numb

Summary

Gene Symbol: numb
Description: numb
Alias: CG3779, Dmel\CG3779, N7-1, Numb, d-numb, dNumb, l(2)03235, l(2)3235, l(2)s2201, numbs, numb, CG3779-PA, CG3779-PB, CG3779-PD, d-Numb, numb-PA, numb-PB, numb-PD
Species: fruit fly

Top Publications

  1. Caussinus E, Gonzalez C. Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat Genet. 2005;37:1125-9 pubmed
    ..We found that larval brain tissue carrying neuroblasts with mutations in raps (also called pins), mira, numb or pros grew to more than 100 times their initial size, invading other tissues and killing the hosts in 2 weeks...
  2. Jafar Nejad H, Andrews H, Acar M, Bayat V, Wirtz Peitz F, Mehta S, et al. Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. Dev Cell. 2005;9:351-63 pubmed
    ..Our data indicate that Sec15 mediates a specific vesicle trafficking event to ensure proper neuronal fate specification in Drosophila...
  3. Emery G, Hutterer A, Berdnik D, Mayer B, Wirtz Peitz F, Gaitan M, et al. Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system. Cell. 2005;122:763-73 pubmed
    ..During SOP division, the determinants Numb and Neuralized segregate into the pIIb daughter cell and establish a distinct cell fate by regulating Notch/Delta ..
  4. Fichelson P, Gho M. Mother-daughter precursor cell fate transformation after Cdc2 down-regulation in the Drosophila bristle lineage. Dev Biol. 2004;276:367-77 pubmed
    ..Cell diversity is achieved by the asymmetric segregation of cell determinants, such as Numb and Neuralized (Neur), resulting in differential activation of the Notch (N) pathway...
  5. Betschinger J, Knoblich J. Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates. Curr Biol. 2004;14:R674-85 pubmed
    ..Here, we outline the steps and factors that are involved in this process in Drosophila and C. elegans and discuss their potential conservation in vertebrates. ..
  6. Frise E, Knoblich J, Younger Shepherd S, Jan L, Jan Y. The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. Proc Natl Acad Sci U S A. 1996;93:11925-32 pubmed
    ..fates in the Drosophila external sense organ lineage requires asymmetric localization of the intrinsic determinant Numb as well as cell-cell interactions mediated by the Delta ligand and Notch receptor...
  7. Bhalerao S, Berdnik D, Torok T, Knoblich J. Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila. Curr Biol. 2005;15:1583-90 pubmed
    During asymmetric cell division, protein determinants are segregated into one of the two daughter cells. The Numb protein acts as a segregating determinant during both mouse and Drosophila development...
  8. Buescher M, Yeo S, Udolph G, Zavortink M, Yang X, Tear G, et al. Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells. Genes Dev. 1998;12:1858-70 pubmed
    ..of sibling neurons is accomplished through the interplay of Notch (N) signaling and the intrinsic fate determinant Numb. We show that GMCs have apical-basal polarity and Numb localization and the orientation of division are coordinated ..
  9. Smith C, Dho S, Donaldson J, Tepass U, McGlade C. The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling. Mol Biol Cell. 2004;15:3698-708 pubmed
    The adaptor protein Numb is necessary for the cell fate specification of progenitor cells in the Drosophila nervous system...
  10. Schaefer M, Petronczki M, Dorner D, Forte M, Knoblich J. Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system. Cell. 2001;107:183-94 pubmed
    ..Thus, asymmetric activation of heterotrimeric G proteins by a receptor-independent mechanism may orient asymmetric cell divisions in different cell types. ..

Detail Information

Publications82

  1. Caussinus E, Gonzalez C. Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat Genet. 2005;37:1125-9 pubmed
    ..We found that larval brain tissue carrying neuroblasts with mutations in raps (also called pins), mira, numb or pros grew to more than 100 times their initial size, invading other tissues and killing the hosts in 2 weeks...
  2. Jafar Nejad H, Andrews H, Acar M, Bayat V, Wirtz Peitz F, Mehta S, et al. Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. Dev Cell. 2005;9:351-63 pubmed
    ..Our data indicate that Sec15 mediates a specific vesicle trafficking event to ensure proper neuronal fate specification in Drosophila...
  3. Emery G, Hutterer A, Berdnik D, Mayer B, Wirtz Peitz F, Gaitan M, et al. Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system. Cell. 2005;122:763-73 pubmed
    ..During SOP division, the determinants Numb and Neuralized segregate into the pIIb daughter cell and establish a distinct cell fate by regulating Notch/Delta ..
  4. Fichelson P, Gho M. Mother-daughter precursor cell fate transformation after Cdc2 down-regulation in the Drosophila bristle lineage. Dev Biol. 2004;276:367-77 pubmed
    ..Cell diversity is achieved by the asymmetric segregation of cell determinants, such as Numb and Neuralized (Neur), resulting in differential activation of the Notch (N) pathway...
  5. Betschinger J, Knoblich J. Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates. Curr Biol. 2004;14:R674-85 pubmed
    ..Here, we outline the steps and factors that are involved in this process in Drosophila and C. elegans and discuss their potential conservation in vertebrates. ..
  6. Frise E, Knoblich J, Younger Shepherd S, Jan L, Jan Y. The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. Proc Natl Acad Sci U S A. 1996;93:11925-32 pubmed
    ..fates in the Drosophila external sense organ lineage requires asymmetric localization of the intrinsic determinant Numb as well as cell-cell interactions mediated by the Delta ligand and Notch receptor...
  7. Bhalerao S, Berdnik D, Torok T, Knoblich J. Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila. Curr Biol. 2005;15:1583-90 pubmed
    During asymmetric cell division, protein determinants are segregated into one of the two daughter cells. The Numb protein acts as a segregating determinant during both mouse and Drosophila development...
  8. Buescher M, Yeo S, Udolph G, Zavortink M, Yang X, Tear G, et al. Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells. Genes Dev. 1998;12:1858-70 pubmed
    ..of sibling neurons is accomplished through the interplay of Notch (N) signaling and the intrinsic fate determinant Numb. We show that GMCs have apical-basal polarity and Numb localization and the orientation of division are coordinated ..
  9. Smith C, Dho S, Donaldson J, Tepass U, McGlade C. The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling. Mol Biol Cell. 2004;15:3698-708 pubmed
    The adaptor protein Numb is necessary for the cell fate specification of progenitor cells in the Drosophila nervous system...
  10. Schaefer M, Petronczki M, Dorner D, Forte M, Knoblich J. Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system. Cell. 2001;107:183-94 pubmed
    ..Thus, asymmetric activation of heterotrimeric G proteins by a receptor-independent mechanism may orient asymmetric cell divisions in different cell types. ..
  11. Spana E, Doe C. Numb antagonizes Notch signaling to specify sibling neuron cell fates. Neuron. 1996;17:21-6 pubmed
    ..Delta-Notch signaling is required to specify vMP2 fate, whereas the localized determinant Numb is segregated into dMP2 and is required to specify dMP2 fate...
  12. Li S, Zwahlen C, Vincent S, McGlade C, Kay L, Pawson T, et al. Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity. Nat Struct Biol. 1998;5:1075-83 pubmed
    The phosphotyrosine-binding (PTB) domain of Numb, a protein involved in asymmetric cell division, has recently been shown to bind to the adapter protein Lnx through an LDNPAY sequence, to the Numb-associated kinase (Nak) through a ..
  13. Gho M, Schweisguth F. Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila. Nature. 1998;393:178-81 pubmed
    ..At each division, distinct fates are conferred on sister cells by the asymmetric segregation of Numb, a negative regulator of Notch signalling...
  14. Siddall N, McLaughlin E, Marriner N, Hime G. The RNA-binding protein Musashi is required intrinsically to maintain stem cell identity. Proc Natl Acad Sci U S A. 2006;103:8402-7 pubmed
    ..We describe the complementary expression patterns of the murine Msi paralogues Msi1 and Msi2 during spermatogenesis, which support the idea of distinct, evolutionarily conserved roles of Msi. ..
  15. Guo M, Bier E, Jan L, Jan Y. tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS. Neuron. 1995;14:913-25 pubmed
    ..ttk is expressed in support cells but not in neurons. It has been shown that numb, a membrane-associated protein asymmetrically distributed during the SOP division, confers different daughter cell ..
  16. Zwahlen C, Li S, Kay L, Pawson T, Forman Kay J. Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb. EMBO J. 2000;19:1505-15 pubmed
    The phosphotyrosine-binding (PTB) domain of the cell fate determinant Numb is involved in the formation of multiple protein complexes in vivo and can bind a diverse array of peptide sequences in vitro...
  17. Wang W, Liu W, Wang Y, Zhou L, Tang X, Luo H. Notch signaling regulates neuroepithelial stem cell maintenance and neuroblast formation in Drosophila optic lobe development. Dev Biol. 2011;350:414-28 pubmed publisher
    ..promotes neuroepithelial cell expansion while suppressing medulla neuroblast formation and neurogenesis; numb loss of function mimics Notch overactivation, suggesting that Numb may inhibit Notch signaling activity in the ..
  18. Guo M, Jan L, Jan Y. Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron. 1996;17:27-41 pubmed
    ..b>Numb, a membrane-associated protein, is asymmetrically segregated into one daughter cell during SOP division and acts as ..
  19. Hutterer A, Knoblich J. Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs. EMBO Rep. 2005;6:836-42 pubmed
    During asymmetric cell division in Drosophila sensory organ precursors (SOPs), the Numb protein segregates into one of the two daughter cells, in which it inhibits Notch signalling to specify pIIb cell fate...
  20. Ruiz Gomez M, Bate M. Segregation of myogenic lineages in Drosophila requires numb. Development. 1997;124:4857-66 pubmed
    ..These differences depend on an asymmetric segregation of Numb between sibling cells...
  21. Lee C, Andersen R, Cabernard C, Manning L, Tran K, Lanskey M, et al. Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes Dev. 2006;20:3464-74 pubmed
    ..This phenotype is due to two independent neuroblast defects: abnormal atypical protein kinase C (aPKC)/Numb cortical polarity and failure to align the mitotic spindle with the cortical polarity axis...
  22. Roegiers F, Younger Shepherd S, Jan L, Jan Y. Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage. Nat Cell Biol. 2001;3:58-67 pubmed
    ..On the basis of these observations, we propose that two distinct mechanisms for controlling asymmetric cell divisions occur within the same lineage in the developing peripheral nervous system in Drosophila. ..
  23. Knoblich J, Jan L, Jan Y. Asymmetric segregation of Numb and Prospero during cell division. Nature. 1995;377:624-7 pubmed
    A cell can divide asymmetrically by specifically segregating a determinant into one of its daughter cells. The Numb protein is a candidate for such a determinant in the asymmetric cell divisions of the developing Drosophila nervous system...
  24. Ohshiro T, Yagami T, Zhang C, Matsuzaki F. Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature. 2000;408:593-6 pubmed
    ..At mitosis, neural fate determinants, including Prospero and Numb, localize to the basal cortex, from which the ganglion mother cell buds off; Inscuteable and Bazooka, which ..
  25. Smith C, Lau K, Rahmani Z, Dho S, Brothers G, She Y, et al. aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb. EMBO J. 2007;26:468-80 pubmed
    ..protein kinase C (aPKC) directs the polarized distribution and unequal segregation of the cell fate determinant Numb during asymmetric cell divisions...
  26. Wang S, Younger Shepherd S, Jan L, Jan Y. Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless. Development. 1997;124:4435-46 pubmed
    ..Shortly after, the IIb cell divides to generate the neuron and the sheath cell. The membrane-associated protein Numb has been shown to be required for the first two asymmetric divisions...
  27. Knoblich J, Jan L, Jan Y. The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization. Proc Natl Acad Sci U S A. 1997;94:13005-10 pubmed
    Drosophila Numb is a membrane associated protein of 557 amino acids (aa) that localizes asymmetrically into a cortical crescent in mitotic neural precursor cells and segregates into one of the daughter cells, where it is required for ..
  28. O Connor Giles K, Skeath J. Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila. Dev Cell. 2003;5:231-43 pubmed
    ..One such mechanism is the asymmetric localization of Numb to ensure that sibling cells respond differently to the extrinsic Notch signal and, thus, adopt distinct fates (A ..
  29. Matsuzaki F. Asymmetric division of Drosophila neural stem cells: a basis for neural diversity. Curr Opin Neurobiol. 2000;10:38-44 pubmed
    ..Our understanding now extends to the molecular nature of the cell polarity that underlies asymmetric divisions. This polarity is conserved among neural stem cells, epithelial cells and fertilized eggs. ..
  30. Wirtz Peitz F, Nishimura T, Knoblich J. Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization. Cell. 2008;135:161-73 pubmed publisher
    Drosophila neural precursor cells divide asymmetrically by segregating the Numb protein into one of the two daughter cells. Numb is uniformly cortical in interphase but assumes a polarized localization in mitosis...
  31. Roegiers F, Jan L, Jan Y. Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs. Mol Biol Cell. 2005;16:3480-7 pubmed
    ..of neural precursors of the central and peripheral nervous system (PNS), where a membrane-associated protein, Numb, is asymmetrically localized during cell division and is segregated to one of the two daughter cells (the pIIb cell)..
  32. Park M, Yaich L, Bodmer R. Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo. Mech Dev. 1998;75:117-26 pubmed
    ..the result of a fixed pattern of asymmetric cell divisions which are directed, in part, by interactions between numb, a localized intracellular-receptor protein, sanpodo (spdo), a potential tropomodulin homolog, and Notch, a ..
  33. Gho M, Bellaiche Y, Schweisguth F. Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell. Development. 1999;126:3573-84 pubmed
    ..Both Numb and Prospero segregated specifically into the basal glial and neuronal cells during the pIIb and pIIIb divisions, ..
  34. Cayouette M, Raff M. Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals. Nat Neurosci. 2002;5:1265-9 pubmed
    ..There is increasing evidence that this mechanism also operates in vertebrate neural development and that Numb proteins, which function as cell-fate determinants during Drosophila development, may also function in this way in ..
  35. Peng C, Manning L, Albertson R, Doe C. The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature. 2000;408:596-600 pubmed
    ..We conclude that Dlg and Lgl promote, and myosin II inhibits, actomyosin-dependent basal protein targeting in neuroblasts. ..
  36. Yu F, Morin X, Cai Y, Yang X, Chia W. Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization. Cell. 2000;100:399-409 pubmed
  37. Berdnik D, Torok T, Gonzalez Gaitan M, Knoblich J. The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev Cell. 2002;3:221-31 pubmed
    During asymmetric cell division in Drosophila sensory organ precursor cells, the Numb protein localizes asymmetrically and segregates into one daughter cell, where it influences cell fate by repressing signal transduction via the Notch ..
  38. Nagel A, Maier D, Preiss A. Su(H)-independent activity of hairless during mechano-sensory organ formation in Drosophila. Mech Dev. 2000;94:3-12 pubmed
    ..Thereby, Hairless and numb may have partly redundant activities...
  39. Hirata J, Nakagoshi H, Nabeshima Y, Matsuzaki F. Asymmetric segregation of the homeodomain protein Prospero during Drosophila development. Nature. 1995;377:627-30 pubmed
    ..We have identified a region in Prospero that is responsible for this event. The region shares a common motif with Numb, which also shows unequal segregation...
  40. Bowman S, Neumüller R, Novatchkova M, Du Q, Knoblich J. The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division. Dev Cell. 2006;10:731-42 pubmed
    ..Our data suggest a model in which asymmetrically localized Pins-G alphai complexes regulate spindle orientation by directly binding to Mud. ..
  41. Shen C, Jan L, Jan Y. Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila. Cell. 1997;90:449-58 pubmed
    ..sensory organ precursor cells, and cells in the procephalic neurogenic region involves the segregation of Numb and Prospero proteins into one of the two daughter cells...
  42. Sousa Nunes R, Chia W, Somers W. Protein phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions. Genes Dev. 2009;23:359-72 pubmed publisher
    ..Our findings suggest that Flfl may target PP4 to the MIra protein complex to facilitate dephosphorylation step(s) crucial for its cortical association/asymmetric localization. ..
  43. Justice N, Roegiers F, Jan L, Jan Y. Lethal giant larvae acts together with numb in notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage. Curr Biol. 2003;13:778-83 pubmed
    ..Neuroblasts that delaminate from the embryonic epithelium require lgl to promote formation of a basal Numb and Prospero crescent, which will be asymmetrically segregated to the basal daughter cell upon division to specify ..
  44. Cai Y, Yu F, Lin S, Chia W, Yang X. Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions. Cell. 2003;112:51-62 pubmed
    ..In sensory organ precursors, Bazooka/DaPKC and Pins/G alpha i localize to opposite sides of the cortex and function in opposition to generate a symmetric spindle. ..
  45. Bowman S, Rolland V, Betschinger J, Kinsey K, Emery G, Knoblich J. The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila. Dev Cell. 2008;14:535-46 pubmed publisher
    ..PAN neuroblasts rely on the segregating determinants Numb and Brat to generate smaller, secondary neuroblasts that in turn give rise to ganglion mother cells (GMCs) and ..
  46. Reddy G, Rodrigues V. Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch. Development. 1999;126:2083-92 pubmed
    ..Pros misexpression is sufficient for the transformation of PIIa to PIIb fate. The expression of Pros in the normal PIIb cell appears to be regulated by Notch signaling. ..
  47. Weng M, Golden K, Lee C. dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila. Dev Cell. 2010;18:126-35 pubmed publisher
    ..We conclude that Erm dependence functionally distinguishes intermediate neural progenitors from neuroblasts in the Drosophila larval brain, balancing neurogenesis with stem cell maintenance. ..
  48. Spana E, Doe C. The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. Development. 1995;121:3187-95 pubmed
    ..Asymmetric cortical localization of prospero in neuroblasts requires entry into mitosis; it does not depend on numb function...
  49. Petronczki M, Knoblich J. DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila. Nat Cell Biol. 2001;3:43-9 pubmed
    ..polarity in DmPAR-6 mutants, asymmetric cell divisions in neuroblasts are misorientated, and the proteins Numb and Miranda do not segregate correctly into the basal daughter cell...
  50. Carmena A, Murugasu Oei B, Menon D, Jimenez F, Chia W. Inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis. Genes Dev. 1998;12:304-15 pubmed
    ..Our results show that Inscuteable and Numb proteins are localized as cortical crescents on opposite sides of dividing progenitor cells...
  51. Posakony J. Nature versus nurture: asymmetric cell divisions in Drosophila bristle development. Cell. 1994;76:415-8 pubmed
  52. Lai E, Orgogozo V. A hidden program in Drosophila peripheral neurogenesis revealed: fundamental principles underlying sensory organ diversity. Dev Biol. 2004;269:1-17 pubmed
    ..We propose that most Drosophila sensory organs are built from an archetypal lineage, and we speculate about how this stereotyped pattern of cell divisions may have been built during evolution...
  53. Skeath J, Doe C. Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS. Development. 1998;125:1857-65 pubmed
    ..Loss of Notch signaling gives the same phenotype, whereas loss of numb gives the opposite phenotype ('A/A')...
  54. Vaessin H, Grell E, Wolff E, Bier E, Jan L, Jan Y. prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell. 1991;67:941-53 pubmed
    ..prospero encodes a large nuclear protein with multiple homopolymeric amino acid stretches and is expressed in neuronal precursors early during their formation. It is probably generally required for proper neuronal differentiation. ..
  55. Kraut R, Chia W, Jan L, Jan Y, Knoblich J. Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature. 1996;383:50-5 pubmed
    ..cells in the procephalic neurogenic region divide perpendicular to the surface, and segregate the proteins Numb and Prospero into the basal daughter cell...
  56. Jan Y, Jan L. Asymmetric cell division. Nature. 1998;392:775-8 pubmed
  57. Yaich L, Ooi J, Park M, Borg J, Landry C, Bodmer R, et al. Functional analysis of the Numb phosphotyrosine-binding domain using site-directed mutagenesis. J Biol Chem. 1998;273:10381-8 pubmed
    The Numb protein is involved in cell fate determination during Drosophila neural development. Numb has a protein domain homologous to the phosphotyrosine-binding domain (PTB) in the adaptor protein Shc...
  58. Simon F, Fichelson P, Gho M, Audibert A. Notch and Prospero repress proliferation following cyclin E overexpression in the Drosophila bristle lineage. PLoS Genet. 2009;5:e1000594 pubmed publisher
    ..Our results demonstrate that the terminal quiescent state and differentiation are regulated by two parallel mechanisms acting simultaneously on fate acquisition and cell cycle progression. ..
  59. Qin H, Percival Smith A, Li C, Jia C, Gloor G, Li S. A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division. J Biol Chem. 2004;279:11304-12 pubmed
    b>Numb, an evolutionarily conserved cell fate-determining factor, plays a pivotal role in the development of Drosophila and vertebrate nervous systems...
  60. Schweisguth F. Regulation of notch signaling activity. Curr Biol. 2004;14:R129-38 pubmed
    ..Recent analyses of the cell biology of the Notch receptor have identified several fundamental mechanisms that contribute to regulate Notch signaling activity in space and time. ..
  61. Wang H, Somers G, Bashirullah A, Heberlein U, Yu F, Chia W. Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Genes Dev. 2006;20:3453-63 pubmed
    ..b>Numb, which also acts as a tumor suppressor in larval brains, is a major downstream target of AurA and aPKC...
  62. Bellaiche Y, Radovic A, Woods D, Hough C, Parmentier M, O Kane C, et al. The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila. Cell. 2001;106:355-66 pubmed
    ..Finally, Baz and the Dlg/Pins complex are required for the asymmetric localization of Numb. Thus, the Dlg/Pins complex responds to Fz signaling to establish planar asymmetry in the pI cell.
  63. Schober M, Schaefer M, Knoblich J. Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts. Nature. 1999;402:548-51 pubmed
    ..Several proteins, including Numb and Miranda, segregate into the basal daughter cell and are needed for the determination of its correct cell fate...
  64. Remaud S, Audibert A, Gho M. S-phase favours notch cell responsiveness in the Drosophila bristle lineage. PLoS ONE. 2008;3:e3646 pubmed publisher
    ..We suggest that high-order chromatin structures associated with the S-phase create favourable conditions that increase the efficiency of the transcriptional machinery with respect to N-target genes. ..
  65. Ouyang Y, Petritsch C, Wen H, Jan L, Jan Y, Lu B. Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila. Development. 2011;138:2185-96 pubmed publisher
    ..Drosophila Numb protein regulates this process through its preferential segregation into the differentiating daughter cell...
  66. Rhyu M, Jan L, Jan Y. Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell. 1994;76:477-91 pubmed
    ..We determined by immunocytochemistry that numb is a membrane-associated protein which localizes asymmetrically to one-half of the predivisional SOP cell...
  67. Dye C, Lee J, Atkinson R, Brewster R, Han P, Bellen H. The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein. Development. 1998;125:1845-56 pubmed
    ..phenotype is similar to that observed when Notch function is lost late in embryonic development and opposite to the numb loss-of-function phenotype. Genetic interaction studies show that sanpodo is epistatic to numb...
  68. Lundell M, Lee H, Perez E, Chadwell L. The regulation of apoptosis by Numb/Notch signaling in the serotonin lineage of Drosophila. Development. 2003;130:4109-21 pubmed
    ..In this paper, we examine the role of Numb/Notch signaling in the development of the serotonin lineage of Drosophila and show that it is necessary for ..
  69. Le Borgne R, Schweisguth F. Unequal segregation of Neuralized biases Notch activation during asymmetric cell division. Dev Cell. 2003;5:139-48 pubmed
    ..asymmetrically in the dividing pI cell and unequally segregates into the pIIb cell, like the Notch inhibitor Numb. Furthermore, Neuralized upregulates endocytosis of the Notch ligand Delta in the pIIb cell and acts in the pIIb ..
  70. Hawkins N, Garriga G. Asymmetric cell division: from A to Z. Genes Dev. 1998;12:3625-38 pubmed
  71. Artavanis Tsakonas S, Rand M, Lake R. Notch signaling: cell fate control and signal integration in development. Science. 1999;284:770-6 pubmed
    ..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis. ..
  72. Spana E, Kopczynski C, Goodman C, Doe C. Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS. Development. 1995;121:3489-94 pubmed
    ..We find that asymmetric localization of the numb protein autonomously controls a binary cell fate decision in the Drosophila CNS...
  73. Lu B, Rothenberg M, Jan L, Jan Y. Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors. Cell. 1998;95:225-35 pubmed
    During mitosis of multiple types of precursor cells in Drosophila, Numb is asymmetrically distributed between the two daughter cells and confers distinct daughter cell fates...
  74. Wang H, Ouyang Y, Somers W, Chia W, Lu B. Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon. Nature. 2007;449:96-100 pubmed
    ..b>Numb is one such factor that is segregated to the differentiating daughter cell during the stem-cell-like neuroblast ..
  75. Bellaiche Y, Gho M, Kaltschmidt J, Brand A, Schweisguth F. Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division. Nat Cell Biol. 2001;3:50-7 pubmed
    ..The anterior pIIb cell specifically inherits the determinant Numb and the adaptor protein Partner of Numb (Pon)...
  76. Ceron J, Gonzalez C, Tejedor F. Patterns of cell division and expression of asymmetric cell fate determinants in postembryonic neuroblast lineages of Drosophila. Dev Biol. 2001;230:125-38 pubmed
    ..vi) Prospero is transiently expressed in one of the two sibling GCs generated by the division of GMCs. The implications of these results on cell fate specification and differentiation of adult brain neurons are discussed. ..
  77. Rajan A, Tien A, Haueter C, Schulze K, Bellen H. The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors. Nat Cell Biol. 2009;11:815-24 pubmed publisher
    ..Our data indicate that WASp-dependent Arp2/3 actin polymerization is crucial for apical presentation of Delta, providing a mechanistic link between actin polymerization and Notch signalling...
  78. Babaoglan A, O Connor Giles K, Mistry H, Schickedanz A, Wilson B, Skeath J. Sanpodo: a context-dependent activator and inhibitor of Notch signaling during asymmetric divisions. Development. 2009;136:4089-98 pubmed publisher
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    ..of dbx and eve, or dbx and hb9, within pairs of sibling neurons is initially established as a result of Notch/Numb-mediated asymmetric divisions...
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    ..miranda thus creates intrinsic differences between sibling cells by mediating the asymmetric segregation of a transcription factor into only one daughter cell during neural stem-cell division. ..