Gene Symbol: Nplp2
Description: Neuropeptide-like precursor 2
Alias: BcDNA:RH08410, CG11051, Dmel\CG11051, NEF, NPLP 2, NPLP2, nplp2, Neuropeptide-like precursor 2, CG11051-PA, CG11051-PB, CG11051-PC, NEF peptide, Nplp2-PA, Nplp2-PB, Nplp2-PC, neuropeptide-like precursor 2
Species: fruit fly
Baggerman G, Cerstiaens A, De Loof A, Schoofs L. Peptidomics of the larval Drosophila melanogaster central nervous system. J Biol Chem. 2002;277:40368-74 pubmed
..This neuropeptide expression profiling study also opens perspectives for other eukaryotic model systems, for which genome projects are completed or in progress. ..
Baggerman G, Boonen K, Verleyen P, De Loof A, Schoofs L. Peptidomic analysis of the larval Drosophila melanogaster central nervous system by two-dimensional capillary liquid chromatography quadrupole time-of-flight mass spectrometry. J Mass Spectrom. 2005;40:250-60 pubmed
..This clearly demonstrates that the two-dimensional capillary LC approach enhances the coverage of the peptidomic analysis. ..
Liu F, Baggerman G, D Hertog W, Verleyen P, Schoofs L, Wets G. In silico identification of new secretory peptide genes in Drosophila melanogaster. Mol Cell Proteomics. 2006;5:510-22 pubmed
..This bioinformatic study opens perspectives for the genome-wide analysis of peptide genes in other eukaryotic model organisms. ..
Yew J, Wang Y, Barteneva N, Dikler S, Kutz Naber K, Li L, et al
. Analysis of neuropeptide expression and localization in adult drosophila melanogaster central nervous system by affinity cell-capture mass spectrometry. J Proteome Res. 2009;8:1271-84 pubmed publisher
..Neuropeptide profiling also was performed on targeted populations of cells which were enriched with immunoaffinity purification using a genetically expressed marker. ..
Hector C, Bretz C, Zhao Y, Johnson E. Functional differences between two CRF-related diuretic hormone receptors in Drosophila. J Exp Biol. 2009;212:3142-7 pubmed publisher
..The functional characterization of this diuretic hormone receptor in Drosophila demonstrates a high degree of conservation of CRF-like signaling. ..
Stern S, Snir O, Mizrachi E, Galili M, Zaltsman I, Soen Y. Reduction in maternal Polycomb levels contributes to transgenerational inheritance of a response to toxic stress in flies. J Physiol. 2014;592:2343-55 pubmed publisher
..Together, this shows that exposure to G418 stress reduces the maternal levels of Polycomb in the offspring embryos and this reduction contributes to the inheritance of induced expression. ..
Zeng Q, Smith D, Shippy S. Proteomic analysis of individual fruit fly hemolymph. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;981-982:33-9 pubmed publisher
..This nano-scale analysis method will facilitate future study of Drosophila and lead to a more complete understanding of the physiology of the fly model system. ..
Verleyen P, Baggerman G, D Hertog W, Vierstraete E, Husson S, Schoofs L. Identification of new immune induced molecules in the haemolymph of Drosophila melanogaster by 2D-nanoLC MS/MS. J Insect Physiol. 2006;52:379-88 pubmed
..Many of the identified peptides are post-translationally modified by an N-terminal pyroglutamic acid and/or a C-terminal amide. Haemolymph of control larvae was treated in the same way and revealed only one peptide. ..