Gene Symbol: osk
Description: oskar
Alias: CG10901, Dm-osk, Dmel\CG10901, OSK, Osk, Oskar, norka, oskar, CG10901-PA, CG10901-PC, CG10901-PD, dmoskar, osk-PA, osk-PC, osk-PD
Species: fruit fly
Products:     osk

Top Publications

  1. Hachet O, Ephrussi A. Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization. Nature. 2004;428:959-63 pubmed
    b>oskar messenger RNA localization at the posterior pole of the Drosophila oocyte is essential for germline and abdomen formation in the future embryo...
  2. Styhler S, Nakamura A, Swan A, Suter B, Lasko P. vasa is required for GURKEN accumulation in the oocyte, and is involved in oocyte differentiation and germline cyst development. Development. 1998;125:1569-78 pubmed
    ..vasa-null oocytes fail to efficiently accumulate many localized RNAs, such as Bicaudal-D, orb, oskar, and nanos, but still accumulate gurken RNA...
  3. Bullock S, Ish Horowicz D. Conserved signals and machinery for RNA transport in Drosophila oogenesis and embryogenesis. Nature. 2001;414:611-6 pubmed
    ..We propose that Egl and BicD are core components of a selective dynein motor complex that drives transcript localization in a variety of tissues. ..
  4. Palacios I, Gatfield D, St Johnston D, Izaurralde E. An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Nature. 2004;427:753-7 pubmed
    The specification of both the germ line and abdomen in Drosophila depends on the localization of oskar messenger RNA to the posterior of the oocyte...
  5. Lim A, Kai T. Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2007;104:6714-9 pubmed
    ..allele exhibited female sterility, defects in karyosome formation and oocyte polarity, and precocious osk translation...
  6. Technau M, Roth S. The Drosophila KASH domain proteins Msp-300 and Klarsicht and the SUN domain protein Klaroid have no essential function during oogenesis. Fly (Austin). 2008;2:82-91 pubmed
    ..Germ line nuclear envelope localization of both KASH domain proteins depends on klaroid, the only Drosophila SUN domain homolog expressed in females. Like Msp-300 and klar, klaroid is also dispensable for normal ovarian development. ..
  7. Sinsimer K, Jain R, Chatterjee S, Gavis E. A late phase of germ plasm accumulation during Drosophila oogenesis requires lost and rumpelstiltskin. Development. 2011;138:3431-40 pubmed publisher
    ..Posterior localization of oskar in the Drosophila oocyte targets the synthesis of Oskar to the posterior, where Oskar initiates the assembly of ..
  8. Reveal B, Garcia C, Ellington A, Macdonald P. Multiple RNA binding domains of Bruno confer recognition of diverse binding sites for translational repression. RNA Biol. 2011;8:1047-60 pubmed publisher
    Bruno protein binds to multiple sites - BREs - in the oskar mRNA 3' UTR, thereby controlling oskar mRNA translation. Bruno also binds and regulates other mRNAs, although the binding sites have not yet been defined...
  9. Rittenhouse K, Berg C. Mutations in the Drosophila gene bullwinkle cause the formation of abnormal eggshell structures and bicaudal embryos. Development. 1995;121:3023-33 pubmed
    ..Unlike other bicaudal mutants, oskar mRNA is localized correctly to the posterior pole of the oocyte at stage 10...

More Information

Publications107 found, 100 shown here

  1. Peifer M, Orsulic S, Sweeton D, Wieschaus E. A role for the Drosophila segment polarity gene armadillo in cell adhesion and cytoskeletal integrity during oogenesis. Development. 1993;118:1191-207 pubmed
    ..The implications of these results for the role of adhesive junctions during development are discussed. ..
  2. Dubnau J, Chiang A, Grady L, Barditch J, Gossweiler S, McNeil J, et al. The staufen/pumilio pathway is involved in Drosophila long-term memory. Curr Biol. 2003;13:286-96 pubmed
    ..In vivo disruptions of four genes--staufen, pumilio, oskar, and eIF-5C--yield defective memory...
  3. Babu K, Cai Y, Bahri S, Yang X, Chia W. Roles of Bifocal, Homer, and F-actin in anchoring Oskar to the posterior cortex of Drosophila oocytes. Genes Dev. 2004;18:138-43 pubmed
    Transport, translation, and anchoring of osk mRNA and proteins are essential for posterior patterning of Drosophila embryos. Here we show that Homer and Bifocal act redundantly to promote posterior anchoring of the osk gene products...
  4. Snee M, Macdonald P. Live imaging of nuage and polar granules: evidence against a precursor-product relationship and a novel role for Oskar in stabilization of polar granule components. J Cell Sci. 2004;117:2109-20 pubmed
    ..Instead, Oskar protein nucleates the formation of polar granules from cytoplasmic pools of the components shared with nuage...
  5. Chang C, Nashchekin D, Wheatley L, Irion U, Dahlgaard K, Montague T, et al. Anterior-posterior axis specification in Drosophila oocytes: identification of novel bicoid and oskar mRNA localization factors. Genetics. 2011;188:883-96 pubmed publisher
    ..Drosophila melanogaster anterior-posterior axis is established during oogenesis by the localization of bicoid and oskar mRNAs to the anterior and posterior poles of the oocyte...
  6. Leibfried A, Muller S, Ephrussi A. A Cdc42-regulated actin cytoskeleton mediates Drosophila oocyte polarization. Development. 2013;140:362-71 pubmed publisher
    ..This most likely allows for the robustness in symmetry breaking in the cell. ..
  7. Chang J, Tan L, Schedl P. The Drosophila CPEB homolog, orb, is required for oskar protein expression in oocytes. Dev Biol. 1999;215:91-106 pubmed
    ..The critical step in the targeting of posterior determinants is the localization of oskar (osk) mRNA to the pole and its on-site translation...
  8. Forrest K, Gavis E. Live imaging of endogenous RNA reveals a diffusion and entrapment mechanism for nanos mRNA localization in Drosophila. Curr Biol. 2003;13:1159-68 pubmed
    ..This mechanism differs from directed transport-based localization mechanisms in its reliance on bulk movement of RNA. ..
  9. DeFalco T, Verney G, Jenkins A, McCaffery J, Russell S, Van Doren M. Sex-specific apoptosis regulates sexual dimorphism in the Drosophila embryonic gonad. Dev Cell. 2003;5:205-16 pubmed
    ..Our work furthers the hypotheses that a conserved pathway controls gonad sexual dimorphism in diverse species and that sex-specific cell recruitment and programmed cell death are common mechanisms for creating sexual dimorphism. ..
  10. Januschke J, Gervais L, Gillet L, Keryer G, Bornens M, Guichet A. The centrosome-nucleus complex and microtubule organization in the Drosophila oocyte. Development. 2006;133:129-39 pubmed
    Molecular motors transport the axis-determining mRNAs oskar, bicoid and gurken along microtubules (MTs) in the Drosophila oocyte. However, it remains unclear how the underlying MT network is organized and how this transport takes place...
  11. Reveal B, Yan N, Snee M, Pai C, Gim Y, Macdonald P. BREs mediate both repression and activation of oskar mRNA translation and act in trans. Dev Cell. 2010;18:496-502 pubmed publisher
    Asymmetric positioning of proteins within cells is crucial for cell polarization and function. Deployment of Oskar protein at the posterior pole of the Drosophila oocyte relies on localization of the oskar mRNA, repression of its ..
  12. Callebaut I, Mornon J. LOTUS, a new domain associated with small RNA pathways in the germline. Bioinformatics. 2010;26:1140-4 pubmed publisher
    ..A LOTUS domain is also present in the Oskar protein, a critical component of the pole plasm in the Drosophila oocyte, which is required for germ cell ..
  13. Rongo C, Gavis E, Lehmann R. Localization of oskar RNA regulates oskar translation and requires Oskar protein. Development. 1995;121:2737-46 pubmed
    The site of oskar RNA and protein localization within the oocyte determines where in the embryo primordial germ cells form and where the abdomen develops. Initiation of oskar RNA localization requires the activity of several genes...
  14. Newmark P, Boswell R. The mago nashi locus encodes an essential product required for germ plasm assembly in Drosophila. Development. 1994;120:1303-13 pubmed
    ..The original mago nashi allele disrupts the localization of oskar mRNA and staufen protein to the posterior pole of the oocyte during oogenesis; anterior localization of bicoid ..
  15. Tan L, Chang J, Costa A, Schedl P. An autoregulatory feedback loop directs the localized expression of the Drosophila CPEB protein Orb in the developing oocyte. Development. 2001;128:1159-69 pubmed
    ..In AP axis formation, Orb is required for the translation of oskar mRNA...
  16. Anne J, Ollo R, Ephrussi A, Mechler B. Arginine methyltransferase Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation in Drosophila. Development. 2007;134:137-46 pubmed
    ..Our results thus reveal the role of a PRMT in protein localization in germ cells. ..
  17. Tanaka T, Nakamura A. The endocytic pathway acts downstream of Oskar in Drosophila germ plasm assembly. Development. 2008;135:1107-17 pubmed publisher
    Cell fate is often determined by the intracellular localization of RNAs and proteins. In Drosophila oocytes, oskar (osk) RNA localization and the subsequent Osk synthesis at the posterior pole direct the assembly of the pole plasm, where ..
  18. Ganguly S, Williams L, Palacios I, Goldstein R. Cytoplasmic streaming in Drosophila oocytes varies with kinesin activity and correlates with the microtubule cytoskeleton architecture. Proc Natl Acad Sci U S A. 2012;109:15109-14 pubmed
    ..as the basis of a model for transport, we suggest that the disordered character of transport at mid-oogenesis, as revealed by streaming, is an important component of the localization dynamics of the body plan determinant oskar mRNA.
  19. Wilson J, Connell J, Macdonald P. aubergine enhances oskar translation in the Drosophila ovary. Development. 1996;122:1631-9 pubmed
    ..In this report, we describe the role of aubergine in oskar translation...
  20. Palacios I. RNA processing: splicing and the cytoplasmic localisation of mRNA. Curr Biol. 2002;12:R50-2 pubmed
    ..The new findings suggest that recruitment of the Mago Nashi and Y14 proteins upon splicing of oskar mRNA is an essential step in the localisation of the RNA to the posterior pole of the Drosophila oocyte.
  21. Vanzo N, Oprins A, Xanthakis D, Ephrussi A, Rabouille C. Stimulation of endocytosis and actin dynamics by Oskar polarizes the Drosophila oocyte. Dev Cell. 2007;12:543-55 pubmed
    In Drosophila, localized activity of oskar at the posterior pole of the oocyte induces germline and abdomen formation in the embryo...
  22. Deng W, Lin H. Spectrosomes and fusomes anchor mitotic spindles during asymmetric germ cell divisions and facilitate the formation of a polarized microtubule array for oocyte specification in Drosophila. Dev Biol. 1997;189:79-94 pubmed
    ..cyst formation, polarized microtubule networks do not form, the dynamics of cytoplasmic dynein is disrupted, and oskar and orb RNAs fail to be transported to the future oocyte...
  23. Van de Bor V, Hartswood E, Jones C, Finnegan D, Davis I. gurken and the I factor retrotransposon RNAs share common localization signals and machinery. Dev Cell. 2005;9:51-62 pubmed
    ..We propose that the transposition of other elements may exploit the host's RNA transport signals and machinery. ..
  24. Kadyrova L, Habara Y, Lee T, Wharton R. Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. Development. 2007;134:1519-27 pubmed
    ..Nanos is the sole spatially limiting factor for regulation of hunchback, regulation of Cyclin B requires another Oskar-dependent factor in addition to Nanos...
  25. Pane A, Wehr K, Schupbach T. zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline. Dev Cell. 2007;12:851-62 pubmed
    ..Mutant females are sterile and show dorsoventral patterning defects during oogenesis. In addition, Oskar protein is ectopically expressed in early oocytes, where it is normally silenced by RNAi mechanisms...
  26. Gavis E. Expeditions to the pole: RNA localization in Xenopus and Drosophila. Trends Cell Biol. 1997;7:485-92 pubmed
    ..While specific aspects of localization differ among RNAs, similarities between pathways used by Xenopus and Drosophila suggest that common themes have been conserved among localization mechanisms. ..
  27. Jambor H, Brunel C, Ephrussi A. Dimerization of oskar 3' UTRs promotes hitchhiking for RNA localization in the Drosophila oocyte. RNA. 2011;17:2049-57 pubmed publisher
    ..In Drosophila, patterning of the embryo requires oskar mRNA transport to the posterior pole of the oocyte and translational repression prior to localization...
  28. Ghosh S, Marchand V, Gaspar I, Ephrussi A. Control of RNP motility and localization by a splicing-dependent structure in oskar mRNA. Nat Struct Mol Biol. 2012;19:441-9 pubmed publisher
    b>oskar RNA localization to the posterior pole of the Drosophila melanogaster oocyte requires splicing of the first intron and the exon junction complex (EJC) core proteins...
  29. Boyle M, DiNardo S. Specification, migration and assembly of the somatic cells of the Drosophila gonad. Development. 1995;121:1815-25 pubmed
    ..Mutations in iab-4 abolish expression of abd A within these cells, and as a result block the coalescence of the gonad. ..
  30. Nakamura A, Amikura R, Hanyu K, Kobayashi S. Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex during Drosophila oogenesis. Development. 2001;128:3233-42 pubmed
    ..These results suggest that Me31B mediates translational silencing of RNAs during their transport to the oocyte. Our data provide evidence that RNA transport and translational control are linked through the assembly of RNP complex. ..
  31. Palacios I, St Johnston D. Kinesin light chain-independent function of the Kinesin heavy chain in cytoplasmic streaming and posterior localisation in the Drosophila oocyte. Development. 2002;129:5473-85 pubmed
    ..component of the plus end-directed microtubule motor Kinesin I are required for the localisation of oskar mRNA to the posterior pole of the Drosophila oocyte, an essential step in the determination of the anteroposterior ..
  32. Farina K, Singer R. The nuclear connection in RNA transport and localization. Trends Cell Biol. 2002;12:466-72 pubmed
    ..These proteins might link nuclear events, such as RNA splicing, with the subsequent cytoplasmic localization of specific transcripts. ..
  33. Juge F, Zaessinger S, Temme C, Wahle E, Simonelig M. Control of poly(A) polymerase level is essential to cytoplasmic polyadenylation and early development in Drosophila. EMBO J. 2002;21:6603-13 pubmed
    ..This demonstrates that regulation of the PAP level is essential for controlled cytoplasmic polyadenylation and early development. ..
  34. Sanghavi P, Laxani S, Li X, Bullock S, Gonsalvez G. Dynein associates with oskar mRNPs and is required for their efficient net plus-end localization in Drosophila oocytes. PLoS ONE. 2013;8:e80605 pubmed publisher
    ..The spatial restriction of oskar mRNA and its subsequent protein product is necessary for embryonic patterning...
  35. Webster P, Liang L, Berg C, Lasko P, Macdonald P. Translational repressor bruno plays multiple roles in development and is widely conserved. Genes Dev. 1997;11:2510-21 pubmed
    b>oskar (osk) mRNA is tightly localized to the posterior pole of the Drosophila oocyte, where the subsequent expression of Osk protein directs abdomen and germ-line formation in the developing embryo...
  36. Tomancak P, Piano F, Riechmann V, Gunsalus K, Kemphues K, Ephrussi A. A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation. Nat Cell Biol. 2000;2:458-60 pubmed
  37. Ferrandon D, Elphick L, Nusslein Volhard C, St Johnston D. Staufen protein associates with the 3'UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner. Cell. 1994;79:1221-32 pubmed
    ..Since staufen is also transported with oskar (osk) mRNA during oogenesis, staufen associates specifically with both osk and bcd mRNAs to mediate their ..
  38. Benton R, Palacios I, St Johnston D. Drosophila 14-3-3/PAR-5 is an essential mediator of PAR-1 function in axis formation. Dev Cell. 2002;3:659-71 pubmed
    ..The C. elegans 14-3-3 protein, PAR-5, is also required for A-P polarization, suggesting that this is a conserved mechanism by which PAR-1 establishes cellular asymmetries. ..
  39. Torres I, Lopez Schier H, St Johnston D. A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila. Dev Cell. 2003;5:547-58 pubmed
    ..The anterior-posterior axis is therefore established by a relay mechanism, which propagates polarity from one cyst to the next. ..
  40. Morris J, Hong A, Lilly M, Lehmann R. twin, a CCR4 homolog, regulates cyclin poly(A) tail length to permit Drosophila oogenesis. Development. 2005;132:1165-74 pubmed
    ..We propose that Twin/Ccr4 functions during early oogenesis to coordinate cyst division, oocyte fate specification and egg chamber maturation. ..
  41. Lin M, Jiao X, Grima D, Newbury S, Kiledjian M, Chou T. Drosophila processing bodies in oogenesis. Dev Biol. 2008;322:276-88 pubmed publisher
    ..This also suggests that a regulated conversion occurs between maternal RNA granules and P-bodies from oogenesis to embryogenesis. ..
  42. Moua P, Fullerton D, Serbus L, Warrior R, Saxton W. Kinesin-1 tail autoregulation and microtubule-binding regions function in saltatory transport but not ooplasmic streaming. Development. 2011;138:1087-92 pubmed publisher
    ..It might instead be crucial for more subtle elements of motor control and coordination in the stop-and-go movements of biased saltatory transport. ..
  43. Hadfield S, Axton J. Germ cells colonized by endosymbiotic bacteria. Nature. 1999;402:482 pubmed
  44. Pellettieri J, Seydoux G. Anterior-posterior polarity in C. elegans and Drosophila--PARallels and differences. Science. 2002;298:1946-50 pubmed
    ..Although clear mechanistic parallels remain to be established, par-dependent regulation of microtubule dynamics and protein stability emerge as common themes. ..
  45. Duncan J, Warrior R. The cytoplasmic dynein and kinesin motors have interdependent roles in patterning the Drosophila oocyte. Curr Biol. 2002;12:1982-91 pubmed
    ..These results indicate that the activity of the two motors is interdependent and suggest a model in which kinesin affects patterning indirectly through its role in the localization and recycling of dynein. ..
  46. Frydman H, Spradling A. The receptor-like tyrosine phosphatase lar is required for epithelial planar polarity and for axis determination within drosophila ovarian follicles. Development. 2001;128:3209-20 pubmed
    ..tyrosine phosphatase Lar that disorganize follicle formation, block egg chamber elongation and disrupt Oskar localization, which is an indicator of oocyte anterior-posterior polarity...
  47. Thomson T, Lasko P. Drosophila tudor is essential for polar granule assembly and pole cell specification, but not for posterior patterning. Genesis. 2004;40:164-70 pubmed
    ..b>OSKAR (OSK) and VASA (VAS) proteins, and nanos (nos) RNA, all initially localize to the pole plasm of tud-null oocytes ..
  48. Munro T, Kwon S, Schnapp B, St Johnston D. A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP. J Cell Biol. 2006;172:577-88 pubmed
    ..by exponential enrichment, we identified the IMP-binding element (IBE) UUUAY, a motif that occurs 13 times in the oskar 3'UTR. IMP colocalizes with oskar mRNA at the oocyte posterior, and this depends on the IBEs...
  49. Zimyanin V, Belaya K, Pecreaux J, Gilchrist M, Clark A, Davis I, et al. In vivo imaging of oskar mRNA transport reveals the mechanism of posterior localization. Cell. 2008;134:843-53 pubmed publisher
    b>oskar mRNA localization to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo...
  50. Clark I, Giniger E, Ruohola Baker H, Jan L, Jan Y. Transient posterior localization of a kinesin fusion protein reflects anteroposterior polarity of the Drosophila oocyte. Curr Biol. 1994;4:289-300 pubmed
    ..of several messenger RNAs and proteins to the posterior of the oocyte, beginning with the localization of oskar mRNA and Staufen protein during stages 8 and 9 of oogenesis...
  51. Manseau L, Calley J, Phan H. Profilin is required for posterior patterning of the Drosophila oocyte. Development. 1996;122:2109-16 pubmed
    ..the microtubule misregulation, mutants in chickadee resemble cappuccino in that they fail to localize STAUFEN and oskar mRNA to the posterior pole of the developing oocyte...
  52. Clegg N, Frost D, Larkin M, Subrahmanyan L, Bryant Z, Ruohola Baker H. maelstrom is required for an early step in the establishment of Drosophila oocyte polarity: posterior localization of grk mRNA. Development. 1997;124:4661-71 pubmed
    ..Mutations in maelstrom disturb the localization of mRNAs for Gurken (a ligand for the Drosophila Egf receptor), Oskar and Bicoid at the posterior of the developing (stage 3-6) oocyte...
  53. Saffman E, Styhler S, Rother K, Li W, Richard S, Lasko P. Premature translation of oskar in oocytes lacking the RNA-binding protein bicaudal-C. Mol Cell Biol. 1998;18:4855-62 pubmed
    ..In addition, oskar translation commences prior to posterior localization of oskar RNA in Bic-C- oocytes, indicating that Bic-C may ..
  54. Hachet O, Ephrussi A. Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport. Curr Biol. 2001;11:1666-74 pubmed
    ..In Drosophila, localization of mRNAs in the oocyte determines the axes of the future embryo. oskar mRNA localization at the posterior pole is essential and sufficient for the specification of the germline and the ..
  55. Besse F, López de Quinto S, Marchand V, Trucco A, Ephrussi A. Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation. Genes Dev. 2009;23:195-207 pubmed publisher
    ..In Drosophila, exclusive accumulation of Oskar protein at the posterior pole of the oocyte is essential for development of the future embryo...
  56. Cha B, Serbus L, Koppetsch B, Theurkauf W. Kinesin I-dependent cortical exclusion restricts pole plasm to the oocyte posterior. Nat Cell Biol. 2002;4:592-8 pubmed
    Microtubules and the plus-end-directed microtubule motor Kinesin I are required for the selective accumulation of oskar mRNA at the posterior cortex of the Drosophila melanogaster oocyte, which is essential to posterior patterning and ..
  57. Tetzlaff M, Jackle H, Pankratz M. Lack of Drosophila cytoskeletal tropomyosin affects head morphogenesis and the accumulation of oskar mRNA required for germ cell formation. EMBO J. 1996;15:1247-54 pubmed
    ..b>oskar mRNA, which is required for both germ cell formation and abdominal segmentation, fails to accumulate at the ..
  58. Lee J, Brandin E, Branton D, Goldstein L. alpha-Spectrin is required for ovarian follicle monolayer integrity in Drosophila melanogaster. Development. 1997;124:353-62 pubmed
    ..These results suggest that the spectrin-based membrane skeleton is required in a developmental pathway that controls follicle cell monolayer integrity and proliferation. ..
  59. Jones J, Macdonald P. Oskar controls morphology of polar granules and nuclear bodies in Drosophila. Development. 2007;134:233-6 pubmed
    ..Several polar granule components, both protein and RNA, have been identified. One of these, the protein Oskar, acts to initiate granule formation during oogenesis and to recruit other granule components...
  60. Gonsalvez G, Rajendra T, Wen Y, Praveen K, Matera A. Sm proteins specify germ cell fate by facilitating oskar mRNA localization. Development. 2010;137:2341-51 pubmed publisher
    ..We demonstrate that Drosophila SmB and SmD3 are specific components of the oskar messenger ribonucleoprotein (mRNP), proper localization of which is required for establishing germline fate and ..
  61. Kim Ha J, Kerr K, Macdonald P. Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential. Cell. 1995;81:403-12 pubmed
    b>Oskar (osk) protein directs the deployment of nanos (nos), the posterior body-patterning morphogen in Drosophila...
  62. Snee M, Macdonald P. Dynamic organization and plasticity of sponge bodies. Dev Dyn. 2009;238:918-30 pubmed publisher
    ..of sponge bodies allow normal development, but show substantial differences in distribution of Staufen protein and oskar mRNA, whose localization within the oocyte is essential for axial patterning...
  63. Loiseau P, Davies T, Williams L, Mishima M, Palacios I. Drosophila PAT1 is required for Kinesin-1 to transport cargo and to maximize its motility. Development. 2010;137:2763-72 pubmed publisher
    Kinesin heavy chain (KHC), the force-generating component of Kinesin-1, is required for the localization of oskar mRNA and the anchoring of the nucleus in the Drosophila oocyte...
  64. Rouget C, Papin C, Boureux A, Meunier A, Franco B, Robine N, et al. Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. Nature. 2010;467:1128-32 pubmed publisher
    ..Because the piRNAs involved in this regulation are produced from transposable elements, this identifies a direct developmental function for transposable elements in the regulation of gene expression. ..
  65. Erdelyi M, Michon A, Guichet A, Glotzer J, Ephrussi A. Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localization. Nature. 1995;377:524-7 pubmed
    The localization of oskar (osk) RNA to the posterior pole of the developing fruit fly (Drosophila) oocyte induces the assembly of pole plasm, causing development of the abdomen and germ line...
  66. Liang L, Diehl Jones W, Lasko P. Localization of vasa protein to the Drosophila pole plasm is independent of its RNA-binding and helicase activities. Development. 1994;120:1201-11 pubmed
    ..Posterior localization of vasa protein depends upon the functions of four genes: capu, spir, osk and stau...
  67. Swan A, Nguyen T, Suter B. Drosophila Lissencephaly-1 functions with Bic-D and dynein in oocyte determination and nuclear positioning. Nat Cell Biol. 1999;1:444-9 pubmed
  68. Castagnetti S, Hentze M, Ephrussi A, Gebauer F. Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries. Development. 2000;127:1063-8 pubmed
    The coupled regulation of oskar mRNA localization and translation in time and space is critical for correct anteroposterior patterning of the Drosophila embryo...
  69. Riechmann V, Gutierrez G, Filardo P, Nebreda A, Ephrussi A. Par-1 regulates stability of the posterior determinant Oskar by phosphorylation. Nat Cell Biol. 2002;4:337-42 pubmed
    ..Here we show that Drosophila Par-1 phosphorylates the posterior determinant Oskar (Osk) and demonstrate genetically that Par-1 is required for accumulation of Osk protein...
  70. Jenkins A, McCaffery J, Van Doren M. Drosophila E-cadherin is essential for proper germ cell-soma interaction during gonad morphogenesis. Development. 2003;130:4417-26 pubmed
    ..E-cadherin expression in the gonad is dramatically decreased in fear of intimacy mutants, indicating that Fear of Intimacy may be a regulator of E-cadherin expression or function. ..
  71. Tian A, Deng W. Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila. Development. 2008;135:463-71 pubmed
    ..Our studies suggest that Lgl and its phosphorylation by aPKC may form a conserved regulatory circuitry in polarization of various cell types. ..
  72. Glotzer J, Saffrich R, Glotzer M, Ephrussi A. Cytoplasmic flows localize injected oskar RNA in Drosophila oocytes. Curr Biol. 1997;7:326-37 pubmed
    The oskar (osk) gene encodes a determinant of posterior identity in Drosophila, and the localization of osk RNA to the pole plasm at the posterior pole of the oocyte is essential for development of the embryo...
  73. Wilhelm J, Hilton M, Amos Q, Henzel W. Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz. J Cell Biol. 2003;163:1197-204 pubmed
    In Drosophila oocytes, precise localization of the posterior determinant, Oskar, is required for posterior patterning...
  74. Li Q, Xin T, Chen W, Zhu M, Li M. Lethal(2)giant larvae is required in the follicle cells for formation of the initial AP asymmetry and the oocyte polarity during Drosophila oogenesis. Cell Res. 2008;18:372-84 pubmed publisher
    ..Thus, we provide the first demonstration that lgl is implicated in the formation of the initial AP asymmetry and the patterning of the AP and DV axes in the oocyte by acting in the specification of a subset of somatic follicle cells. ..
  75. Bardsley A, McDonald K, Boswell R. Distribution of tudor protein in the Drosophila embryo suggests separation of functions based on site of localization. Development. 1993;119:207-19 pubmed
    ..Our results suggest that tudor protein localized in the germ plasm is instrumental in germ cell determination, whereas nuclear-associated tudor protein is involved in determination of segmental pattern in the abdomen. ..
  76. Breitwieser W, Markussen F, Horstmann H, Ephrussi A. Oskar protein interaction with Vasa represents an essential step in polar granule assembly. Genes Dev. 1996;10:2179-88 pubmed
    ..Pole plasm assembly is induced by oskar RNA localized to the posterior pole of the oocyte...
  77. Rivera Pomar R, Jackle H. From gradients to stripes in Drosophila embryogenesis: filling in the gaps. Trends Genet. 1996;12:478-83 pubmed
    ..Recent progress has begun to reveal the mechanisms by which coherent positional information of maternal origin becomes transferred into serially repeated zygotic gene expression domains reflecting the metameric body plan of the larva. ..
  78. Cha B, Koppetsch B, Theurkauf W. In vivo analysis of Drosophila bicoid mRNA localization reveals a novel microtubule-dependent axis specification pathway. Cell. 2001;106:35-46 pubmed
    ..We propose that microtubule-dependent Exuperantia-bicoid mRNA complex formation in the nurse cell cytoplasm allows anterior-specific transport on a grossly nonpolar oocyte microtubule network. ..
  79. Styhler S, Nakamura A, Lasko P. VASA localization requires the SPRY-domain and SOCS-box containing protein, GUSTAVUS. Dev Cell. 2002;3:865-76 pubmed
    ..Therefore, GUS is essential for the posterior localization of VAS. However, gus is not required for the posterior localization of oskar (osk). Apparent gus orthologs are present in mammalian genomes.
  80. Chekulaeva M, Hentze M, Ephrussi A. Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles. Cell. 2006;124:521-33 pubmed
    Prior to reaching the posterior pole of the Drosophila oocyte, oskar mRNA is translationally silenced by Bruno binding to BREs in the 3' untranslated region...
  81. Carrera P, Johnstone O, Nakamura A, Casanova J, Jackle H, Lasko P. VASA mediates translation through interaction with a Drosophila yIF2 homolog. Mol Cell. 2000;5:181-7 pubmed
    ..We conclude that VAS regulates translation of germline mRNAs by specific interaction with dIF2, an essential factor conserved from bacteria to humans. ..
  82. Goodrich J, Clouse K, Schupbach T. Hrb27C, Sqd and Otu cooperatively regulate gurken RNA localization and mediate nurse cell chromosome dispersion in Drosophila oogenesis. Development. 2004;131:1949-58 pubmed
    ..All three mutants share another phenotype, persistent polytene nurse cell chromosomes. Our analyses support dual cooperative roles for Sqd, Hrb27C and Otu during Drosophila oogenesis. ..
  83. Patil V, Kai T. Repression of retroelements in Drosophila germline via piRNA pathway by the Tudor domain protein Tejas. Curr Biol. 2010;20:724-30 pubmed publisher
    ..Aub and Spn-E also bind to the tudor domain at the C terminus. Our data suggest that Tej contributes to the formation of a macromolecular complex at perinuclear region and engages it in the production of germline piRNAs. ..
  84. Macdonald P, Smibert C. Translational regulation of maternal mRNAs. Curr Opin Genet Dev. 1996;6:403-7 pubmed
    ..Substantial progress has also been reported in the identification and characterization of the cis-acting elements and trans-acting factors that mediate translational regulation and their interactions with one another. ..
  85. Cook H, Koppetsch B, Wu J, Theurkauf W. The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification. Cell. 2004;116:817-29 pubmed
    ..The posterior determinant oskar mRNA is translationally silent until mid-oogenesis...
  86. Braat A, Yan N, Arn E, Harrison D, Macdonald P. Localization-dependent oskar protein accumulation; control after the initiation of translation. Dev Cell. 2004;7:125-31 pubmed
    The appearance of Oskar protein occurs coincident with localization of oskar mRNA to the posterior pole of the Drosophila oocyte, and earlier accumulation of the protein is prevented by translational repression...
  87. Abdu U, Bar D, Sch pbach T. spn-F encodes a novel protein that affects oocyte patterning and bristle morphology in Drosophila. Development. 2006;133:1477-84 pubmed publisher
    ..Our results show that we have identified a novel protein that affects oocyte axis determination and the organization of microtubules during Drosophila oogenesis...
  88. Rongo C, Lehmann R. Regulated synthesis, transport and assembly of the Drosophila germ plasm. Trends Genet. 1996;12:102-9 pubmed
    ..These results imply that the limiting steps in the assembly of the germ plasm are localization of the OSK RNA and regulated synthesis of the OSK protein, encoded by oskar, which are components of the germ plasm.
  89. Mohr S, Dillon S, Boswell R. The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosophila oogenesis. Genes Dev. 2001;15:2886-99 pubmed
    ..tsunagi function is removed from the germ line, egg chambers develop in which the oocyte nucleus fails to migrate, oskar mRNA is not localized within the posterior pole, and dorsal-ventral pattern abnormalities are observed...
  90. Filardo P, Ephrussi A. Bruno regulates gurken during Drosophila oogenesis. Mech Dev. 2003;120:289-97 pubmed
    ..In the Drosophila germline, oskar transcript must be translationally repressed until its localization at the posterior pole of the oocyte, as ..
  91. Macchi P, Kroening S, Palacios I, Baldassa S, Grunewald B, Ambrosino C, et al. Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner. J Neurosci. 2003;23:5778-88 pubmed
    ..One candidate is the mammalian homolog of Drosophila Barentsz (Btz), which is essential for the localization of oskar mRNA to the posterior pole of the Drosophila oocyte and is a component of the oskar RNA localization complex along ..
  92. Wang C, Dickinson L, Lehmann R. Genetics of nanos localization in Drosophila. Dev Dyn. 1994;199:103-15 pubmed
    ..Localization of nanos is not affected by mutations in bicoid or torso, confirming that the three maternal systems of anterior-posterior determination initially act independently. ..