Gene Symbol: nrv3
Description: nervana 3
Alias: CG8663, Dmel\CG8663, JYbeta1, Nrv3, nervana3, nervana 3, CG8663-PA, CG8663-PC, CG8663-PD, CG8663-PE, Na,K-ATPase beta-subunit, nrv3-PA, nrv3-PC, nrv3-PD, nrv3-PE
Species: fruit fly

Top Publications

  1. Paul S, Palladino M, Beitel G. A pump-independent function of the Na,K-ATPase is required for epithelial junction function and tracheal tube-size control. Development. 2007;134:147-55 pubmed
    ..When the normally neuronal Nrv3 is expressed in epithelial cells, it does not associate with SJs...
  2. Roy M, Sivan Loukianova E, Eberl D. Cell-type-specific roles of Na+/K+ ATPase subunits in Drosophila auditory mechanosensation. Proc Natl Acad Sci U S A. 2013;110:181-6 pubmed publisher
    ..We knocked down expression of ? subunits (ATP? and ?-like) and ? subunits (nrv1, nrv2, and nrv3) individually in JO with UAS/Gal4-mediated RNAi...
  3. Christie K, Sivan Loukianova E, Smith W, Aldrich B, Schon M, Roy M, et al. Physiological, anatomical, and behavioral changes after acoustic trauma in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2013;110:15449-54 pubmed publisher
    ..In nervana 3 heterozygous flies, which slightly compromise ion homeostasis, trauma had exaggerated effects on SEP amplitude ..
  4. Schneider C, Will C, BROSIUS J, Frilander M, Luhrmann R. Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila. Proc Natl Acad Sci U S A. 2004;101:9584-9 pubmed
    ..A comparison of U11 snRNAs that we have identified from vertebrates, plants, and insects, suggests that an evolutionarily divergent U11 snRNA may be unique to Drosophila and not characteristic of insects in general. ..
  5. Baumann O, Salvaterra P, Takeyasu K. Developmental changes in beta-subunit composition of Na,K-ATPase in the Drosophila eye. Cell Tissue Res. 2010;340:215-28 pubmed publisher
    ..Here, we provide evidence that nrv3 also encodes for a functional Na,K-ATPase beta-subunit, as its protein product co-precipitates with the Na,K-ATPase ..
  6. Günesdogan U, Jackle H, Herzig A. A genetic system to assess in vivo the functions of histones and histone modifications in higher eukaryotes. EMBO Rep. 2010;11:772-6 pubmed publisher
  7. Dalla S, Swarts H, Koenderink J, Dobler S. Amino acid substitutions of Na,K-ATPase conferring decreased sensitivity to cardenolides in insects compared to mammals. Insect Biochem Mol Biol. 2013;43:1109-15 pubmed publisher expressed the ouabain sensitive Na,K-ATPase ?-subunit of Drosophila melanogaster together with the ?-subunit Nrv3 in baculovirus-infected Sf9 cells and introduced the substitutions N122H, T797A, Q111T-N122H, Q111V-N122H, all of ..
  8. Luan Z, Reddig K, Li H. Loss of Na(+)/K(+)-ATPase in Drosophila photoreceptors leads to blindness and age-dependent neurodegeneration. Exp Neurol. 2014;261:791-801 pubmed publisher
    ..Loss of Nrv3, a Na(+)/K(+)-ATPase β subunit, partially reproduced the signaling and degenerative defects observed in ATPα ..
  9. Paul S, Ternet M, Salvaterra P, Beitel G. The Na+/K+ ATPase is required for septate junction function and epithelial tube-size control in the Drosophila tracheal system. Development. 2003;130:4963-74 pubmed

More Information


  1. MacMillan H, Ferguson L, Nicolai A, Donini A, Staples J, Sinclair B. Parallel ionoregulatory adjustments underlie phenotypic plasticity and evolution of Drosophila cold tolerance. J Exp Biol. 2015;218:423-32 pubmed publisher
    ..We propose that this could have served as an evolutionary route by which chill-susceptible insects developed more extreme cold tolerance strategies. ..