Gene Symbol: Odc1
Description: Ornithine decarboxylase 1
Alias: CG8721, Dmel\CG8721, Odc-1, dodc1, ornithine decarboxylase 1, CG8721-PA, Odc1-PA, ornithine decarboxylase, ornithine decarboxylase-1
Species: fruit fly

Top Publications

  1. Rom E, Kahana C. Isolation and characterization of the Drosophila ornithine decarboxylase locus: evidence for the presence of two transcribed ODC genes in the Drosophila genome. DNA Cell Biol. 1993;12:499-508 pubmed
    The polymerase chain reaction (PCR) was used to isolate two Drosophila ornithine decarboxylase (ODC) genes...
  2. Li Y, Jiang Y, Chen Y, Karandikar U, Hoffman K, Chattopadhyay A, et al. optix functions as a link between the retinal determination network and the dpp pathway to control morphogenetic furrow progression in Drosophila. Dev Biol. 2013;381:50-61 pubmed publisher
  3. Burnette M, Zartman J. Spatiotemporal patterning of polyamines in Drosophila development. Amino Acids. 2015;47:2665-70 pubmed publisher
    ..Understanding the regulation driving this accumulation can provide insight into PA metabolism and transport. Our findings suggest that Drosophila has great potential for investigating PAs in developmental biology. ..
  4. Birnbaum M, Gilbert L. Juvenile hormone stimulation of ornithine decarboxylase activity during vitellogenesis in Drosophila melanogaster. J Comp Physiol B. 1990;160:145-51 pubmed
    The activity of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, becomes elevated in intact female Drosophila melanogaster shortly after adult eclosion...
  5. Siebold A, Banerjee R, Tie F, Kiss D, Moskowitz J, Harte P. Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance. Proc Natl Acad Sci U S A. 2010;107:169-74 pubmed publisher
    ..E(z) mutants exhibit derepression of Abd-B, a well-characterized direct target of Polycomb silencing, and Odc1, a putative direct target implicated in stress resistance...
  6. Gupta V, Scheunemann L, Eisenberg T, Mertel S, Bhukel A, Koemans T, et al. Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. Nat Neurosci. 2013;16:1453-60 pubmed publisher
    ..b>Ornithine decarboxylase-1, the rate-limiting enzyme for de novo polyamine synthesis, also protected olfactory memories in aged ..