Gene Symbol: osp
Description: outspread
Alias: BG:DS01486.5, BG:DS01486.7, BG:DS07721.2, CG3479, Dmel\CG3479, alw, anon-WO02059370.75, l(2)rJ571, v(2)rJ571, outspread, CG3479-PC, CG3479-PD, CG3479-PE, CG3479-PF, arc-like wing, arclike wing, osp-PC, osp-PD, osp-PE, osp-PF
Species: fruit fly

Top Publications

  1. Reid D, Muyskens J, Neal J, Gaddini G, Cho L, Wandler A, et al. Identification of genetic modifiers of CagA-induced epithelial disruption in Drosophila. Front Cell Infect Microbiol. 2012;2:24 pubmed publisher
    ..Collectively, these results point to new cellular pathways whose disruption by CagA are likely to contribute to H. pylori-associated disease pathology. ..
  2. Gubb D, Ashburner M, Roote J, Davis T. A novel transvection phenomenon affecting the white gene of Drosophila melanogaster. Genetics. 1990;126:167-76 pubmed
    ..This effect of rearrangements has been used as the basis for a screen, gamma-ray induced aberrations with at least one breakpoint opposite the TE site were recovered by their suppression of the zeste phenotype. ..
  3. Burnette J, Miyamoto Sato E, Schaub M, Conklin J, Lopez A. Subdivision of large introns in Drosophila by recursive splicing at nonexonic elements. Genetics. 2005;170:661-74 pubmed
    ..in vivo processing intermediates and lariat products from four large introns in the unrelated genes kuzbanian, outspread, and Ultrabithorax confirmed that these introns are removed by a series of recursive splicing steps using the ..
  4. Fuse N, Matakatsu H, Taniguchi M, Hayashi S. Snail-type zinc finger proteins prevent neurogenesis in Scutoid and transgenic animals of Drosophila. Dev Genes Evol. 1999;209:573-80 pubmed
    ..Thus, our results suggest that the Scutoid phenotype is due to an ectopic snail expression under the control of no-oceli enhancer, antagonizing neurogenesis through its inhibitory interaction with bHLH proteins. ..
  5. Ashburner M, Tsubota S, Woodruff R. The genetics of a small chromosome region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. IV: scutoid, an antimorphic mutation. Genetics. 1982;102:401-20 pubmed
    ..The simplest hypothesis is that Sco is a small reciprocal transposition, the genes noc, osp, and Adh exchanging places with three genes normally mapping proximal to them: l(2)br34, 1(2)br35 and rd...
  6. Woodruff R, Ashburner M. The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. II. Lethal mutations in the region. Genetics. 1979;92:133-49 pubmed
  7. Gubb D, Roote J, McGill S, Shelton M, Ashburner M. Interactions between WHITE Genes Carried by a Large Transposing Element and the ZESTE Allele in DROSOPHILA MELANOGASTER. Genetics. 1986;112:551-75 pubmed
    ..Second, an inversion breakpoint may disrupt the pairing between two adjacent w(+) alleles, necessary for their suppression by zeste, without physically separating them. ..
  8. Moschetti R, Marsano R, Barsanti P, Caggese C, Caizzi R. FB elements can promote exon shuffling: a promoter-less white allele can be reactivated by FB mediated transposition in Drosophila melanogaster. Mol Genet Genomics. 2004;271:394-401 pubmed
    ..In each case a local promoter drives the expression of white, producing a chimeric mRNA. These findings suggest that, on an evolutionary timescale, FB elements may contribute to the creation of new genes via exon shuffling...
  9. Reese M, Hartzell G, Harris N, Ohler U, Abril J, Lewis S. Genome annotation assessment in Drosophila melanogaster. Genome Res. 2000;10:483-501 pubmed

More Information


  1. Ashburner M. Speculations on the subject of alcohol dehydrogenase and its properties in Drosophila and other flies. Bioessays. 1998;20:949-54 pubmed publisher
    ..I also hint that the ADH enzymes of other flies (e.g., the tephritid fruit flies) may have evolved independently of those of Drosophila, but from a common ancestral gene...
  2. Gubb D, Roote J, Trenear J, Coulson D, Ashburner M. Topological constraints on transvection between white genes within the transposing element TE35B in Drosophila melanogaster. Genetics. 1997;146:919-37 pubmed
    ..Similarly, breakpoints immediately proximal or distal to both w genes give partial suppression. This transvection-dependent downregulation of w genes may result from mis-activation of the X-chromosome dosage compensation mechanism...
  3. Gubb D, McGill S, Ashburner M. A selective screen to recover chromosomal deletions and duplications in Drosophila melanogaster. Genetics. 1988;119:377-90 pubmed
    ..Such aberration breakpoints can be genetically mapped, as synthetic deletions, and then used as transposon-tagged sites for the recovery of genomic clones. ..
  4. Chia W, Karp R, McGill S, Ashburner M. Molecular analysis of the Adh region of the genome of Drosophila melanogaster. J Mol Biol. 1985;186:689-706 pubmed
    ..to 35B1 and includes the structural gene for alcohol dehydrogenase (Adh) as well as at least two other genes, outspread (osp) and no-ocelli (noc), has been characterized by mapping chromosome aberrations to the DNA...
  5. McNabb S, Greig S, Davis T. The alcohol dehydrogenase gene is nested in the outspread locus of Drosophila melanogaster. Genetics. 1996;143:897-911 pubmed
    This report describes the structure and expression of the outspread (osp) gene of Drosophila melanogaster...
  6. Fossett N, Arbour Reily P, Kilroy G, McDaniel M, Mahmoud J, Tucker A, et al. Analysis of ENU-induced mutations at the Adh locus in Drosophila melanogaster. Mutat Res. 1990;231:73-85 pubmed
    ..7 of the 9 intragenic mutations were GC to AT transitions which resulted in 5 single amino acid substitutions, 1 premature translation termination codon, and 1 splice site mutation.(ABSTRACT TRUNCATED AT 400 WORDS) ..
  7. Ashburner M. The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. III. Hypomorphic and hypermorphic mutations affecting the expression of hairless. Genetics. 1982;101:447-59 pubmed
    ..A simple model is proposed to account for the interaction of l(2)br7 and H, assuming that amorphic (or hypomorphic) alleles of l(2)br7 suppress H and that hypermorphic alleles enhance H. ..
  8. Woodruff R, Ashburner M. The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. I. Characterization of deficiencies and mapping of ADH and visible mutations. Genetics. 1979;92:117-32 pubmed
    ..Flies heterozygous for overlapping deficiencies that include both the Adh locus and that for the outspread mutant (osp: a recessive wing phenotype) are homozygous viable and show a complete ADH negative phenotype and ..
  9. Xie G, Yu Z, Jia D, Jiao R, Deng W. E(y)1/TAF9 mediates the transcriptional output of Notch signaling in Drosophila. J Cell Sci. 2014;127:3830-9 pubmed publisher
  10. Ashburner M, Detwiler C, Tsubota S, Woodruff R. The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. VI. Induced revertants of scutoid. Genetics. 1983;104:405-31 pubmed
    ..However, some revertants of Sco are rather more complex, and their properties suggest an interaction between the pu-noc and l(2)br28-l(2)br37 regions of chromosome arm 2L and also demonstrate the genetic complexity of the el-noc region. ..
  11. Grau Y, Carteret C, Simpson P. Mutations and Chromosomal Rearrangements Affecting the Expression of Snail, a Gene Involved in Embryonic Patterning in DROSOPHILA MELANOGASTER. Genetics. 1984;108:347-60 pubmed
    ..It is concluded that the products of all of these genes function together in the process of specification of pattern in the embryo. ..