Gene Symbol: Oct-TyrR
Description: Octopamine-Tyramine receptor
Alias: CG7485, DmTAR1, DmTyrR, Dmel\CG7485, Dmoct/tyr, DrmOTR, OA-R, OAR_DROME, OTR, OcR, Ocr, OctoR1, OctyR99AB, TAR1, TYR, TyR, Tyr, Tyr-dro, TyrR, hono, l(3)neo30, Octopamine-Tyramine receptor, CG7485-PA, CG7485-PB, Oct-TyrR-PA, Oct-TyrR-PB, Oct/Tyr receptor, Tyramine-receptor, honoka, octopamine receptor, octopamine receptor 1, octopamine/tyramine receptor, tyramine receptor
Species: fruit fly

Top Publications

  1. Maqueira B, Chatwin H, Evans P. Identification and characterization of a novel family of Drosophila beta-adrenergic-like octopamine G-protein coupled receptors. J Neurochem. 2005;94:547-60 pubmed publisher
    ..Thus, the pharmacological profile of individual insect tissue responses to octopamine might vary with the combination and the degree of expression of the individual octopamine receptors present...
  2. Cazzamali G, Torp M, Hauser F, Williamson M, Grimmelikhuijzen C. The Drosophila gene CG9918 codes for a pyrokinin-1 receptor. Biochem Biophys Res Commun. 2005;335:14-9 pubmed
    ..This paper is the first conclusive report that CG9918 is a Drosophila pyrokinin-1 receptor gene. ..
  3. Stowers R. An efficient method for recombineering GAL4 and QF drivers. Fly (Austin). 2011;5:371-8 pubmed publisher
    ..The cassettes should, however, be generalizable for recombineering in other species. ..
  4. Watanabe K, Chiu H, Pfeiffer B, Wong A, Hoopfer E, Rubin G, et al. A Circuit Node that Integrates Convergent Input from Neuromodulatory and Social Behavior-Promoting Neurons to Control Aggression in Drosophila. Neuron. 2017;95:1112-1128.e7 pubmed publisher
    ..These results have potential implications for thinking about the role of related neuromodulatory systems in mammals. ..
  5. Arakawa S, Gocayne J, McCombie W, Urquhart D, Hall L, Fraser C, et al. Cloning, localization, and permanent expression of a Drosophila octopamine receptor. Neuron. 1990;4:343-54 pubmed
    ..The insect octopamine receptor has been permanently expressed in mammalian cells, where it mediates the attenuation of adenylate cyclase ..
  6. Blenau W, Baumann A. Molecular and pharmacological properties of insect biogenic amine receptors: lessons from Drosophila melanogaster and Apis mellifera. Arch Insect Biochem Physiol. 2001;48:13-38 pubmed
    ..In this review, the present knowledge on the biochemical, molecular, and pharmacological properties of biogenic amine receptors from Drosophila and Apis will be summarized. Arch...
  7. Chatwin H, Rudling J, Patel D, Reale V, Evans P. Site-directed mutagenesis studies on the Drosophila octopamine/tyramine receptor. Insect Biochem Mol Biol. 2003;33:173-84 pubmed
    The cloned Drosophila octopamine/tyramine receptor can be coupled to second messenger pathways in an agonist-specific fashion by the endogenously occurring biogenic amines, octopamine and tyramine, when expressed in Chinese hamster ovary ..
  8. Bergland A, Tobler R, González J, Schmidt P, Petrov D. Secondary contact and local adaptation contribute to genome-wide patterns of clinal variation in Drosophila melanogaster. Mol Ecol. 2016;25:1157-74 pubmed publisher
    ..melanogaster and provide a context for future studies seeking to identify loci contributing to local adaptation in a wide variety of organisms, including other invasive species as well as temperate endemics. ..
  9. Bayliss A, Roselli G, Evans P. A comparison of the signalling properties of two tyramine receptors from Drosophila. J Neurochem. 2013;125:37-48 pubmed publisher
    ..The ?- and ?-adrenergic classes of insect octopamine receptor are better activated by octopamine than tyramine...

More Information


  1. Nagaya Y, Kutsukake M, Chigusa S, Komatsu A. A trace amine, tyramine, functions as a neuromodulator in Drosophila melanogaster. Neurosci Lett. 2002;329:324-8 pubmed
    ..G protein-coupled receptor for trace amines, cloned in Drosophila melanogaster, and claimed to be either an octopamine receptor or a tyramine receptor...
  2. Pebusque M, Coulier F, Birnbaum D, Pontarotti P. Ancient large-scale genome duplications: phylogenetic and linkage analyses shed light on chordate genome evolution. Mol Biol Evol. 1998;15:1145-59 pubmed
    ..Linkage of some of these genes can be found in the Drosophila melanogaster and Caenorhabditis elegans genomes, suggesting that they were linked in the triploblast Metazoa ancestor. ..
  3. Evans P. Molecular studies on insect octopamine receptors. EXS. 1993;63:286-96 pubmed
    ..receptors have concentrated upon molecular pharmacological approaches to identify the particular subtype of octopamine receptor mediating its effects in a particular tissue and on the modes of action of the receptors in a particular ..
  4. Kutsukake M, Komatsu A, Yamamoto D, Ishiwa Chigusa S. A tyramine receptor gene mutation causes a defective olfactory behavior in Drosophila melanogaster. Gene. 2000;245:31-42 pubmed
    ..The location of the P-element insertion was determined to be about 100bp) upstream of the first exon of the tyramine receptor gene. The level of 3...
  5. Han K, Millar N, Davis R. A novel octopamine receptor with preferential expression in Drosophila mushroom bodies. J Neurosci. 1998;18:3650-8 pubmed
    ..To identify an octopamine receptor mediating this function in Drosophila, putative biogenic amine receptors were cloned by a novel procedure ..
  6. Zumstein N, Forman O, Nongthomba U, Sparrow J, Elliott C. Distance and force production during jumping in wild-type and mutant Drosophila melanogaster. J Exp Biol. 2004;207:3515-22 pubmed
    ..distance and force production in M18, a mutant deficient in octopamine synthesis, and in hono, a tyramine/octopamine receptor mutant, we conclude that in Drosophila, as in locusts, octopamine modulates escape jumping...
  7. Reale V, Hannan F, Midgley J, Evans P. The expression of a cloned Drosophila octopamine/tyramine receptor in Xenopus oocytes. Brain Res. 1997;769:309-20 pubmed
    The expression of a cloned Drosophila octopamine/tyramine receptor (OctyR99AB) is described in Xenopus oocytes...
  8. Robb S, Cheek T, Hannan F, Hall L, Midgley J, Evans P. Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems. EMBO J. 1994;13:1325-30 pubmed
    A cloned seven transmembrane-spanning Drosophila octopamine/tyramine receptor, permanently expressed in a Chinese hamster ovary cell line, both inhibits adenylate cyclase activity and leads to the elevation of intracellular Ca2+ levels ..
  9. Blumenthal E. Regulation of chloride permeability by endogenously produced tyramine in the Drosophila Malpighian tubule. Am J Physiol Cell Physiol. 2003;284:C718-28 pubmed
    ..concentrations; the pharmacology of this response matches that of the previously published cloned insect tyramine receptor. In addition, the tubule appears capable of synthesizing tyramine from applied tyrosine, as shown by direct ..
  10. Enan E. Molecular response of Drosophila melanogaster tyramine receptor cascade to plant essential oils. Insect Biochem Mol Biol. 2005;35:309-21 pubmed
    ..Therefore, the data indicates a correlation between cellular changes and insecticidal activity of tested plant essential oils, and suggests that the toxicity of at least two of these chemicals is mediated through the TA receptor. ..
  11. Evans P, Maqueira B. Insect octopamine receptors: a new classification scheme based on studies of cloned Drosophila G-protein coupled receptors. Invert Neurosci. 2005;5:111-8 pubmed publisher
    ..tissues it will be essential to identify the relative expression levels of the different classes of octopamine receptor present...
  12. Cazzamali G, Klaerke D, Grimmelikhuijzen C. A new family of insect tyramine receptors. Biochem Biophys Res Commun. 2005;338:1189-96 pubmed publisher
    ..In addition to the Drosophila tyramine receptor gene, CG7431, we found another closely related Drosophila gene, CG16766, that probably also codes for a ..
  13. Feng G, Hannan F, Reale V, Hon Y, Kousky C, Evans P, et al. Cloning and functional characterization of a novel dopamine receptor from Drosophila melanogaster. J Neurosci. 1996;16:3925-33 pubmed
    ..The DopR99B receptor maps to 99B3-5, close to the position of the octopamine/tyramine receptor gene at 99A10-B1, suggesting that the two may be related through a gene duplication...
  14. Guven Ozkan T, Davis R. Functional neuroanatomy of Drosophila olfactory memory formation. Learn Mem. 2014;21:519-26 pubmed publisher
    ..Despite this progress, a complete and unified model that details the pathway from acquisition to memory expression remains elusive. ..
  15. Saudou F, Amlaiky N, Plassat J, Borrelli E, Hen R. Cloning and characterization of a Drosophila tyramine receptor. EMBO J. 1990;9:3611-7 pubmed
    ..The Drosophila tyramine receptor that we have isolated might therefore be an invertebrate equivalent of the mammalian alpha 2 adrenergic ..