nub

Summary

Gene Symbol: nub
Description: nubbin
Alias: CG15488, CG15489, CG34395, CG6246, Dmel\CG34395, Dmel_CG15488, Dmel_CG15489, Dmel_CG6246, NUB, Nub, Oct-1, Oct1, PDM-1, PDM1, POU33F1, Pdm, Pdm-1, Pdm1, dOct1, dPOU-19, dPOU-19/pdm-1, dPOU19, pdm, pdm-1, pdm1, twn, CG34395 gene product from transcript CG34395-RB, CG34395-PB, CG34395-PD, CG34395-PE, NUBBIN, POU domain protein 1, nub-PB, nub-PD, nub-PE, twain
Species: fruit fly

Top Publications

  1. ncbi Characterization of two Drosophila POU domain genes, related to oct-1 and oct-2, and the regulation of their expression patterns
    A Lloyd
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112
    Mech Dev 36:87-102. 1991
  2. pmc The miti-mere and pdm1 genes collaborate during specification of the RP2/sib lineage in Drosophila neurogenesis
    K M Bhat
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Mol Cell Biol 15:4052-63. 1995
  3. ncbi On the functional overlap between two Drosophila POU homeo domain genes and the cell fate specification of a CNS neural precursor
    S L Yeo
    Institute of Molecular and Cell Biology, National University of Singapore
    Genes Dev 9:1223-36. 1995
  4. pmc The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila
    G Halder
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706 USA
    Genes Dev 12:3900-9. 1998
  5. ncbi Joint development in the Drosophila leg: cell movements and cell populations
    Christen Mirth
    Department of Zoology, University Museum of Zoology, Downing Street, Cambridge CB2 3EJ, United Kingdom
    Dev Biol 246:391-406. 2002
  6. pmc DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE
    Stephen Malin
    Department of Microbiology and Tumor biology Box 280, Karolinska Institutet, 171 77 Stockholm, Sweden
    Nucleic Acids Res 33:4618-25. 2005
  7. pmc dOct2, a Drosophila Oct transcription factor that functions in yeast
    K Prakash
    Division of Chemistry, California Institute of Technology, Pasadena 91125
    Proc Natl Acad Sci U S A 89:7080-4. 1992
  8. ncbi Isolation of a family of Drosophila POU domain genes expressed in early development
    A N Billin
    Department of Biological Sciences, University of California, Santa Barbara 93106
    Mech Dev 34:75-84. 1991
  9. pmc Two closely linked Drosophila POU domain genes are expressed in neuroblasts and sensory elements
    T Dick
    Institute of Molecular and Cell Biology, National University of Singapore
    Proc Natl Acad Sci U S A 88:7645-9. 1991
  10. ncbi A POU homeo domain protein related to dPOU-19/pdm-1 binds to the regulatory DNA necessary for vital expression of the Drosophila choline acetyltransferase gene
    T Kitamoto
    Division of Neurosciences, Institute of the City of Hope, Duarte, California 91010, USA
    J Neurosci 15:3509-18. 1995

Scientific Experts

Detail Information

Publications123 found, 100 shown here

  1. ncbi Characterization of two Drosophila POU domain genes, related to oct-1 and oct-2, and the regulation of their expression patterns
    A Lloyd
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112
    Mech Dev 36:87-102. 1991
    ..These POU domain genes, pdm-1 and pdm-2, are expressed at high levels during early embryogenesis and at lower levels throughout the rest of ..
  2. pmc The miti-mere and pdm1 genes collaborate during specification of the RP2/sib lineage in Drosophila neurogenesis
    K M Bhat
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Mol Cell Biol 15:4052-63. 1995
    We have investigated (i) the role of pdm1, a Drosophila POU gene, during the elaboration of the GMC-1-->RP2/sib lineage and (ii) the functional relationship between pdm1 and the closely linked second POU gene, miti-mere, in this ..
  3. ncbi On the functional overlap between two Drosophila POU homeo domain genes and the cell fate specification of a CNS neural precursor
    S L Yeo
    Institute of Molecular and Cell Biology, National University of Singapore
    Genes Dev 9:1223-36. 1995
    ..the NB4-2 lineage, two closely linked and structurally related POU homeo domain genes, pdm-2 (dPOU28) and pdm-1 (dPOU19), both encode proteins that accumulate to high levels only in the first GMC (GMC4-2a) and not in its progeny, the ..
  4. pmc The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila
    G Halder
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706 USA
    Genes Dev 12:3900-9. 1998
    ..Combinatorial regulation by selector proteins and signal transducers is likely to be a general feature of the tissue-specific control of gene expression during organogenesis...
  5. ncbi Joint development in the Drosophila leg: cell movements and cell populations
    Christen Mirth
    Department of Zoology, University Museum of Zoology, Downing Street, Cambridge CB2 3EJ, United Kingdom
    Dev Biol 246:391-406. 2002
    ..These markers also define a number of more localised territories within the pupal joint...
  6. pmc DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE
    Stephen Malin
    Department of Microbiology and Tumor biology Box 280, Karolinska Institutet, 171 77 Stockholm, Sweden
    Nucleic Acids Res 33:4618-25. 2005
    ....
  7. pmc dOct2, a Drosophila Oct transcription factor that functions in yeast
    K Prakash
    Division of Chemistry, California Institute of Technology, Pasadena 91125
    Proc Natl Acad Sci U S A 89:7080-4. 1992
    ..Our data strongly suggest possible functions for the Oct factor in pattern formation in Drosophila that might transcend the boundaries of genetically defined segmentation genes...
  8. ncbi Isolation of a family of Drosophila POU domain genes expressed in early development
    A N Billin
    Department of Biological Sciences, University of California, Santa Barbara 93106
    Mech Dev 34:75-84. 1991
    ..We have isolated genomic and cDNA clones from three Drosophila POU domain genes, designated pdm-1, pdm-2, and Cf1a...
  9. pmc Two closely linked Drosophila POU domain genes are expressed in neuroblasts and sensory elements
    T Dick
    Institute of Molecular and Cell Biology, National University of Singapore
    Proc Natl Acad Sci U S A 88:7645-9. 1991
    ..The mRNAs encode 601- and 475-amino acid deduced proteins; their POU domains are most related to those of the human OCT1 and OCT2...
  10. ncbi A POU homeo domain protein related to dPOU-19/pdm-1 binds to the regulatory DNA necessary for vital expression of the Drosophila choline acetyltransferase gene
    T Kitamoto
    Division of Neurosciences, Institute of the City of Hope, Duarte, California 91010, USA
    J Neurosci 15:3509-18. 1995
    ..the 22-mer as a probe, we have isolated a cDNA clone encoding the Drosophila POU homeo domain protein, dPOU-19/pdm-1, whose target genes and specific binding sequences have not been identified...
  11. ncbi Nubbin encodes a POU-domain protein required for proximal-distal patterning in the Drosophila wing
    M Ng
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Development 121:589-99. 1995
    The nubbin gene is required for normal growth and patterning of the wing in Drosophila. We report here that nubbin encodes a member of the POU family of transcription factors...
  12. pmc A universal target sequence is bound in vitro by diverse homeodomains
    B Kalionis
    Department of Biochemistry and Biophysics, University of California at San Francisco 94143 0448
    Mech Dev 43:57-70. 1993
    ..We conclude that during the evolutionary divergence of homeodomains, the specificity of DNA binding has been much more highly conserved than the amino acid sequence...
  13. ncbi The Drosophila miti-mere gene, a member of the POU family, is required for the specification of the RP2/sibling lineage during neurogenesis
    K M Bhat
    Department of Molecular Biology, Princeton University, New Jersey 08544
    Development 120:1483-501. 1994
    ..miti is initially required in this lineage to establish the identity of the parental ganglion mother cell, GMC-1. miti must then be down-regulated to allow the asymmetric division of GMC-1 into the RP2 and its sibling cell...
  14. ncbi Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing
    F J Diaz-Benjumea
    Differentiation Program, European Molecular Biology Laboratory, Heidelberg, Germany
    Development 121:4215-25. 1995
    ..Ligand independent activation of Notch is sufficient to direct Wg expression, which in turn mediates the organizing activity of the D/V boundary...
  15. pmc Proximo-distal specification in the wing disc of Drosophila by the nubbin gene
    F J Cifuentes
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Cantoblanco 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 94:11405-10. 1997
    Mutations in the nubbin (nub) gene have a phenotype consisting of a severe wing size reduction and pattern alterations, such as transformations of distal elements into proximal ones...
  16. pmc Regulation of POU genes by castor and hunchback establishes layered compartments in the Drosophila CNS
    R Kambadur
    The Neurogenetics Unit, Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland 20892 USA
    Genes Dev 12:246-60. 1998
    ..drifter and I-POU depend on cas for full expression, whereas pdm-1 and pdm-2 are negatively regulated...
  17. ncbi Boundary formation in Drosophila wing: Notch activity attenuated by the POU protein Nubbin
    C J Neumann
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Science 281:409-13. 1998
    ..Evidence is presented here that the POU domain protein Nubbin contributes to the formation of a sharp dorsoventral boundary in the Drosophila wing...
  18. ncbi Notch-mediated segmentation and growth control of the Drosophila leg
    C Rauskolb
    Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, New Jersey, 08854, USA
    Dev Biol 210:339-50. 1999
    ..The Notch pathway is also deployed for segmentation during vertebrate somitogenesis, which raises the possibility of a common origin for the segmentation of these distinct tissues...
  19. ncbi Generation of medial and lateral dorsal body domains by the pannier gene of Drosophila
    M Calleja
    Centro de Biologia Molecular, CSIC UAM, Spain
    Development 127:3971-80. 2000
    ..We argue that pnr acts like a classical selector gene but differs in that its expression is not propagated through cell divisions...
  20. ncbi Programmed transformations in neuroblast gene expression during Drosophila CNS lineage development
    T Brody
    Neurogenetics Unit, Laboratory of Neurochemistry, NINDS, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    Dev Biol 226:34-44. 2000
    ..NB) expression of four proteins, Hunchback (Hb), Pou-homeodomain proteins 1 and 2 (referred to collectively as Pdm), and Castor (Cas), identifies a transcription factor network regulating the temporal development of all ganglia...
  21. ncbi The selector gene cut represses a neural cell fate that is specified independently of the Achaete-Scute-Complex and atonal
    R Brewster
    Department of Biology, The University of Michigan, 830 North University, 48109 1048, Ann Arbor, MI, USA
    Mech Dev 105:57-68. 2001
    ..Thus, cut is not only required to promote an ASC-dependent mode of differentiation, but also represses an ASC- and ato-independent fate that leads to dbd and dda1 differentiation...
  22. pmc Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome
    Benjamin P Berman
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:757-62. 2002
    ..We tested one of the newly identified clusters, mapping upstream of the gap gene giant (gt), and show that it acts as an enhancer that recapitulates the posterior expression pattern of gt...
  23. ncbi Temporally dynamic response to Wingless directs the sequential elaboration of the proximodistal axis of the Drosophila wing
    Alexander J Whitworth
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Dev Biol 254:277-88. 2003
    ..activated by Wingless throughout the "wing primordium," but later is repressed by the activity of Vestigial and Nubbin, which together define a more distal domain...
  24. ncbi Proximodistal subdivision of Drosophila legs and wings: the elbow-no ocelli gene complex
    Ulrich Weihe
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 131:767-74. 2004
    ..The homeodomain protein Nubbin is expressed in the wing primordia and required for formation of wings, but not legs...
  25. ncbi Upregulation of Mitimere and Nubbin acts through cyclin E to confer self-renewing asymmetric division potential to neural precursor cells
    Krishna Moorthi Bhat
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Development 131:1123-34. 2004
    ..Here, we report that maintaining high levels of Mitimere or Nubbin, two POU proteins, in a GMC causes it to undergo self-renewing asymmetric divisions...
  26. pmc Transcriptional control in the segmentation gene network of Drosophila
    Mark D Schroeder
    Laboratory of Developmental Neurogenetics, Rockefeller University, New York, New York, USA
    PLoS Biol 2:E271. 2004
    ..The study demonstrates that computational methods are a powerful complement to experimental approaches in the analysis of transcription networks...
  27. ncbi Regulation of temporal identity transitions in Drosophila neuroblasts
    Ruth Grosskortenhaus
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon 1254, Eugene, Oregon 97403, USA
    Dev Cell 8:193-202. 2005
    ..model for studying temporal identity: they sequentially express four genes (hunchback --> Kruppel --> pdm1 --> castor) whose temporal regulation is essential for generating neuronal diversity...
  28. pmc Regulation of neuroblast competence: multiple temporal identity factors specify distinct neuronal fates within a single early competence window
    Michael D Cleary
    University of Oregon Department of Neuroscience, Howard Hughes Medical Institute, Eugene, Oregon 97403, USA
    Genes Dev 20:429-34. 2006
    ..has a single early window of competence to respond to four different temporal identity genes (Hunchback, Krüppel, Pdm, and Castor); that each of these factors specifies distinct motor neuron identities within this competence window ..
  29. pmc Pdm and Castor specify late-born motor neuron identity in the NB7-1 lineage
    Ruth Grosskortenhaus
    Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Genes Dev 20:2618-27. 2006
    ..Embryonic neuroblasts sequentially express Hunchback, Krüppel, Pdm1/Pdm2 (Pdm), and Castor (Cas) transcription factors...
  30. ncbi Isolation of regulators of Drosophila immune defense genes by a double interaction screen in yeast
    Anna Junell
    Department of Molecular Biology and Functional Genomics, Stockholm University, S 109 61 Stockholm, Sweden
    Insect Biochem Mol Biol 37:202-12. 2007
    ..Most interestingly, three transcription factors belonging to the POU domain class of homeodomain proteins, Pdm1, Pdm2 and Dfr/Vvl were isolated as Dif-interacting partners, and subsequently verified as regulators of CecA1 ..
  31. pmc Pdm and Castor close successive temporal identity windows in the NB3-1 lineage
    Khoa D Tran
    Institute of Neuroscience, Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA
    Development 135:3491-9. 2008
    ..embryonic neural progenitors (neuroblasts) sequentially express the transcription factors Hunchback, Kruppel, Pdm1/Pdm2 (Pdm) and Castor as they generate a stereotyped sequence of neuronal and glial progeny...
  32. doi Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation
    Wen Chih Lee
    Department of Developmental Biology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Development 136:2255-64. 2009
    ..Together, these data underscore the essential requirement of Apc in exerting regulatory control over stem cell activity, as well as the consequences that disrupting this regulation can have on tissue homeostasis...
  33. pmc Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc
    Rachel K Smith-Bolton
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Dev Cell 16:797-809. 2009
    ..This system is conducive to forward genetic screens, enabling an unbiased search for genes that regulate both the extent of and the capacity for regeneration...
  34. doi JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage
    Katherine Beebe
    Washington University School of Medicine, Department of Developmental Biology, Campus Box 8103, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 338:28-37. 2010
    ....
  35. pmc Extraction and comparison of gene expression patterns from 2D RNA in situ hybridization images
    Daniel L Mace
    Computational Biology and Bioinformatics Graduate Program, Duke University, Durham, NC 27708, USA
    Bioinformatics 26:761-9. 2010
    ..In order to deal with available large datasets, fully automated analysis methods must be developed to properly normalize and model spatial expression patterns...
  36. pmc A transient niche regulates the specification of Drosophila intestinal stem cells
    Divya Mathur
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Science 327:210-3. 2010
    ..Our results demonstrate a paradigm for stem cell-niche biology, where progenitors generate transient niches that determine stem cell fate and may give insights into stem cell specification in other tissues...
  37. pmc Robustness under functional constraint: the genetic network for temporal expression in Drosophila neurogenesis
    Akihiko Nakajima
    Department of Basic Science, University of Tokyo, Komaba, Tokyo, Japan
    PLoS Comput Biol 6:e1000760. 2010
    ..This study suggests that the Drosophila network for sequential expression has evolved to generate the robust temporal expression for neuronal specification...
  38. pmc The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration
    Rachael L Shaw
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3LY, UK
    Development 137:4147-58. 2010
    ..Our results suggest that the Hpo pathway is a mediator of the regenerative response in the Drosophila midgut...
  39. pmc Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways
    Fangfang Ren
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:21064-9. 2010
    ..Finally, we show that the Hpo pathway mediator Yorkie (Yki) is also required in precursor cells for injury-induced ISC proliferation in response to tissue-damaging reagent DSS...
  40. doi Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine
    Carolina N Perdigoto
    Institut Pasteur, Developmental Biology Department, F 75015 Paris, France
    Development 138:4585-95. 2011
    ..Our work suggests that a commitment requirement for high-level Notch activity safeguards the stem cells from loss through differentiation, revealing a novel role for the importance of Notch signaling levels in this system...
  41. doi Progressive tarsal patterning in the Drosophila by temporally dynamic regulation of transcription factor genes
    Kohei Natori
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 5 1 5 Kashiwanoha, Kashiwa City, Chiba 277 8562, Japan
    Dev Biol 361:450-62. 2012
    ..The results indicate that nubbin is expressed over a broad region at early stages but gradually disappears from the middle of the tarsal region...
  42. doi Trachea-derived dpp controls adult midgut homeostasis in Drosophila
    Zhouhua Li
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Dev Cell 24:133-43. 2013
    ..This work will provide important insights into the mechanisms of tissue homeostasis control by interorgan communication...
  43. doi Multiple roles of the gene zinc finger homeodomain-2 in the development of the Drosophila wing
    Daniel Perea
    Centro de Biologia Molecular Severo Ochoa, Universidad Autónoma Cantoblanco, 28049 Madrid, Spain
    Mech Dev 130:467-81. 2013
    ....
  44. ncbi Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny
    T Isshiki
    Institute of Neuroscience Institute of Molecular Biology, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, OR 97403, USA
    Cell 106:511-21. 2001
    ..neural precursors (neuroblasts) sequentially express the transcription factors Hunchback --> Krüppel --> Pdm --> Castor, with differentiated progeny maintaining the transcription factor profile present at their birth...
  45. ncbi Hunchback is required for the specification of the early sublineage of neuroblast 7-3 in the Drosophila central nervous system
    Tanja Novotny
    Institut fur Genetik, Universitat Mainz, Saarstrasse 21, D 55122 Mainz, Germany
    Development 129:1027-36. 2002
    ....
  46. ncbi The Drosophila kekkon genes: novel members of both the leucine-rich repeat and immunoglobulin superfamilies expressed in the CNS
    M Musacchio
    Department of Genetics, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Dev Biol 178:63-76. 1996
    ..Genetic analysis reveals that deletion of the kek1 gene causes no obvious developmental defects. The coexpression of kek2 in the CNS leads us to suggest that Kek1 is part of a family of cell surface proteins with redundant function...
  47. ncbi Wg and Egfr signalling antagonise the development of the peripodial epithelium in Drosophila wing discs
    Luis Alberto Baena-Lopez
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Facultad de Ciencias, 28049, Madrid, Spain
    Development 130:6497-506. 2003
    ..These findings suggest that suppression of Wg and Egfr activities is an early step in the development of the peripodial epithelium of the wing discs...
  48. ncbi The role of the T-box gene optomotor-blind in patterning the Drosophila wing
    David del Alamo Rodríguez
    Centro de Biología Molecular C S I C, Universidad Autonoma de Madrid Cantoblanco, Madrid E 28049, Spain
    Dev Biol 268:481-92. 2004
    ..The lack of optomotor-blind produces massive cell death in its expression domain, which leads to the mis-activation of the Notch pathway and the overproliferation of lateral wing cells...
  49. ncbi Mother-daughter precursor cell fate transformation after Cdc2 down-regulation in the Drosophila bristle lineage
    Pierre Fichelson
    UMR 7622, CNRS Universite Paris VI, 9, quai St Bernard, 75252 Paris Cedex 05, France
    Dev Biol 276:367-77. 2004
    ..These transformations in cell identity suggest that, although synchronized, cell cycle and fate determination are independent phenomena in the bristle lineage...
  50. ncbi The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
    Eric C Lai
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, 545 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    Development 132:2319-32. 2005
    ..We conclude that ubiquitination of Delta and Serrate by Neuralized and D-mib is an obligate feature of DSL ligand activation throughout Drosophila development...
  51. pmc Hox control of organ size by regulation of morphogen production and mobility
    Michael A Crickmore
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Science 313:63-8. 2006
    ..Because morphogens control tissue growth in many contexts, these findings provide a potentially general mechanism for how selector genes modify organ sizes...
  52. ncbi Notch signal organizes the Drosophila olfactory circuitry by diversifying the sensory neuronal lineages
    Keita Endo
    Laboratory for Neural Network Development, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minami, Chuo, Kobe, Hyogo 650 0047, Japan
    Nat Neurosci 10:153-60. 2007
    ..Thus, Notch signaling contributes to the diversification of ORNs, thereby regulating multiple developmental events that establish the olfactory map in Drosophila...
  53. pmc Functional screening identifies miR-315 as a potent activator of Wingless signaling
    Serena J Silver
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:18151-6. 2007
    ..In summary, activity-based screening can selectively identify miRNAs whose deregulation can lead to interpretable phenotypic consequences...
  54. pmc Evolution of nubbin function in hemimetabolous and holometabolous insect appendages
    Nataliya Turchyn
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Dev Biol 357:83-95. 2011
    ..A recent study in a hemipteran, Oncopeltus fasciatus (milkweed bug), showed that nubbin (nub) affects antenna morphogenesis, labial patterning, the length of the femoral segment in legs, and the ..
  55. pmc The role of the histone H2A ubiquitinase Sce in Polycomb repression
    Luis Gutierrez
    EMBL, Gene Expression Programme, Meyerhofstr 1, 69117 Heidelberg, Germany
    Development 139:117-27. 2012
    ..Sce synergizes with the Polycomb repressive deubiquitinase (PR-DUB) complex to repress transcription at class I genes, suggesting that H2A monoubiquitylation must be appropriately balanced for their transcriptional repression...
  56. pmc JAK/STAT signaling is required for hinge growth and patterning in the Drosophila wing disc
    Aidee Ayala-Camargo
    Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York 10016 6402, USA
    Dev Biol 382:413-26. 2013
    ..Within the hinge, Stat92E activity becomes restricted to gap domain cells that lack Nubbin and Teashirt...
  57. pmc The metazoan-specific mediator subunit 26 (Med26) is essential for viability and is found at both active genes and pericentric heterochromatin in Drosophila melanogaster
    Sharon K Marr
    Mol Cell Biol 34:2710-20. 2014
    ..This work is the first characterization of the metazoan-specific Mediator subunit in an animal model...
  58. pmc Courtship song does not increase the rate of adaptation to a thermally stressful environment in a Drosophila melanogaster laboratory population
    Larry G Cabral
    Department of Biological Sciences, California State University, Sacramento, California, United States of America
    PLoS ONE 9:e111148. 2014
    ..There were no differences between the treatments. Possible explanations for these results are discussed. ..
  59. pmc Neuronal Cell Fate Specification by the Convergence of Different Spatiotemporal Cues on a Common Terminal Selector Cascade
    Hugo Gabilondo
    Departamento de Biologia, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    PLoS Biol 14:e1002450. 2016
    ..Here, we find that the same terminal selector cascade is triggered by Kr/pdm>grn in dAp neurons, but by Antp/hth/exd/lbe/cas in Tv1 neurons...
  60. ncbi Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans
    M Muckenthaler
    European Molecular Biology Laboratory, Heidelberg, Germany
    Eur J Biochem 254:230-7. 1998
    ..elegans will facilitate a genetic analysis of the IRE/IRP system, thus opening a new avenue to explore this regulatory network...
  61. pmc Drosophila octamer elements and Pdm-1 dictate the coordinated transcription of core histone genes
    Mei Chin Lee
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore
    J Biol Chem 285:9041-53. 2010
    ..These elements recruit transcription factor POU-domain protein in D. melanogaster 1 (Pdm-1), which along with co-activator dmOct-1 coactivator in S-phase (dmOCA-S), activates transcription from at least ..
  62. doi Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene
    María Losada-Pérez
    Departamento de Biologia, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Mech Dev 127:458-71. 2010
    ..Furthermore, these results imply that the activation of a particular terminal differentiation gene in temporally unrestricted...
  63. doi Getting real with real-time qPCR: a case study of reference gene selection for morphological variation in Drosophila melanogaster wings
    Bruna P Matta
    Laboratório de Evolução de Caracteres Complexos, Departamento de Genetica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, s n Prédio do CCS, Bloco A, sala A2 075 Cidade Universitária, Rio de Janeiro, 21941 617, RJ, Brazil
    Dev Genes Evol 221:49-57. 2011
    ....
  64. pmc A novel tissue in an established model system: the Drosophila pupal midgut
    Shigeo Takashima
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Dev Genes Evol 221:69-81. 2011
    ..The formation of a pupal midgut has been reported from several other species and may represent a general feature of intestinal metamorphosis in insects...
  65. ncbi Tag team specification of a neural precursor in the Drosophila embryonic central nervous system
    J B Skeath
    Department of Cell and Structural Biology, Howard Hughes Medical Institute, University of Illinois, Urbana 61801, USA
    Bioessays 17:829-31. 1995
    ..A recent report details the roles that two genes, pdm-1 and pdm-2, play within an identified neural stem cell lineage in the Drosophila embryonic central nervous system...
  66. ncbi huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfinding
    Q Chu-LaGraff
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Neuron 15:1041-51. 1995
    ..Thus, huckebein regulates aspects of GMC and neuronal identity required for proper motoneuron axon pathfinding in the NB 4-2 lineage...
  67. ncbi Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGF beta homologs during Drosophila embryogenesis
    M Affolter
    Biozentrum, Universitat Basel, Switzerland
    Development 120:3105-17. 1994
    ..The requirements for tkv in dorsal closure, visceral mesoderm and trachea development assign novel functions to dpp or a closely related member of the TGF beta superfamily...
  68. ncbi Regional repression of a Drosophila POU box gene in the endoderm involves inductive interactions between germ layers
    M Affolter
    Biozentrum, University of Basel, Switzerland
    Development 117:1199-210. 1993
    ..We report here that proper spatial regulation of the Drosophila POU box gene pdm-1 products also involves interaction between these two germ layers...
  69. ncbi Regulation of expression domains and effects of ectopic expression reveal gap gene-like properties of the linked pdm genes of Drosophila
    K A Cockerill
    Department of Biology, University of California Santa Barbara 93106
    Mech Dev 41:139-53. 1993
    The closely linked POU domain genes pdm-1 and pdm-2 are first expressed early during cellularization in the presumptive abdomen in a broad domain that soon resolves into two stripes...
  70. ncbi Distinct mitogenic and cell fate specification functions of wingless in different regions of the wing
    C J Neumann
    European Molecular Biology Laboratory, Heidelberg, Germany
    Development 122:1781-9. 1996
    ..By contrast, overexpression of wg in the wing blade leads to repatterning and only secondarily to proliferation. These results suggest that the Wg signal elicits very different responses in different regions of the wing imaginal disc...
  71. ncbi Neurogenesis in the insect central nervous system
    C Q Doe
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Curr Opin Neurobiol 6:18-24. 1996
    ..And finally, new cell-lineage methods are being used to determine the entire lineage of identified neuroblasts, including axon projections and synaptic contacts...
  72. ncbi Wing development and specification of dorsal cell fates in the absence of apterous in Drosophila
    T Klein
    Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK
    Curr Biol 8:417-20. 1998
    ..In ap mutants, the wing is lost [5] [9], and here we report that this phenotype can be rescued by ectopic expression of either Ser or fng and that, surprisingly, the resulting wings have both dorsal and ventral cell fates...
  73. pmc Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells
    M Buescher
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Genes Dev 12:1858-70. 1998
    ..Moreover, our data suggest that the fate of some sibling neurons may be regulated by signals that do not require lateral interaction between the sibling cells...
  74. ncbi Growth and patterning from the engrailed interface
    A Hidalgo
    Department of Genetics, University of Cambridge, United Kingdom
    Int J Dev Biol 42:317-24. 1998
    ..Finally, regulatory interactions between en/En-1 and hh/Shh may be significant in the context of morphogenetic regulation during normal development...
  75. ncbi Positive and negative control of Serrate expression during early development of the Drosophila wing
    A Bachmann
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225, Dusseldorf, Germany
    Mech Dev 76:67-78. 1998
    ..The results clearly show that some of the previously described transactivators of Serrate protein expression, e.g. fringe, act on elements required for later aspects of Serrate expression...
  76. ncbi Genetic and molecular analyses of motoneuron development
    J S Eisen
    Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403, USA
    Curr Opin Neurobiol 8:697-704. 1998
    ..Many of the same molecules participate in the guidance of both vertebrate and fly motor axons. It is less clear, however, whether the same molecular mechanisms establish vertebrate and fly motoneuron identities...
  77. ncbi Fringe, Notch, and making developmental boundaries
    K D Irvine
    Waksman Institute, Department of Molecular Biology and Biochemistry, 190 Frelinghuysen Rd, Rutgers University, Piscataway, New Jersey 08854, USA
    Curr Opin Genet Dev 9:434-41. 1999
    ..of Notch signaling by Fringe, autonomous inhibition by Notch ligands, and inhibition of Notch target genes by Nubbin. Recent studies have revealed that Fringe also modulates a Notch-mediated signaling process between dorsal and ..
  78. ncbi A dual role for homothorax in inhibiting wing blade development and specifying proximal wing identities in Drosophila
    F Casares
    Department of Biochemistry and Molecular Biophysics, Columbia University, HHSC 1108, New York, NY 10032 USA
    Development 127:1499-508. 2000
    ..Our results suggest that tsh and hth block wing blade development by repressing some of the activities of the Notch pathway at the D/V compartment boundary...
  79. ncbi Cell behaviour of Drosophila fat cadherin mutations in wing development
    F Garoia
    Dipartimento di Biologia Evoluzionistica Sperimentale, Universita di Bologna, Italy
    Mech Dev 94:95-109. 2000
    ..Mutant ft cells show, in addition, smaller cell sizes during proliferation and abnormal cuticular differentiation, which reflect cell membrane and cytoskeleton anomalies, which are not modulated by the DER pathway...
  80. ncbi Functional interactions between Drosophila bHLH/PAS, Sox, and POU transcription factors regulate CNS midline expression of the slit gene
    Y Ma
    Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Neurosci 20:4596-605. 2000
    ..Functional interactions between members of these protein families may be important for numerous developmental and physiological processes...
  81. ncbi Jumeaux, a novel Drosophila winged-helix family protein, is required for generating asymmetric sibling neuronal cell fates
    P Y Cheah
    Institute of Molecular and Cell Biology, National University of Singapore Campus, Singapore 117609
    Development 127:3325-35. 2000
    ..Our results suggest that in addition to the correct formation of an apical complex, transcription mediated by Jumu is also necessary to facilitate the correct asymmetric localisation and segregation of Pon/Numb...
  82. ncbi Roles for scalloped and vestigial in regulating cell affinity and interactions between the wing blade and the wing hinge
    X Liu
    Howard Hughes Medical Institute, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Dev Biol 228:287-303. 2000
    ....
  83. pmc Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes
    R T Collins
    Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Genes Dev 14:3140-52. 2000
    ..The Wingless-regulated genes nubbin, Distal-less, and decapentaplegic and a minimal enhancer from the Ultrabithorax gene are misexpressed in osa ..
  84. ncbi Neurobiology. Developing order
    R Livesey
    Nature 413:471, 473. 2001
  85. ncbi Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS
    B Mehta
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Development 128:3161-8. 2001
    ..In GMC-1 of the RP2/sib lineage, Slit promotes asymmetric division by down regulating two POU proteins, Nubbin and Mitimere...
  86. ncbi Context-dependent utilization of Notch activity in Drosophila glial determination
    Yoshihiko Umesono
    Division of Developmental Genetics, National Institute of Genetics, Department of Genetics, Graduate University for Advanced Studies, Mishima, 411 8540, Japan
    Development 129:2391-9. 2002
    ..We present evidence that POU-domain protein Nubbin/PDM-1 is one of the factors that provide such context.
  87. ncbi Different mechanisms initiate and maintain wingless expression in the Drosophila wing hinge
    David del Alamo Rodríguez Dd
    Centro de Biología Molecular Severo Ochoa C S I C, Facultad de Ciencias CV, Universidad Autónoma Cantoblanco, 28049 Madrid, Spain
    Development 129:3995-4004. 2002
    ..evidence that wingless is initially activated by a secreted signal that requires the genes vestigial, rotund and nubbin. Later in development, wingless expression in the wing hinge is maintained by a different mechanism, which ..
  88. ncbi Size isn't everything
    David Tyler
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Bioessays 25:5-8. 2003
    ..A recent paper suggests that a hitherto overlooked cellular behaviour governs the size and shape of a growing tissue, and issues a challenge to developmental biologists to identify the molecular mechanisms involved...
  89. ncbi The regulation of apoptosis by Numb/Notch signaling in the serotonin lineage of Drosophila
    Martha J Lundell
    Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249, USA
    Development 130:4109-21. 2003
    ..These data suggest that the distribution of Numb during terminal mitotic divisions of the CNS can distinguish between a neuronal cell fate and programmed cell death...
  90. ncbi Wingless promotes cell survival but constrains growth during Drosophila wing development
    Laura A Johnston
    Department of Genetics and Development, College of Physicians and Surgeons Columbia University 701 West 168th Street, New York, NY 10032, USA
    Nat Cell Biol 5:827-33. 2003
    ..We propose that the cell-survival- and growth-constraining activities of Wg function to sculpt and delimit final wing size as part of its overall patterning programme...
  91. ncbi Heterochronic genes
    Allison L Abbott
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Curr Biol 13:R824-5. 2003
  92. ncbi The odd-skipped family of zinc finger genes promotes Drosophila leg segmentation
    Irene Hao
    Waksman Institute, Rutgers, The State University of New Jersey, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Dev Biol 263:282-95. 2003
    ....
  93. ncbi Differing strategies for the establishment and maintenance of teashirt and homothorax repression in the Drosophila wing
    Jonathan D Zirin
    Department of Biological Sciences, Columbia University, 701 West 168th Street, HHSC 1104, New York, NY 10032, USA
    Development 131:5683-93. 2004
    ..Thus, despite their overall similar expression patterns, tsh and hth repression in the wing disc is controlled by two very different mechanisms...
  94. ncbi Changing fates on the road to neuronal diversity
    Ward F Odenwald
    Neural Cell Fate Determinants Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, MD 20892, USA
    Dev Cell 8:133-4. 2005
    ..Two new studies, in this issue of Developmental Cell, provide novel insights into the molecular details of how Drosophila NPCs transition from one offspring identity program to the next...
  95. pmc FlyPNS, a database of the Drosophila embryonic and larval peripheral nervous system
    Virginie Orgogozo
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    BMC Dev Biol 5:4. 2005
    ..One main advantage of this system is the ability to study the origin and development of individual sensory cells. However, there remain several discrepancies regarding the organization of sensory organs in each abdominal segment A1-A7...
  96. ncbi Mutual repression between msh and Iro-C is an essential component of the boundary between body wall and wing in Drosophila
    Eugenia Villa-Cuesta
    Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, 28049 Madrid, Spain
    Development 132:4087-96. 2005
    ..In addition, we find that msh is necessary for proper growth of the hinge territory and the differentiation of hinge structures. msh also participates in the patterning of the notum, where it is expressed at low levels...
  97. pmc Functional analysis of genes differentially expressed in the Drosophila wing disc: role of transcripts enriched in the wing region
    Thomas L Jacobsen
    Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Genetics 174:1973-82. 2006
    ..However, there are both technical and biological limitations to this approach, including the efficacy of RNAi and the role that gene redundancy may play in masking phenotypes...
  98. ncbi tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specification
    Joaquín de Navascués
    Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, Madrid, Spain
    Development 134:1779-88. 2007
    ..Our data support a model in which the EGFR and Dpp signalling pathways, with their respective downstream Iro-C and tup genes, converge and cooperate to commit cells to the notum developmental fate...
  99. pmc Precise registration of gene expression boundaries by a repressive morphogen in Drosophila
    Danyang Yu
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Curr Biol 18:868-76. 2008
    ..Despite intensive study, it is still unclear how the concentration profiles within gradients are spatially related to the critical patterning thresholds they generate...
  100. doi Neuroblast entry into quiescence is regulated intrinsically by the combined action of spatial Hox proteins and temporal identity factors
    Takuya Tsuji
    Center for Frontier Research, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Development 135:3859-69. 2008
    ....

Research Grants7

  1. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
    ..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
  2. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
    ....
  3. CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKER
    Gerard Campbell; Fiscal Year: 2004
    ..Consequently, the present research should have direct relevance to our understanding of how defects in TGF-B signaling can lead to disease. ..
  4. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2007
    ..Our proposed studies will provide insights that should facilitate new therapies for treatment of motoneuron diseases and injury. ..
  5. University of Oregon Animal Resource Improvements
    Judith Eisen; Fiscal Year: 2008
    ..This will significantly increase our ability to ensure the health of our many genetically-distinct, and therefore irreplaceable lines of stickleback. [unreadable] [unreadable] [unreadable]..
  6. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    GERARD L CAMPBELL; Fiscal Year: 2010
    ..Consequently, the proposed studies should provide insights into diseases such as these, potentially leading to improved diagnosis and treatment. ..
  7. Functional Analysis of Mouse Numb and Numblike in Neural Development
    Weimin Zhong; Fiscal Year: 2010
    ..Such knowledge may point to mechanisms that cause brain cells to revert to less differentiated states in brain tumors or degenerate in neurological disorders. ..