Gene Symbol: Or59a
Description: Odorant receptor 59a
Alias: 59D.1, 59a, AN6, CG9820, DOR46, DOR59D.1, Dmel\CG9820, Or46, Or59D.1, dor46, odorant receptor 59a, CG9820-PA, Or59a-PA, olfactory receptor 59D.1
Species: fruit fly
Masuda Nakagawa L, Gendre N, O Kane C, Stocker R. Localized olfactory representation in mushroom bodies of Drosophila larvae. Proc Natl Acad Sci U S A. 2009;106:10314-9 pubmed publisher
..Stereotypic representation of single OSN input in calyx glomeruli provides a mechanism for MB neurons to detect and discriminate olfactory cues. ..
Guo S, Kim J. Dissecting the molecular mechanism of drosophila odorant receptors through activity modeling and comparative analysis. Proteins. 2010;78:381-99 pubmed publisher
..Twelve mainly polar or charged key residues, both SDRs and conserved, are located in this pocket and postulated to distinguish docked odorants via primarily geometry fitting and hydrogen-bond interaction. ..
MONTAGUE S, Mathew D, Carlson J. Similar odorants elicit different behavioral and physiological responses, some supersustained. J Neurosci. 2011;31:7891-9 pubmed publisher
..responses they elicit from the Or repertoire, with most strong responses deriving from two receptors, Or33b and Or59a. Surprisingly, 2-ethylpyrazine and 2-methylpyrazine, which elicit strikingly similar physiological responses ..
Giardina T, Beavis A, Clark A, Fiumera A. Female influence on pre- and post-copulatory sexual selection and its genetic basis in Drosophila melanogaster. Mol Ecol. 2011;20:4098-108 pubmed publisher
..05. Several other associations, including those impacting both fertility and female remating rate suggest that sperm storage might be an important factor mitigating female influence on sexual selection. ..
Clyne P, Warr C, Freeman M, Lessing D, Kim J, Carlson J. A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila. Neuron. 1999;22:327-38 pubmed
..Some of the genes are not expressed in a mutant of the Acj6 POU-domain transcription factor, a mutant in which a subset of ORNs show abnormal odorant specificities. ..
Vosshall L, Amrein H, Morozov P, Rzhetsky A, Axel R. A spatial map of olfactory receptor expression in the Drosophila antenna. Cell. 1999;96:725-36 pubmed
..The isolation of candidate odorant receptor genes along with a genetic analysis of olfactory-driven behavior in insects may ultimately afford a system to understand the mechanistic link between odor recognition and behavior. ..
Gao Q, Chess A. Identification of candidate Drosophila olfactory receptors from genomic DNA sequence. Genomics. 1999;60:31-9 pubmed
..Moreover, the powerful genetic manipulations available in Drosophila, when combined with electrophysiological and behavioral analyses, make this an attractive model system in which to study olfactory discrimination. ..
Hoare D, Humble J, Jin D, Gilding N, Petersen R, Cobb M, et al
. Modeling peripheral olfactory coding in Drosophila larvae. PLoS ONE. 2011;6:e22996 pubmed publisher
..We conclude that our model of the peripheral code represents basic features of odor detection and discrimination, yielding insights into the information available to higher processing structures in the brain. ..
Mathew D, Martelli C, Kelley Swift E, Brusalis C, Gershow M, Samuel A, et al
. Functional diversity among sensory receptors in a Drosophila olfactory circuit. Proc Natl Acad Sci U S A. 2013;110:E2134-43 pubmed publisher
..Some odorants elicited strong physiological responses but weak behavioral responses or weak physiological responses but strong behavioral responses. ..