Gene Symbol: or
Description: orange
Alias: AP-3sigma, CG3029, Dmel\CG3029, aps3, cg3029, sigma3, orange, CG3029-PA, adaptor protein complex 3, sigma subunit, or-PA
Species: fruit fly
Products:     or

Top Publications

  1. Spritz R. Multi-organellar disorders of pigmentation: intracellular traffic jams in mammals, flies and yeast. Trends Genet. 1999;15:337-40 pubmed
    ..Recent discoveries show that several of these mutations directly affect components in the pathway of organelle-specific protein trafficking, and provide new insights into the relationships of these pathways in mammals, flies and yeast. ..
  2. Gridley T, Gray D, Orr Weaver T, Soriano P, Barton D, Francke U, et al. Molecular analysis of the Mov 34 mutation: transcript disrupted by proviral integration in mice is conserved in Drosophila. Development. 1990;109:235-42 pubmed
    ..In situ hybridization to Drosophila polytene chromosomes localizes the Drosophila homolog to 60B,C on chromosome 2. Several Drosophila lethal mutations also map to this region. ..
  3. Lloyd V, Ramaswami M, Kramer H. Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery. Trends Cell Biol. 1998;8:257-9 pubmed
    ..Thus, classical work describing more than 85 eye-colour mutations and their genetic interactions offers a remarkable, untapped resource for the genetic analysis of protein delivery to lysosomes. ..
  4. Boehm M, Bonifacino J. Genetic analyses of adaptin function from yeast to mammals. Gene. 2002;286:175-86 pubmed
    ..Here, we review recent progress in the genetic analysis of the function of AP complexes, focusing on studies that make use of targeted interference or naturally-occurring mutations in various model organisms.
  5. Cherry S, Perrimon N. Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis. Nat Immunol. 2004;5:81-7 pubmed
    ..Thus, this virus model provides a sensitive and efficient approach for identifying components required for pathogenesis. ..
  6. Tearle R. Tissue specific effects of ommochrome pathway mutations in Drosophila melanogaster. Genet Res. 1991;57:257-66 pubmed
    ..Two mutations affecting the red eye pigments (drosopterins), bw and mal, do not substantially perturb brown pigment synthesis in any of the four organs. ..
  7. Shaik K, Meyer F, Vázquez A, Flötenmeyer M, Cerdán M, Moussian B. δ-Aminolevulinate synthase is required for apical transcellular barrier formation in the skin of the Drosophila larva. Eur J Cell Biol. 2012;91:204-15 pubmed publisher
    ..We conclude that at least two modules--an apical protein-chitin lattice and the lateral septate junctions, act in parallel to ensure Drosophila skin impermeability. ..
  8. Wang X, Reynolds E, Deak P, Hall L. The seizure locus encodes the Drosophila homolog of the HERG potassium channel. J Neurosci. 1997;17:882-90 pubmed
    ..This rescue decays with a t1/2 of approximately 1-1.5 d after gene induction is discontinued, providing the first estimate of ion channel stability in an intact, multicellular animal. ..
  9. Dell Angelica E, Mullins C, Caplan S, Bonifacino J. Lysosome-related organelles. FASEB J. 2000;14:1265-78 pubmed

More Information


  1. Mullins C, Hartnell L, Bonifacino J. Distinct requirements for the AP-3 adaptor complex in pigment granule and synaptic vesicle biogenesis in Drosophila melanogaster. Mol Gen Genet. 2000;263:1003-14 pubmed
    ..We report that the Drosophila pigmentation mutants orange and ruby carry genetic lesions in the sigma3 and beta3-adaptin subunits of the AP-3 complex, respectively...
  2. Mullins C, Bonifacino J. The molecular machinery for lysosome biogenesis. Bioessays. 2001;23:333-43 pubmed
    ..Other recently identified components, however, appear to be unique to higher eukaryotes. BioEssays 23:333-343, 2001. Published 2001 John Wiley & Sons, Inc. ..
  3. Falcon Perez J, Romero Calderon R, Brooks E, Krantz D, Dell Angelica E. The Drosophila pigmentation gene pink (p) encodes a homologue of human Hermansky-Pudlak syndrome 5 (HPS5). Traffic. 2007;8:154-68 pubmed
    ..The phenotype of pink mutants was exacerbated by mutations in AP-3 subunits or in the orthologs of VPS33A and Rab38. These results validate D...
  4. Boehm M, Bonifacino J. Adaptins: the final recount. Mol Biol Cell. 2001;12:2907-20 pubmed
    ..Additional diversification of AP complexes arises from the existence of adaptin isoforms encoded by distinct genes or resulting from alternative splicing of mRNAs...
  5. Kashevsky H, Wallace J, Reed B, Lai C, Hayashi Hagihara A, Orr Weaver T. The anaphase promoting complex/cyclosome is required during development for modified cell cycles. Proc Natl Acad Sci U S A. 2002;99:11217-22 pubmed
    ..In one common example, most animals and plants have tissues in which the cells become polyploid or polytene by means of an S-G cycle, but the mechanism by which mitosis is inhibited in the endo cycle is not ..
  6. Sevrioukov E, Moghrabi N, Kuhn M, KRAMER H. A mutation in dVps28 reveals a link between a subunit of the endosomal sorting complex required for transport-I complex and the actin cytoskeleton in Drosophila. Mol Biol Cell. 2005;16:2301-12 pubmed
    ..The first of these complexes, ESCRT-I, consists of three proteins: Vps28p, Vps37p, and Vps23p or Tsg101 in mammals. Here, we characterize a mutation in the Drosophila homolog of vps28...
  7. Elias V, Nicolas C, Abramson C. Eye color as an indicator of behavior: revisiting Worthy and Scott. Psychol Rep. 2008;102:759-78 pubmed
    ..melanogaster pointed to significant behavioral differences among cell-defect groups, indicating that the cell defect which causes eye color, rather than eye color itself, may serve as a crude indicator of behavior. ..