomyosin remodeling during embryonic wound repair. J Cell Biol. 2015;210:801-16 pubmed publisher
    ..Our results demonstrate a central role for endocytosis in wound healing and indicate that polarized E-cadherin endocytosis is necessary for actomyosin remodeling during embryonic wound repair. ..

More Information


  1. Förster D, Luschnig S. Src42A-dependent polarized cell shape changes mediate epithelial tube elongation in Drosophila. Nat Cell Biol. 2012;14:526-34 pubmed publisher
    ..Whereas exocytosis-dependent membrane growth drives circumferential tube expansion, Src42A is required to orient membrane growth in the axial dimension of the tube. ..
  2. Oda H, Takeichi M. Evolution: structural and functional diversity of cadherin at the adherens junction. J Cell Biol. 2011;193:1137-46 pubmed publisher
    ..An evolutionary reconstruction of cadherin structure and function provides a comprehensive framework with which to appreciate the diversity of morphogenetic mechanisms in animals. ..
  3. Coulthard A, Alm C, Cealiac I, Sinclair D, Honda B, Rossi F, et al. Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. Genetics. 2010;185:479-95 pubmed publisher
  4. Vidal M, Salavaggione L, Ylagan L, Wilkins M, Watson M, Weilbaecher K, et al. A role for the epithelial microenvironment at tumor boundaries: evidence from Drosophila and human squamous cell carcinomas. Am J Pathol. 2010;176:3007-14 pubmed publisher
    ..The result was a consistent change in 'border cells' at the edge of transformed patches including delocalized p120-catenin and E-cadherin as well as invasive migration through the basal lamina...
  5. Sch fer G, Narasimha M, Vogelsang E, Leptin M. Cadherin switching during the formation and differentiation of the Drosophila mesoderm - implications for epithelial-to-mesenchymal transitions. J Cell Sci. 2014;127:1511-22 pubmed publisher
    ..These results suggest that the downregulation of E-cadherin in the mesoderm might be required to facilitate optimal levels of Wingless signalling...
  6. Grice S, Liu J, Webber C. Synergistic interactions between Drosophila orthologues of genes spanned by de novo human CNVs support multiple-hit models of autism. PLoS Genet. 2015;11:e1004998 pubmed publisher
    ..Our study illustrates mechanisms through which synergistic effects resulting from large structural variation can contribute to human disease. ..
  7. Shimada Y, Yonemura S, Ohkura H, Strutt D, Uemura T. Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium. Dev Cell. 2006;10:209-22 pubmed
    ..Furthermore, there appeared to be a bias in the P-D MTs, with slightly more plus ends oriented distally. The hypothesis of polarized vesicular trafficking of Fz is discussed. ..
  8. Tikhmyanova N, Tulin A, Roegiers F, Golemis E. Dcas supports cell polarization and cell-cell adhesion complexes in development. PLoS ONE. 2010;5:e12369 pubmed publisher
    ..modified the embryonal lethal phenotypes of embryos with mutations in E-cadherin (Shg) or its signaling partners p120- and beta-catenin (Arm)...
  9. Fox D, Homem C, Myster S, Wang F, Bain E, Peifer M. Rho1 regulates Drosophila adherens junctions independently of p120ctn. Development. 2005;132:4819-31 pubmed
    ..Previous studies linked both p120catenin and the small GTPase Rho to AJ regulation and revealed that p120 may negatively regulate Rho...
  10. Bulgakova N, Brown N. Drosophila p120-catenin is crucial for endocytosis of the dynamic E-cadherin-Bazooka complex. J Cell Sci. 2016;129:477-82 pubmed publisher
    ..the direct binding of two catenins: β-catenin and p120-catenin (also known as CTNND1 in vertebrates, and p120ctn in Drosophila)...
  11. Toret C, D Ambrosio M, Vale R, Simon M, Nelson W. A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell-cell adhesion. J Cell Biol. 2014;204:265-79 pubmed publisher
    ..These experiments reveal roles for a diversity of cellular pathways that are required for cadherin function in Metazoa, including cytoskeleton organization, cell-substrate interactions, and nuclear and cytoplasmic signaling. ..
  12. Fernandez B, Jezowska B, Janody F. Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene. Oncogene. 2014;33:2027-39 pubmed publisher
    ..overexpressing Src64B drives JNK-independent loss of epithelial integrity and JNK-dependent apoptosis via Btk29A, p120ctn and Rho1...
  13. Larson D, Liberman Z, Cagan R. Cellular behavior in the developing Drosophila pupal retina. Mech Dev. 2008;125:223-32 pubmed publisher
    ..Finally, we establish a role for the adherens junction regulator P120-Catenin in retinal patterning through its regulation of normal adherens junction integrity...
  14. Tepass U, Harris K. Adherens junctions in Drosophila retinal morphogenesis. Trends Cell Biol. 2007;17:26-35 pubmed
    ..Adherens junctions are involved in the organization of simple cellular patterns, and more complex cell shape changes and cell movements that depend on the dynamic modulation of adherens junctions. ..
  15. Vidal M, Larson D, Cagan R. Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis. Dev Cell. 2006;10:33-44 pubmed
    ..These latter phenotypes required sharp differences in dCsk activity between neighbors; dE-cadherin, P120-catenin, Rho1, JNK, and MMP2 mediated this signal...
  16. Li W, Li Y, Gao F. Abelson, enabled, and p120 catenin exert distinct effects on dendritic morphogenesis in Drosophila. Dev Dyn. 2005;234:512-22 pubmed
    ..In contrast, p120 catenin (p120 ctn) primarily enhances the development of spine-like protrusions...