Gene Symbol: Oda
Description: Ornithine decarboxylase antizyme
Alias: CG16747, D-AZ, Dmel\CG16747, ODA, guf, l(2)02833, l(2)k09037, oda, ornithine decarboxylase antizyme, CG16747-PA, CG16747-PB, CG16747-PC, Oda-PA, Oda-PB, Oda-PC, antizyme, gut feeling, gutfeeling, ornithine deacarboxylase antizyme, orthinine decarboyxlase antizyme
Species: fruit fly

Top Publications

  1. Ivanov I, Simin K, Letsou A, Atkins J, Gesteland R. The Drosophila gene for antizyme requires ribosomal frameshifting for expression and contains an intronic gene for snRNP Sm D3 on the opposite strand. Mol Cell Biol. 1998;18:1553-61 pubmed
    ..a Drosophila melanogaster sequence with high homology to the sequence for mammalian antizyme (ornithine decarboxylase antizyme) was reported...
  2. Salzberg A, Golden K, Bodmer R, Bellen H. gutfeeling, a Drosophila gene encoding an antizyme-like protein, is required for late differentiation of neurons and muscles. Genetics. 1996;144:183-96 pubmed
    ..cloned and found to encode a 21-kD protein with a significant sequence similarity to the mammalian ornithine decarboxylase antizyme (OAZ)...
  3. Schenkel H, Hanke S, De Lorenzo C, Schmitt R, Mechler B. P elements inserted in the vicinity of or within the Drosophila snRNP SmD3 gene nested in the first intron of the Ornithine Decarboxylase Antizyme gene affect only the expression of SmD3. Genetics. 2002;161:763-72 pubmed
    ..gene for snRNP SmD3 (SmD3) is contained in reverse orientation within the first intron of the Ornithine Decarboxylase Antizyme (AZ) gene...
  4. Murai N, Murakami Y, Matsufuji S. Identification of nuclear export signals in antizyme-1. J Biol Chem. 2003;278:44791-8 pubmed
    b>Antizyme-1 (AZ1) is a protein that negatively regulates polyamine synthesis by inhibiting the key synthetic enzyme ornithine decarboxylase and targeting it for degradation by the 26 S proteasome...
  5. Metzstein M, Krasnow M. Functions of the nonsense-mediated mRNA decay pathway in Drosophila development. PLoS Genet. 2006;2:e180 pubmed
  6. Xiong H, Qian J, He T, Li F. Independent transcription of miR-281 in the intron of ODA in Drosophila melanogaster. Biochem Biophys Res Commun. 2009;378:883-9 pubmed publisher
    ..The MiR-281 in Drosophila melanogaster is located in the first intron of isoform RA of the ornithine decarboxylase antizyme (ODA) gene. ODA has three isoforms because of alternative transcription start sites (TSSs)...
  7. QuiƱones Coello A, Petrella L, Ayers K, Melillo A, Mazzalupo S, Hudson A, et al. Exploring strategies for protein trapping in Drosophila. Genetics. 2007;175:1089-104 pubmed
    ..We report a total of 335 genes associated with protein or enhancer traps and a web-accessible database for viewing molecular information and expression data for these genes. ..
  8. Behm Ansmant I, Gatfield D, Rehwinkel J, Hilgers V, Izaurralde E. A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay. EMBO J. 2007;26:1591-601 pubmed
    ..These findings reveal a conserved role for PABPC1 in mRNA surveillance. ..
  9. Cziko A, McCann C, Howlett I, Barbee S, Duncan R, Luedemann R, et al. Genetic modifiers of dFMR1 encode RNA granule components in Drosophila. Genetics. 2009;182:1051-60 pubmed publisher
    ..Thus, the encoded proteins may function as miRNA- and/or mRNA-specific translational regulators in vivo. ..

More Information


  1. Avery P, Vicente Crespo M, Francis D, Nashchekina O, Alonso C, Palacios I. Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner. RNA. 2011;17:624-38 pubmed publisher
    ..Furthermore, our results show that Upf3 is not always essential in NMD. ..
  2. Frizzell K, Rynearson S, Metzstein M. Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6. RNA. 2012;18:1475-86 pubmed publisher
    ..elegans and yeast. ..
  3. Torok T, Tick G, Alvarado M, Kiss I. P-lacW insertional mutagenesis on the second chromosome of Drosophila melanogaster: isolation of lethals with different overgrowth phenotypes. Genetics. 1993;135:71-80 pubmed
    ..In this paper, 16 overgrowth mutants are described. As revealed by in situ hybridization, none of the mutations corresponds to any of the previously known overgrowth mutations on the second chromosome. ..
  4. Ivanov I, Gesteland R, Atkins J. Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit. Nucleic Acids Res. 2000;28:3185-96 pubmed
    The efficiency of programmed ribosomal frameshifting in decoding antizyme mRNA is the sensor for an autoregulatory circuit that controls cellular polyamine levels in organisms ranging from the yeast Schizosaccharomyces pombe to Drosophila ..
  5. Vied C, Halachmi N, Salzberg A, Horabin J. Antizyme is a target of sex-lethal in the Drosophila germline and appears to act downstream of hedgehog to regulate sex-lethal and cyclin B. Dev Biol. 2003;253:214-29 pubmed
    ..targets of Sex-lethal in early germ cells, the RNA encoded by gutfeeling, the Drosophila homolog of Ornithine Decarboxylase Antizyme, was isolated. gutfeeling interacts genetically with Sex-lethal...
  6. Gatfield D, Izaurralde E. Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila. Nature. 2004;429:575-8 pubmed
    ..We conclude that, despite conservation in the NMD machinery, PTC-containing transcripts are degraded in Drosophila by a mechanism that differs considerably from those described in yeast and mammals. ..
  7. Burnette M, Zartman J. Spatiotemporal patterning of polyamines in Drosophila development. Amino Acids. 2015;47:2665-70 pubmed publisher
    ..Understanding the regulation driving this accumulation can provide insight into PA metabolism and transport. Our findings suggest that Drosophila has great potential for investigating PAs in developmental biology. ..