Gene Symbol: Nmdar1
Description: NMDA receptor 1
Alias: CG2902, DMNMDAR1, DNMDAR-I, DNmdar, DmelNmdar1, Dmel\CG2902, DrNR1, NMDA, NMDA R1, NMDAR, NMDAR1, NMdar1, NR1, NRI, Nmdar, dNR1, dnmdar-I, dsNR1, nmr, nr1, NMDA receptor 1, CG2902-PA, NMDA receptor, NMDA receptor I, NMDAR, Nmdar1-PA, dNR1
Species: fruit fly
Products:     Nmdar1

Top Publications

  1. Xia S, Miyashita T, Fu T, Lin W, Wu C, Pyzocha L, et al. NMDA receptors mediate olfactory learning and memory in Drosophila. Curr Biol. 2005;15:603-15 pubmed
    ..Because of the nonspecificity of drugs that modulate NMDAR function or the relatively chronic genetic manipulations of various NMDAR subunits from mammalian studies, ..
  2. Ultsch A, Schuster C, Laube B, Betz H, Schmitt B. Glutamate receptors of Drosophila melanogaster. Primary structure of a putative NMDA receptor protein expressed in the head of the adult fly. FEBS Lett. 1993;324:171-7 pubmed
    ..Here we describe a cDNA isolated from Drosophila melanogaster which encodes a putative invertebrate NMDA receptor protein (DNMDAR-I)...
  3. Völkner M, Lenz Böhme B, Betz H, Schmitt B. Novel CNS glutamate receptor subunit genes of Drosophila melanogaster. J Neurochem. 2000;75:1791-9 pubmed
    ..genes from Drosophila melanogaster that encode novel ionotropic glutamate receptor proteins, named DGluR-IB and DNMDAR-II, and that are located on chromosome 3L, region 67AB, and the X chromosome, position 2B, respectively...
  4. Tamura T, Horiuchi D, Chen Y, Sone M, Miyashita T, Saitoe M, et al. Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning. J Neurosci. 2010;30:14091-101 pubmed publisher
    ..were not reduced in number and their fiber connections were not changed, whereas gene expressions including NMDA receptor subunit 1 (NR1) were decreased in PNs...
  5. Chiang A, Lin W, Liu H, Pszczolkowski M, Fu T, Chiu S, et al. Insect NMDA receptors mediate juvenile hormone biosynthesis. Proc Natl Acad Sci U S A. 2002;99:37-42 pubmed
    ..Finally, we used the same primers for DNMDAR1 to demonstrate a fragment of putative NMDA receptor in the corpora allata of Diploptera punctata...
  6. Coyle J, Balu D, Puhl M, Konopaske G. History of the Concept of Disconnectivity in Schizophrenia. Harv Rev Psychiatry. 2016;24:80-6 pubmed publisher
    ..several risk genes for schizophrenia are within two degrees of separation from the N-methy-D-aspartate receptor (NMDAR), a subtype of glutamate receptor that is critical to synapse formation and synaptic plasticity...
  7. Qin H, Dubnau J. Genetic disruptions of Drosophila Pavlovian learning leave extinction learning intact. Genes Brain Behav. 2010;9:203-12 pubmed publisher
    ..We find that extinction is intact in each of these mutants, suggesting that extinction learning relies on different molecular mechanisms than does Pavlovian learning. ..
  8. French R, Heberlein U. Glycogen synthase kinase-3/Shaggy mediates ethanol-induced excitotoxic cell death of Drosophila olfactory neurons. Proc Natl Acad Sci U S A. 2009;106:20924-9 pubmed publisher
    ..Ethanol-induced death of olfactory neurons requires both their neural activity and functional NMDA receptors...
  9. Guven Ozkan T, Davis R. Functional neuroanatomy of Drosophila olfactory memory formation. Learn Mem. 2014;21:519-26 pubmed publisher
    ..Despite this progress, a complete and unified model that details the pathway from acquisition to memory expression remains elusive. ..

More Information


  1. Miyashita T, Oda Y, Horiuchi J, Yin J, Morimoto T, Saitoe M. Mg(2+) block of Drosophila NMDA receptors is required for long-term memory formation and CREB-dependent gene expression. Neuron. 2012;74:887-98 pubmed publisher
    b>NMDA receptor (NMDAR) channels allow Ca(2+) influx only during correlated activation of both pre- and postsynaptic cells; a Mg(2+) block mechanism suppresses NMDAR activity when the postsynaptic cell is inactive...
  2. Tsubouchi A, Caldwell J, Tracey W. Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae. Curr Biol. 2012;22:2124-34 pubmed publisher
    ..RNAi screen of ion channels, we identified Ripped Pocket (rpk), No Mechanoreceptor Potential C (nompC), and NMDA Receptors 1 and 2 (Nmdars) as playing critical roles in both behavioral responses to touch and in the formation of ..
  3. Koenig J, Goto J, Ikeda K. Novel NMDA receptor-specific desensitization/inactivation produced by ingestion of the neurotoxins, β-N-methylamino-L-alanine (BMAA) or β-N-oxalylamino-L-alanine (BOAA/β-ODAP). Comp Biochem Physiol C Toxicol Pharmacol. 2015;167:43-50 pubmed publisher
    ..Furthermore, both BMAA and BOAA cause an NMDAR-specific desensitization in response to repetitive stimulation at the physiological frequency for the postsynaptic ..
  4. Sudhakaran I, Holohan E, Osman S, Rodrigues V, Vijayraghavan K, Ramaswami M. Plasticity of recurrent inhibition in the Drosophila antennal lobe. J Neurosci. 2012;32:7225-31 pubmed publisher
    ..We propose that recurrent inhibitory motifs common in neural circuits may similarly underlie habituation to other complex stimuli. ..
  5. Glanzman D. Associative learning: Hebbian flies. Curr Biol. 2005;15:R416-9 pubmed
    ..New findings indicate that disrupting the expression of N-methyl-D-aspartate (NMDA) receptors in flies impairs olfactory conditioning...
  6. Rothenfluh A, Heberlein U. Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion. Curr Opin Neurobiol. 2002;12:639-45 pubmed
    ..Surprising similarities between flies and mammals have begun to emerge at the behavioral, neurochemical and molecular levels. ..
  7. Acharya J, Jalink K, Hardy R, Hartenstein V, Zuker C. InsP3 receptor is essential for growth and differentiation but not for vision in Drosophila. Neuron. 1997;18:881-7 pubmed
    ..We also generated adult mosaic animals and demonstrate that phototransduction, a model PLC pathway thought to require InsP3R, does not require InsP3R for signaling. ..
  8. Zwarts L, Magwire M, Carbone M, Versteven M, Herteleer L, Anholt R, et al. Complex genetic architecture of Drosophila aggressive behavior. Proc Natl Acad Sci U S A. 2011;108:17070-5 pubmed publisher
  9. Zhou M, Lei Z, Li H, Yi W, Zhang Z, Guo A. NMDA receptors-dependent plasticity in the phototaxis preference behavior induced by visual deprivation in young and adult flies. Genes Brain Behav. 2010;9:325-34 pubmed publisher
    ..Here, we used the genetic approaches to demonstrate that NMDAR1, which is NMDARs subunit in Drosophila, can mediate PPB plasticity in young and adult flies...
  10. Ichinose T, Aso Y, Yamagata N, Abe A, Rubin G, Tanimoto H. Reward signal in a recurrent circuit drives appetitive long-term memory formation. elife. 2015;4:e10719 pubmed publisher
    ..Our results suggest that a reward signal transforms a nascent memory trace into a stable LTM using a feedback circuit at the cost of memory specificity. ..
  11. Zachepilo T, Il inykh Y, Lopatina N, Molotkov D, Popov A, Savvateeva Popova E, et al. Comparative analysis of the locations of the NR1 and NR2 NMDA receptor subunits in honeybee (Apis mellifera) and fruit fly (Drosophila melanogaster, Canton-S wild-type) cerebral ganglia. Neurosci Behav Physiol. 2008;38:369-72 pubmed publisher
    ..The data obtained here lead to the conclusion that the distributions of the NR1 and NR2 subunits of the NMDA receptor complex in the cerebral ganglia of the honeybee and fruit fly are similar; areas with the highest ..
  12. Robinson J, Paluch J, Dickman D, Joiner W. ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity. Nat Commun. 2016;7:10512 pubmed publisher
    ..Specifically, the vesicular glutamate transporter is upregulated, leading to over-activation of NMDA receptors, and the reserve pool of glutamatergic synaptic vesicles is selectively expanded in Adar mutants...
  13. Maiya R, Lee S, Berger K, Kong E, Slawson J, Griffith L, et al. DlgS97/SAP97, a neuronal isoform of discs large, regulates ethanol tolerance. PLoS ONE. 2012;7:e48967 pubmed publisher
    ..Consistent with these observations, flies expressing reduced levels of the essential NMDA receptor subunit dNR1 also showed reduced ethanol tolerance, as did mutants in the gene calcium/calmodulin-dependent ..
  14. Das S, Sadanandappa M, Dervan A, Larkin A, Lee J, Sudhakaran I, et al. Plasticity of local GABAergic interneurons drives olfactory habituation. Proc Natl Acad Sci U S A. 2011;108:E646-54 pubmed publisher
    ..The odorant selectivity of STH and LTH is mirrored by requirement for NMDA receptors and GABA(A) receptors in odorant-selective, glomerulus-specific projection neurons(PNs)...
  15. Sinakevitch I, Grau Y, Strausfeld N, Birman S. Dynamics of glutamatergic signaling in the mushroom body of young adult Drosophila. Neural Dev. 2010;5:10 pubmed publisher
    ..In a Drosophila model of fragile X syndrome, the main cause of inherited mental retardation, treatment with metabotropic Glu receptor (mGluR) antagonists can rescue memory deficits and MB structural defects...
  16. Huang J, Tian L, Peng C, Abdou M, Wen D, Wang Y, et al. DPP-mediated TGFbeta signaling regulates juvenile hormone biosynthesis by activating the expression of juvenile hormone acid methyltransferase. Development. 2011;138:2283-91 pubmed publisher
    ..Reduced dpp expression was detected in larvae mutant for Nmdar1, a CA-expressed glutamate receptor...
  17. Paranjpe P, Rodrigues V, Vijayraghavan K, Ramaswami M. Gustatory habituation in Drosophila relies on rutabaga (adenylate cyclase)-dependent plasticity of GABAergic inhibitory neurons. Learn Mem. 2012;19:627-35 pubmed publisher
    ..The proposed inhibitory potentiation requires glutamate/NMDA-receptor signaling, possibly playing a role in stimulus selectivity...
  18. Hu W, Wang T, Wang X, Han J. Ih channels control feedback regulation from amacrine cells to photoreceptors. PLoS Biol. 2015;13:e1002115 pubmed publisher
    ..These results provide new mechanistic insight into how synaptic feedback regulation can participate in network processing by modulating neural information transfer and circuit excitability. ..
  19. Larkin A, Karak S, Priya R, Das A, Ayyub C, Ito K, et al. Central synaptic mechanisms underlie short-term olfactory habituation in Drosophila larvae. Learn Mem. 2010;17:645-53 pubmed publisher
    ..Our observations suggest a model in which NMDAR-dependent depression of the OSN-PN synapse and/or NMDAR-dependent facilitation of inhibitory transmission from LNs ..
  20. Dylla K, Galili D, Szyszka P, Lüdke A. Trace conditioning in insects-keep the trace!. Front Physiol. 2013;4:67 pubmed publisher
    ..Moreover, we examine proposed molecular and computational models and reassess different experimental approaches used for trace conditioning. ..
  21. Sudhakaran I, Hillebrand J, Dervan A, Das S, Holohan E, H lsmeier J, et al. FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control. Proc Natl Acad Sci U S A. 2014;111:E99-E108 pubmed publisher
    ..Together, these data indicate that dFmr1 and Atx2 function in long-term but not short-term memory, regulating translation of at least some common presynaptic and postsynaptic target mRNAs in the same cells...
  22. Dubnau J, Chiang A, Tully T. Neural substrates of memory: from synapse to system. J Neurobiol. 2003;54:238-53 pubmed
    ..Our objective here is to offer a conceptually unifying perspective and to discuss this perspective in relation to an experiment analysis of memory in Drosophila. ..
  23. Wu C, Xia S, Fu T, Wang H, Chen Y, Leong D, et al. Specific requirement of NMDA receptors for long-term memory consolidation in Drosophila ellipsoid body. Nat Neurosci. 2007;10:1578-86 pubmed
    ..Targeted dsRNA-mediated silencing of Nmdar1 and Nmdar2 (also known as dNR1 or dNR2, respectively) in cholinergic R4m-subtype large-field neurons of the ..
  24. Verma P, Augustine G, Ammar M, Tashiro A, Cohen S. A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity. Nat Neurosci. 2015;18:379-85 pubmed publisher
    ..Drosophila miR-1000 showed activity-dependent expression, which might serve as a mechanism to allow neuronal activity to fine-tune the strength of excitatory synaptic transmission. ..
  25. Chen C, Wu J, Lin H, Pai T, Fu T, Wu C, et al. Visualizing long-term memory formation in two neurons of the Drosophila brain. Science. 2012;335:678-85 pubmed publisher
    ..These findings suggest an extra-MB memory circuit in Drosophila: LTM consolidation (MB to DAL), storage (DAL), and retrieval (DAL to MB)...
  26. Betz H, Schuster C, Ultsch A, Schmitt B. Molecular biology of ionotropic glutamate receptors in Drosophila melanogaster. Trends Pharmacol Sci. 1993;14:428-31 pubmed
  27. Venkiteswaran G, Hasan G. Intracellular Ca2+ signaling and store-operated Ca2+ entry are required in Drosophila neurons for flight. Proc Natl Acad Sci U S A. 2009;106:10326-31 pubmed publisher
    ..Our data show that replenishment of intracellular store Ca(2+) in neurons is required for Drosophila flight. ..
  28. Singh A, Vijayraghavan K, Rodrigues V. Dendritic refinement of an identified neuron in the Drosophila CNS is regulated by neuronal activity and Wnt signaling. Development. 2010;137:1351-60 pubmed publisher
    ..1 results in increased dendritic length. We show that sensory input, possibly acting through NMDA receptors, is necessary for dendritic refinement...
  29. Pai T, Chen C, Lin H, Chin A, Lai J, Lee P, et al. Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation. Proc Natl Acad Sci U S A. 2013;110:7898-903 pubmed publisher
  30. Tomita J, Ueno T, Mitsuyoshi M, Kume S, Kume K. The NMDA Receptor Promotes Sleep in the Fruit Fly, Drosophila melanogaster. PLoS ONE. 2015;10:e0128101 pubmed publisher
    ..The NMDA receptor (NMDAR) plays an important role in learning and memory both in Drosophila and mammals...
  31. Kolodziejczyk A, Sun X, Meinertzhagen I, Nassel D. Glutamate, GABA and acetylcholine signaling components in the lamina of the Drosophila visual system. PLoS ONE. 2008;3:e2110 pubmed publisher
    ..In summary, this paper describes novel features of two distinct types of tangential neurons in the Drosophila lamina and assigns putative neurotransmitters and some receptors to a few identified neuron types. ..
  32. Tamura T, Sone M, Nakamura Y, Shimamura T, Imoto S, Miyano S, et al. A restricted level of PQBP1 is needed for the best longevity of Drosophila. Neurobiol Aging. 2013;34:356.e11-20 pubmed publisher
    ..Collectively, given that dPQBP1 affects multiple pathways in different dose-dependent and tissue-specific manners, dPQBP1 at a restricted expression level is needed for the best longevity. ..
  33. Naganos S, Ueno K, Horiuchi J, Saitoe M. Learning defects in Drosophila growth restricted chico mutants are caused by attenuated adenylyl cyclase activity. Mol Brain. 2016;9:37 pubmed publisher
    ..Our results suggest that some cognitive defects associated with reduced IIS may occur, independently of developmental defects, from acute reductions in cAMP signaling. ..