Gene Symbol: Nlg2
Description: Neuroligin 2
Alias: CG13772, DNlg2, Dmel\CG13772, dnl2, dnlg2, neuroligin, nl2, nlg2, neuroligin 2, CG13772-PA, CG13772-PB, CG13772-PC, Nlg2-PA, Nlg2-PB, Nlg2-PC, neuroligin
Species: fruit fly

Top Publications

  1. Banovic D, Khorramshahi O, Owald D, Wichmann C, Riedt T, Fouquet W, et al. Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions. Neuron. 2010;66:724-38 pubmed publisher
    ..In a genetic screen, we recovered several mutant alleles of Drosophila neuroligin 1 (dnlg1) that cause a severe reduction in bouton numbers at neuromuscular junctions (NMJs)...
  2. Stark A, Kheradpour P, Parts L, Brennecke J, Hodges E, Hannon G, et al. Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes. Genome Res. 2007;17:1865-79 pubmed
    ..For mir-10 in particular, both arms show abundant processing, and both show highly conserved target sites in Hox genes, suggesting a possible cooperation of the two arms, and their role as a master Hox regulator. ..
  3. Sun M, Xing G, Yuan L, Gan G, Knight D, With S, et al. Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction. J Neurosci. 2011;31:687-99 pubmed publisher
    ..In the present study, we have analyzed the function of Drosophila neuroligin 2 (dnl2) in synaptic development and function...
  4. Li Y, Zhou Z, Zhang X, Tong H, Li P, Zhang Z, et al. Drosophila neuroligin 4 regulates sleep through modulating GABA transmission. J Neurosci. 2013;33:15545-54 pubmed publisher
    ..These results demonstrate that DNlg4 regulates sleep through modulating GABA transmission in l-LNvs, which provides the first known link between a synaptic adhesion molecule and sleep in Drosophila. ..
  5. Qian J, Tu R, Yuan L, Xie W. Intronic miR-932 targets the coding region of its host gene, Drosophila neuroligin2. Exp Cell Res. 2016;344:183-93 pubmed publisher
    ..The conserved miR-932 is embedded in the fourth intron of Drosophila neuroligin2 (dnlg2), which encodes a synaptic cell adhesion molecule, DNlg2...
  6. Chen Y, Lin Y, Banerjee S, Venken K, Li J, Ismat A, et al. Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission. J Neurosci. 2012;32:16018-30 pubmed publisher
    ..Here we report the generation and phenotypic characterization of Drosophila neuroligin 2 (dnlg2) mutants...
  7. Hahn N, Geurten B, Gurvich A, Piepenbrock D, Kastner A, Zanini D, et al. Monogenic heritable autism gene neuroligin impacts Drosophila social behaviour. Behav Brain Res. 2013;252:450-7 pubmed publisher
    ..Among these are the neuroligin genes which code for postsynaptic cell adhesion molecules that induce the formation of presynapses, promote ..
  8. Mosca T, Hong W, Dani V, Favaloro V, Luo L. Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choice. Nature. 2012;484:237-41 pubmed publisher
    ..Supporting this, Ten-m physically interacts with ?-Spectrin. Genetic analyses of teneurin and neuroligin reveal that they have differential roles that synergize to promote synapse assembly...
  9. Logan M, Hackett R, Doherty J, Sheehan A, Speese S, Freeman M. Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury. Nat Neurosci. 2012;15:722-30 pubmed publisher

More Information


  1. Tu R, Qian J, Rui M, Tao N, Sun M, Zhuang Y, et al. Proteolytic cleavage is required for functional neuroligin 2 maturation and trafficking in Drosophila. J Mol Cell Biol. 2017;9:231-242 pubmed publisher
    ..Here, we found that Drosophila neuroligin 2 (DNlg2) undergoes proteolytic cleavage in the ER in a variety of Drosophila tissues throughout developmental ..