nos

Summary

Gene Symbol: nos
Description: nanos
Alias: CG5637, DRONANOS, Dmel\CG5637, Dronanos, NANOS, NOS, Nanos, Nos, l(3)07117, l(3)j3B6, l(3)j4B6, nNOS, nanos, CG5637-PA, CG5637-PB, nos-PA, nos-PB
Species: fruit fly

Top Publications

  1. McDermott S, Meignin C, Rappsilber J, Davis I. Drosophila Syncrip binds the gurken mRNA localisation signal and regulates localised transcripts during axis specification. Biol Open. 2012;1:488-97 pubmed publisher
    ..We propose that Syncrip/SYNCRIP is part of a conserved complex associated with localised transcripts and required for their correct translational regulation in flies and mammals. ..
  2. Kobayashi S, Amikura R, Nakamura A, Saito H, Okada M. Mislocalization of oskar product in the anterior pole results in ectopic localization of mitochondrial large ribosomal RNA in Drosophila embryos. Dev Biol. 1995;169:384-6 pubmed
    ..This clearly shows, contrary to the previous report by Ding et al. (1994, Developmental Biology 163, 503-515), that localization of mtlrRNA depends on oskar function even at the anterior pole. ..
  3. Harris R, Pargett M, Sutcliffe C, Umulis D, Ashe H. Brat promotes stem cell differentiation via control of a bistable switch that restricts BMP signaling. Dev Cell. 2011;20:72-83 pubmed publisher
    Drosophila ovarian germline stem cells (GSCs) are maintained by Dpp signaling and the Pumilio (Pum) and Nanos (Nos) translational repressors...
  4. Ye B, Petritsch C, Clark I, Gavis E, Jan L, Jan Y. Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons. Curr Biol. 2004;14:314-21 pubmed
    ..in adult Drosophila requires Pumilio (Pum), an RNA binding protein that interacts with the RNA binding protein Nanos (Nos) to form a localized translation repression complex essential for anterior-posterior body patterning in early ..
  5. Barker D, Wang C, Moore J, Dickinson L, Lehmann R. Pumilio is essential for function but not for distribution of the Drosophila abdominal determinant Nanos. Genes Dev. 1992;6:2312-26 pubmed
    ..As with pumilio, the maternal effect gene nanos is specifically required for abdomen formation...
  6. Hoch M, Seifert E, Jackle H. Gene expression mediated by cis-acting sequences of the Krüppel gene in response to the Drosophila morphogens bicoid and hunchback. EMBO J. 1991;10:2267-78 pubmed
    ..Our results show that this fragment represents a target for the redundant activator/repressor system provided by the anterior morphogens bcd and hb. ..
  7. Leatherman J, Dinardo S. Zfh-1 controls somatic stem cell self-renewal in the Drosophila testis and nonautonomously influences germline stem cell self-renewal. Cell Stem Cell. 2008;3:44-54 pubmed publisher
    ..In contrast, germline-intrinsic STAT activation was insufficient for GSC renewal. These data reveal unexpected complexity in cell interactions in the niche, implicating CPCs in GSC self-renewal. ..
  8. Goodrich J, Clouse K, Schupbach T. Hrb27C, Sqd and Otu cooperatively regulate gurken RNA localization and mediate nurse cell chromosome dispersion in Drosophila oogenesis. Development. 2004;131:1949-58 pubmed
    ..All three mutants share another phenotype, persistent polytene nurse cell chromosomes. Our analyses support dual cooperative roles for Sqd, Hrb27C and Otu during Drosophila oogenesis. ..
  9. Hanyu Nakamura K, Kobayashi S, Nakamura A. Germ cell-autonomous Wunen2 is required for germline development in Drosophila embryos. Development. 2004;131:4545-53 pubmed
    ..In somatic cells, Wun and Wun2 may provide a repulsive environment for pole cell migration by depleting this extracellular substrate. ..

More Information

Publications83

  1. Muraro N, Weston A, Gerber A, Luschnig S, Moffat K, Baines R. Pumilio binds para mRNA and requires Nanos and Brat to regulate sodium current in Drosophila motoneurons. J Neurosci. 2008;28:2099-109 pubmed publisher
    ..Additionally, the cofactor Nanos is essential for Pum-dependent para repression, whereas the requirement for Brain Tumor (Brat) is cell type ..
  2. Markussen F, Michon A, Breitwieser W, Ephrussi A. Translational control of oskar generates short OSK, the isoform that induces pole plasma assembly. Development. 1995;121:3723-32 pubmed
    ..Finally, we show that when oskar RNA is localized, accumulation of Oskar protein requires the functions of vasa and tudor, as well as oskar itself, suggesting a positive feedback mechanism in the induction of pole plasm by oskar. ..
  3. Wharton R, Struhl G. RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos. Cell. 1991;67:955-67 pubmed
    In Drosophila embryos, graded activity of the posterior determinant nanos (nos) generates abdominal segmentation by blocking protein expression from maternal transcripts of the hunchback (hb) gene...
  4. Sonoda J, Wharton R. Recruitment of Nanos to hunchback mRNA by Pumilio. Genes Dev. 1999;13:2704-12 pubmed
    ..This regulation is mediated by sequences in the 3'-untranslated region of hb mRNA (the Nanos response elements or NREs), as well as two trans-acting factors-Nanos and Pumilio...
  5. Tautz D. Regulation of the Drosophila segmentation gene hunchback by two maternal morphogenetic centres. Nature. 1988;332:281-4 pubmed
  6. Rhiner C, Diaz B, Portela M, Poyatos J, Fernández Ruíz I, López Gay J, et al. Persistent competition among stem cells and their daughters in the Drosophila ovary germline niche. Development. 2009;136:995-1006 pubmed publisher
    ..Moreover, competitive interactions among stem cells may be relevant for the successful application of stem cell therapies in humans. ..
  7. Starz Gaiano M, Cho N, Forbes A, Lehmann R. Spatially restricted activity of a Drosophila lipid phosphatase guides migrating germ cells. Development. 2001;128:983-91 pubmed
    ..We propose that spatially restricted phospholipid hydrolysis creates a gradient of signal necessary and specific for the migration and survival of germ cells. ..
  8. Gavis E, Lehmann R. Translational regulation of nanos by RNA localization. Nature. 1994;369:315-8 pubmed
    Localization of the maternally synthesized nanos (nos) RNA to the posterior pole of the Drosophila embryo provides the source for a posterior-to-anterior gradient of Nos protein...
  9. Wang C, Dickinson L, Lehmann R. Genetics of nanos localization in Drosophila. Dev Dyn. 1994;199:103-15 pubmed
    The Drosophila gene nanos is required for two processes. During oogenesis, nanos function is required for the continued production of egg chambers, and nanos is expressed in the early germarium...
  10. Nakamura A, Amikura R, Mukai M, Kobayashi S, Lasko P. Requirement for a noncoding RNA in Drosophila polar granules for germ cell establishment. Science. 1996;274:2075-9 pubmed
    ..These results support an essential role for Pgc RNA in germline development. ..
  11. Fernandez Gonzalez R, Simões S, Röper J, Eaton S, Zallen J. Myosin II dynamics are regulated by tension in intercalating cells. Dev Cell. 2009;17:736-43 pubmed publisher
    ..These results demonstrate that myosin II dynamics are regulated by tension in a positive feedback loop that leads to multicellular actomyosin cable formation and efficient tissue elongation. ..
  12. Kadyrova L, Habara Y, Lee T, Wharton R. Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. Development. 2007;134:1519-27 pubmed
    In the Drosophila embryo, Nanos and Pumilio collaborate to repress the translation of hunchback mRNA in the somatic cytoplasm...
  13. Murata Y, Wharton R. Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos. Cell. 1995;80:747-56 pubmed
    Posterior patterning in Drosophila embryos is governed by nanos (nos), which acts by repressing the translation of maternal transcripts of the hunchback (hb) gene...
  14. Kobayashi S, Yamada M, Asaoka M, Kitamura T. Essential role of the posterior morphogen nanos for germline development in Drosophila. Nature. 1996;380:708-11 pubmed
    ..The critical factor for abdomen formation is the nanos (nos) protein (nanos)...
  15. Nakamura A, Amikura R, Hanyu K, Kobayashi S. Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex during Drosophila oogenesis. Development. 2001;128:3233-42 pubmed
    ..These results suggest that Me31B mediates translational silencing of RNAs during their transport to the oocyte. Our data provide evidence that RNA transport and translational control are linked through the assembly of RNP complex. ..
  16. Li Y, Maines J, Tastan O, McKearin D, Buszczak M. Mei-P26 regulates the maintenance of ovarian germline stem cells by promoting BMP signaling. Development. 2012;139:1547-56 pubmed publisher
    ..The Nanos-Pumilio translational repressor complex and the miRNA pathway also help to promote GSC self-renewal...
  17. Rongo C, Gavis E, Lehmann R. Localization of oskar RNA regulates oskar translation and requires Oskar protein. Development. 1995;121:2737-46 pubmed
    ..We propose that initially localization of oskar RNA permits translation into Oskar protein and that subsequently Oskar protein regulates its own RNA localization through a positive feedback mechanism. ..
  18. St Johnston D, Beuchle D, Nusslein Volhard C. Staufen, a gene required to localize maternal RNAs in the Drosophila egg. Cell. 1991;66:51-63 pubmed
    ..By the time the egg is laid, staufen protein is also concentrated at the anterior pole, in the same region as bicoid RNA. ..
  19. Kraut R, Levine M. Spatial regulation of the gap gene giant during Drosophila development. Development. 1991;111:601-9 pubmed
    ..The maternal morphogen bicoid (bcd) initiates the anterior gt pattern, while nanos (nos) plays a role in the posterior pattern...
  20. Wang Z, Lin H. Nanos maintains germline stem cell self-renewal by preventing differentiation. Science. 2004;303:2016-9 pubmed
    ..Here, we show that removing the translational repressor Nanos from either GSCs or their precursors, the primordial germ cells (PGCs), causes both cell types to differentiate ..
  21. Rørth P. Gal4 in the Drosophila female germline. Mech Dev. 1998;78:113-8 pubmed
    ..FGF signaling guides tracheal cell migration in the embryo. However, misexpression of branchless in the ovary had no effect on border cell migration. Thus border cells and tracheal cells appear to be guided differently. ..
  22. Deshpande G, Calhoun G, Yanowitz J, Schedl P. Novel functions of nanos in downregulating mitosis and transcription during the development of the Drosophila germline. Cell. 1999;99:271-81 pubmed
    It has previously been shown that germ cells in embryos derived from nos mutant mothers do not migrate to the primitive gonad and prematurely express several germline-specific markers...
  23. Gavis E. Expeditions to the pole: RNA localization in Xenopus and Drosophila. Trends Cell Biol. 1997;7:485-92 pubmed
    ..While specific aspects of localization differ among RNAs, similarities between pathways used by Xenopus and Drosophila suggest that common themes have been conserved among localization mechanisms. ..
  24. Forbes A, Lehmann R. Nanos and Pumilio have critical roles in the development and function of Drosophila germline stem cells. Development. 1998;125:679-90 pubmed
    The zinc-finger protein Nanos and the RNA-binding protein Pumilio act together to repress the translation of maternal hunchback RNA in the posterior of the Drosophila embryo, thereby allowing abdomen formation...
  25. Seydoux G, Dunn M. Transcriptionally repressed germ cells lack a subpopulation of phosphorylated RNA polymerase II in early embryos of Caenorhabditis elegans and Drosophila melanogaster. Development. 1997;124:2191-201 pubmed
    ..In addition, these studies also suggest that different phosphorylated isoforms of RNA polymerase II perform distinct functions. ..
  26. Tastan O, Maines J, Li Y, McKearin D, Buszczak M. Drosophila ataxin 2-binding protein 1 marks an intermediate step in the molecular differentiation of female germline cysts. Development. 2010;137:3167-76 pubmed publisher
    ..Biochemical analysis reveals that A2BP1 isoforms bind to each other and associate with Bruno, a known translational repressor protein. These data show that A2BP1 promotes the molecular differentiation of ovarian germline cysts. ..
  27. Xia L, Zheng X, Zheng W, Zhang G, Wang H, Tao Y, et al. The niche-dependent feedback loop generates a BMP activity gradient to determine the germline stem cell fate. Curr Biol. 2012;22:515-21 pubmed publisher
    ..Our mathematic modeling reveals a bistable behavior of the feedback-loop system in controlling the bam transcriptional on/off switch and determining GSC fate. ..
  28. Cho P, Gamberi C, Cho Park Y, Cho Park I, Lasko P, Sonenberg N. Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos. Curr Biol. 2006;16:2035-41 pubmed
    ..Inhibition of hb mRNA translation requires an mRNP complex (the NRE complex), which consists of Nanos (Nos), Pumilio (Pum), and Brain tumor (Brat) proteins, and the Nos responsive element (NRE) present in the 3' UTR ..
  29. Blankenship J, Backovic S, Sanny J, Weitz O, Zallen J. Multicellular rosette formation links planar cell polarity to tissue morphogenesis. Dev Cell. 2006;11:459-70 pubmed
    ..We propose that the generation of higher-order rosette structures links local cell interactions to global tissue reorganization during morphogenesis. ..
  30. Forrest K, Gavis E. Live imaging of endogenous RNA reveals a diffusion and entrapment mechanism for nanos mRNA localization in Drosophila. Curr Biol. 2003;13:1159-68 pubmed
    Localization of nanos mRNA to the posterior pole of the Drosophila embryo directs local synthesis of Nanos protein that is essential for patterning of the anterior-posterior body axis and germ cell function...
  31. Bergsten S, Gavis E. Role for mRNA localization in translational activation but not spatial restriction of nanos RNA. Development. 1999;126:659-69 pubmed
    Patterning of the anterior-posterior body axis during Drosophila development depends on the restriction of Nanos protein to the posterior of the early embryo...
  32. Lasko P. RNA sorting in Drosophila oocytes and embryos. FASEB J. 1999;13:421-33 pubmed
    ..control, and the translational control of two RNAs that localize to the posterior of the oocyte, oskar and nanos, is also discussed...
  33. Smith J, Wilson J, Macdonald P. Overexpression of oskar directs ectopic activation of nanos and presumptive pole cell formation in Drosophila embryos. Cell. 1992;70:849-59 pubmed
    ..One determinant is the posterior body patterning morphogen nanos, and the other directs germ cell formation...
  34. Schulz C, Tautz D. Autonomous concentration-dependent activation and repression of Krüppel by hunchback in the Drosophila embryo. Development. 1994;120:3043-9 pubmed
    ..In addition, we show that the artificially created hunchback gradient can organize a large part of the segment pattern, although it is expressed at a different position and in a different shape than the wild-type gradient of hunchback. ..
  35. Bashirullah A, Cooperstock R, Lipshitz H. Spatial and temporal control of RNA stability. Proc Natl Acad Sci U S A. 2001;98:7025-8 pubmed
    ..Similar mechanisms are likely to act later in development to restrict certain classes of transcripts to particular cell types within somatic cell lineages. Functions of transcript degradation and protection are discussed. ..
  36. Wawersik M, Van Doren M. nanos is required for formation of the spectrosome, a germ cell-specific organelle. Dev Dyn. 2005;234:22-7 pubmed
    ..Furthermore, the germ plasm component nanos (nos) is essential for spectrosome formation...
  37. Rothe M, Wimmer E, Pankratz M, Gonzalez Gaitan M, Jackle H. Identical transacting factor requirement for knirps and knirps-related Gene expression in the anterior but not in the posterior region of the Drosophila embryo. Mech Dev. 1994;46:169-81 pubmed
  38. Struhl G, Johnston P, Lawrence P. Control of Drosophila body pattern by the hunchback morphogen gradient. Cell. 1992;69:237-249 pubmed
    ..of these genes depends on two maternal determinants: bicoid, which activates hb transcription anteriorly, and nanos, which blocks translation of hb transcripts posteriorly...
  39. Sonoda J, Wharton R. Drosophila Brain Tumor is a translational repressor. Genes Dev. 2001;15:762-73 pubmed
    ..interaction assay, we show that Brain Tumor is recruited to hunchback (hb) mRNA through interactions with Nanos and Pumilio, which bind to the RNA to repress its translation...
  40. Zaessinger S, Busseau I, Simonelig M. Oskar allows nanos mRNA translation in Drosophila embryos by preventing its deadenylation by Smaug/CCR4. Development. 2006;133:4573-83 pubmed
    Anteroposterior patterning of the Drosophila embryo depends on a gradient of Nanos protein arising from the posterior pole...
  41. Rivera Pomar R, Jackle H. From gradients to stripes in Drosophila embryogenesis: filling in the gaps. Trends Genet. 1996;12:478-83 pubmed
    ..Recent progress has begun to reveal the mechanisms by which coherent positional information of maternal origin becomes transferred into serially repeated zygotic gene expression domains reflecting the metameric body plan of the larva. ..
  42. Erdelyi M, Michon A, Guichet A, Glotzer J, Ephrussi A. Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localization. Nature. 1995;377:524-7 pubmed
    ..Here we show that mutations in tropomyosin II (TmII) virtually abolish oskar RNA localization to the posterior pole, suggesting an involvement of the actin network in oskar RNA localization. ..
  43. Wharton R, Sonoda J, Lee T, Patterson M, Murata Y. The Pumilio RNA-binding domain is also a translational regulator. Mol Cell. 1998;1:863-72 pubmed
    Posterior patterning in the Drosophila embryo requires the action of Nanos (Nos) and Pumilio (Pum), which collaborate to regulate the translation of maternal hunchback (hb) mRNA...
  44. Gilboa L, Lehmann R. Repression of primordial germ cell differentiation parallels germ line stem cell maintenance. Curr Biol. 2004;14:981-6 pubmed
    ..Furthermore, PGCs that are mutant for nanos (nos), pumilio (pum) or for signaling components of the decapentaplegic (dpp) pathway also differentiate...
  45. Kondo S, Ueda R. Highly improved gene targeting by germline-specific Cas9 expression in Drosophila. Genetics. 2013;195:715-21 pubmed publisher
    ..The system comprises two transgenic strains: one expressing Cas9 protein from the germline-specific nanos promoter and the other ubiquitously expressing a custom guide RNA (gRNA) that targets a unique site in the genome...
  46. Sanchez L, Thieffry D. A logical analysis of the Drosophila gap-gene system. J Theor Biol. 2001;211:115-41 pubmed
    ..The proposed model allows not only the qualitative reproduction of the patterns of gene expression characterized experimentally, but also the simulation and prediction of single and multiple mutant phenotypes. ..
  47. Tetzlaff M, Jackle H, Pankratz M. Lack of Drosophila cytoskeletal tropomyosin affects head morphogenesis and the accumulation of oskar mRNA required for germ cell formation. EMBO J. 1996;15:1247-54 pubmed
    ..b>nanos mRNA, however, which is required exclusively for abdominal segmentation, is localized at wild-type levels...
  48. Asaoka M, Sano H, Obara Y, Kobayashi S. Maternal Nanos regulates zygotic gene expression in germline progenitors of Drosophila melanogaster. Mech Dev. 1998;78:153-8 pubmed
    Maternal Nanos (Nos) protein is required for germline development in Drosophila embryos. Here we show that Nos regulates zygotic gene expression in the germline progenitors, or pole cells...
  49. Hayashi Y, Hayashi M, Kobayashi S. Nanos suppresses somatic cell fate in Drosophila germ line. Proc Natl Acad Sci U S A. 2004;101:10338-42 pubmed
    b>Nanos (Nos) is one of the evolutionarily conserved proteins known to direct germ-line development...
  50. van Eeden F, Palacios I, Petronczki M, Weston M, St Johnston D. Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole. J Cell Biol. 2001;154:511-23 pubmed
    ..Thus, Barentsz is essential for the posterior localization of oskar mRNA and behaves as a specific component of the oskar RNA transport complex. ..
  51. Perkins T, Jaeger J, Reinitz J, Glass L. Reverse engineering the gap gene network of Drosophila melanogaster. PLoS Comput Biol. 2006;2:e51 pubmed
    ..Interestingly, some relationships in standard textbook models of gap gene regulation appear to be unnecessary for or even inconsistent with the details of gap gene expression during wild-type development. ..
  52. Kim Ha J, Kerr K, Macdonald P. Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential. Cell. 1995;81:403-12 pubmed
    Oskar (osk) protein directs the deployment of nanos (nos), the posterior body-patterning morphogen in Drosophila...
  53. Asaoka Taguchi M, Yamada M, Nakamura A, Hanyu K, Kobayashi S. Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos. Nat Cell Biol. 1999;1:431-7 pubmed
    The maternal RNA-binding proteins Pumilio (Pum) and Nanos (Nos) act together to specify the abdomen in Drosophila embryos. Both proteins later accumulate in pole cells, the germline progenitors...
  54. Kim J, Lee Y, Kim C. Direct inhibition of Pumilo activity by Bam and Bgcn in Drosophila germ line stem cell differentiation. J Biol Chem. 2010;285:4741-6 pubmed publisher
    ..The RNA-binding translational repressor Pumilio (Pum) in conjunction with Nanos (Nos) is required for self-renewal, whereas Bam (bag-of-marbles) and Bgcn (benign gonial cell neoplasm) promote ..
  55. Chau J, Kulnane L, Salz H. Sex-lethal enables germline stem cell differentiation by down-regulating Nanos protein levels during Drosophila oogenesis. Proc Natl Acad Sci U S A. 2012;109:9465-70 pubmed publisher
    ..We address the mechanism by which Sxl regulates this transition through the identification of nanos as one of its target genes...
  56. Verrotti A, Wharton R. Nanos interacts with cup in the female germline of Drosophila. Development. 2000;127:5225-32 pubmed
    b>Nanos (Nos) is a translational regulator that governs abdominal segmentation of the Drosophila embryo in collaboration with Pumilio (Pum)...
  57. Wilhelm J, Mansfield J, Hom Booher N, Wang S, Turck C, Hazelrigg T, et al. Isolation of a ribonucleoprotein complex involved in mRNA localization in Drosophila oocytes. J Cell Biol. 2000;148:427-40 pubmed
    ..We propose that Exu is a core component of a large protein complex involved in localizing mRNAs both within nurse cells and the developing oocyte. ..
  58. Gavis E, Lehmann R. Localization of nanos RNA controls embryonic polarity. Cell. 1992;71:301-13 pubmed
    ..The RNA of the posterior morphogen nanos is localized to the posterior pole, where nanos protein is required for abdomen formation...
  59. Ephrussi A, Dickinson L, Lehmann R. Oskar organizes the germ plasm and directs localization of the posterior determinant nanos. Cell. 1991;66:37-50 pubmed
    ..The colocalization of oskar and nanos in wild-type and bicaudal embryos suggests that oskar directs localization of the posterior determinant nanos...
  60. Li Y, Minor N, Park J, McKearin D, Maines J. Bam and Bgcn antagonize Nanos-dependent germ-line stem cell maintenance. Proc Natl Acad Sci U S A. 2009;106:9304-9 pubmed publisher
    ..self-renewal and differentiation in Drosophila ovaries is mediated by the antagonistic relationship between the Nanos (Nos)-Pumilio translational repressor complex, which promotes GSC self-renewal, and expression of Bam, a key ..
  61. Norvell A, Kelley R, Wehr K, Schupbach T. Specific isoforms of squid, a Drosophila hnRNP, perform distinct roles in Gurken localization during oogenesis. Genes Dev. 1999;13:864-76 pubmed
    ..These results demonstrate the isoform-specific contributions of individual hnRNP proteins in the regulation of a specific mRNA. Moreover, these data suggest a novel role for hnRNPs in localization and translational regulation of mRNAs. ..
  62. Deshpande G, Calhoun G, Jinks T, Polydorides A, Schedl P. Nanos downregulates transcription and modulates CTD phosphorylation in the soma of early Drosophila embryos. Mech Dev. 2005;122:645-57 pubmed
    b>nanos (nos) specifies posterior development in the Drosophila embryo by repressing the translation of maternal hb mRNA...
  63. Norvell A, Debec A, Finch D, Gibson L, Thoma B. Squid is required for efficient posterior localization of oskar mRNA during Drosophila oogenesis. Dev Genes Evol. 2005;215:340-9 pubmed
    ..These results also place Sqd among an emerging class of proteins, including such other members as Bruno (Bru) and Hrb27C/Hrp48, which function in multiple aspects of both grk and osk mRNA regulation during Drosophila oogenesis. ..
  64. Macdonald P, Smibert C. Translational regulation of maternal mRNAs. Curr Opin Genet Dev. 1996;6:403-7 pubmed
    ..Substantial progress has also been reported in the identification and characterization of the cis-acting elements and trans-acting factors that mediate translational regulation and their interactions with one another. ..
  65. Weil T, Forrest K, Gavis E. Localization of bicoid mRNA in late oocytes is maintained by continual active transport. Dev Cell. 2006;11:251-62 pubmed
    ..Furthermore, our results indicate that association of bicoid with the anterior oocyte cortex is dynamic and support a model for maintenance of bicoid localization by continual active transport on microtubules. ..
  66. Kim Ha J, Smith J, Macdonald P. oskar mRNA is localized to the posterior pole of the Drosophila oocyte. Cell. 1991;66:23-35 pubmed
    ..In addition, we find that nonsense oskar mutations disrupt osk mRNA localization, while missense oskar mutations do not. ..
  67. Li Y, Zhang Q, Carreira Rosario A, Maines J, McKearin D, Buszczak M. Mei-p26 cooperates with Bam, Bgcn and Sxl to promote early germline development in the Drosophila ovary. PLoS ONE. 2013;8:e58301 pubmed publisher
    ..Here we present data showing that Mei-P26 associates with Bam, Bgcn and Sxl and nanos mRNA during early cyst development, suggesting that this protein helps to repress the translation of nanos mRNA...
  68. Casanueva M, Ferguson E. Germline stem cell number in the Drosophila ovary is regulated by redundant mechanisms that control Dpp signaling. Development. 2004;131:1881-90 pubmed
  69. Breitwieser W, Markussen F, Horstmann H, Ephrussi A. Oskar protein interaction with Vasa represents an essential step in polar granule assembly. Genes Dev. 1996;10:2179-88 pubmed
    ..These results suggest that the Oskar-Vasa interaction constitutes an initial step in polar granule assembly. In addition, we discuss the possible biological role of the Oskar-Staufen interaction. ..
  70. Sato K, Hayashi Y, Ninomiya Y, Shigenobu S, Arita K, Mukai M, et al. Maternal Nanos represses hid/skl-dependent apoptosis to maintain the germ line in Drosophila embryos. Proc Natl Acad Sci U S A. 2007;104:7455-60 pubmed
    b>Nanos (Nos) is an evolutionarily conserved protein essential for the survival of primordial germ cells. In Drosophila, maternal Nos partitions into pole cells and suppresses apoptosis to permit proper germ-line development...
  71. Rouget C, Papin C, Boureux A, Meunier A, Franco B, Robine N, et al. Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. Nature. 2010;467:1128-32 pubmed publisher
    ..Using mRNA encoding the embryonic posterior morphogen Nanos (Nos) as a paradigm to study maternal mRNA decay, we found that CCR4-mediated deadenylation of nos depends on ..
  72. Rittenhouse K, Berg C. Mutations in the Drosophila gene bullwinkle cause the formation of abnormal eggshell structures and bicaudal embryos. Development. 1995;121:3023-33 pubmed
    ..Consistent with the mislocalization of oskar mRNA, a fraction of the VASA protein and nanos mRNA are also mislocalized to the anterior pole of bullwinkle embryos...
  73. Van Doren M, Williamson A, Lehmann R. Regulation of zygotic gene expression in Drosophila primordial germ cells. Curr Biol. 1998;8:243-6 pubmed
    ..This expression does not require proper patterning of the soma, indicating that it is likely to be controlled by the germ plasm. ..
  74. Simpson Brose M, Treisman J, Desplan C. Synergy between the hunchback and bicoid morphogens is required for anterior patterning in Drosophila. Cell. 1994;78:855-65 pubmed
    ..bcd may be a newly acquired Drosophila gene, which is gradually replacing some of the functions performed by maternal hb in other species. ..