Gene Symbol: ninaB
Description: neither inactivation nor afterpotential B
Alias: CG9347, DRPE65, Dmel\CG9347, RPE65, anon-WO0148162.1, anon-WO0148163.1, beta-diox, neither inactivation nor afterpotential B, CG9347-PA, beta-carotene dioxygenase, ninaB-PA
Species: fruit fly

Top Publications

  1. von Lintig J, Vogt K. Filling the gap in vitamin A research. Molecular identification of an enzyme cleaving beta-carotene to retinal. J Biol Chem. 2000;275:11915-20 pubmed
    ..The carotene-cleaving enzyme, identified here for the first time on the molecular level, is the basis of the numerous branches of vitamin A action and links plant and animal carotene metabolism. ..
  2. von Lintig J, Dreher A, Kiefer C, Wernet M, Vogt K. Analysis of the blind Drosophila mutant ninaB identifies the gene encoding the key enzyme for vitamin A formation invivo. Proc Natl Acad Sci U S A. 2001;98:1130-5 pubmed
    ..To prove its identity with the key enzyme for vitamin A formation in vivo, we analyzed the blind Drosophila mutant ninaB. In two independent ninaB alleles, we found mutations in the gene encoding the beta,beta-carotene-15,15'-..
  3. Gu G, Yang J, Mitchell K, O Tousa J. Drosophila ninaB and ninaD act outside of retina to produce rhodopsin chromophore. J Biol Chem. 2004;279:18608-13 pubmed
    The Drosophila ninaB gene encodes a beta,beta-carotene-15,15'-oxygenase responsible for the centric cleavage of beta-carotene that produces the retinal chromophore of rhodopsin...
  4. Wang T, Montell C. Rhodopsin formation in Drosophila is dependent on the PINTA retinoid-binding protein. J Neurosci. 2005;25:5187-94 pubmed
    ..Moreover, our data implicate Drosophila retinal pigment cells as functioning in the conversion of dietary all-trans-retinol to 11-cis-retinal and suggest that these cells are the closest invertebrate equivalent to the RPE. ..
  5. Krstic D, Boll W, Noll M. Sensory integration regulating male courtship behavior in Drosophila. PLoS ONE. 2009;4:e4457 pubmed publisher
    ..The model will complement studies on the connectivity and intrinsic properties of the neurons forming the circuitry that regulates male courtship behavior. ..
  6. Stephenson R, O TOUSA J, Scavarda N, Randall L, Pak W. Drosophila mutants with reduced rhodopsin content. Symp Soc Exp Biol. 1983;36:477-501 pubmed
  7. Smith D, Shieh B, Zuker C. Isolation and structure of an arrestin gene from Drosophila. Proc Natl Acad Sci U S A. 1990;87:1003-7 pubmed
    ..However, the arrestin gene does not appear to be the ninaD locus, as sequence analysis of three ethylmethane sulfate-induced ninaD mutant alleles reveals no alteration in amino acid sequence. ..
  8. Zuker C. The biology of vision of Drosophila. Proc Natl Acad Sci U S A. 1996;93:571-6 pubmed
    ..In this manuscript I review some of our recent findings and the strategies used to dissect this process. ..
  9. Ramin M, Domocos C, Slawaska Eng D, Rao Y. Aggression and social experience: genetic analysis of visual circuit activity in the control of aggressiveness in Drosophila. Mol Brain. 2014;7:55 pubmed publisher
    ..In wild type, group housing greatly suppresses aggressiveness. Loss of vision by mutating the ninaB gene does not affect social suppression of fly aggression...

More Information


  1. Halme A, Cheng M, Hariharan I. Retinoids regulate a developmental checkpoint for tissue regeneration in Drosophila. Curr Biol. 2010;20:458-63 pubmed publisher
    ..Our findings demonstrate that retinoid biosynthesis in Drosophila is important for the maintenance of a condition that is permissive for regenerative growth. ..
  2. Ranganathan R, Harris W, Zuker C. The molecular genetics of invertebrate phototransduction. Trends Neurosci. 1991;14:486-93 pubmed
    ..The results of a combination of molecular, genetic, physiological and biochemical studies are beginning to produce a clearer model for the complex mechanisms involved in invertebrate visual transduction. ..
  3. Selinger Z, Doza Y, Minke B. Mechanisms and genetics of photoreceptors desensitization in Drosophila flies. Biochim Biophys Acta. 1993;1179:283-99 pubmed
  4. Krstic D, Boll W, Noll M. Influence of the White locus on the courtship behavior of Drosophila males. PLoS ONE. 2013;8:e77904 pubmed publisher
    ..Implications of these findings for the proper interpretation of behavioral studies with white mutant flies are discussed. ..
  5. Kim W, Jan L, Jan Y. Contribution of visual and circadian neural circuits to memory for prolonged mating induced by rivals. Nat Neurosci. 2012;15:876-83 pubmed publisher
    ..Our study thus delineates parts of the molecular and cellular basis for LMD, a plastic social behavior elicited by visual cues. ..
  6. Peschel N, Veleri S, Stanewsky R. Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock. Proc Natl Acad Sci U S A. 2006;103:17313-8 pubmed
  7. Kacsoh B, Lynch Z, Mortimer N, Schlenke T. Fruit flies medicate offspring after seeing parasites. Science. 2013;339:947-50 pubmed publisher
    ..Our data reveal a behavioral immune response based on anticipatory medication of offspring and outline a nonassociative memory paradigm based on innate parasite recognition by the host. ..
  8. Voolstra O, Oberhauser V, Sumser E, Meyer N, Maguire M, Huber A, et al. NinaB is essential for Drosophila vision but induces retinal degeneration in opsin-deficient photoreceptors. J Biol Chem. 2010;285:2130-9 pubmed publisher
    ..related enzymes, the carotenoid oxygenase beta-carotenoid-15,15'-monooxygenase and the retinoid isomerase RPE65 (retinal pigment epithelium protein of 65 kDa)...
  9. Oberhauser V, Voolstra O, Bangert A, von Lintig J, Vogt K. NinaB combines carotenoid oxygenase and retinoid isomerase activity in a single polypeptide. Proc Natl Acad Sci U S A. 2008;105:19000-5 pubmed publisher
    ..Evidence from cell culture systems has implicated that the retinal pigment epithelium protein of 65 kDa (RPE65) is the long-sought all-trans to 11-cis retinoid isomerase...
  10. Wang T, Jiao Y, Montell C. Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction. J Cell Biol. 2007;177:305-16 pubmed
    ..The protein is coexpressed and functionally coupled with the beta, beta-carotene-15, 15'-monooxygenase, NINAB, which converts beta-carotene to all-trans-retinal...
  11. Yang J, O Tousa J. Cellular sites of Drosophila NinaB and NinaD activity in vitamin A metabolism. Mol Cell Neurosci. 2007;35:49-56 pubmed
    The Drosophila genes ninaB and ninaD, encoding a beta-carotene oxygenase and a type B scavenger receptor respectively, are essential for the biosynthesis of the 3-hydroxyretinal chromophore of rhodopsin...
  12. Zuker C. Phototransduction in Drosophila: a paradigm for the genetic dissection of sensory transduction cascades. Curr Opin Neurobiol. 1992;2:622-7 pubmed
    ..The availability of Drosophila mutants with defects in visual physiology allows for an in vivo dissection of this complex sensory signal transduction process. ..
  13. Meyer N, Joel Almagor T, Frechter S, Minke B, Huber A. Subcellular translocation of the eGFP-tagged TRPL channel in Drosophila photoreceptors requires activation of the phototransduction cascade. J Cell Sci. 2006;119:2592-603 pubmed
    ..The critical role of Ca2+ influx was directly demonstrated when the light-induced TRPL-eGFP translocation was blocked by removing extracellular Ca2+. ..
  14. Kacsoh B, Bozler J, Ramaswami M, Bosco G. Social communication of predator-induced changes in Drosophila behavior and germ line physiology. elife. 2015;4: pubmed publisher
    ..The ability to teach does not require ovarian apoptosis. This work provides new insight into genetic and physiological mechanisms that underlie an ecologically relevant form of learning and mechanisms for its social transmission. ..