Gene Symbol: Nup214
Description: Nucleoporin 214kD
Alias: CAN, CAN/Nup214, CG3820, DCAN, DNup214, Dmel\CG3820, NUP214, Nup, Nup 214, dCAN, l(2)10444, nup214, nucleoporin 214kD, CG3820-PA, Nup214-PA, nucleoporin 214
Species: fruit fly

Top Publications

  1. Roth P, Xylourgidis N, Sabri N, Uv A, Fornerod M, Samakovlis C. The Drosophila nucleoporin DNup88 localizes DNup214 and CRM1 on the nuclear envelope and attenuates NES-mediated nuclear export. J Cell Biol. 2003;163:701-6 pubmed
    ..We show that the nuclear accumulation of the Drosophila Rel protein Dorsal requires CRM1. DNup88 binds to DNup214 and DCRM1 in vitro, and both proteins become mislocalized from the nuclear rim into the nucleus of mbo mutants...
  2. Xylourgidis N, Roth P, Sabri N, Tsarouhas V, Samakovlis C. The nucleoporin Nup214 sequesters CRM1 at the nuclear rim and modulates NFkappaB activation in Drosophila. J Cell Sci. 2006;119:4409-19 pubmed
    ..Here, we show that the NFkappaB transcription factor Dorsal is a substrate of CRM1 and requires the nucleoporin Nup214 for its nuclear translocation upon signaling...
  3. Mason D, Goldfarb D. The nuclear transport machinery as a regulator of Drosophila development. Semin Cell Dev Biol. 2009;20:582-9 pubmed publisher
    ..Rather, they support the idea that the basal nuclear transport machinery has adapted during the evolution of the metazoan body plan to play important regulatory roles in key developmental events. ..
  4. Kozlova N, Braga J, Lundgren J, Rino J, Young P, Carmo Fonseca M, et al. Studies on the role of NonA in mRNA biogenesis. Exp Cell Res. 2006;312:2619-30 pubmed
    ..Our data suggest that NonA facilitates the intranuclear mobility of mRNP particles. ..
  5. Sabri N, Roth P, Xylourgidis N, Sadeghifar F, Adler J, Samakovlis C. Distinct functions of the Drosophila Nup153 and Nup214 FG domains in nuclear protein transport. J Cell Biol. 2007;178:557-65 pubmed
    ..We report a surprisingly antagonistic relationship between RanBP3 and the Nup214 FG region in determining CRM1 localization and its function in protein export...
  6. Juhola M, Shah Z, Grivell L, Jacobs H. The mitochondrial inner membrane AAA metalloprotease family in metazoans. FEBS Lett. 2000;481:91-5 pubmed
    ..A full elucidation of the cellular and physiological roles of mt-AAA metalloproteases in metazoans will require the creation of targeted mutations. ..
  7. Forler D, Rabut G, Ciccarelli F, Herold A, Kocher T, Niggeweg R, et al. RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export. Mol Cell Biol. 2004;24:1155-67 pubmed
    ..role of RanBP2 in the recruitment of NXF1 to the NPC is highlighted by the observation that depletion of CAN/Nup214 also inhibits cell proliferation and mRNA export but does not affect NXF1 localization...
  8. Osouda S, Nakamura Y, de Saint Phalle B, McConnell M, Horigome T, Sugiyama S, et al. Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation. Dev Biol. 2005;284:219-32 pubmed
    ..In contrast, both gonadal and CNS tissues exhibited underdevelopment. ..
  9. Gawlinski P, Nikolay R, Goursot C, Lawo S, Chaurasia B, Herz H, et al. The Drosophila mitotic inhibitor Frühstart specifically binds to the hydrophobic patch of cyclins. EMBO Rep. 2007;8:490-6 pubmed
    ..We propose that binding of Frs to cyclins blocks the hydrophobic patch to interfere with Cdk1 substrate recognition. ..

More Information


  1. Chen X, Xu L. Specific nucleoporin requirement for Smad nuclear translocation. Mol Cell Biol. 2010;30:4022-34 pubmed publisher
    ..Thus, we have delineated the nucleoporin requirement of MAD nuclear import, reflecting a unique trans-NPC mechanism. ..
  2. Mensch J, Serra F, Lavagnino N, Dopazo H, Hasson E. Positive selection in nucleoporins challenges constraints on early expressed genes in Drosophila development. Genome Biol Evol. 2013;5:2231-41 pubmed publisher
    ..Understanding these exceptions to the broad evolutionary conservation of early expressed developmental genes can shed light into relevant processes driving the evolution of species divergence.