NimC1

Summary

Gene Symbol: NimC1
Description: Nimrod C1
Alias: BG:DS00180.10, CG8942, CT25688, Dmel\CG8942, Nim, NimC, nimC1, nimrod, nimrod C1, CG8942-PA, CG8942-PB, CG8942-PC, NimC1-PA, NimC1-PB, NimC1-PC, NimrodC1, nimrod
Species: fruit fly

Top Publications

  1. Kocks C, Cho J, Nehme N, Ulvila J, Pearson A, Meister M, et al. Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Cell. 2005;123:335-46 pubmed
    ..Our results suggest that Eater is a major phagocytic receptor for a broad range of bacterial pathogens in Drosophila and provide a powerful model to address the role of phagocytosis in vivo. ..
  2. Kurucz E, Márkus R, Zsámboki J, Folkl Medzihradszky K, Darula Z, Vilmos P, et al. Nimrod, a putative phagocytosis receptor with EGF repeats in Drosophila plasmatocytes. Curr Biol. 2007;17:649-54 pubmed
    ..On the surface of circulating and sessile plasmatocytes, we have now identified a protein, Nimrod C1 (NimC1), which is involved in the phagocytosis of bacteria...
  3. Charroux B, Royet J. Elimination of plasmatocytes by targeted apoptosis reveals their role in multiple aspects of the Drosophila immune response. Proc Natl Acad Sci U S A. 2009;106:9797-802 pubmed publisher
    ..Finally, we show that plasmatocytes are involved in immune surveillance during pupal development, because they prevent bacterial infection that causes pupal lethality...
  4. Márkus R, Laurinyecz B, Kurucz E, Honti V, Bajusz I, Sipos B, et al. Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2009;106:4805-9 pubmed publisher
    ..We set out to analyze this phenomenon systematically. As a result, we define the sessile hemocytes as a novel hematopoietic compartment, and the main source of lamellocytes. ..
  5. Anderl I, Vesala L, Ihalainen T, Vanha aho L, Ando I, Ramet M, et al. Transdifferentiation and Proliferation in Two Distinct Hemocyte Lineages in Drosophila melanogaster Larvae after Wasp Infection. PLoS Pathog. 2016;12:e1005746 pubmed publisher
    ..Our data indicate that lamellocyte differentiation upon wasp parasitism is a plastic and dynamic process. Flow cytometry with in vivo hemocyte reporters can be used to study this phenomenon in detail. ..
  6. Parra G, Blanco E, Guigo R. GeneID in Drosophila. Genome Res. 2000;10:511-5 pubmed
    ..These results show that the accuracy of GeneID predictions compares currently with that of other existing tools but that GeneID is likely to be more efficient in terms of speed and memory usage. ..
  7. Horn L, Leips J, Starz Gaiano M. Phagocytic ability declines with age in adult Drosophila hemocytes. Aging Cell. 2014;13:719-28 pubmed publisher
    ..Our results have broad implications for understanding how the breakdown in cellular processes influences immune function with age. ..
  8. Benmimoun B, Polesello C, Waltzer L, Haenlin M. Dual role for Insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila. Development. 2012;139:1713-7 pubmed publisher
    ..Hence, our study highlights the role of the IIS/TOR pathways in orchestrating hematopoietic progenitor fate and links blood cell fate to nutritional status. ..
  9. Bras S, Martin Lannerée S, Gobert V, Augé B, Breig O, Sanial M, et al. Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis. Proc Natl Acad Sci U S A. 2012;109:4986-91 pubmed publisher
    ..Thus, we propose that the regulation of RUNX protein levels is a conserved feature of MLF family members that could be critical for normal and pathological blood cell development. ..

More Information

Publications24

  1. Hyrsl P, Dobes P, Wang Z, Hauling T, Wilhelmsson C, Theopold U. Clotting factors and eicosanoids protect against nematode infections. J Innate Immun. 2011;3:65-70 pubmed publisher
    ..We also provide biochemical and genetic evidence for an involvement of eicosanoids in the same infection model. Taken together, our results confirm the conserved nature of the immune function of clot formation...
  2. Cordero J, Macagno J, Stefanatos R, Strathdee K, Cagan R, Vidal M. Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. Dev Cell. 2010;18:999-1011 pubmed publisher
    ..Our evidence suggests that tumors can evolve into malignancy through oncogenic Ras activation and the hijacking of TNF signaling. ..
  3. Honti V, Csordás G, Márkus R, Kurucz E, Jankovics F, Ando I. Cell lineage tracing reveals the plasticity of the hemocyte lineages and of the hematopoietic compartments in Drosophila melanogaster. Mol Immunol. 2010;47:1997-2004 pubmed publisher
  4. Schirling C, Heseding C, Heise F, Kesper D, Klebes A, Klein Hitpass L, et al. Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60. Chromosoma. 2010;119:99-113 pubmed publisher
  5. Hashimoto Y, Tabuchi Y, Sakurai K, Kutsuna M, Kurokawa K, Awasaki T, et al. Identification of lipoteichoic acid as a ligand for draper in the phagocytosis of Staphylococcus aureus by Drosophila hemocytes. J Immunol. 2009;183:7451-60 pubmed publisher
    ..ltaS-dependent phagocytosis of S. aureus required the receptor Draper but not Eater or Nimrod C1, and Draper-lacking flies showed reduced resistance to a septic infection of S...
  6. Honti V, Cinege G, Csordás G, Kurucz E, Zsámboki J, Evans C, et al. Variation of NimC1 expression in Drosophila stocks and transgenic strains. Fly (Austin). 2013;7:263-6 pubmed publisher
    The NimC1 molecule has been described as a phagocytosis receptor, and is being used as a marker for professional phagocytes, the plasmatocytes, in Drosophila melanogaster...
  7. Somogyi K, Sipos B, Penzes Z, Kurucz E, Zsámboki J, Hultmark D, et al. Evolution of genes and repeats in the Nimrod superfamily. Mol Biol Evol. 2008;25:2337-47 pubmed publisher
    The recently identified Nimrod superfamily is characterized by the presence of a special type of EGF repeat, the NIM repeat, located right after a typical CCXGY/W amino acid motif...
  8. Woodcock K, Kierdorf K, Pouchelon C, Vivancos V, Dionne M, Geissmann F. Macrophage-derived upd3 cytokine causes impaired glucose homeostasis and reduced lifespan in Drosophila fed a lipid-rich diet. Immunity. 2015;42:133-44 pubmed
  9. Bernard F, Krejci A, Housden B, Adryan B, Bray S. Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors. Development. 2010;137:2633-42 pubmed publisher
  10. Somogyi K, Sipos B, Penzes Z, Ando I. A conserved gene cluster as a putative functional unit in insect innate immunity. FEBS Lett. 2010;584:4375-8 pubmed publisher
    The Nimrod gene superfamily is an important component of the innate immune response...
  11. Ye Y, Chenoweth S, McGraw E. Effective but costly, evolved mechanisms of defense against a virulent opportunistic pathogen in Drosophila melanogaster. PLoS Pathog. 2009;5:e1000385 pubmed publisher
    ..aeruginosa infection than previously reported. This work reveals novel pathways by which Drosophila can survive infection with a virulent pathogen that may be rare in wild populations, however, due to their cost. ..
  12. Pastor Pareja J, Wu M, Xu T. An innate immune response of blood cells to tumors and tissue damage in Drosophila. Dis Model Mech. 2008;1:144-54; discussion 153 pubmed publisher
    ..Our findings reveal common mechanisms in the response to tumors and wounds in flies. A similar innate reaction may underlie the response to tumors and tissue damage in vertebrates and humans. ..
  13. Shravage B, Hill J, Powers C, Wu L, Baehrecke E. Atg6 is required for multiple vesicle trafficking pathways and hematopoiesis in Drosophila. Development. 2013;140:1321-9 pubmed publisher
    ..Thus, like mammals, altered Atg6 function in flies causes hematopoietic abnormalities and lethality, and our data indicate that this is due to defects in multiple membrane trafficking processes. ..
  14. Khadilkar R, Rodrigues D, Mote R, Sinha A, Kulkarni V, Magadi S, et al. ARF1-GTP regulates Asrij to provide endocytic control of Drosophila blood cell homeostasis. Proc Natl Acad Sci U S A. 2014;111:4898-903 pubmed publisher
    ..We propose that the conserved ARF1-Asrij endocytic axis modulates signals that govern hematopoietic development. Thus, Asrij affords tissue-specific control of global mechanisms involved in molecular traffic. ..
  15. Tolhuis B, de Wit E, Muijrers I, Teunissen H, Talhout W, van Steensel B, et al. Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster. Nat Genet. 2006;38:694-9 pubmed
    ..These results highlight the extensive involvement of PcG proteins in the coordination of development through the formation of large repressive chromatin domains. ..