Gene Symbol: Nup153
Description: Nucleoporin 153kD
Alias: CG4453, Dmel\CG4453, NUP153, Nup 153, dNup153, dmNup153, nup153, nucleoporin 153kD, CG4453-PA, CG4453-PC, CG4453-PD, Nup153-PA, Nup153-PC, Nup153-PD, nucleoporin 153
Species: fruit fly

Top Publications

  1. Katsani K, Karess R, Dostatni N, Doye V. In vivo dynamics of Drosophila nuclear envelope components. Mol Biol Cell. 2008;19:3652-66 pubmed publisher
    ..Surprisingly, Drosophila Nup107 shows no evidence of localization to kinetochores, despite the demonstrated importance of this association in mammalian cells. ..
  2. Prestel M, Feller C, Straub T, Mitlöhner H, Becker P. The activation potential of MOF is constrained for dosage compensation. Mol Cell. 2010;38:815-26 pubmed publisher
  3. Mason D, Goldfarb D. The nuclear transport machinery as a regulator of Drosophila development. Semin Cell Dev Biol. 2009;20:582-9 pubmed publisher
    ..Rather, they support the idea that the basal nuclear transport machinery has adapted during the evolution of the metazoan body plan to play important regulatory roles in key developmental events. ..
  4. Vaquerizas J, Suyama R, Kind J, Miura K, Luscombe N, Akhtar A. Nuclear pore proteins nup153 and megator define transcriptionally active regions in the Drosophila genome. PLoS Genet. 2010;6:e1000846 pubmed publisher
    ..Using chromatin-immunoprecipitation combined with microarray hybridisation, we show that Nup153 and Megator (Mtor) bind to 25% of the genome in continuous domains extending 10 kb to 500 kb...
  5. Straub T, Becker P. Dosage compensation: the beginning and end of generalization. Nat Rev Genet. 2007;8:47-57 pubmed
  6. Grimaud C, Becker P. The dosage compensation complex shapes the conformation of the X chromosome in Drosophila. Genes Dev. 2009;23:2490-5 pubmed publisher
    ..We propose that nuclear organization of HAS is central to the faithful distribution of the DCC along the X chromosome. ..
  7. Kozlova N, Braga J, Lundgren J, Rino J, Young P, Carmo Fonseca M, et al. Studies on the role of NonA in mRNA biogenesis. Exp Cell Res. 2006;312:2619-30 pubmed
    ..Our data suggest that NonA facilitates the intranuclear mobility of mRNP particles. ..
  8. Patalano S, Mihailovich M, Belacortu Y, Paricio N, Gebauer F. Dual sex-specific functions of Drosophila Upstream of N-ras in the control of X chromosome dosage compensation. Development. 2009;136:689-98 pubmed publisher
    ..These results uncover dual sex-specific functions of UNR in dosage compensation: to repress DCC formation in female flies and to promote DCC assembly on the male X chromosome. ..
  9. Stenberg P, Larsson J. Buffering and the evolution of chromosome-wide gene regulation. Chromosoma. 2011;120:213-25 pubmed publisher
    ..In this review, we discuss the origin and function of buffering and compensation using Drosophila as a model. ..

More Information


  1. Chen H, Chen X, Zheng Y. The nuclear lamina regulates germline stem cell niche organization via modulation of EGFR signaling. Cell Stem Cell. 2013;13:73-86 pubmed publisher
    ..Thus, we have uncovered a role for the nuclear lamina in the integration of EGF signaling to regulate stem cell niche function. ..
  2. Doumanis J, Wada K, Kino Y, Moore A, Nukina N. RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. PLoS ONE. 2009;4:e7275 pubmed publisher
    ..Newly identified modifiers including genes related to nuclear transport, nucleotide processes, and signaling, may be involved in polyglutamine aggregate formation and Huntington disease cascades. ..
  3. Burns L, Wente S. From hypothesis to mechanism: uncovering nuclear pore complex links to gene expression. Mol Cell Biol. 2014;34:2114-20 pubmed publisher
    ..These examples highlight new and unpredicted mechanisms for Nup impacts on transcription and questions that are left to be explored. ..
  4. Senger S, Csokmay J, Akbar T, Tanveer A, Jones T, Sengupta P, et al. The nucleoporin Seh1 forms a complex with Mio and serves an essential tissue-specific function in Drosophila oogenesis. Development. 2011;138:2133-42 pubmed publisher
    ..In summary, our studies demonstrate that Mio is a novel interacting partner of the conserved nucleoporin Seh1 and add to the growing body of evidence that structural nucleoporins can have novel tissue-specific roles. ..
  5. Presgraves D, Stephan W. Pervasive adaptive evolution among interactors of the Drosophila hybrid inviability gene, Nup96. Mol Biol Evol. 2007;24:306-14 pubmed publisher
    ..interactors--3 stable Nup107 subcomplex proteins (Nup75, Nup107, and Nup133) and 2 mobile nucleoporins (Nup98 and Nup153)--and show that all 5 have experienced recurrent adaptive evolution...
  6. Clark N, Aquadro C. A novel method to detect proteins evolving at correlated rates: identifying new functional relationships between coevolving proteins. Mol Biol Evol. 2010;27:1152-61 pubmed publisher
  7. Mihailovic M, Mihailovich M, Wurth L, Zambelli F, Abaza I, Militti C, et al. Widespread generation of alternative UTRs contributes to sex-specific RNA binding by UNR. RNA. 2012;18:53-64 pubmed publisher
    ..These results suggest that UNR exploits the transcript diversity generated by alternative processing and alternative promoter usage to bind and regulate target genes in a sex-specific manner. ..
  8. Ryu T, Spatola B, Delabaere L, Bowlin K, Hopp H, Kunitake R, et al. Heterochromatic breaks move to the nuclear periphery to continue recombinational repair. Nat Cell Biol. 2015;17:1401-11 pubmed publisher
  9. Chen X, Xu L. Specific nucleoporin requirement for Smad nuclear translocation. Mol Cell Biol. 2010;30:4022-34 pubmed publisher
    ..Thus, we have delineated the nucleoporin requirement of MAD nuclear import, reflecting a unique trans-NPC mechanism. ..
  10. Dimaano C, Ball J, Prunuske A, Ullman K. RNA association defines a functionally conserved domain in the nuclear pore protein Nup153. J Biol Chem. 2001;276:45349-57 pubmed
    ..One such protein, the nucleoporin Nup153, is localized to the nuclear basket of the pore complex and has been shown to be a central component of the ..
  11. Sabri N, Roth P, Xylourgidis N, Sadeghifar F, Adler J, Samakovlis C. Distinct functions of the Drosophila Nup153 and Nup214 FG domains in nuclear protein transport. J Cell Biol. 2007;178:557-65 pubmed
    ..The fly homologues of FG nucleoporins Nup358, Nup153, and Nup54 are selectively required for import...
  12. Pennisi E. Evolution. Two rapidly evolving genes spell trouble for hybrids. Science. 2006;314:1238-9 pubmed publisher
  13. Jang A, Moravcevic K, Saez L, Young M, Sehgal A. Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus. PLoS Genet. 2015;11:e1004974 pubmed publisher
    ..addition to IMPα1, rhythmic behavior and nuclear expression of PER-TIM require a specific nuclear pore protein, Nup153, and Ran-GTPase...
  14. Freibaum B, Lu Y, López González R, Kim N, Almeida S, Lee K, et al. GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport. Nature. 2015;525:129-33 pubmed publisher
    ..These studies show that a primary consequence of G4C2 repeat expansion is the compromise of nucleocytoplasmic transport through the nuclear pore, revealing a novel mechanism of neurodegeneration. ..
  15. Osouda S, Nakamura Y, de Saint Phalle B, McConnell M, Horigome T, Sugiyama S, et al. Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation. Dev Biol. 2005;284:219-32 pubmed
    ..In contrast, both gonadal and CNS tissues exhibited underdevelopment. ..