p

Summary

Gene Symbol: p
Description: pink
Alias: CG9770, Dmel\CG9770, dHPS5, snb, CG9770-PA, drosophila Hermansky-Pudlak syndrome 5 subunit, p-PA, pink-peach, sunburst
Species: fruit fly

Top Publications

  1. ncbi Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery
    V Lloyd
    Dept of Biology and Biochemistry, Mt Allison University, Sackville, NB, Canada
    Trends Cell Biol 8:257-9. 1998
  2. ncbi The pink gene encodes the Drosophila orthologue of the human Hermansky-Pudlak syndrome 5 (HPS5) gene
    Monika Syrzycka
    Simon Fraser University, Department of Molecular Biology and Biochemistry, 8888 University Drive, Burnaby, BC V5A 1S6, Canada
    Genome 50:548-56. 2007
  3. ncbi The Drosophila pigmentation gene pink (p) encodes a homologue of human Hermansky-Pudlak syndrome 5 (HPS5)
    Juan M Falcon-Perez
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Traffic 8:154-68. 2007
  4. pmc Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing
    Dinari A Harris
    Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA
    J Cell Biol 194:77-87. 2011
  5. ncbi Eye color as an indicator of behavior: revisiting Worthy and Scott
    Vicky L Elias
    Department of Sociology, Oklahoma State University, USA
    Psychol Rep 102:759-78. 2008
  6. ncbi Isolation of 88F actin mutants of Drosophila melanogaster and possible alterations in the mutant actin structures
    H S An
    Department of Physics, Graduate School of Science, University of Tokyo, Japan
    J Mol Biol 260:492-505. 1996
  7. ncbi Characterization of sepiapterin reductase activity from Drosophila melanogaster
    P Ruiz-Vázquez
    Departamento de Genetica, Universitat de Valencia, Spain
    Comp Biochem Physiol B Biochem Mol Biol 113:131-6. 1996
  8. pmc A sex-influenced modifier in Drosophila that affects a broad spectrum of target loci including the histone repeats
    U Bhadra
    Division of Biological Sciences, University of Missouri Columbia 65211, USA
    Genetics 146:903-17. 1997
  9. pmc The homeobox gene cut interacts genetically with the homeotic genes proboscipedia and Antennapedia
    L A Johnston
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Genetics 149:131-42. 1998
  10. ncbi Genetic analysis of oxygen defense mechanisms in Drosophila melanogaster and identification of a novel behavioural mutant with a Shaker phenotype
    J M Humphreys
    Department of Molecular Biology and Genetics, University of Guelph, ON, Canada
    Genome 39:749-57. 1996

Scientific Experts

  • Lev Y Yampolsky
  • Sara Cherry
  • Richard Spritz
  • V Lloyd
  • Dinari A Harris
  • Vicky L Elias
  • Juan M Falcon-Perez
  • Monika Syrzycka
  • Peter J Neuburger
  • L P Wu
  • Kevin Kim
  • Kenji Nakahara
  • Constanza Vásquez-Doorman
  • Richard W Carthew
  • Charles I Abramson
  • Cindy L Nicolas
  • Elizabeth S Brooks
  • Lori A McEachern
  • Kathleen Fitzpatrick
  • Rafael Romero-Calderon
  • Barry M Honda
  • David E Krantz
  • ESTEBAN C DELL'ANGELICA
  • John M Rawls
  • Donald A R Sinclair
  • Kristel Prabhu
  • Jennifer Kinneard
  • Sandra Schulze
  • Kerrie Ann Smyth
  • Jue Zeng
  • John M Belote
  • Kenneth J Saville
  • L A Johnston
  • U Bhadra
  • H S An
  • P Ruiz-Vázquez
  • J M Humphreys
  • K V Anderson
  • Y Lu
  • J A Birchler
  • K M Choe
  • F J Silva
  • K Blochlinger
  • B D Ostrow
  • C Jasoni
  • J C Hiebert
  • M Pal-Bhadra
  • J Ferre
  • K Mogami
  • M L Joiner
  • B Duyf
  • J P Phillips
  • R Falk
  • A J Hilliker
  • E A Leonhardt
  • T C Kaufman
  • K J Kemphues
  • J E Rinehart
  • S Schwartz
  • J B Boyd
  • M T Fuller
  • D S Henderson
  • E C Raff
  • T S Hays
  • I W Duncan
  • R Lehmann
  • B B Wallis
  • J J Holden
  • W K Jones
  • R Tearle
  • M L Aparisi
  • M Bender
  • M L Alexander
  • E Ordoño
  • C Najera
  • B Robertson
  • A S Fox
  • J H Caulton
  • J M Rawls
  • R Deuring
  • F R Turner
  • R A Raff
  • D T Suzuki
  • J A Hutchens
  • C Nusslein-Volhard
  • M Prout
  • B Escriche

Detail Information

Publications33

  1. ncbi Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery
    V Lloyd
    Dept of Biology and Biochemistry, Mt Allison University, Sackville, NB, Canada
    Trends Cell Biol 8:257-9. 1998
    ..Thus, classical work describing more than 85 eye-colour mutations and their genetic interactions offers a remarkable, untapped resource for the genetic analysis of protein delivery to lysosomes...
  2. ncbi The pink gene encodes the Drosophila orthologue of the human Hermansky-Pudlak syndrome 5 (HPS5) gene
    Monika Syrzycka
    Simon Fraser University, Department of Molecular Biology and Biochemistry, 8888 University Drive, Burnaby, BC V5A 1S6, Canada
    Genome 50:548-56. 2007
    ..An examination of the chromosomal positioning of Drosophila HPS gene orthologues suggested that CG9770, the Drosophila HPS5 orthologue, might correspond to the pink locus...
  3. ncbi The Drosophila pigmentation gene pink (p) encodes a homologue of human Hermansky-Pudlak syndrome 5 (HPS5)
    Juan M Falcon-Perez
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Traffic 8:154-68. 2007
    ..the gene encoding the Drosophila ortholog of the HPS5 subunit of BLOC-2 is identical to the granule group gene pink (p), which was first studied in 1910 but had not been identified at the molecular level...
  4. pmc Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing
    Dinari A Harris
    Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA
    J Cell Biol 194:77-87. 2011
    ..Negative regulation is also not linked to sorting into all LROs but only a specific class of pigment LRO. Thus, regulation of siRNA activity is tied to sorting of specific types of cargo to particular LROs...
  5. ncbi Eye color as an indicator of behavior: revisiting Worthy and Scott
    Vicky L Elias
    Department of Sociology, Oklahoma State University, USA
    Psychol Rep 102:759-78. 2008
    ..melanogaster pointed to significant behavioral differences among cell-defect groups, indicating that the cell defect which causes eye color, rather than eye color itself, may serve as a crude indicator of behavior...
  6. ncbi Isolation of 88F actin mutants of Drosophila melanogaster and possible alterations in the mutant actin structures
    H S An
    Department of Physics, Graduate School of Science, University of Tokyo, Japan
    J Mol Biol 260:492-505. 1996
    ..On the basis of these phenotypes and the known atomic structure of actin, possible alterations in the structure of actin brought about by these mutations are discussed...
  7. ncbi Characterization of sepiapterin reductase activity from Drosophila melanogaster
    P Ruiz-Vázquez
    Departamento de Genetica, Universitat de Valencia, Spain
    Comp Biochem Physiol B Biochem Mol Biol 113:131-6. 1996
    ..0. A study of the activity in different eye-color mutant strains revealed significantly decreased levels in clot, red Malpighian tubules and garnet...
  8. pmc A sex-influenced modifier in Drosophila that affects a broad spectrum of target loci including the histone repeats
    U Bhadra
    Division of Biological Sciences, University of Missouri Columbia 65211, USA
    Genetics 146:903-17. 1997
    ..Thus, Low is a modifier that plays a role in modulating the expression of genes governing various processes including pigment deposition, eye development, chromosomal proteins and position effect variegation...
  9. pmc The homeobox gene cut interacts genetically with the homeotic genes proboscipedia and Antennapedia
    L A Johnston
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Genetics 149:131-42. 1998
    ..Our results implicate ct in the regulation of expression and/or function of two homeotic genes and document a new role of ct in the control of segmental identity...
  10. ncbi Genetic analysis of oxygen defense mechanisms in Drosophila melanogaster and identification of a novel behavioural mutant with a Shaker phenotype
    J M Humphreys
    Department of Molecular Biology and Genetics, University of Guelph, ON, Canada
    Genome 39:749-57. 1996
    ..Two mutants were identified as being new alleles of the previously identified doublesex (dsx) and pink (p) genes...
  11. ncbi Multi-organellar disorders of pigmentation: intracellular traffic jams in mammals, flies and yeast
    R A Spritz
    Human Medical Genetics Program, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, B161, Denver, CO 80262, USA
    Trends Genet 15:337-40. 1999
    ..Recent discoveries show that several of these mutations directly affect components in the pathway of organelle-specific protein trafficking, and provide new insights into the relationships of these pathways in mammals, flies and yeast...
  12. ncbi Enhancer of garnet/deltaAP-3 is a cryptic allele of the white gene and identifies the intracellular transport system for the white protein
    Vett K Lloyd
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Genome 45:296-312. 2002
    ..This observation supports a role for these genes in intracellular transport and leads to a model whereby incorrect sorting of the white gene product can explain the pigmentation phenotypes of an entire group of eye-color genes...
  13. ncbi Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis
    Sara Cherry
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Immunol 5:81-7. 2004
    ..Thus, this virus model provides a sensitive and efficient approach for identifying components required for pathogenesis...
  14. pmc Persistence time of loss-of-function mutations at nonessential loci affecting eye color in Drosophila melanogaster
    Lev Y Yampolsky
    Dept of Biological Sciences, East Tennessee State University, Johnson City, TN 37614 1710, USA
    Genetics 171:2133-8. 2005
    ..In both cases, deleterious alleles are apparently eliminated by selection against heterozygous individuals, which show no visible phenotypic differences from wild type...
  15. pmc A genetic suppressor of two dominant temperature-sensitive lethal proteasome mutants of Drosophila melanogaster is itself a mutated proteasome subunit gene
    Peter J Neuburger
    Department of Biology, Syracuse University, Syracuse, New York 13244, USA
    Genetics 173:1377-87. 2006
    ..While Prosbeta2(1) shows a modest increase in the number of defective mitotic figures, there were no defects seen with the other two mutants, other than slightly reduced mitotic indexes...
  16. pmc Characterization of the mus308 gene in Drosophila melanogaster
    E A Leonhardt
    Department of Genetics, University of California, Davis 95616
    Genetics 133:87-96. 1993
    ..In addition, observations of elevated embryo mortality are potentially explained by an aberrant distribution of nuclear material in early embryos which is similar to that seen in the mutant giant nuclei...
  17. pmc MORGAN's hypothesis of the genetic control of development
    R Falk
    Department of Genetics, Hebrew University of Jerusalem, Israel
    Genetics 134:671-4. 1993
  18. pmc Genetic damage at specific gene loci in Drosophila with betatron X-rays
    M L Alexander
    Genetics 81:493-500. 1975
    ..Although the two types of irradiations differ by an ion density of approximately ten, the amount and types of inheritable genetic damage induced by the two radiations in mature sperm were not significantly different...
  19. ncbi Genetic and biochemical characterization of little isoxanthopterin (lix), a gene controlling dihydropterin oxidase activity in Drosophila melanogaster
    F J Silva
    Department de Genetica, Universitat de Valencia, Burjassot, Spain
    Mol Gen Genet 230:97-103. 1991
    ..Isoxanthopterin was quantitated in strains carrying deficiencies for the region in which lix has been mapped by recombination. This allowed us to assign the lix locus to the 7D10-7F1-2 segment of the X chromosome...
  20. ncbi Tissue specific effects of ommochrome pathway mutations in Drosophila melanogaster
    R Tearle
    Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia
    Genet Res 57:257-66. 1991
    ..Two mutations affecting the red eye pigments (drosopterins), bw and mal, do not substantially perturb brown pigment synthesis in any of the four organs...
  21. ncbi Genetic location and biochemical characterization of eye-colour mutants from natural populations of Drosophila melanogaster
    M L Aparisi
    Departamento de Genetica, Facultad de Ciencias Biologicas, Universidad de Valencia, Burjassot, Spain
    Genome 33:203-8. 1990
    ..The eye-colour mutants show large effects on the red and brown pigments. The high variability of the eye-colour loci is discussed in relation to the mutation and selection hypotheses...
  22. pmc Interacting proteins identified by genetic interactions: a missense mutation in alpha-tubulin fails to complement alleles of the testis-specific beta-tubulin gene of Drosophila melanogaster
    T S Hays
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309 0347
    Mol Cell Biol 9:875-84. 1989
    ..Thus, the failure to complement appears to require the presence of the altered alpha-tubulin encoded by the nc33 allele, which may act as a structural poison when incorporated into either the tubulin heterodimer or microtubules...
  23. pmc Genetic and molecular mapping of chromosome region 85A in Drosophila melanogaster
    W K Jones
    T H Morgan School of Biological Sciences, University of Kentucky, Lexington 40506
    Genetics 120:733-42. 1988
    ..The breakpoint sites of a number of 85A chromosome rearrangements were localized on the molecular map, thereby delimiting regions of the DNA that contain the various genetic complementation groups...
  24. ncbi A development genetic analysis of the gene regulator of postbithorax in Drosophila melanogaster
    M Bender
    Dev Biol 119:418-32. 1987
    ..A possible formal relationship between Rg-pbx, ftz, and the postbithorax (pbx) locus is proposed...
  25. pmc Cytogenic analysis of chromosome 3 in Drosophila melanogaster: mapping of the proximal portion of the right arm
    I W Duncan
    Genetics 80:733-52. 1975
    ....
  26. pmc Mutations that encode partially functional beta 2 tubulin subunits have different effects on structurally different microtubule arrays
    M T Fuller
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309 0347
    J Cell Biol 107:141-52. 1988
    ....
  27. ncbi hunchback, a gene required for segmentation of an anterior and posterior region of the Drosophila embryo
    R Lehmann
    Dev Biol 119:402-17. 1987
    ..Heterozygous mutant embryos derived from a homozygous mutant germ line develop normally, indicating that maternal gene expression is not required for normal development...
  28. pmc Temperature-sensitive mutations in Drosophila melanogaster. XII. The genetic and developmental effects of dominant lethals on chromosome 3
    J J Holden
    Genetics 73:445-58. 1973
    ..Only DTS-4 exhibited dominant lethality in triploid females...
  29. ncbi Genetic and developmental relationships between two alkaline phosphatases in Drosophilia melanogaster
    B B Wallis
    Biochem Genet 2:141-58. 1968
  30. pmc Genetic analysis of B2t, the structural gene for a testis-specific beta-tubulin subunit in Drosophila melanogaster
    K J Kemphues
    Genetics 105:345-56. 1983
    ..All four mutant genes encode beta 2-tubulin subunits that are synthesized at normal rates but do not accumulate. All mutants are completely male sterile as homozygotes...
  31. ncbi Mutation in a testis-specific beta-tubulin in Drosophila: analysis of its effects on meiosis and map location of the gene
    K J Kemphues
    Cell 21:445-51. 1980
    ..Chromosomal events unrelated to microtubule function, such as replication and condensation, occur normally. Results obtained during mapping of the B2t locus strongly suggest a haplo-insufficient site at or closely linked to this locus...
  32. pmc Effects of the maleless mutation on X and autosomal gene expression in Drosophila melanogaster
    J C Hiebert
    Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138
    Genetics 136:913-26. 1994
    ..These observations suggest that if mle plays a role in the discrimination of the X and the autosomes, it may do so by modification of the effects of dosage sensitive regulatory genes...
  33. pmc Drosophila immunity: genes on the third chromosome required for the response to bacterial infection
    L P Wu
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    Genetics 159:189-99. 2001
    ..These genetic studies should provide a basis for a comprehensive understanding of the genetic control of immune responses in Drosophila...

Research Grants33

  1. STUDIES OF HUMAN PIGMENTATION DISORDERS
    Richard Spritz; Fiscal Year: 2005
    ....
  2. GENE DISCOVERY FOR CRANIOFACIAL DISORDERS
    Richard Spritz; Fiscal Year: 2006
    ..The most frequent craniofacial birth defects are orofacial clefts: cleft lip +/- cleft palate (CL/P) affects ~1 per 1100 births in the USA, and cleft palate ~1 per 1600 births...
  3. Missing Mutations in Oculocutaneous and Ocular Albinism
    Richard Spritz; Fiscal Year: 2006
    ..Together, these studies should provide a greatly improved understanding of the molecular pathogenesis of oculocutaneous and ocular albinism. ..
  4. MAPPING OF VITILIGO SUSCEPTIBILITY GENES
    Richard Spritz; Fiscal Year: 2007
    ..The long-term significance of this work may be to develop specific approaches to disease therapy and prevention and to apply those modalities to patients at high genetic risk. ..
  5. GENE DISCOVERY FOR CRANIOFACIAL DISORDERS
    Richard Spritz; Fiscal Year: 2007
    ..Isolated, "non-syndromic" CL/P (nsCb'P) is the most common craniofacial birth defect, accounting for -70% of all cases of CL/P...
  6. Mapping and Functional Analysis of Vitiligo Susceptibility Genes
    Richard Spritz; Fiscal Year: 2009
    ....
  7. VitGene International Consortium to Identify Susceptibility Genes for Generalized
    Richard Spritz; Fiscal Year: 2009
    ..The long-term goal of these studies is improve understanding of disease pathogenesis to facilitate developing novel treatments for vitiligo and perhaps other autoimmune diseases. ..
  8. VitGene International Consortium to Identify Susceptibility Genes for Generalized
    Richard A Spritz; Fiscal Year: 2010
    ....
  9. GENETIC STUDIES OF HUMAN PIGMENTATION DISORDERS
    Richard Spritz; Fiscal Year: 2000
    ..The first specific aim is to continue mutational and functional analyses of known OCA genes, particularly the P gene, associated with OCA2...
  10. GENETIC STUDIES OF MARGARITA ISLAND ECTODERMAL DYSPLASIA
    Richard Spritz; Fiscal Year: 2002
    ..The last aim is to initiate studies to determine the function of the ED4 gene. ..
  11. MAPPING OF VITILIGO SUSCEPTIBILITY GENES
    Richard Spritz; Fiscal Year: 2002
    ..abstract_text> ..
  12. Mapping and Functional Analysis of Vitiligo Susceptibility Genes
    Richard A Spritz; Fiscal Year: 2010
    ....