Orc3

Summary

Gene Symbol: Orc3
Description: Origin recognition complex subunit 3
Alias: CG4088, DmORC3, DmOrc3, Dmel\CG4088, LAT, ORC, ORC3, l(2)49Fd, l(2)vr6, lat, latheo, orc3, vr-6, vr6, origin recognition complex subunit 3, CG4088-PA, CG4088-PB, Orc3-PA, Orc3-PB, latheo
Species: fruit fly

Top Publications

  1. Lasko P, Pardue M. Studies of the genetic organization of the vestigial microregion of Drosophila melanogaster. Genetics. 1988;120:495-502 pubmed
    ..The distal breakpoints of twelve of 20 deficiencies overlapping Df(2R)vgB are genetically identical to that of Df(2R)vgD, coinciding with the position of a complex, pleiotropic locus, l(2)49Ea-Psc-Su(z)2. ..
  2. Duronio R, Bonnette P, O Farrell P. Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition. Mol Cell Biol. 1998;18:141-51 pubmed
  3. DiAntonio A. Learning something ORIGINal at the Drosophila neuromuscular junction. Neuron. 1999;23:1-2 pubmed
  4. Pak D, Pflumm M, Chesnokov I, Huang D, Kellum R, Marr J, et al. Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes. Cell. 1997;91:311-23 pubmed
    The origin recognition complex (ORC) is required to initiate eukaryotic DNA replication and also engages in transcriptional silencing in S. cerevisiae...
  5. Clarey M, Erzberger J, Grob P, Leschziner A, Berger J, Nogales E, et al. Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nat Struct Mol Biol. 2006;13:684-90 pubmed
    ..EM reconstructions of the Drosophila melanogaster origin recognition complex (ORC) reveal nucleotide-dependent conformational changes in the core of the complex...
  6. Chesnokov I, Gossen M, Remus D, Botchan M. Assembly of functionally active Drosophila origin recognition complex from recombinant proteins. Genes Dev. 1999;13:1289-96 pubmed
    ..DNA replication are believed to be determined in part by the binding of a heteromeric origin recognition complex (ORC) to DNA. We have cloned the genes encoding the subunits of the Drosophila ORC...
  7. Badugu R, Shareef M, Kellum R. Novel Drosophila heterochromatin protein 1 (HP1)/origin recognition complex-associated protein (HOAP) repeat motif in HP1/HOAP interactions and chromocenter associations. J Biol Chem. 2003;278:34491-8 pubmed
    ..was identified as a component of a multiprotein complex of HP1 containing Drosophila origin recognition complex (ORC) subunits in the early Drosophila embryo...
  8. Vorobyeva N, Mazina M, Golovnin A, Kopytova D, Gurskiy D, Nabirochkina E, et al. Insulator protein Su(Hw) recruits SAGA and Brahma complexes and constitutes part of Origin Recognition Complex-binding sites in the Drosophila genome. Nucleic Acids Res. 2013;41:5717-30 pubmed publisher
    ..data on the properties of replication origins, molecular mechanisms underlying origin recognition complex (ORC) positioning in the genome are still poorly understood...
  9. de Belle J. Drosophila mushroom body subdomains: innate or learned representations of odor preference and sexual orientation?. Neuron. 1995;15:245-7 pubmed

More Information

Publications46

  1. van Swinderen B. Attention-like processes in Drosophila require short-term memory genes. Science. 2007;315:1590-3 pubmed
    ..These processes were modulated by genes involved in short-term memory formation, namely dunce and rutabaga. Attention defects in these mutants were associated with distinct optomotor effects in behavioral assays. ..
  2. Mehren J, Ejima A, Griffith L. Unconventional sex: fresh approaches to courtship learning. Curr Opin Neurobiol. 2004;14:745-50 pubmed
    ..Advances in transgenic tools and developments in behavioral assays have increased the power of studying courtship learning in the fruit fly. ..
  3. Morley K, Montgomery G. The genetics of cognitive processes: candidate genes in humans and animals. Behav Genet. 2001;31:511-31 pubmed
    ..This survey confirms that many genes are associated with cognitive variation and highlights the potential importance of animal models in the study of human cognition. ..
  4. Belvin M, Yin J. Drosophila learning and memory: recent progress and new approaches. Bioessays. 1997;19:1083-9 pubmed
  5. Pflumm M, Botchan M. Orc mutants arrest in metaphase with abnormally condensed chromosomes. Development. 2001;128:1697-707 pubmed
    The origin recognition complex (ORC) is a six subunit complex required for eukaryotic DNA replication initiation and for silencing of the heterochromatic mating type loci in Saccharomyces cerevisiae...
  6. Park S, Asano M. The origin recognition complex is dispensable for endoreplication in Drosophila. Proc Natl Acad Sci U S A. 2008;105:12343-8 pubmed publisher
    The origin recognition complex (ORC) is an essential component of the prereplication complex (pre-RC) in mitotic cell cycles. The role of ORC as a foundation to assemble the pre-RC is conserved from yeast to human...
  7. Wu C, Howe M. A genetic analysis of the Suppressor 2 of zeste complex of Drosophila melanogaster. Genetics. 1995;140:139-81 pubmed
    ..Psc is a member of the homeotic Polycomb group of genes. A general discussion of the Polycomb and trithorax group of genes, position-effect variegation, transvection, chromosome pairing and chromatin structure is presented...
  8. Bleichert F, Botchan M, Berger J. Crystal structure of the eukaryotic origin recognition complex. Nature. 2015;519:321-6 pubmed publisher
    ..In eukaryotes, the heterohexameric origin recognition complex (ORC) is essential for coordinating replication onset. Here we describe the crystal structure of Drosophila ORC at 3...
  9. Tully T, Boynton S, Brandes C, Dura J, Mihalek R, Preat T, et al. Genetic dissection of memory formation in Drosophila melanogaster. Cold Spring Harb Symp Quant Biol. 1990;55:203-11 pubmed
  10. Ashburner M, Ball C, Blake J, Botstein D, Butler H, Cherry J, et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 2000;25:25-9 pubmed
  11. Waddell S, Quinn W. What can we teach Drosophila? What can they teach us?. Trends Genet. 2001;17:719-26 pubmed
  12. Tamura T, Chiang A, Ito N, Liu H, Horiuchi J, Tully T, et al. Aging specifically impairs amnesiac-dependent memory in Drosophila. Neuron. 2003;40:1003-11 pubmed
    ..The absence of AMI in amn flies is restored by expression of an amn transgene predominantly in DPM cells. Thus, we propose that AMI in flies results from a specific decrease in amn-dependent MTM. ..
  13. Badugu R, Yoo Y, Singh P, Kellum R. Mutations in the heterochromatin protein 1 (HP1) hinge domain affect HP1 protein interactions and chromosomal distribution. Chromosoma. 2005;113:370-84 pubmed
    ..Hypo-phosphorylated HP1 is associated with the DNA-binding activities of the origin recognition complex (ORC) and an HMG-like HP1/ORC-Associated Protein (HOAP)...
  14. Ostrowski D, Kahsai L, Kramer E, Knutson P, Zars T. Place memory retention in Drosophila. Neurobiol Learn Mem. 2015;123:217-24 pubmed publisher
    ..The role of the rutabaga type I adenylyl cyclase was confirmed, and the latheo Orc3 origin of recognition complex component, the novel gene encoded by pastrel, and the small GTPase rac were all ..
  15. Boynton S, Tully T. latheo, a new gene involved in associative learning and memory in Drosophila melanogaster, identified from P element mutagenesis. Genetics. 1992;131:655-72 pubmed
    ..lethal alleles, produced by excision of the latheoP1 insert or by EMS or gamma-rays, in the 49F region mapped the latheo mutation to one vital complementation group...
  16. Kopytova D, Popova V, Kurshakova M, Shidlovskii Y, Nabirochkina E, Brechalov A, et al. ORC interacts with THSC/TREX-2 and its subunits promote Nxf1 association with mRNP and mRNA export in Drosophila. Nucleic Acids Res. 2016;44:4920-33 pubmed publisher
    ..The knockdown of Orc5 led to a drop in the Nxf1 association with mRNP, while Orc3 knockdown increased the level of mRNP-bound Nxf1...
  17. Pflugfelder G. Genetic lesions in Drosophila behavioural mutants. Behav Brain Res. 1998;95:3-15 pubmed
    ..Various mutagens are reviewed as to their suitability in inducing selective regulatory mutations. ..
  18. Davis R. Mushroom bodies and Drosophila learning. Neuron. 1993;11:1-14 pubmed
  19. Li Y, Kirschmann D, Wallrath L. Does heterochromatin protein 1 always follow code?. Proc Natl Acad Sci U S A. 2002;99 Suppl 4:16462-9 pubmed
    ..Such sequences are likely to include HP1 "target genes" whose discovery will aid in our understanding of HP1 lethality in Drosophila and metastasis of breast cancer cells. ..
  20. Tully T. Discovery of genes involved with learning and memory: an experimental synthesis of Hirschian and Benzerian perspectives. Proc Natl Acad Sci U S A. 1996;93:13460-7 pubmed
    ..In addition, more specific conclusions will be obtained from reverse-genetic experiments, in which gene disruptions are restricted in time and/or space. ..
  21. Bleichert F, Balasov M, Chesnokov I, Nogales E, Botchan M, Berger J. A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation. elife. 2013;2:e00882 pubmed publisher
    ..ORC; biochemical studies reveal that this region of Orc6 associates with a previously uncharacterized domain of Orc3 and is required for ORC function and MCM2-7 loading in vivo...
  22. Guo H, Zhong Y. Requirement of Akt to mediate long-term synaptic depression in Drosophila. J Neurosci. 2006;26:4004-14 pubmed
  23. Wakimoto B. Beyond the nucleosome: epigenetic aspects of position-effect variegation in Drosophila. Cell. 1998;93:321-4 pubmed
  24. Tully T, Preat T, Boynton S, del Vecchio M. Genetic dissection of consolidated memory in Drosophila. Cell. 1994;79:35-47 pubmed
    ..LTM showed no appreciable decay over 7 days, was sensitive to CXM, and was not disrupted by the radish mutation. ..
  25. Seugnet L, Suzuki Y, Stidd R, Shaw P. Aversive phototaxic suppression: evaluation of a short-term memory assay in Drosophila melanogaster. Genes Brain Behav. 2009;8:377-89 pubmed publisher
    ..These data indicate that APS is a simple and effective assay that can be used to evaluate fly models of human conditions associated with cognitive deficits. ..
  26. Rohrbough J, Pinto S, Mihalek R, Tully T, Broadie K. latheo, a Drosophila gene involved in learning, regulates functional synaptic plasticity. Neuron. 1999;23:55-70 pubmed
    Mutations in the latheo (lat) gene disrupt associative learning in Drosophila , but a role for LAT in regulating neuronal function has not been demonstrated...
  27. Dubnau J, Chiang A, Tully T. Neural substrates of memory: from synapse to system. J Neurobiol. 2003;54:238-53 pubmed
    ..Our objective here is to offer a conceptually unifying perspective and to discuss this perspective in relation to an experiment analysis of memory in Drosophila. ..
  28. Dubnau J, Tully T. Gene discovery in Drosophila: new insights for learning and memory. Annu Rev Neurosci. 1998;21:407-44 pubmed
    ..Second, because core cellular mechanisms of simple forms of learning are evolutionarily conserved, biological pathways discovered in invertebrates are likely to be conserved in vertebrate systems as well. ..
  29. Pinto S, Quintana D, Smith P, Mihalek R, Hou Z, Boynton S, et al. latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant. Neuron. 1999;23:45-54 pubmed
    The Drosophila latheo (lat) gene was identified in a behavioral screen for olfactory memory mutants. The original hypomorphic latP1 mutant (Boynton and Tully, 1992) shows a structural defect in adult brain...
  30. Davis R. Physiology and biochemistry of Drosophila learning mutants. Physiol Rev. 1996;76:299-317 pubmed
    ..An appendix describing the currently used paradigms to test Drosophila behavior is included...
  31. Hao X, Alphey L, Bandara L, Lam E, Glover D, La Thangue N. Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster. J Cell Sci. 1995;108 ( Pt 9):2945-54 pubmed
    ..The distinct expression patterns of DmDP and DmE2F-1 suggest that the formation of DP/E2F heterodimers, and hence DRTF1/E2F, is subject to complex regulatory cues. ..
  32. Renn S, Tomkinson B, Taghert P. Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster. J Biol Chem. 1998;273:19173-82 pubmed
    ..Recombinant dTPP II displays the predicted activity following expression in HEK cells. TPP II maps to cytological position 49F4-7; animals deficient for this interval show reduced TPP II activity. ..
  33. Maqbool S, Mehrotra S, Kolpakas A, Durden C, Zhang B, Zhong H, et al. Dampened activity of E2F1-DP and Myb-MuvB transcription factors in Drosophila endocycling cells. J Cell Sci. 2010;123:4095-106 pubmed publisher
    ..Our data suggest that dampened transcriptional activation by E2F1-DP and Myb-MuvB is important to repress mitosis and coordinate the endocycle transcriptional and protein stability oscillators. ..
  34. Bielinsky A, Blitzblau H, Beall E, Ezrokhi M, Smith H, Botchan M, et al. Origin recognition complex binding to a metazoan replication origin. Curr Biol. 2001;11:1427-31 pubmed
    ..initiation of DNA replication in eukaryotic cells at the onset of S phase requires the origin recognition complex (ORC) [1]. This six-subunit complex, first isolated in Saccharomyces cerevisiae [2], is evolutionarily conserved [1]...
  35. Tully T, Bolwig G, Christensen J, Connolly J, Delvecchio M, DeZazzo J, et al. A return to genetic dissection of memory in Drosophila. Cold Spring Harb Symp Quant Biol. 1996;61:207-18 pubmed
  36. Greenspan R. Flies, genes, learning, and memory. Neuron. 1995;15:747-50 pubmed
  37. Roman G, Davis R. Molecular biology and anatomy of Drosophila olfactory associative learning. Bioessays. 2001;23:571-81 pubmed
    ..In this review, we discuss the nature of the behavioral tasks, the molecules, and the neuronal circuits involved in olfactory learning in Drosophila. ..