os

Summary

Gene Symbol: os
Description: outstretched
Alias: CG5993, Dmel\CG5993, UPD, Upd, Upd1, bdw, l(1)YC43, l(1)YM55, odsy, sis-C, sis-c, sisC, unp, upa, upd, upd1, CG5993-PA, CG5993-PB, Unpaired/Out-stretched, bending-wings, os-PA, os-PB, outstreched, outstretched small eye, outstretched-smalleye, sisterless c, small-eye, unpaired, unpaired 1, upd homolog
Species: fruit fly

Top Publications

  1. ncbi Dosage requirements for runt in the segmentation of Drosophila embryos
    J P Gergen
    Cell 45:289-99. 1986
  2. pmc Dedifferentiating spermatogonia outcompete somatic stem cells for niche occupancy in the Drosophila testis
    X Rebecca Sheng
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Stem Cell 5:191-203. 2009
  3. pmc Zfh-1 controls somatic stem cell self-renewal in the Drosophila testis and nonautonomously influences germline stem cell self-renewal
    Judith L Leatherman
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Stem Cell 3:44-54. 2008
  4. pmc Regulation of adult stem cell behavior by nutrient signaling
    Lei Wang
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA
    Cell Cycle 10:2628-34. 2011
  5. ncbi Male and female Drosophila germline stem cells: two versions of immortality
    Margaret T Fuller
    Departments of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 316:402-4. 2007
  6. pmc Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling
    Shree Ram Singh
    Mouse Cancer Genetics Program, National Institutes of Health, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Cell Physiol 223:500-10. 2010
  7. ncbi GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo
    Erika A Bach
    Pharmacology Department, New York University School of Medicine, New York, NY 10016 6402, USA
    Gene Expr Patterns 7:323-31. 2007
  8. ncbi The Drosophila cytokine receptor Domeless controls border cell migration and epithelial polarization during oogenesis
    Christian Ghiglione
    Institute of Signaling, Developmental Biology and Cancer, UMR 6543 CNRS, Parc Valrose, 06108 Nice Cedex 2, France
    Development 129:5437-47. 2002
  9. pmc A Drosophila PIAS homologue negatively regulates stat92E
    A Betz
    Laboratories of Molecular Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:9563-8. 2001
  10. ncbi The JAK/STAT pathway is required for border cell migration during Drosophila oogenesis
    Simone Beccari
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    Mech Dev 111:115-23. 2002

Scientific Experts

Detail Information

Publications99

  1. ncbi Dosage requirements for runt in the segmentation of Drosophila embryos
    J P Gergen
    Cell 45:289-99. 1986
    ..Significantly, increased runt+ dosage causes an anti-runt phenotype consisting of periodic pattern deletions that are out of phase with those caused by runt mutations...
  2. pmc Dedifferentiating spermatogonia outcompete somatic stem cells for niche occupancy in the Drosophila testis
    X Rebecca Sheng
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Stem Cell 5:191-203. 2009
    ....
  3. pmc Zfh-1 controls somatic stem cell self-renewal in the Drosophila testis and nonautonomously influences germline stem cell self-renewal
    Judith L Leatherman
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Stem Cell 3:44-54. 2008
    ..In contrast, germline-intrinsic STAT activation was insufficient for GSC renewal. These data reveal unexpected complexity in cell interactions in the niche, implicating CPCs in GSC self-renewal...
  4. pmc Regulation of adult stem cell behavior by nutrient signaling
    Lei Wang
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA
    Cell Cycle 10:2628-34. 2011
    ..Here we discuss our data regarding the effects and mechanisms by which changes in systemic nutritional conditions may influence the maintenance and activity of adult stem cells via insulin signaling...
  5. ncbi Male and female Drosophila germline stem cells: two versions of immortality
    Margaret T Fuller
    Departments of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 316:402-4. 2007
    ..Comparing these two stem cells and their niches in detail is likely to reveal how a common heritage has been adapted to the differing requirements of male and female gamete production...
  6. pmc Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling
    Shree Ram Singh
    Mouse Cancer Genetics Program, National Institutes of Health, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Cell Physiol 223:500-10. 2010
    ..The hub expresses a growth factor unpaired (Upd) that activates the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway in GSCs ..
  7. ncbi GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo
    Erika A Bach
    Pharmacology Department, New York University School of Medicine, New York, NY 10016 6402, USA
    Gene Expr Patterns 7:323-31. 2007
    ..JAK/STAT pathway activity at larval stages, as their expression pattern overlaps that of the activating ligand unpaired in imaginal discs. Moreover, the STAT92E-GFP reporters are activated by ectopic JAK/STAT signaling...
  8. ncbi The Drosophila cytokine receptor Domeless controls border cell migration and epithelial polarization during oogenesis
    Christian Ghiglione
    Institute of Signaling, Developmental Biology and Cancer, UMR 6543 CNRS, Parc Valrose, 06108 Nice Cedex 2, France
    Development 129:5437-47. 2002
    ..During embryogenesis, transduction of the Unpaired [Upd; also known as Outstretched (Os)] ligand through the JAK/STAT pathway requires Domeless, a putative membrane ..
  9. pmc A Drosophila PIAS homologue negatively regulates stat92E
    A Betz
    Laboratories of Molecular Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:9563-8. 2001
    ..To this end we use a LOF allele and conditionally overexpressed dpias in JAK-STAT pathway mutant backgrounds. We conclude that the correct dpias/stat92E ratio is crucial for blood cell and eye development...
  10. ncbi The JAK/STAT pathway is required for border cell migration during Drosophila oogenesis
    Simone Beccari
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    Mech Dev 111:115-23. 2002
    ..The activating ligand for the pathway, Unpaired, is expressed in polar cells...
  11. pmc Interpretation of the UPD/JAK/STAT morphogen gradient in Drosophila follicle cells
    Michelle Starz-Gaiano
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Cell Cycle 8:2917-25. 2009
    ..Under the influence of a graded signal, Unpaired (UPD), JAK/STAT becomes activated first in a graded fashion...
  12. pmc An innate immune response of blood cells to tumors and tissue damage in Drosophila
    Jose Carlos Pastor-Pareja
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06519, USA
    Dis Model Mech 1:144-54; discussion 153. 2008
    ..Our findings reveal common mechanisms in the response to tumors and wounds in flies. A similar innate reaction may underlie the response to tumors and tissue damage in vertebrates and humans...
  13. ncbi Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury
    Herve Agaisse
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Dev Cell 5:441-50. 2003
    ..We show that septic injury triggers the hemocyte-specific expression of upd3, a gene encoding a novel Upd-like cytokine that is necessary for the JAK/STAT-dependent activation of totA in the Drosophila counterpart of the ..
  14. ncbi Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue
    A A Kiger
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Science 294:2542-5. 2001
    ..Hub cells express the ligand Unpaired (Upd), which activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway in ..
  15. ncbi Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl
    Frank W Avila
    Department of Biology, Texas A and M University, 3258 TAMU, College Station, TX 77843, USA
    Curr Biol 17:643-8. 2007
    ..Most XSEs encode transcription factors that bind SxlPe, but the XSE unpaired (upd) encodes a secreted ligand for the JAK/STAT pathway [5-7]...
  16. ncbi Long-range effect of upd, a ligand for Jak/STAT pathway, on cell cycle in Drosophila eye development
    Yu Chen Tsai
    Institute of Genetics, National Yang Ming University, Taipei, Taiwan, Republic of China
    Genesis 39:141-53. 2004
    b>unpaired (upd) encodes a ligand for the Jak/STAT signaling pathway in Drosophila. In the second instar and early third larval eye disc, upd is expressed in the center of the posterior margin...
  17. ncbi JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila
    Laura A Ekas
    Pharmacology Department, New York University School of Medicine, New York, NY 10016 6402, USA
    Development 133:4721-9. 2006
    ..Overexpression of the JAK/STAT activating ligand Unpaired in the eye leads to loss of wg expression and ectopic morphogenetic furrow initiation from the lateral margins...
  18. pmc Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis
    Justin Voog
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 454:1132-6. 2008
    ..These data highlight the dynamic relationship between stem cells and the niche and provide insight into genetic programmes that regulate niche size and function to support normal tissue homeostasis and organ regeneration throughout life...
  19. ncbi The Drosophila ovarian and testis stem cell niches: similar somatic stem cells and signals
    Eva Decotto
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21218, USA
    Dev Cell 9:501-10. 2005
    ..These observations reveal striking similarities in the stem cell niches of male and female gonads, and suggest that they are largely governed by common mechanisms...
  20. ncbi Cloning and expression of Drosophila SOCS36E and its potential regulation by the JAK/STAT pathway
    Peter Karsten
    Department of Molecular Developmental Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Mech Dev 117:343-6. 2002
    ..SOCS36E is expressed in an essentially identical pattern to the Drosophila JAK/STAT pathway ligand unpaired (Upd)...
  21. ncbi The stem-cell niche theory: lessons from flies
    Haifan Lin
    Department of Cell Biology, Box 3709, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Genet 3:931-40. 2002
    ..These findings are illuminating our understanding of the self-renewing mechanisms of tissue stem cells in general...
  22. pmc vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis
    Hans Martin Herz
    University of Heidelberg ZMBH, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Development 133:1871-80. 2006
    ..In summary, the phenotypic analysis of vps25 mutants highlights the importance of receptor downregulation by endosomal protein sorting for appropriate tissue homeostasis, and may serve as a model for human cancer...
  23. ncbi Ken & barbie selectively regulates the expression of a subset of Jak/STAT pathway target genes
    Natalia I Arbouzova
    Department of Molecular Developmental Biology, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Curr Biol 16:80-8. 2006
    ..Ken therefore represents a novel regulator of JAK/STAT signaling whose dynamic spatial and temporal expression is capable of selectively modulating the transcriptional repertoire elicited by activated STAT92E in vivo...
  24. ncbi Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand
    James Castelli Gair Hombria
    Centro Andaluz de Biologia del Desarrollo, CSIC Universidad Pablo de Olavide, Carretera de Utrera, km 1, 41013 Seville, Spain
    Dev Biol 288:420-33. 2005
    ..we describe our analysis of the only invertebrate JAK/STAT pathway ligands identified to date, the Drosophila unpaired-like family...
  25. ncbi Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila
    Barry J Thompson
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Cell 9:711-20. 2005
    ..These results highlight the importance of endocytic trafficking in regulating signaling and epithelial organization and suggest a possible role for ESCRT components in human cancer...
  26. ncbi Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth
    Kenneth H Moberg
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Dev Cell 9:699-710. 2005
    ..This causes increased Notch-mediated signaling and ectopic expression of the Notch target gene unpaired (upd), which encodes the secreted ligand of the JAK-STAT pathway...
  27. ncbi Novel level of signalling control in the JAK/STAT pathway revealed by in situ visualisation of protein-protein interaction during Drosophila development
    Stephen Brown
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Development 130:3077-84. 2003
    ..These results reveal a novel level of JAK/STAT signalling regulation that could also apply to vertebrates...
  28. ncbi The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking
    Thomas Vaccari
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA
    Dev Cell 9:687-98. 2005
    ..Increased Notch activity leads to ectopic production of the mitogenic JAK-STAT pathway ligand Unpaired, which is secreted from mutant cells to induce overproliferation of the surrounding epithelium...
  29. ncbi A novel functional activator of the Drosophila JAK/STAT pathway, unpaired2, is revealed by an in vivo reporter of pathway activation
    M Melissa Gilbert
    Graduate Program in Genetics, Stony Brook University, Stony Brook, NY 11794 5222, USA
    Mech Dev 122:939-48. 2005
    ..sites can be detected throughout embryogenesis, and is responsive to the Janus Kinase hopscotch and the ligand upd. The system has enabled us to identify the effect of a predicted gene related to upd, designated upd2, whose ..
  30. ncbi Stem cells find their niche
    A Spradling
    HHMI Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Nature 414:98-104. 2001
    ..These studies are beginning to unify our understanding of stem cell regulation at the cellular and molecular levels, and promise to advance efforts to use stem cells therapeutically...
  31. ncbi The fertile field of Drosophila Jak/STAT signalling
    James Castelli Gair Hombria
    Department of Zoology, Downing Street, University of Cambridge, CB2 3EJ, Cambridge, UK
    Curr Biol 12:R569-75. 2002
    ..Drosophila's streamlined pathway offers a simple model to find new elements and analyse the function of existing ones...
  32. ncbi The Drosophila homolog of the human tumor suppressor gene BHD interacts with the JAK-STAT and Dpp signaling pathways in regulating male germline stem cell maintenance
    S R Singh
    Mouse Cancer Genetics Program, National Institutes of Health, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Oncogene 25:5933-41. 2006
    ..of DBHD gene activity suppresses the GSC overproliferation phenotype associated with overexpression of either unpaired (upd) or decapentaplegic (dpp)...
  33. pmc Plasticity of Drosophila Stat DNA binding shows an evolutionary basis for Stat transcription factor preferences
    María Luisa Rivas
    Centro Andaluz de Biologia del Desarrollo, CSIC UPO, Universidad Pablo de Olavide, Carretera de Utrera Km 1, 41013 Seville, Spain
    EMBO Rep 9:1114-20. 2008
    ..Our results indicate that the ancestral STAT protein had the capacity to bind to 3n and 4n sites and that specific STAT binding preferences evolved with the radiation of the vertebrate STAT family...
  34. doi Polarized subcellular localization of Jak/STAT components is required for efficient signaling
    Sol Sotillos
    CABD CSIC, Universidad Pablo de Olavide, 41013 Sevilla, Spain
    Curr Biol 18:624-9. 2008
    ..Our results also suggest that receptor polarization in the ectoderm cell membrane restricts the cell's response to ligands provided by neighboring cells...
  35. pmc Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway
    D A Harrison
    Department of Genetics, Boston, Massachusetts 02115 USA
    Genes Dev 12:3252-63. 1998
    ..We have characterized the unpaired (upd) gene, which displays the same distinctive embryonic mutant defects as mutations in the Drosophila JAK (..
  36. ncbi Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless
    S Brown
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom
    Curr Biol 11:1700-5. 2001
    ..This suggests that the vertebrate families evolved from a single ancestral receptor that also gave rise to dome...
  37. ncbi Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling
    N Tulina
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Science 294:2546-9. 2001
    ..The hub specifically expresses Unpaired, a ligand activating the JAK-STAT (Janus kinase-signal transducer and activator of transcription) signaling ..
  38. ncbi The roles of the Drosophila JAK/STAT pathway
    M P Zeidler
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, MA 02115, USA
    Oncogene 19:2598-606. 2000
    ..Oncogene (2000)...
  39. pmc mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family
    Hua Wei Chen
    The Laboratory of Immunobiology, National Institutes of Health, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Genes Dev 16:388-98. 2002
    ..We named this gene master of marelle (mom). Genetic analyses place mom's function between upd (the ligand) and hop...
  40. pmc Polarity determination in the Drosophila eye: a novel role for unpaired and JAK/STAT signaling
    M P Zeidler
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 13:1342-53. 1999
    ..We show that a localized source of the pathway ligand, Unpaired, is present at the midline of the developing eye, which is capable of activating the JAK/STAT pathway over long ..
  41. pmc Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila
    Anna T Chao
    Department of Biology, Duke University, Durham, North Carolina 27708 1000, USA
    Genetics 165:601-12. 2003
    ..Our findings have important implications for assigning null mutant phenotypes and for selecting appropriate alleles to use in suppressor screens...
  42. ncbi Requirement for JAK/STAT signaling throughout border cell migration in Drosophila
    Debra L Silver
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 212052, USA
    Development 132:3483-92. 2005
    ..Together, our findings suggest that the requirement for STAT in border cells extends beyond the initial specification and delamination of cells from the epithelium...
  43. ncbi Opposing roles for Drosophila JAK/STAT signalling during cellular proliferation
    Tina Mukherjee
    Department of Molecular Developmental Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Oncogene 24:2503-11. 2005
    ..Pro- and antiproliferative roles therefore represent ancestral activities conserved through evolution and subsequently assigned to distinct molecules...
  44. ncbi Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila
    D L Silver
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cell 107:831-41. 2001
    ..The ligand for this pathway, Unpaired (UPD), is expressed by two central cells within the migratory cell cluster...
  45. ncbi Coordinated control of cell adhesion, polarity, and cytoskeleton underlies Hox-induced organogenesis in Drosophila
    Bridget Lovegrove
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
    Curr Biol 16:2206-16. 2006
    ..Importantly, very few of the direct Hox targets known are "realizator" genes involved directly in the cellular processes of organogenesis...
  46. ncbi The JAK/STAT pathway and Drosophila development
    H Luo
    The Cardiovascular Research Institute, Division of Molecular Cardiology, The Texas A and M University System Health Science Center, College of Medicine, Temple, Texas 76504, USA
    Bioessays 23:1138-47. 2001
    ..Hence, the JAK/STAT pathway in Drosophila serves as an attractive model for in vivo functional analyses of JAK/STAT signaling...
  47. ncbi JAK signaling is somatically required for follicle cell differentiation in Drosophila
    Jennifer R McGregor
    University of Kentucky, T H Morgan School of Biological Sciences, 101 Morgan Building, Lexington, KY 40506, USA
    Development 129:705-17. 2002
    ..Here we describe several roles for JAK signaling in Drosophila oogenesis. The gene for a JAK pathway ligand, unpaired, is expressed specifically in the polar follicle cells, two pairs of somatic cells at the anterior and posterior ..
  48. ncbi A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium
    Rongwen Xi
    University of Kentucky, Department of Biology, 101 Morgan Building, Lexington, KY 40506, USA
    Dev Cell 4:167-77. 2003
    ..Here we demonstrate that the graded activity of the Janus kinase (JAK) pathway, stimulated by the Unpaired ligand, patterns the anterior-posterior axis of the follicular epithelium...
  49. pmc Loss of the Polycomb group gene polyhomeotic induces non-autonomous cell overproliferation
    Siqian Feng
    Department of Entomology, University of Maryland, 4112 Plant Sciences Building, College Park, Maryland 20742, USA
    EMBO Rep 12:157-63. 2011
    ..We propose that PcG misregulation promotes tumorigenesis through several cellular mechanisms...
  50. pmc The Drosophila BCL6 homolog Ken and Barbie promotes somatic stem cell self-renewal in the testis niche
    Melanie Issigonis
    Department of Cell Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Dev Biol 368:181-92. 2012
    ..Studies of ken may inform our understanding of its vertebrate orthologue B-Cell Lymphoma 6 (BCL6) and how misregulation of this oncogene leads to human lymphomas...
  51. pmc Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants
    Thomas Vaccari
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94702, USA
    J Cell Sci 122:2413-23. 2009
    ....
  52. ncbi The four-jointed gene is required in the Drosophila eye for ommatidial polarity specification
    M P Zeidler
    Department of Genetics, Harvard Medical School, Boston, 02115, USA
    Curr Biol 9:1363-72. 1999
    ..These three pathways are thought to act by setting up a gradient of a signalling molecule (or molecules) often referred to as the 'second signal'. Thus far, no candidate for a second signal has been identified...
  53. ncbi The JAK/STAT pathway regulates proximo-distal patterning in Drosophila
    Aidee Ayala-Camargo
    Pharmacology Department, New York University School of Medicine, New York, New York 10016 6402, USA
    Dev Dyn 236:2721-30. 2007
    ..We also show that the pathway ligand Unpaired is expressed in two domains in leg and antenna that abuts those of wingless and decapentaplegic...
  54. pmc Transformation of eye to antenna by misexpression of a single gene
    Hao A Duong
    Department of Chemistry and Biochemistry, University of California Los Angeles, 607 Charles E Young Drive East, Los Angeles, CA 90095 1569, USA
    Mech Dev 125:130-41. 2008
    ..The finding that this transformation occurs only in the eye disc, and not in other imaginal discs, suggests a close developmental and therefore evolutionary relationship between eyes and antennae...
  55. doi Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT
    Tetsuo Yasugi
    Laboratory of Pattern Formation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    Development 135:1471-80. 2008
    ..Thus, proneural wave precedes and induces transition of NE cells to NBs. Unpaired (Upd), the ligand for the JAK/STAT signaling pathway, is expressed in the most lateral NE cells...
  56. ncbi JAKs and STATs in invertebrate model organisms
    C R Dearolf
    Department of Pediatrics, Massachusetts General Hospital, Boston, USA
    Cell Mol Life Sci 55:1578-84. 1999
    ..Future research utilizing these organisms should continue to provide insights into the roles and regulation of these proteins and their signaling pathways...
  57. ncbi Polarity determination in the Drosophila eye
    H Strutt
    Developmental Genetics Programme, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK
    Curr Opin Genet Dev 9:442-6. 1999
    ..Furthermore, important functions have been elucidated for Notch signalling in specifying the position of the axis of symmetry and then later in development in interpreting gradient information...
  58. doi SOCS36E specifically interferes with Sevenless signaling during Drosophila eye development
    Isabel Almudi
    Departament de Genetica, Facultat de Biologia and Institut de Biomedicina IBUB, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Dev Biol 326:212-23. 2009
    ..The SOCS family of adaptor proteins may have evolved as modulators of specific signaling pathways that contribute to the robustness and precision of cell fate specification...
  59. pmc Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc
    Rachel K Smith-Bolton
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Dev Cell 16:797-809. 2009
    ..This system is conducive to forward genetic screens, enabling an unbiased search for genes that regulate both the extent of and the capacity for regeneration...
  60. ncbi Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the Jak/STAT signal transduction pathway in Drosophila
    Xiu Chen
    Laboratory of Immunobiology, National Institutes of Health, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Dev Cell 4:179-90. 2003
    ..STAT92E regulates gene expression for various biological processes, including the endocycle S phase. These data suggest that Cyclin D-Cdk4 and Cyclin E-Cdk2 play more versatile roles in Drosophila development...
  61. pmc The position and function of the Notch-mediated eye growth organizer: the roles of JAK/STAT and four-jointed
    Francisco Jose Gutierrez-Aviño
    Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas, Universidad Miguel Hernandez, Campus de Sant Joan, Avd Santiago Ramon y Cajal s n Crta Alicante Valencia km 87, Alicante, Apartado 18, E 03550, San Juan de Alicante, Spain
    EMBO Rep 10:1051-8. 2009
    ..selector Iroquois complex defines the position of the organizer at the mid-first instar, and through its ligand, unpaired, the Janus kinase (JAK)/signal transducers and activator of transcription (STAT) pathway is thought to mediate ..
  62. ncbi The function of hairy-related bHLH repressor proteins in cell fate decisions
    A Fisher
    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York, USA
    Bioessays 20:298-306. 1998
    ..This general function in cell fate specification has been conserved from Drosophila to vertebrates and has implications for human disease pathogenesis...
  63. pmc A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling
    Anne Kathrin Classen
    Department of Molecular and Cellular Biology, University of California, Berkeley, California, USA
    Nat Genet 41:1150-5. 2009
    ..is strongly and specifically activated in mutant tissue; activation is driven by transcriptional upregulation of Unpaired (Upd, also known as Outstretched, Os) family ligands...
  64. doi JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage
    Katherine Beebe
    Washington University School of Medicine, Department of Developmental Biology, Campus Box 8103, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 338:28-37. 2010
    ....
  65. pmc Cooperative regulation of the induction of the novel antibacterial Listericin by peptidoglycan recognition protein LE and the JAK-STAT pathway
    Akira Goto
    Graduate School of Pharmaceutical Science, Tohoku University, Sendai 980 8578, Japan
    J Biol Chem 285:15731-8. 2010
    ..Based on these findings, we propose that the Listericin gene encodes a novel antibacterial peptide-like protein whose induction is cooperatively regulated by PGRP-LE and the JAK-STAT pathway...
  66. pmc chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila
    Maria Sol Flaherty
    Pharmacology Department, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 18:556-68. 2010
    ..Like hyperactivated Stat92E, Chinmo misexpression in CySCs is sufficient to maintain GSCs nonautonomously. Chinmo is therefore a key effector of JAK/STAT signaling in a variety of developmental and pathological contexts...
  67. pmc Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila
    Laura A Ekas
    Pharmacology Department, New York University School of Medicine, New York, New York 10016 6402, USA
    Dev Biol 344:621-36. 2010
    ....
  68. ncbi Secretion of Wnt ligands requires Evi, a conserved transmembrane protein
    Kerstin Bartscherer
    German Cancer Research Center, Boveri Group Signaling and Functional Genomics, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cell 125:523-33. 2006
    ..Our results show that Wg is retained by evi mutant cells and suggest that evi is the founding member of a gene family specifically required for Wg/Wnt secretion...
  69. ncbi Embryo morphogenesis: getting down to cells and molecules
    Lila Solnica-Krezel
    Vanderbilt University, VU Station B 351634, Nashville, TN 37235 1634, USA
    Development 130:4229-33. 2003
  70. pmc Biological functions of the ISWI chromatin remodeling complex NURF
    Paul Badenhorst
    Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda Maryland 20892 4255, USA
    Genes Dev 16:3186-98. 2002
    ..Finally, mutants in NURF subunits exhibit neoplastic transformation of larval blood cells that causes melanotic tumors to form...
  71. ncbi A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila
    Isabel L Torres
    The Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Dev Cell 5:547-58. 2003
    ..The anterior-posterior axis is therefore established by a relay mechanism, which propagates polarity from one cyst to the next...
  72. pmc Genetic analysis of the aberrant behavior of an X-chromosome duplication in the germ line of Drosophila melanogaster males
    S J Gabay
    Genetics 65:249-65. 1970
  73. ncbi JAK/STAT signalling in Drosophila controls cell motility during germ cell migration
    Stephen Brown
    Faculty of Life Sciences, University of Manchester, C 1247 Michael Smith Building, Oxford Road, Manchester M13 9PT, U K
    Dev Dyn 235:958-66. 2006
    ..Interestingly, activation of the JAK/STAT pathway is required for these filopodia to form, and ectopic JAK/STAT activation enhances their formation...
  74. ncbi Organizer activity of the polar cells during Drosophila oogenesis
    Muriel Grammont
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway NJ 08854, USA
    Development 129:5131-40. 2002
    ..The origin of asymmetry during Drosophila development can thus be traced back to the specification of the polar cells during early oogenesis...
  75. pmc Coactivation of STAT and Ras is required for germ cell proliferation and invasive migration in Drosophila
    Jinghong Li
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Dev Cell 5:787-98. 2003
    ..A requirement for RTK in Drosophila PGC development is analogous to the mouse, in which the RTK c-kit is required, suggesting a conserved molecular mechanism governing PGC behavior in flies and mammals...
  76. ncbi Cooperation of JAK/STAT and Notch signaling in the Drosophila foregut
    Frank Josten
    Universitat Bonn, Institut für Molekulare Physiologie und Entwicklungsbiologie, Abteilung für molekulare Entwicklungsbiologie, D 53115 Bonn, Germany
    Dev Biol 267:181-9. 2004
    ..Whereas the JAK/STAT receptor is expressed in all proventricular precursor cells, expression of upd encoding its ligand and of STAT92E, the signal transducer of the pathway, is locally restricted to cells that ..
  77. ncbi The roles of JAK/STAT signaling in Drosophila immune responses
    Herve Agaisse
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Immunol Rev 198:72-82. 2004
    ....
  78. ncbi A cytokine in the Drosophila stress response
    Dan Hultmark
    Umea Centre for Molecular Pathogenesis, Umea University, S 901 87, Umea, Sweden
    Dev Cell 5:360-1. 2003
    ..However, in this issue of Developmental Cell, show that cytokines do play a role in mediating an acute phase response in this organism...
  79. ncbi Expression of COPI components during development of Drosophila melanogaster
    Nicole C Grieder
    Biozentrum der Universitat Basel, Abteilung Zellbiologie, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Gene Expr Patterns 6:11-21. 2005
    ....
  80. ncbi A Drosophila derailed homolog, doughnut, expressed in invaginating cells during embryogenesis
    S Savant-Bhonsale
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Gene 231:155-61. 1999
    ..Many aspects of the expression pattern resembled that of unpaired, a gene that encodes a secreted protein that stimulates the Drosophila JAK/STAT signaling pathway...
  81. ncbi Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes
    S DiNardo
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143
    Genes Dev 1:1212-25. 1987
    ....
  82. ncbi The Drm-Bowl-Lin relief-of-repression hierarchy controls fore- and hindgut patterning and morphogenesis
    Katherine A Johansen
    Department of Molecular, Cell, and Developmental Biology, University of California, Box 160606, Los Angeles, CA 90095 1606, USA
    Mech Dev 120:1139-51. 2003
    ..then acts to promote spatially localized expression of genes (particularly the JAK/STAT pathway ligand encoded by upd) that control fore- and hindgut morphogenesis...
  83. ncbi Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye
    Ju Lan Chao
    Institute of Genetics, National Yang Ming University, Taipei 111, Taiwan, Republic of China
    Development 131:3839-47. 2004
    ..In addition, we showed that N and eyg could induce expression of upd, which encodes the ligand for the Jak/STAT pathway and acts over long distance to promote cell proliferation...
  84. ncbi Dynamics of the basement membrane in invasive epithelial clusters in Drosophila
    Caroline Medioni
    Institute of Signaling, Developmental Biology and Cancer, UMR 6543 CNRS, University of Nice Sophia Antipolis, Parc Valrose, 06108 Nice, Cedex 2, France
    Development 132:3069-77. 2005
    ..The dynamics of the BM represents a marker of migratory BC, revealing a novel developmentally regulated behaviour of BM coupled to epithelial cell invasiveness...
  85. ncbi Drumstick is a zinc finger protein that antagonizes Lines to control patterning and morphogenesis of the Drosophila hindgut
    Ryan B Green
    Molecular Biology Institute, UCLA, Los Angeles, CA 90095 1606, USA
    Development 129:3645-56. 2002
    ..We have thus defined a pathway in which a spatially localized zinc finger protein antagonizes a globally expressed protein, thereby leading to specification of a domain (the small intestine) necessary for oriented cell rearrangement...
  86. ncbi Molecular control of spermatogonial stem cell self-renewal by glycoprotein unpaired, a cytokine homolog, in Drosophila melanogaster
    N M Tulina
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul Vavilova 32, Moscow, 117984 Russia
    Dokl Biol Sci 388:79-82. 2003
  87. ncbi The control of sexual identity in the Drosophila germline
    Abbie Casper
    Department of Biology, 302 Mudd Hall, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Development 133:2783-91. 2006
    ..Here, we explore how sexual identity is established in the Drosophila germline, how this affects other aspects of germ cell development and what studies in Drosophila can teach us about mammalian germ cells...
  88. ncbi Signaling meets chromatin during tissue regeneration in Drosophila
    Cédric Maurange
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Curr Opin Genet Dev 16:485-9. 2006
    ..Understanding how signaling pathways can integrate to switch determined cells into multipotent cells has a great medical potential, especially in the field of tissue engineering and remodeling...
  89. pmc Genetic analysis of the Shaker gene complex of Drosophila melanogaster
    A Ferrus
    Instituto Cajal, CSIC, Madrid, Spain
    Genetics 125:383-98. 1990
    ..We discuss the relationship between the genetic organization of ShC and the functional coupling of potassium currents with the other functions encoded in the complex...
  90. ncbi Development. Staying a boy forever
    S A Wasserman
    Center for Molecular Genetics, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093 0634, USA
    Science 294:2495-7. 2001
  91. ncbi Sex determination: co-opted signals determine gender
    M P Zeidler
    Hughes Medical Institute, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Curr Biol 10:R682-4. 2000
    The Drosophila JAK-STAT pathway and its ligand Unpaired are required for a wide range of developmental processes...
  92. ncbi The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster
    T M Jinks
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Mol Cell 5:581-7. 2000
    ..GOF activity requires the X-linked unpaired (upd) gene, which encodes a ligand for the Drosophila JAK/STAT signaling pathway...
  93. ncbi Localized JAK/STAT signaling is required for oriented cell rearrangement in a tubular epithelium
    Katherine A Johansen
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095 1606, USA
    Development 130:135-45. 2003
    ..The difference in effect between localized expression of ligand (Unpaired) and dominant active JAK (Hopscotch) demonstrates that the ligand plays a cell non-autonomous role in hindgut ..
  94. ncbi Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis
    Hong Wang
    The Laboratory of Immunobiology, National Institutes of Health National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Dev Cell 10:117-26. 2006
    ..of 12 nondividing somatic cells, called the hub, identifies the stem cell niche by producing the growth factor Unpaired (Upd)...
  95. ncbi An extracellular activator of the Drosophila JAK/STAT pathway is a sex-determination signal element
    L Sefton
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3204, USA
    Nature 405:970-3. 2000
    ..activator of transcription' (STAT) signal transduction pathway and is allelic to outstretched (os, also called unpaired)...
  96. ncbi STAT signalling in cell proliferation and in development
    J G Williams
    Department of Anatomy and Physiology, University of Dundee, Wellcome Trust Building Complex, Dow Street, DD1 5EH, Dundee, UK
    Curr Opin Genet Dev 10:503-7. 2000
    ..Two different ways in which STAT signalling pathways can interface with Smad signalling pathways significantly increasing combinatorial signalling possibilities, have also been described...
  97. pmc The evolution of the Drosophila sex-determination pathway
    Andrew Pomiankowski
    Department of Biology, University College, London NW1 2HE, United Kingdom
    Genetics 166:1761-73. 2004
    ..Our hypothesis is built on the available data from Drosophila and other insect species, and we point out where it is amenable to further experimental and comparative tests...
  98. ncbi Eye development: Notch lends a handedness
    S S Blair
    Department of Zoology, University of Wisconsin, 250 N Mills Street, Madison, Wisconsin 53706, USA
    Curr Biol 9:R356-60. 1999
    ..Notch signalling helps determine this handedness, first by establishing a signalling center at the eye equator, and second by mediating a choice between two photoreceptor fates..
  99. pmc Genetic analysis of contributions of dorsal group and JAK-Stat92E pathway genes to larval hemocyte concentration and the egg encapsulation response in Drosophila
    Richard Paul Sorrentino
    Department of Biology, City College and Graduate School and University Center of the City University of New York, New York, New York 10031, USA
    Genetics 166:1343-56. 2004
    ....

Research Grants32

  1. Control of tissue growth and architecture by Drosophila Tsg101
    KENNETH MOBERG; Fiscal Year: 2007
    ..one is a non-cell autonomous pathway involving ectopic activation of the Notch receptor and expression of unpaired, the secreted ligand of the Jak-STAT pathway; the second involves the Crumbs protein, an established component of ..
  2. Physiological regulation and function of asymmetric stem cell division
    Yukiko Yamashita; Fiscal Year: 2009
    ..Understanding of such mechanisms may allow us to manipulate stem cell behavior; for example, normal stem cells can be expanded in culture for transplantation, or we can inhibit the expansion of cancerous stem cells. ..
  3. Role of the Archipelago gene in Drosophila tracheal morphogenesis
    KENNETH MOBERG; Fiscal Year: 2009
    ..Thus, we hypothesize that ago plays an important role in the homeostatic mechanisms that restrain tracheal branching. Our goal in Specific Aim 3 is to define this role and elucidate its molecular basis. ..
  4. Control of tissue growth and architecture by Drosophila Tsg101
    KENNETH MOBERG; Fiscal Year: 2009
    ..one is a non-cell autonomous pathway involving ectopic activation of the Notch receptor and expression of unpaired, the secreted ligand of the Jak-STAT pathway; the second involves the Crumbs protein, an established component of ..
  5. Physiological regulation and function of asymmetric stem cell division
    Yukiko Yamashita; Fiscal Year: 2010
    ..Understanding of such mechanisms may allow us to manipulate stem cell behavior;for example, normal stem cells can be expanded in culture for transplantation, or we can inhibit the expansion of cancerous stem cells. ..
  6. Role of the Archipelago gene in Drosophila tracheal morphogenesis
    Kenneth H Moberg; Fiscal Year: 2010
    ..Thus, we hypothesize that ago plays an important role in the homeostatic mechanisms that restrain tracheal branching. Our goal in Specific Aim 3 is to define this role and elucidate its molecular basis. ..
  7. Structure and Function of Drosophila NF-kappaB Signaling Pathways
    STEVEN ALEXANDER WASSERMAN; Fiscal Year: 2010
    ..By studying the mechanism and regulation of such response pathways, we will therefore obtain knowledge of broad and substantial significance to human health. ..
  8. Physiological regulation and function of asymmetric stem cell division
    Yukiko Yamashita; Fiscal Year: 2009
    ..Understanding of such mechanisms may allow us to manipulate stem cell behavior; for example, normal stem cells can be expanded in culture for transplantation, or we can inhibit the expansion of cancerous stem cells. ..
  9. Control of tissue growth and architecture by Drosophila Tsg101
    Kenneth H Moberg; Fiscal Year: 2010
    ..one is a non-cell autonomous pathway involving ectopic activation of the Notch receptor and expression of unpaired, the secreted ligand of the Jak-STAT pathway;the second involves the Crumbs protein, an established component of ..
  10. Structure and Function of Drosophila NF-kappaB Signaling Pathways
    Steven Wasserman; Fiscal Year: 2009
    ..By studying the mechanism and regulation of such response pathways, we will therefore obtain knowledge of broad and substantial significance to human health. ..
  11. Role of the Archipelago gene in Drosophila tracheal morphogenesis
    KENNETH MOBERG; Fiscal Year: 2007
    ..Thus, we hypothesize that ago plays an important role in the homeostatic mechanisms that restrain tracheal branching. Our goal in Specific Aim 3 is to define this role and elucidate its molecular basis. ..
  12. PHOSPHORYLATION IN A DEVELOPMENTAL SIGNALING PATHWAY
    Steven Wasserman; Fiscal Year: 2001
    ....
  13. Signaling Mechanisms of the Drosophila JAK/STAT Pathway
    Hong Luo; Fiscal Year: 2003
    ..abstract_text> ..
  14. Technique to Obtain Intra-Locus Deletions in Eukaryotes
    Charles Dearolf; Fiscal Year: 2003
    ..However, this research could have a very high impact, providing a method to generate deletion mutations in any gene or chromosomal region for a wide range of organisms. ..
  15. A Novel Mutagenesis Technology for Drosophila
    Charles Dearolf; Fiscal Year: 2003
    ..It will also allow the recovery of mutations without any selection based upon phenotype. Finally, this technology should ultimately be applicable to other model genetic organisms as well as to Drosophila. ..
  16. REGULATION OF MEIOSIS IN SPERMATOGENESIS
    Steven Wasserman; Fiscal Year: 2003
    ..abstract_text> ..
  17. PHOSPHORYLATION IN A DEVELOPMENT SIGNALING PATHWAY
    Steven Wasserman; Fiscal Year: 2006
    ..Given the conserved nature of the signaling pathway, the results of the proposed research should be of substantial interest with regard to signal transduction and innate immunity in a broad range of organisms. ..
  18. Physiological regulation and function of asymmetric stem cell division
    Yukiko Yamashita; Fiscal Year: 2011
    ..Understanding of such mechanisms may allow us to manipulate stem cell behavior;for example, normal stem cells can be expanded in culture for transplantation, or we can inhibit the expansion of cancerous stem cells. ..