Gene Symbol: Nup50
Description: Nucleoporin 50kD
Alias: CG2158, Dmel\CG2158, NUP50, Nup, nup50, nucleoporin 50kD, CG2158-PA, Nup50-PA, nuclear pore protein 50, nucleoporin 50
Species: fruit fly
Burns L, Wente S. From hypothesis to mechanism: uncovering nuclear pore complex links to gene expression. Mol Cell Biol. 2014;34:2114-20 pubmed publisher
..Studies of several model organisms provide credence for Nup functions in transcription, mRNA export, and genome organization...
Kalverda B, Pickersgill H, Shloma V, Fornerod M. Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm. Cell. 2010;140:360-71 pubmed publisher
..We analyzed genomic interactions of full-length nucleoporins Nup98, Nup50, and Nup62 and nucleoplasmic and NPC-tethered forms of Nup98...
Chen X, Xu L. Specific nucleoporin requirement for Smad nuclear translocation. Mol Cell Biol. 2010;30:4022-34 pubmed publisher
..Thus, we have delineated the nucleoporin requirement of MAD nuclear import, reflecting a unique trans-NPC mechanism. ..
Kusch T. Brca2-Pds5 complexes mobilize persistent meiotic recombination sites to the nuclear envelope. J Cell Sci. 2015;128:717-27 pubmed publisher
..The identification of Brca2-Pds5 complexes as key mediators of this process provides a first mechanistic explanation for the contribution of lamins and cohesins to meiotic recombination. ..
Freibaum B, Lu Y, López González R, Kim N, Almeida S, Lee K, et al
. GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport. Nature. 2015;525:129-33 pubmed publisher
..These studies show that a primary consequence of G4C2 repeat expansion is the compromise of nucleocytoplasmic transport through the nuclear pore, revealing a novel mechanism of neurodegeneration. ..
Ryu T, Spatola B, Delabaere L, Bowlin K, Hopp H, Kunitake R, et al
. Heterochromatic breaks move to the nuclear periphery to continue recombinational repair. Nat Cell Biol. 2015;17:1401-11 pubmed publisher
Gawlinski P, Nikolay R, Goursot C, Lawo S, Chaurasia B, Herz H, et al
. The Drosophila mitotic inhibitor Frühstart specifically binds to the hydrophobic patch of cyclins. EMBO Rep. 2007;8:490-6 pubmed
..We propose that binding of Frs to cyclins blocks the hydrophobic patch to interfere with Cdk1 substrate recognition. ..
Vaquerizas J, Suyama R, Kind J, Miura K, Luscombe N, Akhtar A. Nuclear pore proteins nup153 and megator define transcriptionally active regions in the Drosophila genome. PLoS Genet. 2010;6:e1000846 pubmed publisher
..Therefore, we suggest that NAR-binding is used for chromosomal organization that enables gene expression control. ..
Mensch J, Serra F, Lavagnino N, Dopazo H, Hasson E. Positive selection in nucleoporins challenges constraints on early expressed genes in Drosophila development. Genome Biol Evol. 2013;5:2231-41 pubmed publisher
..Understanding these exceptions to the broad evolutionary conservation of early expressed developmental genes can shed light into relevant processes driving the evolution of species divergence. ..