Genomes and Genes
Gene Symbol: Nrt
Alias: BP106, BcDNA:LD22004, CG9704, DAB, Dab, Dmel\CG9704, MabBP106, NRT, NRT BP106, Neur, Nrt BP106, dab, l(3)73Be, neu, nrt, neurotactin, CG9704-PA, CG9704-PB, CG9704-PC, Nrt-PA, Nrt-PB, Nrt-PC, disabled
Species: fruit fly
- Pereanu W, Hartenstein V. Neural lineages of the Drosophila brain: a three-dimensional digital atlas of the pattern of lineage location and projection at the late larval stage. J Neurosci. 2006;26:5534-53 pubmed..In this paper, we visualized secondary lineages by the global marker BP106 (neurotactin), as well as green fluorescent protein-labeled clones and thereby establish a comprehensive digital atlas of ..
- Gryzik T, Müller H. FGF8-like1 and FGF8-like2 encode putative ligands of the FGF receptor Htl and are required for mesoderm migration in the Drosophila gastrula. Curr Biol. 2004;14:659-67 pubmed..Our results suggest that FGF8-like1 and FGF8-like2 represent ligands of the Htl FGF receptor. ..
- Bertet C, Rauzi M, Lecuit T. Repression of Wasp by JAK/STAT signalling inhibits medial actomyosin network assembly and apical cell constriction in intercalating epithelial cells. Development. 2009;136:4199-212 pubmed publisher..We discuss possible models for the role of Wasp activity in the regulation of Myo-II distribution. ..
- Martin A, Gelbart M, Fernandez Gonzalez R, Kaschube M, Wieschaus E. Integration of contractile forces during tissue invagination. J Cell Biol. 2010;188:735-49 pubmed publisher..Thus, pulsed actomyosin contractions require a supracellular, tensile meshwork to transmit cellular forces to the tissue level during morphogenesis. ..
- Stein J, Broihier H, Moore L, Lehmann R. Slow as molasses is required for polarized membrane growth and germ cell migration in Drosophila. Development. 2002;129:3925-34 pubmed
- Cardona A, Saalfeld S, Arganda I, Pereanu W, Schindelin J, Hartenstein V. Identifying neuronal lineages of Drosophila by sequence analysis of axon tracts. J Neurosci. 2010;30:7538-53 pubmed publisher..We describe for the first time an algorithm that quantifies neuronal projection stereotypy in the Drosophila brain and use the algorithm for automatic neuron and lineage recognition...
- Viktorin G, Riebli N, Popkova A, Giangrande A, Reichert H. Multipotent neural stem cells generate glial cells of the central complex through transit amplifying intermediate progenitors in Drosophila brain development. Dev Biol. 2011;356:553-65 pubmed publisher..Moreover, they indicate that type II neuroblasts are remarkably multipotent neural stem cells that can generate both the neuronal and the glial progeny that make major contributions to one and the same complex brain structure. ..
- Zallen J, Wieschaus E. Patterned gene expression directs bipolar planar polarity in Drosophila. Dev Cell. 2004;6:343-55 pubmed..These results indicate that spatial patterns of gene expression coordinate planar polarity across a multicellular population through the localized distribution of proteins required for cell movement. ..
- Henkemeyer M, West S, Gertler F, Hoffmann F. A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization. Cell. 1990;63:949-60 pubmed
- Bilder D, Schober M, Perrimon N. Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat Cell Biol. 2003;5:53-8 pubmed..Our data suggest a model in which the maturation of epithelial cell polarity is driven by integration of the sequential activities of PDZ-based protein complexes. ..
- Bennett R, Hoffmann F. Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactions. Development. 1992;116:953-66 pubmed..The expression patterns and mutant phenotypes indicate a role for abl in establishing and maintaining cell-cell interactions. ..
- Blankenship J, Backovic S, Sanny J, Weitz O, Zallen J. Multicellular rosette formation links planar cell polarity to tissue morphogenesis. Dev Cell. 2006;11:459-70 pubmed..We propose that the generation of higher-order rosette structures links local cell interactions to global tissue reorganization during morphogenesis. ..
- Gertler F, Doctor J, Hoffmann F. Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog. Science. 1990;248:857-60 pubmed..The mutations are recessive embryonic lethal mutations but act as dominant mutations to compensate for the neural defects of abl mutants. Thus, mutations in a specific gene can compensate for the absence of a tyrosine kinase. ..
- Dawes Hoang R, Parmar K, Christiansen A, Phelps C, Brand A, Wieschaus E. folded gastrulation, cell shape change and the control of myosin localization. Development. 2005;132:4165-78 pubmed..Our analysis of fog function therefore provides a direct link from patterning to cell shape change. ..
- Larsen C, Shy D, Spindler S, Fung S, Pereanu W, Younossi Hartenstein A, et al. Patterns of growth, axonal extension and axonal arborization of neuronal lineages in the developing Drosophila brain. Dev Biol. 2009;335:289-304 pubmed publisher..Arbors of secondary neurons form within or adjacent to the larval compartments, resulting in smaller compartment subdivisions and additional, adult specific compartments. ..
- Gertler F, Bennett R, Clark M, Hoffmann F. Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled. Cell. 1989;58:103-13 pubmed..In the absence of abl function, however, heterozygous mutations or deletions of disabled (dab) exert dominant effects, disrupting axonal organization and shifting the lethal phase of the animals to ..
- Bilder D, Perrimon N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature. 2000;403:676-80 pubmed..Our results show that the lateral domain of epithelia, particularly the septate junction, functions in restricting apical membrane identity and correctly placing adherens junctions. ..
- Van Etten R. Cycling, stressed-out and nervous: cellular functions of c-Abl. Trends Cell Biol. 1999;9:179-86 pubmed..This review summarizes our current understanding of the many facets of c-Abl biology, emphasizing recent studies on Drosophila and mammalian Abl. ..
- Wodarz A, Ramrath A, Grimm A, Knust E. Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J Cell Biol. 2000;150:1361-74 pubmed..This study is the first functional analysis of an atypical protein kinase C isoform using a loss-of-function allele in a genetically tractable organism. ..
- Fung S, Wang F, Chase M, Godt D, Hartenstein V. Expression profile of the cadherin family in the developing Drosophila brain. J Comp Neurol. 2008;506:469-88 pubmed..We conclude from this analysis that cadherins are likely to play a role in 'generic' neural functions, such as neurite fasciculation, branching, and synapse formation. ..
- Lecuit T, Samanta R, Wieschaus E. slam encodes a developmental regulator of polarized membrane growth during cleavage of the Drosophila embryo. Dev Cell. 2002;2:425-36 pubmed..Our results suggest that developmental induction of Slam organizes the polarized growth of membrane via the recruitment of membrane-targeting proteins at adherens junctions. ..
- Sotillos S, Diaz Meco M, Caminero E, Moscat J, Campuzano S. DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J Cell Biol. 2004;166:549-57 pubmed..These results provide a mechanistic framework for the functional interaction between the Par-3-Par-6-aPKC and Crumbs-Sdt-Patj complexes based in the posttranslational modification of Crb by DaPKC. ..
- Blankenship J, Fuller M, Zallen J. The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity. J Cell Sci. 2007;120:3099-110 pubmed..These results suggest that epithelial polarity in the Drosophila embryo is actively maintained by exocyst-dependent apical localization of the Crumbs transmembrane protein. ..
- Pelissier A, Chauvin J, Lecuit T. Trafficking through Rab11 endosomes is required for cellularization during Drosophila embryogenesis. Curr Biol. 2003;13:1848-57 pubmed..In shibire mutants, the transmembrane protein Neurotactin follows the secretory pathway normally but is not properly inserted in the plasma membrane and accumulates ..
- Lecuit T, Wieschaus E. Polarized insertion of new membrane from a cytoplasmic reservoir during cleavage of the Drosophila embryo. J Cell Biol. 2000;150:849-60 pubmed..We thus identify a tightly regulated scheme of polarized membrane insertion during cellularization. We propose that such a mechanism could participate in the progressive emergence of apical-basal polarity. ..
- Xu N, Keung B, Myat M. Rho GTPase controls invagination and cohesive migration of the Drosophila salivary gland through Crumbs and Rho-kinase. Dev Biol. 2008;321:88-100 pubmed publisher..Our genetic and live-imaging analyses provide novel evidence that the proximal gland cells play an essential and active role in salivary gland migration that propels the entire gland to turn and migrate posteriorly. ..
- Hill K, Bedian V, Juang J, Hoffmann F. Genetic interactions between the Drosophila Abelson (Abl) tyrosine kinase and failed axon connections (fax), a novel protein in axon bundles. Genetics. 1995;141:595-606 pubmed..The conditional, extragenic noncomplementation between fax and another Abl modifier gene, disabled, reveal that the two proteins are likely to function together in a process downstream or parallel to the Abl ..
- Frémion F, Darboux I, Diano M, Hipeau Jacquotte R, Seeger M, Piovant M. Amalgam is a ligand for the transmembrane receptor neurotactin and is required for neurotactin-mediated cell adhesion and axon fasciculation in Drosophila. EMBO J. 2000;19:4463-72 pubmedb>Neurotactin (NRT), a member of the cholinesterase-homologous protein family, is a heterophilic cell adhesion molecule that is required for proper axon guidance during Drosophila development...
- Lichtneckert R, Bello B, Reichert H. Cell lineage-specific expression and function of the empty spiracles gene in adult brain development of Drosophila melanogaster. Development. 2007;134:1291-300 pubmed
- Kramer H. The ups and downs of life in an epithelium. J Cell Biol. 2000;151:F15-8 pubmed
- Steinhauer J, Gijón M, Riekhof W, Voelker D, Murphy R, Treisman J. Drosophila lysophospholipid acyltransferases are specifically required for germ cell development. Mol Biol Cell. 2009;20:5224-35 pubmed publisher..Our findings suggest that lysophospholipid acyltransferase activity is essential for germline development and could provide a mechanistic explanation for the etiology of the human MBOAT1 mutation. ..
- Grosshans J, Wieschaus E. A genetic link between morphogenesis and cell division during formation of the ventral furrow in Drosophila. Cell. 2000;101:523-31 pubmed..When overexpressed in a microinjection assay, Tribbles directly inhibits mitosis. We propose that Frühstart and Tribbles form a link between the morphogenetic movements and mitotic control. ..
- Satoh T, Ohba A, Liu Z, Inagaki T, Satoh A. dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors. elife. 2015;4: pubmed publisher..These results collectively indicate that EMC is a key factor in the biogenesis of multi-pass transmembrane proteins, including Rh1, and its loss causes retinal degeneration. ..
- Cantera R, Lüer K, Rusten T, Barrio R, Kafatos F, Technau G. Mutations in spalt cause a severe but reversible neurodegenerative phenotype in the embryonic central nervous system of Drosophila melanogaster. Development. 2002;129:5577-86 pubmed..Effects on the expression of these genes are persistent but many morphological aspects of the phenotype are transient, leading to the concept of sequential redundancy for stable organisation of the central nervous system. ..
- Merdes G, Soba P, Loewer A, Bilic M, Beyreuther K, Paro R. Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. EMBO J. 2004;23:4082-95 pubmed..identified Numb as a potential target and provided evidence for a direct involvement of Disabled and Neurotactin in the induction of the phenotypes...
- Pilot F, Philippe J, Lemmers C, Lecuit T. Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz. Nature. 2006;442:580-4 pubmed..These results provide a mechanism for the spatial order of actin organization underlying junction stabilization in primary embryonic epithelia. ..
- Beronja S, Tepass U. Cellular morphogenesis: slow-as-molasses accelerates polarized membrane growth. Dev Cell. 2002;2:382-4 pubmed..The gene slow-as-molasses encodes a novel protein essential for the formation of a plasma membrane domain that initiates membrane growth during cellularization. ..
- Izumi Y, Ohta N, Itoh Furuya A, Fuse N, Matsuzaki F. Differential functions of G protein and Baz-aPKC signaling pathways in Drosophila neuroblast asymmetric division. J Cell Biol. 2004;164:729-38 pubmed..We thus suggest that the two apical signaling pathways have overlapping but different roles in asymmetric NB division. ..
- Settle M, Gordon M, Nadella M, Dankort D, Muller W, Jacobs J. Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model. Oncogene. 2003;22:1916-26 pubmedThe ErbB-2/Neu receptor tyrosine kinase plays a causal role in tumorigenesis in mammals...
- Murthy M, Teodoro R, Miller T, Schwarz T. Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization. Development. 2010;137:2773-83 pubmed publisher..A zygotically translated membrane protein, Neurotactin, is not inserted into the plasma membrane and instead accumulates in cytoplasmic puncta...
- Deng W, Schneider M, Frock R, Castillejo Lopez C, Gaman E, Baumgartner S, et al. Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila. Development. 2003;130:173-84 pubmed..These data suggest that the primary function of Dystroglycan in oogenesis is to organize cellular polarity; and this study sets the stage for analyzing the Dystroglycan complex by using the power of Drosophila molecular genetics. ..
- Hortsch M. Duplications in nomenclature. Nature. 1997;389:539 pubmed
- Belote J, Hoffmann F, McKeown M, Chorsky R, Baker B. Cytogenetic analysis of chromosome region 73AD of Drosophila melanogaster. Genetics. 1990;125:783-93 pubmed..2 interval, representing two lethal complementation groups, one new visible mutant, plucked (plk), and a previously known visible, dark body (db). There is no evidence of a complex of sex determination genes in the region near tra. ..
- Sawyer J, Choi W, Jung K, He L, Harris N, Peifer M. A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension. Mol Biol Cell. 2011;22:2491-508 pubmed publisher..We propose a model in which an actomyosin network linked at AP AJs by Canoe and coupled to apical polarity proteins regulates convergent extension. ..
- Marhold J, Papagiannouli F, Li M, Patel A, Mechler B. Requirements for scribble expression in newly formed gonads of Drosophila embryos. Gene Expr Patterns. 2003;3:143-6 pubmed..In contrast, Scrib1 synthesis in pole cells required contact with gonadal mesodermal cells as revealed by the absence of Scrib1 in wunen or tinman-zinc finger homeodomain-1 pseudo-gonads made only of aggregated pole cells. ..
- Hartenstein V, Younossi Hartenstein A, Lovick J, Kong A, Omoto J, Ngo K, et al. Lineage-associated tracts defining the anatomy of the Drosophila first instar larval brain. Dev Biol. 2015;406:14-39 pubmed publisher..forming the brain of the early Drosophila larva, based on the use of global markers (anti-Neuroglian, anti-Neurotactin, inscuteable-Gal4>UAS-chRFP-Tub) and lineage-specific reporters...
- Bieber A. Analysis of cellular adhesion in cultured cells. Methods Cell Biol. 1994;44:683-96 pubmed
- Rice D, Curran T. Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS. Genes Dev. 1999;13:2758-73 pubmed
- Blankenship J, Wieschaus E. Two new roles for the Drosophila AP patterning system in early morphogenesis. Development. 2001;128:5129-38 pubmed..Our results therefore suggest a link between cytoskeletal organization during cellularization and subsequent morphogenetic processes of gastrulation. ..
- Doerflinger H, Benton R, Shulman J, St Johnston D. The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium. Development. 2003;130:3965-75 pubmed..Although the direct targets of PAR-1 are unknown, we suggest that it functions by regulating the plus ends, possibly by capping them at the basal cortex. ..
- Field C, Coughlin M, Doberstein S, Marty T, Sullivan W. Characterization of anillin mutants reveals essential roles in septin localization and plasma membrane integrity. Development. 2005;132:2849-60 pubmed..Cumulatively, our data point to an important role for Anillin in scaffolding cleavage furrow components, directly stabilizing intracellular bridges, and indirectly stabilizing newly deposited plasma membrane during cellularization. ..
- Hortsch M, Bieber A. Sticky molecules in not-so-sticky cells. Trends Biochem Sci. 1991;16:283-7 pubmed..As such, they have proved to be a useful tool for the functional characterization of putative cell-adhesion molecules. ..
- Ruel L, Gallet A, Raisin S, Truchi A, Staccini Lavenant L, Cervantes A, et al. Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling. Development. 2007;134:3677-89 pubmed..This study provides new insight into the mechanistic regulation of the protein complex that mediates Hh signalling and a unique antibody tool for directly monitoring Hh receptor activity in all activated cells. ..
- Francois V, Solloway M, O Neill J, Emery J, Bier E. Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene. Genes Dev. 1994;8:2602-16 pubmed..These putative soluble Sog peptides may then diffuse into the dorsal region to antagonize the activity of Dpp, leading to the subdivision of the dorsal territory into amnioserosa and dorsal ectoderm. ..
- Freer S, Lau D, Pearson J, Talsky K, Crews S. Molecular and functional analysis of Drosophila single-minded larval central brain expression. Gene Expr Patterns. 2011;11:533-46 pubmed publisher..This resembles the roles of vertebrate sim that have an early role in neuronal migration and a later role in axonogenesis. ..
- Dunlop J, Morin X, Corominas M, Serras F, Tear G. glaikit is essential for the formation of epithelial polarity and neuronal development. Curr Biol. 2004;14:2039-45 pubmed..A mutation in the human homolog of gkt causes the neurodegenerative disease spinocerebellar ataxia with neuropathy (SCAN1), making it possible that a failure of membrane protein localization is a cause of this disease. ..
- Asha H, De Ruiter N, Wang M, Hariharan I. The Rap1 GTPase functions as a regulator of morphogenesis in vivo. EMBO J. 1999;18:605-15 pubmed..Rap1 mutations also disrupt cell migrations and cause abnormalities in cell shape. These findings indicate a role for Rap proteins as regulators of morphogenesis in vivo. ..
- Zecca M, Basler K, Struhl G. Direct and long-range action of a wingless morphogen gradient. Cell. 1996;87:833-44 pubmed..We interpret these findings as evidence that Wg can act directly and at long range as a gradient morphogen during normal development. ..
- Grevengoed E, Loureiro J, Jesse T, Peifer M. Abelson kinase regulates epithelial morphogenesis in Drosophila. J Cell Biol. 2001;155:1185-98 pubmed..We discuss possible models for Abl function during epithelial morphogenesis in light of these data. ..
- Oakeshott J, Claudianos C, Russell R, Robin G. Carboxyl/cholinesterases: a case study of the evolution of a successful multigene family. Bioessays. 1999;21:1031-42 pubmed..Furthermore, we postulate that the versatility of the substrate binding motifs underpins the recruitment of several family members to additional noncatalytic signal transduction functions. ..
- Gallet A, Rodriguez R, Ruel L, Therond P. Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog. Dev Cell. 2003;4:191-204 pubmed
- Kim J, Kim Y, Kim Ha J. Blood-brain barrier defects associated with Rbp9 mutation. Mol Cells. 2010;29:93-8 pubmed publisher..Putative Rbp9-binding sites were found in introns of genes that function in cell adhesion. Therefore, Rbp9 may regulate the splicing of cell adhesion molecules, critical for the formation of the BBB...
- MacMullin A, Jacobs J. Slit coordinates cardiac morphogenesis in Drosophila. Dev Biol. 2006;293:154-64 pubmed..in the heart, slit has little or no phenotypic interaction with Robo-related genes, including Robo2, Nck2, and Disabled. However, there is a strong phenotypic interaction with Integrin genes and their ligands, including Laminin and ..
- Mora N, Almudi I, Alsina B, Corominas M, Serras F. ? amyloid protein precursor-like (Appl) is a Ras1/MAPK-regulated gene required for axonal targeting in Drosophila photoreceptor neurons. J Cell Sci. 2013;126:53-9 pubmed publisher..Moreover, axon mistargeting and inappropriate light discrimination are enhanced in combination with neurotactin mutants...
- Steinhauer J, Liu H, Miller E, Treisman J. Trafficking of the EGFR ligand Spitz regulates its signaling activity in polarized tissues. J Cell Sci. 2013;126:4469-78 pubmed publisher..Taken together, our data support the model that localized trafficking of the pro-protein restricts its ability to activate the receptor in polarized tissues. ..
- Zeev Ben Mordehai T, Paz A, Peleg Y, Toker L, Wolf S, Rydberg E, et al. Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization. Protein Expr Purif. 2009;63:147-57 pubmed publisher..during Drosophila development in which it interacts with the extracellular domain of the transmembrane protein, neurotactin, to promote adhesion...
- Cowan C, Henkemeyer M. More cables to Abl. Neuron. 2000;26:543-4 pubmed
- Steinberg R, Shemer Avni Y, Adler N, Neuman Silberberg S. Human cytomegalovirus immediate-early-gene expression disrupts embryogenesis in transgenic Drosophila. Transgenic Res. 2008;17:105-19 pubmed
- Spindler S, Ortiz I, Fung S, Takashima S, Hartenstein V. Drosophila cortex and neuropile glia influence secondary axon tract growth, pathfinding, and fasciculation in the developing larval brain. Dev Biol. 2009;334:355-68 pubmed publisher..Our study provides, for the first time, an analysis of glial function in the brain during axon formation and growth in larval development. ..