Genomes and Genes
Gene Symbol: nub
Alias: CG15488, CG15489, CG34395, CG6246, Dmel\CG34395, Dmel_CG15488, Dmel_CG15489, Dmel_CG6246, NUB, Nub, Oct-1, Oct1, PDM-1, PDM1, POU33F1, Pdm, Pdm-1, Pdm1, dOct1, dPOU-19, dPOU-19/pdm-1, dPOU19, pdm, pdm-1, pdm1, twn, CG34395 gene product from transcript CG34395-RB, CG34395-PB, CG34395-PD, CG34395-PE, NUBBIN, POU domain protein 1, nub-PB, nub-PD, nub-PE, twain
Species: fruit fly
Publications123 found, 100 shown here
- Characterization of two Drosophila POU domain genes, related to oct-1 and oct-2, and the regulation of their expression patternsA Lloyd
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112
Mech Dev 36:87-102. 1991..These POU domain genes, pdm-1 and pdm-2, are expressed at high levels during early embryogenesis and at lower levels throughout the rest of ..
- The miti-mere and pdm1 genes collaborate during specification of the RP2/sib lineage in Drosophila neurogenesisK M Bhat
Department of Molecular Biology, Princeton University, New Jersey 08544, USA
Mol Cell Biol 15:4052-63. 1995We have investigated (i) the role of pdm1, a Drosophila POU gene, during the elaboration of the GMC-1-->RP2/sib lineage and (ii) the functional relationship between pdm1 and the closely linked second POU gene, miti-mere, in this ..
- On the functional overlap between two Drosophila POU homeo domain genes and the cell fate specification of a CNS neural precursorS L Yeo
Institute of Molecular and Cell Biology, National University of Singapore
Genes Dev 9:1223-36. 1995..the NB4-2 lineage, two closely linked and structurally related POU homeo domain genes, pdm-2 (dPOU28) and pdm-1 (dPOU19), both encode proteins that accumulate to high levels only in the first GMC (GMC4-2a) and not in its progeny, the ..
- The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in DrosophilaG Halder
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706 USA
Genes Dev 12:3900-9. 1998..Combinatorial regulation by selector proteins and signal transducers is likely to be a general feature of the tissue-specific control of gene expression during organogenesis...
- Joint development in the Drosophila leg: cell movements and cell populationsChristen Mirth
Department of Zoology, University Museum of Zoology, Downing Street, Cambridge CB2 3EJ, United Kingdom
Dev Biol 246:391-406. 2002..These markers also define a number of more localised territories within the pupal joint...
- DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLEStephen Malin
Department of Microbiology and Tumor biology Box 280, Karolinska Institutet, 171 77 Stockholm, Sweden
Nucleic Acids Res 33:4618-25. 2005....
- dOct2, a Drosophila Oct transcription factor that functions in yeastK Prakash
Division of Chemistry, California Institute of Technology, Pasadena 91125
Proc Natl Acad Sci U S A 89:7080-4. 1992..Our data strongly suggest possible functions for the Oct factor in pattern formation in Drosophila that might transcend the boundaries of genetically defined segmentation genes...
- Isolation of a family of Drosophila POU domain genes expressed in early developmentA N Billin
Department of Biological Sciences, University of California, Santa Barbara 93106
Mech Dev 34:75-84. 1991..We have isolated genomic and cDNA clones from three Drosophila POU domain genes, designated pdm-1, pdm-2, and Cf1a...
- Two closely linked Drosophila POU domain genes are expressed in neuroblasts and sensory elementsT Dick
Institute of Molecular and Cell Biology, National University of Singapore
Proc Natl Acad Sci U S A 88:7645-9. 1991..The mRNAs encode 601- and 475-amino acid deduced proteins; their POU domains are most related to those of the human OCT1 and OCT2...
- A POU homeo domain protein related to dPOU-19/pdm-1 binds to the regulatory DNA necessary for vital expression of the Drosophila choline acetyltransferase geneT Kitamoto
Division of Neurosciences, Institute of the City of Hope, Duarte, California 91010, USA
J Neurosci 15:3509-18. 1995..the 22-mer as a probe, we have isolated a cDNA clone encoding the Drosophila POU homeo domain protein, dPOU-19/pdm-1, whose target genes and specific binding sequences have not been identified...
- Nubbin encodes a POU-domain protein required for proximal-distal patterning in the Drosophila wingM Ng
Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany
Development 121:589-99. 1995The nubbin gene is required for normal growth and patterning of the wing in Drosophila. We report here that nubbin encodes a member of the POU family of transcription factors...
- A universal target sequence is bound in vitro by diverse homeodomainsB Kalionis
Department of Biochemistry and Biophysics, University of California at San Francisco 94143 0448
Mech Dev 43:57-70. 1993..We conclude that during the evolutionary divergence of homeodomains, the specificity of DNA binding has been much more highly conserved than the amino acid sequence...
- The Drosophila miti-mere gene, a member of the POU family, is required for the specification of the RP2/sibling lineage during neurogenesisK M Bhat
Department of Molecular Biology, Princeton University, New Jersey 08544
Development 120:1483-501. 1994..miti is initially required in this lineage to establish the identity of the parental ganglion mother cell, GMC-1. miti must then be down-regulated to allow the asymmetric division of GMC-1 into the RP2 and its sibling cell...
- Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wingF J Diaz-Benjumea
Differentiation Program, European Molecular Biology Laboratory, Heidelberg, Germany
Development 121:4215-25. 1995..Ligand independent activation of Notch is sufficient to direct Wg expression, which in turn mediates the organizing activity of the D/V boundary...
- Proximo-distal specification in the wing disc of Drosophila by the nubbin geneF J Cifuentes
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Cantoblanco 28049 Madrid, Spain
Proc Natl Acad Sci U S A 94:11405-10. 1997Mutations in the nubbin (nub) gene have a phenotype consisting of a severe wing size reduction and pattern alterations, such as transformations of distal elements into proximal ones...
- Regulation of POU genes by castor and hunchback establishes layered compartments in the Drosophila CNSR Kambadur
The Neurogenetics Unit, Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland 20892 USA
Genes Dev 12:246-60. 1998..drifter and I-POU depend on cas for full expression, whereas pdm-1 and pdm-2 are negatively regulated...
- Boundary formation in Drosophila wing: Notch activity attenuated by the POU protein NubbinC J Neumann
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Science 281:409-13. 1998..Evidence is presented here that the POU domain protein Nubbin contributes to the formation of a sharp dorsoventral boundary in the Drosophila wing...
- Notch-mediated segmentation and growth control of the Drosophila legC Rauskolb
Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, New Jersey, 08854, USA
Dev Biol 210:339-50. 1999..The Notch pathway is also deployed for segmentation during vertebrate somitogenesis, which raises the possibility of a common origin for the segmentation of these distinct tissues...
- Generation of medial and lateral dorsal body domains by the pannier gene of DrosophilaM Calleja
Centro de Biologia Molecular, CSIC UAM, Spain
Development 127:3971-80. 2000..We argue that pnr acts like a classical selector gene but differs in that its expression is not propagated through cell divisions...
- Programmed transformations in neuroblast gene expression during Drosophila CNS lineage developmentT Brody
Neurogenetics Unit, Laboratory of Neurochemistry, NINDS, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
Dev Biol 226:34-44. 2000..NB) expression of four proteins, Hunchback (Hb), Pou-homeodomain proteins 1 and 2 (referred to collectively as Pdm), and Castor (Cas), identifies a transcription factor network regulating the temporal development of all ganglia...
- The selector gene cut represses a neural cell fate that is specified independently of the Achaete-Scute-Complex and atonalR Brewster
Department of Biology, The University of Michigan, 830 North University, 48109 1048, Ann Arbor, MI, USA
Mech Dev 105:57-68. 2001..Thus, cut is not only required to promote an ASC-dependent mode of differentiation, but also represses an ASC- and ato-independent fate that leads to dbd and dda1 differentiation...
- Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genomeBenjamin P Berman
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 99:757-62. 2002..We tested one of the newly identified clusters, mapping upstream of the gap gene giant (gt), and show that it acts as an enhancer that recapitulates the posterior expression pattern of gt...
- Temporally dynamic response to Wingless directs the sequential elaboration of the proximodistal axis of the Drosophila wingAlexander J Whitworth
Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
Dev Biol 254:277-88. 2003..activated by Wingless throughout the "wing primordium," but later is repressed by the activity of Vestigial and Nubbin, which together define a more distal domain...
- Proximodistal subdivision of Drosophila legs and wings: the elbow-no ocelli gene complexUlrich Weihe
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Development 131:767-74. 2004..The homeodomain protein Nubbin is expressed in the wing primordia and required for formation of wings, but not legs...
- Upregulation of Mitimere and Nubbin acts through cyclin E to confer self-renewing asymmetric division potential to neural precursor cellsKrishna Moorthi Bhat
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Development 131:1123-34. 2004..Here, we report that maintaining high levels of Mitimere or Nubbin, two POU proteins, in a GMC causes it to undergo self-renewing asymmetric divisions...
- Transcriptional control in the segmentation gene network of DrosophilaMark D Schroeder
Laboratory of Developmental Neurogenetics, Rockefeller University, New York, New York, USA
PLoS Biol 2:E271. 2004..The study demonstrates that computational methods are a powerful complement to experimental approaches in the analysis of transcription networks...
- Regulation of temporal identity transitions in Drosophila neuroblastsRuth Grosskortenhaus
Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon 1254, Eugene, Oregon 97403, USA
Dev Cell 8:193-202. 2005..model for studying temporal identity: they sequentially express four genes (hunchback --> Kruppel --> pdm1 --> castor) whose temporal regulation is essential for generating neuronal diversity...
- Regulation of neuroblast competence: multiple temporal identity factors specify distinct neuronal fates within a single early competence windowMichael D Cleary
University of Oregon Department of Neuroscience, Howard Hughes Medical Institute, Eugene, Oregon 97403, USA
Genes Dev 20:429-34. 2006..has a single early window of competence to respond to four different temporal identity genes (Hunchback, Krüppel, Pdm, and Castor); that each of these factors specifies distinct motor neuron identities within this competence window ..
- Pdm and Castor specify late-born motor neuron identity in the NB7-1 lineageRuth Grosskortenhaus
Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
Genes Dev 20:2618-27. 2006..Embryonic neuroblasts sequentially express Hunchback, Krüppel, Pdm1/Pdm2 (Pdm), and Castor (Cas) transcription factors...
- Isolation of regulators of Drosophila immune defense genes by a double interaction screen in yeastAnna Junell
Department of Molecular Biology and Functional Genomics, Stockholm University, S 109 61 Stockholm, Sweden
Insect Biochem Mol Biol 37:202-12. 2007..Most interestingly, three transcription factors belonging to the POU domain class of homeodomain proteins, Pdm1, Pdm2 and Dfr/Vvl were isolated as Dif-interacting partners, and subsequently verified as regulators of CecA1 ..
- Pdm and Castor close successive temporal identity windows in the NB3-1 lineageKhoa D Tran
Institute of Neuroscience, Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA
Development 135:3491-9. 2008..embryonic neural progenitors (neuroblasts) sequentially express the transcription factors Hunchback, Kruppel, Pdm1/Pdm2 (Pdm) and Castor as they generate a stereotyped sequence of neuronal and glial progeny...
- Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferationWen Chih Lee
Department of Developmental Biology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Development 136:2255-64. 2009..Together, these data underscore the essential requirement of Apc in exerting regulatory control over stem cell activity, as well as the consequences that disrupting this regulation can have on tissue homeostasis...
- Regenerative growth in Drosophila imaginal discs is regulated by Wingless and MycRachel K Smith-Bolton
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Dev Cell 16:797-809. 2009..This system is conducive to forward genetic screens, enabling an unbiased search for genes that regulate both the extent of and the capacity for regeneration...
- JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineageKatherine Beebe
Washington University School of Medicine, Department of Developmental Biology, Campus Box 8103, 660 South Euclid Avenue, St Louis, MO 63110, USA
Dev Biol 338:28-37. 2010....
- Extraction and comparison of gene expression patterns from 2D RNA in situ hybridization imagesDaniel L Mace
Computational Biology and Bioinformatics Graduate Program, Duke University, Durham, NC 27708, USA
Bioinformatics 26:761-9. 2010..In order to deal with available large datasets, fully automated analysis methods must be developed to properly normalize and model spatial expression patterns...
- A transient niche regulates the specification of Drosophila intestinal stem cellsDivya Mathur
Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
Science 327:210-3. 2010..Our results demonstrate a paradigm for stem cell-niche biology, where progenitors generate transient niches that determine stem cell fate and may give insights into stem cell specification in other tissues...
- Robustness under functional constraint: the genetic network for temporal expression in Drosophila neurogenesisAkihiko Nakajima
Department of Basic Science, University of Tokyo, Komaba, Tokyo, Japan
PLoS Comput Biol 6:e1000760. 2010..This study suggests that the Drosophila network for sequential expression has evolved to generate the robust temporal expression for neuronal specification...
- The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regenerationRachael L Shaw
Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3LY, UK
Development 137:4147-58. 2010..Our results suggest that the Hpo pathway is a mediator of the regenerative response in the Drosophila midgut...
- Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathwaysFangfang Ren
Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 107:21064-9. 2010..Finally, we show that the Hpo pathway mediator Yorkie (Yki) is also required in precursor cells for injury-induced ISC proliferation in response to tissue-damaging reagent DSS...
- Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestineCarolina N Perdigoto
Institut Pasteur, Developmental Biology Department, F 75015 Paris, France
Development 138:4585-95. 2011..Our work suggests that a commitment requirement for high-level Notch activity safeguards the stem cells from loss through differentiation, revealing a novel role for the importance of Notch signaling levels in this system...
- Progressive tarsal patterning in the Drosophila by temporally dynamic regulation of transcription factor genesKohei Natori
Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 5 1 5 Kashiwanoha, Kashiwa City, Chiba 277 8562, Japan
Dev Biol 361:450-62. 2012..The results indicate that nubbin is expressed over a broad region at early stages but gradually disappears from the middle of the tarsal region...
- Trachea-derived dpp controls adult midgut homeostasis in DrosophilaZhouhua Li
State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
Dev Cell 24:133-43. 2013..This work will provide important insights into the mechanisms of tissue homeostasis control by interorgan communication...
- Multiple roles of the gene zinc finger homeodomain-2 in the development of the Drosophila wingDaniel Perea
Centro de Biologia Molecular Severo Ochoa, Universidad Autónoma Cantoblanco, 28049 Madrid, Spain
Mech Dev 130:467-81. 2013....
- Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progenyT Isshiki
Institute of Neuroscience Institute of Molecular Biology, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, OR 97403, USA
Cell 106:511-21. 2001..neural precursors (neuroblasts) sequentially express the transcription factors Hunchback --> Krüppel --> Pdm --> Castor, with differentiated progeny maintaining the transcription factor profile present at their birth...
- Hunchback is required for the specification of the early sublineage of neuroblast 7-3 in the Drosophila central nervous systemTanja Novotny
Institut fur Genetik, Universitat Mainz, Saarstrasse 21, D 55122 Mainz, Germany
Development 129:1027-36. 2002....
- The Drosophila kekkon genes: novel members of both the leucine-rich repeat and immunoglobulin superfamilies expressed in the CNSM Musacchio
Department of Genetics, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
Dev Biol 178:63-76. 1996..Genetic analysis reveals that deletion of the kek1 gene causes no obvious developmental defects. The coexpression of kek2 in the CNS leads us to suggest that Kek1 is part of a family of cell surface proteins with redundant function...
- Wg and Egfr signalling antagonise the development of the peripodial epithelium in Drosophila wing discsLuis Alberto Baena-Lopez
Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Facultad de Ciencias, 28049, Madrid, Spain
Development 130:6497-506. 2003..These findings suggest that suppression of Wg and Egfr activities is an early step in the development of the peripodial epithelium of the wing discs...
- The role of the T-box gene optomotor-blind in patterning the Drosophila wingDavid del Alamo Rodríguez
Centro de Biología Molecular C S I C, Universidad Autonoma de Madrid Cantoblanco, Madrid E 28049, Spain
Dev Biol 268:481-92. 2004..The lack of optomotor-blind produces massive cell death in its expression domain, which leads to the mis-activation of the Notch pathway and the overproliferation of lateral wing cells...
- Mother-daughter precursor cell fate transformation after Cdc2 down-regulation in the Drosophila bristle lineagePierre Fichelson
UMR 7622, CNRS Universite Paris VI, 9, quai St Bernard, 75252 Paris Cedex 05, France
Dev Biol 276:367-77. 2004..These transformations in cell identity suggest that, although synchronized, cell cycle and fate determination are independent phenomena in the bristle lineage...
- The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and DeltaEric C Lai
Department of Molecular and Cell Biology, Howard Hughes Medical Institute, 545 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720 3200, USA
Development 132:2319-32. 2005..We conclude that ubiquitination of Delta and Serrate by Neuralized and D-mib is an obligate feature of DSL ligand activation throughout Drosophila development...
- Hox control of organ size by regulation of morphogen production and mobilityMichael A Crickmore
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Science 313:63-8. 2006..Because morphogens control tissue growth in many contexts, these findings provide a potentially general mechanism for how selector genes modify organ sizes...
- Notch signal organizes the Drosophila olfactory circuitry by diversifying the sensory neuronal lineagesKeita Endo
Laboratory for Neural Network Development, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minami, Chuo, Kobe, Hyogo 650 0047, Japan
Nat Neurosci 10:153-60. 2007..Thus, Notch signaling contributes to the diversification of ORNs, thereby regulating multiple developmental events that establish the olfactory map in Drosophila...
- Functional screening identifies miR-315 as a potent activator of Wingless signalingSerena J Silver
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:18151-6. 2007..In summary, activity-based screening can selectively identify miRNAs whose deregulation can lead to interpretable phenotypic consequences...
- Evolution of nubbin function in hemimetabolous and holometabolous insect appendagesNataliya Turchyn
Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
Dev Biol 357:83-95. 2011..A recent study in a hemipteran, Oncopeltus fasciatus (milkweed bug), showed that nubbin (nub) affects antenna morphogenesis, labial patterning, the length of the femoral segment in legs, and the ..
- The role of the histone H2A ubiquitinase Sce in Polycomb repressionLuis Gutierrez
EMBL, Gene Expression Programme, Meyerhofstr 1, 69117 Heidelberg, Germany
Development 139:117-27. 2012..Sce synergizes with the Polycomb repressive deubiquitinase (PR-DUB) complex to repress transcription at class I genes, suggesting that H2A monoubiquitylation must be appropriately balanced for their transcriptional repression...
- JAK/STAT signaling is required for hinge growth and patterning in the Drosophila wing discAidee Ayala-Camargo
Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York 10016 6402, USA
Dev Biol 382:413-26. 2013..Within the hinge, Stat92E activity becomes restricted to gap domain cells that lack Nubbin and Teashirt...
- The metazoan-specific mediator subunit 26 (Med26) is essential for viability and is found at both active genes and pericentric heterochromatin in Drosophila melanogasterSharon K Marr
Mol Cell Biol 34:2710-20. 2014..This work is the first characterization of the metazoan-specific Mediator subunit in an animal model...
- Courtship song does not increase the rate of adaptation to a thermally stressful environment in a Drosophila melanogaster laboratory populationLarry G Cabral
Department of Biological Sciences, California State University, Sacramento, California, United States of America
PLoS ONE 9:e111148. 2014..There were no differences between the treatments. Possible explanations for these results are discussed. ..
- Neuronal Cell Fate Specification by the Convergence of Different Spatiotemporal Cues on a Common Terminal Selector CascadeHugo Gabilondo
Departamento de Biologia, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
PLoS Biol 14:e1002450. 2016..Here, we find that the same terminal selector cascade is triggered by Kr/pdm>grn in dAp neurons, but by Antp/hth/exd/lbe/cas in Tv1 neurons...
- Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegansM Muckenthaler
European Molecular Biology Laboratory, Heidelberg, Germany
Eur J Biochem 254:230-7. 1998..elegans will facilitate a genetic analysis of the IRE/IRP system, thus opening a new avenue to explore this regulatory network...
- Drosophila octamer elements and Pdm-1 dictate the coordinated transcription of core histone genesMei Chin Lee
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore
J Biol Chem 285:9041-53. 2010..These elements recruit transcription factor POU-domain protein in D. melanogaster 1 (Pdm-1), which along with co-activator dmOct-1 coactivator in S-phase (dmOCA-S), activates transcription from at least ..
- Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation geneMaría Losada-Pérez
Departamento de Biologia, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
Mech Dev 127:458-71. 2010..Furthermore, these results imply that the activation of a particular terminal differentiation gene in temporally unrestricted...
- Getting real with real-time qPCR: a case study of reference gene selection for morphological variation in Drosophila melanogaster wingsBruna P Matta
Laboratório de Evolução de Caracteres Complexos, Departamento de Genetica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, s n Prédio do CCS, Bloco A, sala A2 075 Cidade Universitária, Rio de Janeiro, 21941 617, RJ, Brazil
Dev Genes Evol 221:49-57. 2011....
- A novel tissue in an established model system: the Drosophila pupal midgutShigeo Takashima
Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
Dev Genes Evol 221:69-81. 2011..The formation of a pupal midgut has been reported from several other species and may represent a general feature of intestinal metamorphosis in insects...
- Tag team specification of a neural precursor in the Drosophila embryonic central nervous systemJ B Skeath
Department of Cell and Structural Biology, Howard Hughes Medical Institute, University of Illinois, Urbana 61801, USA
Bioessays 17:829-31. 1995..A recent report details the roles that two genes, pdm-1 and pdm-2, play within an identified neural stem cell lineage in the Drosophila embryonic central nervous system...
- huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfindingQ Chu-LaGraff
Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
Neuron 15:1041-51. 1995..Thus, huckebein regulates aspects of GMC and neuronal identity required for proper motoneuron axon pathfinding in the NB 4-2 lineage...
- Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGF beta homologs during Drosophila embryogenesisM Affolter
Biozentrum, Universitat Basel, Switzerland
Development 120:3105-17. 1994..The requirements for tkv in dorsal closure, visceral mesoderm and trachea development assign novel functions to dpp or a closely related member of the TGF beta superfamily...
- Regional repression of a Drosophila POU box gene in the endoderm involves inductive interactions between germ layersM Affolter
Biozentrum, University of Basel, Switzerland
Development 117:1199-210. 1993..We report here that proper spatial regulation of the Drosophila POU box gene pdm-1 products also involves interaction between these two germ layers...
- Regulation of expression domains and effects of ectopic expression reveal gap gene-like properties of the linked pdm genes of DrosophilaK A Cockerill
Department of Biology, University of California Santa Barbara 93106
Mech Dev 41:139-53. 1993The closely linked POU domain genes pdm-1 and pdm-2 are first expressed early during cellularization in the presumptive abdomen in a broad domain that soon resolves into two stripes...
- Distinct mitogenic and cell fate specification functions of wingless in different regions of the wingC J Neumann
European Molecular Biology Laboratory, Heidelberg, Germany
Development 122:1781-9. 1996..By contrast, overexpression of wg in the wing blade leads to repatterning and only secondarily to proliferation. These results suggest that the Wg signal elicits very different responses in different regions of the wing imaginal disc...
- Neurogenesis in the insect central nervous systemC Q Doe
Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
Curr Opin Neurobiol 6:18-24. 1996..And finally, new cell-lineage methods are being used to determine the entire lineage of identified neuroblasts, including axon projections and synaptic contacts...
- Wing development and specification of dorsal cell fates in the absence of apterous in DrosophilaT Klein
Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK
Curr Biol 8:417-20. 1998..In ap mutants, the wing is lost  , and here we report that this phenotype can be rescued by ectopic expression of either Ser or fng and that, surprisingly, the resulting wings have both dorsal and ventral cell fates...
- Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cellsM Buescher
Institute of Molecular and Cell Biology, National University of Singapore, Singapore
Genes Dev 12:1858-70. 1998..Moreover, our data suggest that the fate of some sibling neurons may be regulated by signals that do not require lateral interaction between the sibling cells...
- Growth and patterning from the engrailed interfaceA Hidalgo
Department of Genetics, University of Cambridge, United Kingdom
Int J Dev Biol 42:317-24. 1998..Finally, regulatory interactions between en/En-1 and hh/Shh may be significant in the context of morphogenetic regulation during normal development...
- Positive and negative control of Serrate expression during early development of the Drosophila wingA Bachmann
Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225, Dusseldorf, Germany
Mech Dev 76:67-78. 1998..The results clearly show that some of the previously described transactivators of Serrate protein expression, e.g. fringe, act on elements required for later aspects of Serrate expression...
- Genetic and molecular analyses of motoneuron developmentJ S Eisen
Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403, USA
Curr Opin Neurobiol 8:697-704. 1998..Many of the same molecules participate in the guidance of both vertebrate and fly motor axons. It is less clear, however, whether the same molecular mechanisms establish vertebrate and fly motoneuron identities...
- Fringe, Notch, and making developmental boundariesK D Irvine
Waksman Institute, Department of Molecular Biology and Biochemistry, 190 Frelinghuysen Rd, Rutgers University, Piscataway, New Jersey 08854, USA
Curr Opin Genet Dev 9:434-41. 1999..of Notch signaling by Fringe, autonomous inhibition by Notch ligands, and inhibition of Notch target genes by Nubbin. Recent studies have revealed that Fringe also modulates a Notch-mediated signaling process between dorsal and ..
- A dual role for homothorax in inhibiting wing blade development and specifying proximal wing identities in DrosophilaF Casares
Department of Biochemistry and Molecular Biophysics, Columbia University, HHSC 1108, New York, NY 10032 USA
Development 127:1499-508. 2000..Our results suggest that tsh and hth block wing blade development by repressing some of the activities of the Notch pathway at the D/V compartment boundary...
- Cell behaviour of Drosophila fat cadherin mutations in wing developmentF Garoia
Dipartimento di Biologia Evoluzionistica Sperimentale, Universita di Bologna, Italy
Mech Dev 94:95-109. 2000..Mutant ft cells show, in addition, smaller cell sizes during proliferation and abnormal cuticular differentiation, which reflect cell membrane and cytoskeleton anomalies, which are not modulated by the DER pathway...
- Functional interactions between Drosophila bHLH/PAS, Sox, and POU transcription factors regulate CNS midline expression of the slit geneY Ma
Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
J Neurosci 20:4596-605. 2000..Functional interactions between members of these protein families may be important for numerous developmental and physiological processes...
- Jumeaux, a novel Drosophila winged-helix family protein, is required for generating asymmetric sibling neuronal cell fatesP Y Cheah
Institute of Molecular and Cell Biology, National University of Singapore Campus, Singapore 117609
Development 127:3325-35. 2000..Our results suggest that in addition to the correct formation of an apical complex, transcription mediated by Jumu is also necessary to facilitate the correct asymmetric localisation and segregation of Pon/Numb...
- Roles for scalloped and vestigial in regulating cell affinity and interactions between the wing blade and the wing hingeX Liu
Howard Hughes Medical Institute, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854, USA
Dev Biol 228:287-303. 2000....
- Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genesR T Collins
Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
Genes Dev 14:3140-52. 2000..The Wingless-regulated genes nubbin, Distal-less, and decapentaplegic and a minimal enhancer from the Ultrabithorax gene are misexpressed in osa ..
- Neurobiology. Developing orderR Livesey
Nature 413:471, 473. 2001
- Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNSB Mehta
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Development 128:3161-8. 2001..In GMC-1 of the RP2/sib lineage, Slit promotes asymmetric division by down regulating two POU proteins, Nubbin and Mitimere...
- Context-dependent utilization of Notch activity in Drosophila glial determinationYoshihiko Umesono
Division of Developmental Genetics, National Institute of Genetics, Department of Genetics, Graduate University for Advanced Studies, Mishima, 411 8540, Japan
Development 129:2391-9. 2002..We present evidence that POU-domain protein Nubbin/PDM-1 is one of the factors that provide such context.
- Different mechanisms initiate and maintain wingless expression in the Drosophila wing hingeDavid del Alamo Rodríguez Dd
Centro de Biología Molecular Severo Ochoa C S I C, Facultad de Ciencias CV, Universidad Autónoma Cantoblanco, 28049 Madrid, Spain
Development 129:3995-4004. 2002..evidence that wingless is initially activated by a secreted signal that requires the genes vestigial, rotund and nubbin. Later in development, wingless expression in the wing hinge is maintained by a different mechanism, which ..
- Size isn't everythingDavid Tyler
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Bioessays 25:5-8. 2003..A recent paper suggests that a hitherto overlooked cellular behaviour governs the size and shape of a growing tissue, and issues a challenge to developmental biologists to identify the molecular mechanisms involved...
- The regulation of apoptosis by Numb/Notch signaling in the serotonin lineage of DrosophilaMartha J Lundell
Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249, USA
Development 130:4109-21. 2003..These data suggest that the distribution of Numb during terminal mitotic divisions of the CNS can distinguish between a neuronal cell fate and programmed cell death...
- Wingless promotes cell survival but constrains growth during Drosophila wing developmentLaura A Johnston
Department of Genetics and Development, College of Physicians and Surgeons Columbia University 701 West 168th Street, New York, NY 10032, USA
Nat Cell Biol 5:827-33. 2003..We propose that the cell-survival- and growth-constraining activities of Wg function to sculpt and delimit final wing size as part of its overall patterning programme...
- Heterochronic genesAllison L Abbott
Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Curr Biol 13:R824-5. 2003
- The odd-skipped family of zinc finger genes promotes Drosophila leg segmentationIrene Hao
Waksman Institute, Rutgers, The State University of New Jersey, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA
Dev Biol 263:282-95. 2003....
- Differing strategies for the establishment and maintenance of teashirt and homothorax repression in the Drosophila wingJonathan D Zirin
Department of Biological Sciences, Columbia University, 701 West 168th Street, HHSC 1104, New York, NY 10032, USA
Development 131:5683-93. 2004..Thus, despite their overall similar expression patterns, tsh and hth repression in the wing disc is controlled by two very different mechanisms...
- Changing fates on the road to neuronal diversityWard F Odenwald
Neural Cell Fate Determinants Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, MD 20892, USA
Dev Cell 8:133-4. 2005..Two new studies, in this issue of Developmental Cell, provide novel insights into the molecular details of how Drosophila NPCs transition from one offspring identity program to the next...
- FlyPNS, a database of the Drosophila embryonic and larval peripheral nervous systemVirginie Orgogozo
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
BMC Dev Biol 5:4. 2005..One main advantage of this system is the ability to study the origin and development of individual sensory cells. However, there remain several discrepancies regarding the organization of sensory organs in each abdominal segment A1-A7...
- Mutual repression between msh and Iro-C is an essential component of the boundary between body wall and wing in DrosophilaEugenia Villa-Cuesta
Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, 28049 Madrid, Spain
Development 132:4087-96. 2005..In addition, we find that msh is necessary for proper growth of the hinge territory and the differentiation of hinge structures. msh also participates in the patterning of the notum, where it is expressed at low levels...
- Functional analysis of genes differentially expressed in the Drosophila wing disc: role of transcripts enriched in the wing regionThomas L Jacobsen
Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA
Genetics 174:1973-82. 2006..However, there are both technical and biological limitations to this approach, including the efficacy of RNAi and the role that gene redundancy may play in masking phenotypes...
- tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specificationJoaquín de Navascués
Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, Madrid, Spain
Development 134:1779-88. 2007..Our data support a model in which the EGFR and Dpp signalling pathways, with their respective downstream Iro-C and tup genes, converge and cooperate to commit cells to the notum developmental fate...
- Precise registration of gene expression boundaries by a repressive morphogen in DrosophilaDanyang Yu
Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
Curr Biol 18:868-76. 2008..Despite intensive study, it is still unclear how the concentration profiles within gradients are spatially related to the critical patterning thresholds they generate...
- Neuroblast entry into quiescence is regulated intrinsically by the combined action of spatial Hox proteins and temporal identity factorsTakuya Tsuji
Center for Frontier Research, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
Development 135:3859-69. 2008....
- MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONSChris Doe; Fiscal Year: 2002..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
- Analysis of fringe-dependent cell-signalingKenneth Irvine; Fiscal Year: 2004....
- CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKERGerard Campbell; Fiscal Year: 2004..Consequently, the present research should have direct relevance to our understanding of how defects in TGF-B signaling can lead to disease. ..
- DEVELOPMENT OF IDENTIFIED MOTONEURONSJudith Eisen; Fiscal Year: 2007..Our proposed studies will provide insights that should facilitate new therapies for treatment of motoneuron diseases and injury. ..
- University of Oregon Animal Resource ImprovementsJudith Eisen; Fiscal Year: 2008..This will significantly increase our ability to ensure the health of our many genetically-distinct, and therefore irreplaceable lines of stickleback. [unreadable] [unreadable] [unreadable]..
- MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILAGERARD L CAMPBELL; Fiscal Year: 2010..Consequently, the proposed studies should provide insights into diseases such as these, potentially leading to improved diagnosis and treatment. ..
- Functional Analysis of Mouse Numb and Numblike in Neural DevelopmentWeimin Zhong; Fiscal Year: 2010..Such knowledge may point to mechanisms that cause brain cells to revert to less differentiated states in brain tumors or degenerate in neurological disorders. ..